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Journal of Forestry Research 2021年第5期32卷 2181-2188页

作者： Ki-Won Kim Kyoung-Mi Lee Soon-Ho Kwon Ji-Min park Yang-Gil Kim hye-In Kang Da-Bin Yum Kyu-Suk Kang Department of Agriculture Forestry and BioresourcesSeoul National UniversitySeoul 08826Republic of Korea Department of Forest Bioresources National Institute of Forest ScienceSuwon 16631Republic of Korea Department of Plant Resource Research Korea National ArboretumPocheon 11186Republic of Korea Research Institute of Agriculture and Life Sciences CALS_SNUSeoul 08826Republic of Korea

Growth traits and genetic diversity of 23 provenances of Quercus rubra introduced from North America were analyzed in a provenance trial established with a randomized block design in Hwaseong,Gyeonggi,South Korea in *** variables and survival at age 25 were compared with results from early ***,DBH,volume and stem straightness of *** was better than those of the domestic oak(Quercus accutissima).Growth of the Dunham Island provenance from New York was the best among the 23 provenances that of the Eagle River provenance from Wisconsin was *** rate at age25 was on average 52%.The longitude of seed origin and growth of provenance were consistently significantly negatively correlated at all *** of coastal provenances was superior to that of the inland provenances,which were separated by the Appalachian *** diversity and genetic distance among the provenances were evaluated using micro satellite *** allelic frequencies showed high polymorphism in 10 microsatellite loci,and 292 alleles were *** 10 loci,two were commonly found in the 23 *** mean allelic diversity and heterozygosity observed among the provenances were similar to those from the native populations of *** in North ***’s genetic distance among the 23 was estimated and showed that a clear trend between geographic and genetic distances,indicating that some provenances have high genetic diversity with superior growth performance.

关键词： Introduction breeding Provenance test Adaptation Microsatellite marker Genetic distance

Risk factors for computed tomography interpretation discrepancy in emergently transferred patients

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World Journal of Emergency Medicine 2022年第1期13卷 54-58页

作者： Hyun Sim Lee Jinwoo Myung Min Ji Choi hye Jung Shin Incheol park Sung Phil Chung Ji Hoon Kim Department of Emergency Nursing Yonsei University Health systemSeoul 03722the Republic of Korea Department of Emergency Medicine College of MedicineYonsei UniversitySeoul 03722the Republic of Korea Department of Biostatistics Collaboration Unit College of MedicineYonsei UniversitySeoul 03722the Republic of Korea Department of Preventive Medicine and Public Health College of MedicineYonsei UniversitySeoul 03722the Republic of Korea

Radiologic imaging is a diagnostic tool that greatly affects patient outcomes,[1]and with the recent development of imaging technology,advanced imaging tests such as computed tomography(CT)have gained widespread accessibility in *** particular,CT is essential in the evaluation of patients in low-level emergency departments(EDs)because of its ability to answer clinical questions accurately and quickly.[2]

关键词： patients transferred clinical

Quality of life outcomes including neuropathy-associated scale from a phase II,multicenter,randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer:Korean Cancer Study Group Trial(KCSG BR13-11)

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Cancer Communications 2019年第1期39卷 271-278页

作者： Ji-Yeon Kim Seri park Seock-Ah Im Sung-Bae Kim Joohyuk Sohn Keun Seok Lee Yee Soo Chae Ki hyeong Lee Jee Hyun Kim Young-Hyuck Im Tae-Yong Kim Kyung-Hun Lee Jin-Hee Ahn Gun Min Kim In Hae park Soo Jung Lee hye sook Han Se Hyun Kim Kyung Hae Jung Yeon Hee park Korean Cancer Study Group Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of Medicine81 Irwon-roGangnam-guSeoul 06351South Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and TechnologySungkyunkwan UniversitySeoul 06351South Korea Department of Internal Medicine Seoul National University HospitalCancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 03080South Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Division of Medical Oncology Department of Internal MedicineYonsei University College of MedicineSeoul 03722South Korea Center for Breast Cancer National Cancer CenterGoyang 10408South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Deparment of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam 13620South Korea

Background: A phase II clinical trial of the comparison between eribulin plus gemcitabine (EG) and paclitaxel plus gemcitabine (PG) as first-line chemotherapy for patients with metastatic breast cancer (MBC) found that the EG regimen was less neurotoxic, but was similar in efficacy to the PG regimen. In the present study, we analyzed functional assessment of cancer therapy-taxane (FACT-Taxane) questionnaires from patients in this clinical trial to determine their quality of life (QoL). Methods: QoL was assessed using the Korean version of the FACT-Taxane questionnaires. After baseline assessment, QoL was assessed every 2 cycles for 12 cycles and every 3 cycles thereafter. The linear mixed model was used to evaluate the difference in QoL between the EG and PG arms. Results: Of the 118 enrolled patients, 117 responded to the FACT-Taxane questionnaires at baseline, 1 in the PG arm did not. Baseline QoL scores were not different between the EG and PG arms. During treatment, taxane subscale scores were significantly higher in the PG arm than in the EG arm after 2-13 cycles of chemotherapy (all P < 0.05), except for the 11th cycle. Neuropathy-specific analysis showed that patients in the PG arm had earlier and more severe neuropathic symptoms than those in the EG arm (P < 0.001). Conclusions: In our QoL analysis, the EG regimen delayed and decreased neuropathy as compared with the PG regimen. Therefore, eribulin would be a reasonable substitute for paclitaxel as first-line chemotherapy for MBC.

关键词： Metastatic breast cancer Eribulin Paclitaxel Neuropathy Quality of life Functional assessment of cancer therapy-taxane questionnaires

Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4

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World Journal of Gastroenterology 2005年第30期11卷 4674-4678页

作者： Youn-Jung Kim Hae-Jeong park Seo-Hyun Yoon Mi-Ja Kim Kang-Hyun Leem Joo-Ho Chung hye-Kyung Kim Department of Dental Hygiene Department of Pharmacology Department of Obesity Management College of Oriental Medicine Department of Food and Biotechnology

AIM: Oligomeric proanthocyanidins (OPC), natural polyphenolic compounds found in plants, are known to have antioxidant and anti-cancer effects. We investigated whether the anti-cancer effects of the OPC are induced by apoptosis on human colorectal cancer cell line, ***: Colorectal cancer cell line, SNU-C4 was cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum. The cytotoxic effect of OPC was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylt-etrazolium bromide (MTT) assay. To find out the apoptotic cell death, 4, 6-diamidino-2-phenylindole (DAPI) staining,terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), and caspase-3 enzyme assay were ***: In this study, cytotoxic effect of OPC on SNUC4 cells appeared in a dose-dependent manner. OPC treatment (100 μg/mL) revealed typical morphological apoptotic features. Additionally OPC treatment (100 μg/mL)increased level of BAX and CASPASE-3, and decreased level of BCL-2 mRNA expression. Caspase-3 enzyme activity was also significantly increased by treatment of OPC (100 μg/mL) compared with ***: These data indicate that OPC caused cell death by apoptosis through caspase pathways on human colorectal cancer cell line, SNU-C4.

关键词： Oligomeric pranthocyanidins Apoptosis Anticancer effects Colorectal cancer

Gallbladder Metastasis of Non-small Cell Lung Cancer Presenting as Acute Cholecystitis

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Chinese Journal of Cancer Research 2012年第3期24卷 249-252页

作者： Yu-sook Jeong hye-Suk Han Sung-Nam Lim Mi-Jin Kim Joung-Ho Han Min-Ho Kang Dong-Hee Ryu Ok-Jun Lee Ki-hyeong Lee Seung-Taik Kim Department of Internal Medicine College of MedicineChungbuk National University Department of Radiology College of MedicineChungbuk National University Department of Surgery College of MedicineChungbuk National University Department of Pathology College of MedicineChungbuk National University Department of Internal Medicine College of MedicineChungbuk National University

Although non-small cell lung cancer （NSCLC） can metastasize to almost any organ, metastasis to the gallbladder with significant clinical manifestation is relatively rare. Here, we report a case of gallbladder metastasis of NSCLC presenting as acute cholecystitis. A 79-year-old man presented with pain in the right upper quadrant and fever. A computed tomography （CT） scan of the chest and abdomen showed a cavitary mass in the right lower lobe of the lung and irregular wall thickening of the gallbladder. Open cholecystectomy and needle biopsy of the lung mass were performed. Histological examination of the gallbladder revealed a moderately-differentiated squamous cell carcinoma displaying the same morphology as the lung mass assessed by needle biopsy. Subsequent immunohistochemical examination of the gallbladder and lung tissue showed that the tumor cells were positive for P63 but negative for cytokeratin 7, cytokeratin 20 and thyroid transcription factor-1. A second primary tumor of the gallbladder was excluded by immunohistochemical methods, and the final pathological diagnosis was gallbladder metastasis of NSCLC. Although the incidence is extremely rare, acute cholecystitis can occur in association with lung cancer metastasis to the gallbladder.

关键词： Cholecystitis Gallbladder Non-small cell lung cancer Metastasis

Effect of Cristobalite and Quartz on the Properties of Gypsum Bonded Investment

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Journal of Materials Science & Technology 2008年第1期24卷 143-144页

作者： Yun-Jong Kim Sang-Bae Kim Hyun-hye park Myeong-Deok Seo Byoung-Cheon Lee Man-So Han Taik-Nam Kim Sung-Baek Cho Korea Institute of Geoscience and Mineral Resources (KIGAM) Gajeong-dong 30 Yuseong-kuDaejeon 305-350Korea Department of Materials Engineering Graduate School Paichai UniversityDaejeon 302-735Korea Dept.of Dental Laboratory Technology Daejeon Health Science College Korea

Generally the gold investment material consists of cristobalite,quartz and *** physical property of gold investment materials depends on its thermal expansion coefficients,compressive strength,and particles size *** the thermal expansion coefficient of cristobalite and quartz are 2.6×10^-6/℃and 2.32×10^-6/℃respectively,the composition ratio of each components influence the thermal and physical properties of gold investment *** the clinical applications,it is necessary to improve the properties of gold investment materials such as homogeneous size distribution and thermal expansion *** the present study,effect of inorganic fillers such as cristobalite and quartz on gold alloy investment was investigated to improve the properties of *** compressive strength and thermal expansion coefficients of the specimens were *** results showed that cristobalite and quartz were homogeneously distributed by milling. The optimum compressive strength was obtained at the ratio of 42：22 cristobalite and quartz,respectively.

关键词： Investment Cristobalite Quartz Thermal expansion coefficient Compressivestrength

Successful kidney transplantation from an expanded criteria donor with long-term extracorporeal membrane oxygenation treatment: A case report

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World Journal of Clinical Cases 2020年第3期8卷 540-545页

作者： hye Won Seo Sua Lee Hwa Young Lee Sun Cheol park Byung Ha Chung Chul Woo Yang Tae Hyun Ban Division of Nephrology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Transplant Research Center Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Division of Nephrology Department of Internal MedicineJeju National University HospitalJeju-do 63241South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea222 Banpo-daeroSeoul 06591South Korea Division of Nephrology Department of Internal MedicineEunpyeong St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaEunpyeong-guSeoul 03312South Korea

BACKGROUND Due to a shortage of donor kidneys, many centers have utilized graft kidneys from brain-dead donors with expanded criteria. Kidney transplantation(KT)from donors on extracorporeal membrane oxygenation(ECMO) has been identified as a successful way of expanding donor pools. However, there are currently no guidelines or recommendations that guarantee successful KT from donors undergoing ECMO treatment. Therefore, acceptance of appropriate allografts from those donors is solely based on clinician *** SUMMARY We report a case of successful KT from a brain-dead donor supported by ECMO for the longest duration to date. A 69-year-old male received a KT from a 63-yearold brain-dead donor who had been on therapeutic ECMO treatment for the previous three weeks. The recipient experienced slow recovery of graft function after surgery but was discharged home on post-operative day 17 free from hemodialysis. Allograft function gradually improved thereafter and was comparatively acceptable up to the 12 mo follow-up, with serum creatinine level of 1.67 mg/d *** This case suggests that donation even after long-term ECMO treatment could provide successful KT to suitable candidates.

关键词： Extracorporeal membrane oxygenation Kidney transplantation Delayed graft function Donor selection Case report

Quality of life for primary caregivers of muscular dystrophy patients in South Korea

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Chinese Medical Journal 2010年第4期123卷 452-457页

作者： Sang Hee Im Sang Chul Lee Jae Ho Moon Eun sook park Yoon Ghil park Department of Rehabilitation Medicine Jeju National University School of Medicine Jeju & Yonsei University Graduate School Seoul Korea Department of Physical Medicine and Rehabilitation Myongji Hospital Kwandong University College of Medicine Goyang Korea Department of Rehabilitation Medicine and Rehabilitation Institute of Muscular Disease Yonsei University College of Medicine Seoul Korea Department and Research Institute of Rehabilitation Medicine Yonsei University College of Medicine Seoul Korea

Background Although some studies measured the burden of caregivers and the factors that influenced their feelings of burden, few studies have measured the quality of life （QOL） for primary caregivers of patients with muscular dystrophy （MD）. We assessed the QOL for primary caregivers of patients with MD in South Korea and identified factors associated with caregivers＇ QOL. Methods Ninety dyads of patients with MD and their primary caregivers were enrolled in this study. The QOL of caregivers of patients with MD was assessed subjectively using the World Health Organization Quality of Life Assessment, Life Brief Form. Caregivers＇ emotional status was assessed using the Beck Depression Inventory （BDI） and family function level was evaluated using the Family APGAR scale. Patients reported their emotional status using the BDI or the Children＇s Depression Inventory. The functional levels of patients were evaluated by the modified Barthel Index. Results Caregivers＇ QOL was statistically associated with family income, family function, emotional status of patients, level of education, and emotional status of caregivers （P 〈0.05）. Caregivers who were employed had a significantly higher QOL than those who were not （P 〈0.05）. In multiple regression analyses, emotional and employment status of caregivers was strongly associated with caregivers＇ QOL. Conclusion Rehabilitation teams should consider not only the physical factors of patients but also the psychological and demographic factors of primary caregivers of patients with MD.

关键词： caregiver quality of life muscular dystrophy

Fluorescent nanoswitch for monitoring specific pluripotency-related microRNAs of induced pluripotent stem cells： Development of polyethyleneimine- oligonucleotide hybridization probes

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Nano Research 2017年第8期10卷 2545-2559页

作者： Seungmin Han hye Young Son Byunghoon Kang Eunji Jang Jisun Ki Na Geum Lee Jongjin park Moo-Kwang Shin Byeonggeol Mun Jeong-Ki Min Seungjoo Haam Department of Chemical and Biomolecular Engineering College of Engineering Yonsei University Seou1120-749 Republic of Korea Department of Radiology College of Medicine Yonsei University Seou1120-752 Republic of Korea Severance Biomedical Science Institute College of Medicine Yonsei University Seou1120-752 Republic of Korea Biotherapeutics Translational Research Center Korea Research Institute of Bioscience and Biotechnology Daejeon 34141 Republic of Korea Department of Biomolecular Science University of Science & Technology Daejeon 34113 Republic of Korea

The isolation of high-grade （i.e. high-pluripotency） human induced pluripotent stem cells （hiPSCs） is a decisive factor for enhancing the purity of hiPSC populations or differentiation efficiency. A non-invasive imaging system that can monitor microRNA （miRNA） expression provides a useful tool to identify and analyze specific cell populations. However, previous studies on the monitoring/isolation of hiPSCs by miRNA expression have limited hiPSCs＇ differentiation system owing to long-term incubation with miRNA imaging probe-nanocarriers. Therefore, we focused on monitoring high-grade hiPSCs without influencing the pluripotency of hiPSCs. We reduced nanoparticle transfection time, because hiPSCs are prone to spontaneous differentiation under external factors during incubation. The fluorescent nanoswitch （＂ON＂ with target miRNA）, which can be applied for either imaging or sorting specific cells by fluorescence signals, contains an miRNA imaging probe （miP） and a PEI-PEG nanoparticle （miP-P）. Consequently, this nanoswitch can sense various endogenous target miRNAs within 30 min in vitro, and demonstrates strong potential for not only imaging but also sorting pluripotent hiPSCs without affecting pluripotency. Moreover, miP-P-treated hiPSCs differentiate well into endothelial cells, indicating that miP-P does not alter the pluripotency of hiPSCs. We envisage that this miRNA imaging system could be valuable for identifying and sorting high-grade hiPSCs for improved practical applications.

关键词： induced pluripotent stem cells (iPSCs) pluripotency microRNA (miRNA) fluorescence imaging nanoparticle