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Hwangryunhaedoktang exerts anti-inflammation on LPS-induced NO production by suppressing MAPK and NF-κB activation in RAW264.7 macrophages

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Journal of Integrative Medicine 2017年第4期15卷 326-336页

作者： Byung Hyuk Han Yun jung Lee jung Joo Yoon Eun Sik Choi seung Namgung Xian Jun Jin Da hye Jeong Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Body-fluid Research Center Wonkwang University

OBJECTIVE： This study aimed to evaluate whether Hwangryunhaedoktang （HHT）, a herbal compound, has an inhibitory effect on lipopolysaccharide （LPS）-induced inflammation in RAW264.7 macrophages. METHODS： The effects of HHT were evaluated by confirming nitric oxide （NO） production and expression of inducible NO synthase （iNOS） and mitogen-activated protein kinases （MAPKs） in LPS-stimulated RAW264.7 macrophages via the Griess assay, Western blotting, and real-time reverse transcription quantitative polymerase chain reaction. Western blot analyses and luciferase assays were used to evaluate whether HHT has an effect on the phosphorylation and translocation of nuclear factor-κB （NF-κB）. The secretion and expression of tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） were determined via enzyme-linked immunosorbent assay and Western blot analyses. RESULTS： HHT suppressed LPS-induced NO production and expression of iNOS in a dose-dependent manner. Additionally, MAPKs activation was also attenuated via inhibition of phosphorylation of extracellular signal-regulated kinases 1/2, c-Jun N-terminal kinase and p38 which were related to inflammatory pathway. Furthermore, HHT also effectively attenuated NF-κB activation and its translocation to the nucleus, a process that is closely linked to inflammation. LPS normally induced the expression of inflammatory cytokines such as TNF-α and IL-6, but the secretion and expression of TNF-α and IL-6 were significantly attenuated by pretreating the cells with HHT. CONCLUSION： HHT suppressed LPS-induced NO production by blocking the activation of NF-κB and MAPK signaling pathways in RAW264.7 macrophages. Furthermore, HHT may have an anti-inflammatory effect by suppressing the LPS-induced secretion of TNF-α and IL-6. Therefore, the traditional herbal formula HHT might be a useful potential therapeutic agent for inflammation.

关键词： medicine, Chinese traditional lipopolysaccharide nitric oxide nuclear factor-κB mitogen-activatedprotein kinases tumor necrosis factor-a inflammation

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Involvement of heme oxygenase-1 induction in anti-vascular inflammation effects of Xanthoceras sorbifolia in human umbilical vein endothelial cells

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Journal of Traditional Chinese Medicine 2018年第6期38卷 803-814页

作者： jung Joo Yoon Byung Hyuk Han Eun Sik Choi seung Namgung Da hye Jeong Song Nan Jin Yun jung Lee Dae Gill Kang Ho Sub Lee College of Oriental Medicine and Professional Graduate School of Oriental Medicine Wonkwang University Hanbang Cardio-Renal Syndrome Research Center Wonkwang University Institute of Materia Medica Taishan Medical University

OBJECTIVE: To define the effects of Xanthoceras sorbifolia(EXS) on vascular inflammation and the mechanisms in endothelial ***: Vascular protective effects of an ethanol extract of seeds from EXS(1-50 μg/mL) against tumor necrosis factor-α(TNF-α)-induced vascularinflammation were examined in human umbilical vein endothelial cells(HUVECs).RESULTS: EXS significantly decreased TNF-α-induced expression of cell adhesion molecules, such as intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial cell selectin,in a dose-dependent manner. Pre-treatment with EXS significantly inhibited translocation and transcriptional activity of nuclear factor-κB(NF-κB) increased by TNF-α. EXS also significantly inhibited formation of intracellular reactive oxygen species(ROS). Moreover, the vascular protective effects of EXS were linked to up-regulation of heme oxygenase-1(HO-1) and nuclear factor E2-related factor-2(Nrf-2) expression. EXS-induced HO-1 expression was significantly decreased in SnPP(HO-1 inhibitor)-and HO-1 siRNA-treated cells, whereas an increase was found in cobalt protoporphyrin IX(CoPP)(HO-1 inducer)-treated cells. In addition, pretreatment with EXS increased HO-1 and Nrf-2 expression under TNF-α stimulation with or without N-acetyl-L-cysteine. Furthermore, the inhibitory effects of EXS on TNF-α-induced vascular inflammation were partially reversed in SnPP-and of HO-1siRNA-treated cells but increased by ***: These results suggest that EXS may have important implications for prevention of vascular complications associated with vascular inflammation by inhibition of the NF-κB/ROS pathway and activation of the Nrf-2/HO-1 pathway.

关键词： Sapindaceae Vascular disease inflammation Human umbilical vein endothelial cells Cell adhesion molecules NF-kappa B Heme oxy-genase-1

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The Effect of Fabrication Conditions for GDC Buffer Layer on Electrochemical Performance of Solid Oxide Fuel Cells

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Nano-Micro Letters 2013年第3期5卷 151-158页

作者： jung-Hoon Song Myung Geun jung hye Won Park Hyung-Tae Lim Fuel Cell Project Research Institute of Industrial Science and Technology (RIST) School of Nano & Advanced Materials Engineering Changwon National University

A Gd-doped ceria（GDC） buffer layer is required between a conventional yttria-stabilized zirconia（YSZ） electrolyte and a La-Sr-Co-Fe-O3（LSCF） cathode to prevent their chemical reaction. In this study,the effect of varying the conditions for fabricating the GDC buffer layer, such as sintering temperature and amount of sintering aid, on the solid oxide fuel cell（SOFC） performance was investigated. A finer GDC powder（i.e., ultra-high surface area）, a higher sintering temperature（1290℃）, and a larger amount of sintering aid（12%） resulted in improved densification of the buffer layer; however, the electrochemical performance of an anode-supported cell containing this GDC buffer layer was poor. These conflicting results are attributed to the formation of（Zr, Ce）O2 and/or excess cobalt grain boundaries（GBs） at higher sintering temperatures with a large amount of sintering aid（i.e., cobalt oxide）. A cell comprising of a cobalt-free GDC buffer layer, which was fabricated using a low-temperature process, had lower cell resistance and higher stability. The results indicate that electrochemical performance and stability of SOFCs strongly depend on fabrication conditions for the GDC buffer layer.

关键词： Solid oxide fuel cell(SOFC) Gd-doped ceria Sintering aid Sol-gel spin coating

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Stick-and-play system based on interfacial adhesion control enhanced by micro/nanostructures

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Nano Research 2021年第9期14卷 3143-3158页

作者： jung II Yoo seung Hyun Kim Heung Cho Ko School of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)Gwangju 61005Republic of Korea

The evolution of membrane-type electronics has facilitated the development of stick-and-play systems,which confer diverse electrical functions to various planar or arbitrary curvilinear *** stick-and-play concept is based on the development of thin electronic devices in a printable format and their subsequent transfer to target *** development of this technology requires control of the interfacial adhesion of the electronic prints for retrieval from a carrier and transfer to the target ***,we discuss the transfer printing for membrane-type electronics,starting from an overview of materials available for flexible substrates,transfer printing of electronic prints for retrieval,and assembly for further ***,we explain the stick-and-play concept based on fabricated membrane-type electronics;"stick" and “play"refer to the transfer of electronic devices and the performance of their electronic functions,*** particular,we broadly survey various methods based on micro/nanostructures,including gecko-inspired,interlocking,cephalopod-sucker-inspired,and cilia structures,which can be employed to stick-and-play systems for enhancing interfacial adhesion with complex target surfaces under dynamic and wet ***,we highlight the stick-and-play system application of micro/nanostructures for skin-attachable biomedical electronics,e-textiles,and environmental monitoring electronics.

关键词： transfer printing interfacial adhesion flexible electronics stick-and-play system bioinspired adhesive

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Suicide risk in juvenile open angle glaucoma patients

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1880-1886页

作者： hye-Jeong Seong Sukyoung jung Sooyeon Choe Department of Ophthalmology Chungnam National University HospitalDaejeon 35015Republic of Korea Department of Ophthalmology Chungnam National University College of MedicineDaejeon 35015Republic of Korea Department of Health Care Policy Research Korea Institute for Health and Social AffairsSejong 30147Republic of Korea

AIM:To investigate the association between juvenile open angle glaucoma(JOAG)and mental health among ***:This study used nationally representative data from the 8th Korea National Health and Nutrition Examination Survey(KNHANES)*** diagnosis followed the International Society of Geographical and Epidemiological Ophthalmology criteria based on glaucomatous structural defects,visual field defects,corrected vision,and intraocular *** outcomes,suicidal behaviors,psychiatric counseling,and depression were evaluated through mental health *** ratios(ORs)with 95%confidence intervals(CIs)were estimated using logistic regression models,adjusting for ***:Among 7090 participants,3446 met the inclusion criteria for analysis,and 88(2.6%)were diagnosed with open angle glaucoma(OAG).After adjusting for age,sex,and best-corrected visual acuity(VA),participants with OAG were revealed to have significantly higher odds of suicidal behaviors(i.e.,ideation,planning,or attempts)compared with those without OAG(OR:2.70;95%CI:1.12-6.54;P=0.028).This association remained significant after further adjustments for socioeconomic status,lifestyle factors,and presence of chronic conditions(P=0.031 and 0.035,respectively).However,there was no significant difference for the other two outcomes,psychiatric counseling and *** age-stratified analysis revealed a stronger association between OAG and suicidal behaviors in younger JOAG participants(<40y)than in older OAG participants(≥40y;OR:3.80 vs 2.22;95%CI:0.79-18.22 vs 0.56-8.80,respectively).CONCLUSION:OAG patients show a higher risk of suicidal behaviors than those without glaucoma particularly in JOAG patients.

关键词： glaucoma juvenile open angle glaucoma suicide suicidal behavior

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Environmental friendly synthesis of hierarchical mesoporous platinum nanoparticles templated by fucoidan biopolymer for enhanced hydrogen evolution reaction

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Journal of Materials Science & Technology 2020年第11期42卷 185-190页

作者： seung Man Lim Kyunglee Kang Hongje Jang jung Tae Park Department of Chemical Engineering Konkuk University120 Neungdong-roGwangjin-guSeoul 05029Republic of Korea Department of Chemistry Kwangwoon University20 Cwangwoon-roNowon-guSeoul 01897Republic of Korea

Researching novel hydrogen evolution reaction(HER)catalysts with enhanced electrocatalytic activity,excellent stability,and cost-efficiency is of great significance for the large-scale hydrogen production from industrial electrolysis *** report the preparation of hierarchical mesoporous-Pt nanoparticles(HM-Pt NPs)with coral-like rough surface morphologies using environmental friendly and biocompatible fucoidan(Fu)biopolymer as a surface engineering compound and its application to electrocatalysts for *** designed HM-Pt NPs yields better mass activity of electrocatalysts compared to a commercial Pt/***-Pt NPs showed an overpotential of 33 mV at 10 mA cm-2 for the HER in 0.5 MH2SO4,which was highly comparable to that of the commercial Pt/C catalysts(29 mV).However,the amount of HM-Pt NPs loaded in glassy carbon electrode(0.033 mg mL-1)was approximately 20 times lower than that of the commercial Pt/C(0.64 mg *** HM-Pt NPs also maintained high catalytic stability with a consistent HER current density after 1000 continuous *** excellent HER performance is attributed to the improved electrochemical surface area,highly porous structure,and good surface wettability of the HM-Pt NPs,which results in enhanced electrocatalytic activity,decreased resistance at the electrode/electrolyte interface,and facile penetration of the electrolytes inside the electrode.

关键词： Mesoporous Fucoidan Biopolymer Low Pt content Hydrogen evolution reaction

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SMARCA4-deficient undifferentiated thoracic tumor:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2521-2527页

作者： Hee jung Kwon Min hye Jang Department of Pathology Yeungnam University Medical CenterDaegu 42415South Korea

BACKGROUND SMARCA4-deficient undifferentiated tumors(SMARCA4-DUTs)present with diverse clinical manifestations and progress to metastasis and even cause death within a few *** novel subset of undifferentiated tumors occurs in the middle-aged population and is strongly associated with a smoking ***-guishing it from other malignancies is *** SUMMARY A 62-year-old man presented with chest pain for 7 *** patient had no respiratory symptoms and normal pulmonary function test *** patient had been a smoker for 8 years and quit smoking 2 years *** computed tomography revealed a huge mass involving the left upper and lower lung lobes with pericardial invasion and multiple *** samples were obtained using open frozen biopsy,after several unsuccessful *** tumor was composed of sheets of undifferentiated disclosive cells with vesicular nuclei and prominent *** differential diagnosis included high-grade lymphoma,germ cell tumor,NUT carcinoma,undifferentiated carcinoma,and *** tumor cells were large,arranged in sheets,and did not exhibit glandular or squamous *** foci of necrosis were *** was no evidence of epithelial differentiation on immunohistochemical *** SMARCA4 stain showed complete loss of expression of SMARCA4,which is *** In the present case,thoracic SMARCA4-DUT was diagnosed based on clinical features,absence of epithelial differentiation,and negative SMARCA4 expression.

关键词： SMARCA4 BRG1 Deficient Undifferentiated tumor Thoracic Case report

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Materialization of strained CVD-graphene using thermal mismatch

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Nano Research 2015年第6期8卷 2082-2091页

作者： seung-Mo Lee Sang-Min Kim Min Young Na hye jung Chang Kwang-Seop Kim Hyunung Yu Hak-Joo Lee Jae-Hyun Kim Nano-Convergence Mechanical Systems Research Division Korea Institute of Machinery & Materials (KIMM) 156 Gajungbuk-ro Yuseong-gu Daejeon 305-343 Republic of Korea Nano Mechatronics University of Science and Technology (UST) 217 Gajeong-ro Yuseong-gu Daejeon 305-333 Republic of Korea Graduate School of Energy Environment Water and Sustainability Korea Advanced Institute of Science & Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Materials Science and Engineering Yonsei University SO Yonsei-ro Seodaemun-gu Seou1120-749 Republic of Korea Advanced Analysis Center Korea Institute of Science and Technology (KIST) Hwarang-ro 14-gil 5 Seongbuk-gu Seoul 130-791 Republic of Korea Korea Research Institute of Standards and Science (KRISS) 267 Gajeong-ro Yuseong-gu Daejeon 305-343 Republic of Korea

Theoretical physics foretells that ＂strain engineering＂ of graphene could hold the key to finding treasures still hidden in two-dimensional （2D） condensed matter physics and commercializing graphene-based devices. However, to produce strained graphene in large quantities is not an easy task by any means. Here, we demonstrate that thermal annealing of graphene placed on various substrates could be a surprisingly simple method for preparing strained graphene with a large area. We found that enhanced graphene-substrate interfacial adhesion plays a critical role in developing strained graphene. Creative device architectures that consider the thermal mismatch between graphene and the target substrate could enable the resulting strain to be intentionally tailored. We believe that our proposed method could suggest a shortcut to realization of graphene straintronics.

关键词： graphene strain engineering thermal mismatch strained graphene

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Fabrication and characterization of Ag flake hybrid circuits with IPL-sintering

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Journal of Materials Science & Technology 2020年第18期52卷 13-18页

作者： Choong-Jae Lee Kwang-Ho jung Kyung Deuk Min Bum-Geun Park seung-Boo jung School of Advanced Materials Science Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-si16419Republic of Korea Visual Display Business Samsung Electronics Co.Ltd.129Samsung-roYeongtong-guSuwon-si16677Republic of Korea

The study of photonic sintering has gained interest based on the advantages of fast processing at room ***,printed electronics made from photonic sintering with an intensive pulsed light(IPL)energy source exhibit more mechanical instability than those made from conventional thermal sintering *** solve the mechanical instability problems,we fabricated Ag flake hybrid pastes with a variety of concentrations of Ag flake(0,25,50,75,and 100 wt.%).All of the screen-printed hybrid Ag circuits were fabricated on polyimide substrates and were sintered at 3.5 *** porosity was analyzed using the Brunauer-Emmett-Teller *** IPC(Packaging Electronic Circuits)sliding test was performed to analyze the flexibility of the screen-printed Ag flake hybrid *** adhesion strength of the hybrid circuits was evaluated with a roll-type 90°peel *** hybrid Ag printed circuit showed improvements in both the flexibility and adhesion strength with the addition of Ag flake.

关键词： Low-temperature sintering Flexibility Flaky powders Adhesion strength Intensive pulsed light

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Tenofovir disoproxil fumarate is not associated with a lower risk of hepatocellular carcinoma compared to entecavir in patients with chronic hepatitis B

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Hepatoma Research 2022年第1期8卷 188-192页

作者： hye Won Lee seung Up Kim Department of Internal Medicine Yonsei University College of MedicineSeoul 03722Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 03722Korea Yonsei Liver Center Severance HospitalSeoul 03722Korea

A paper published several years ago suggested that tenofovir disoproxil fumarate(TDF)was superior to entecavir(ETV)for reducing the risk of hepatocellular carcinoma(HCC).Since then,many observational studies have been conducted comparing TDF and *** studies in Asia demonstrated similar HCC risks between ETV and TDF ***,recent studies involving Caucasian and European did not observe any differences in HCC risk between these *** this article,we briefly review studies that compared the incidence rates of HCC between ETV and TDF and discuss potential reasons for the discrepant results.

关键词： Hepatitis B entecavir tenofovir hepatocellular carcinoma

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