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Glucagon-like peptide-1 agonists:Role of the gut in hypoglycemia unawareness,and the rationale in type 1 diabetes

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World Journal of Diabetes 2024年第11期15卷 2167-2172页

作者： hyder o.mirghani Internal Medicine University of TabukTabuk 51941TabukSaudi Arabia

Type 1 diabetes is increasing and the majority of patients have poor glycemic *** advanced technology and nanoparticle use have greatly enhanced insulin delivery and glucose monitoring,weight gain and hypoglycemia remain major challenges and a constant source of concern for patients with type 1 *** 1 diabetes shares some pathophysiology with type 2 diabetes,and an overlap has been *** above observation created great interest in glucagon-like peptide-1 receptor agonists(GLP-1)as adjuvants for type 1 *** trials confirmed the positive influence of GLP-1 agonists onβcell ***,hypoglycemia unawareness and dysregulated glucagon response have been previously reported in patients with recurrent hypoglycemia using GLP-1 *** et al found that the source of glucagon dysregulation due to GLP-1 agonists resides in the *** explanations could be gut nervous system dysregulation or gut microbiota *** review evaluates the potential of GLP-1 agonists in managing type 1 diabetes,particularly focusing on their impact on glycemic control,weight management,and glucagon *** provide a broader insight into the problem of type 1 diabetes mellitus management in the light of recent findings and provide future research directions.

关键词： Glucagon-like peptide-1 receptor agonists Glucagon response Hypoglycemia unawareness Gut Type 1 diabetes

Effect of dates on blood glucose and lipid profile among patients with type 2 diabetes

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World Journal of Diabetes 2024年第6期15卷 1079-1085页

作者： hyder osman mirghani Internal Medicine University of TabukSaudi ArabiaTabuk 51941TabukSaudi Arabia

Poor fruit and vegetable consumption is one of the 10 major risk factors for *** is a misconception regarding the consumption of dates among patients with *** manuscript assessed the effects of date consumption on fasting and postprandial blood glucose,glycated hemoglobin,total cholesterol,triglycerides,low-density lipoproteins,high-density lipoproteins,and microbial *** literature databases were searched for relevant *** the 595 studies retrieved,24 assessed the effects of dates on glycemic control and ***,the evidence suggests that dates have a lowering effect on blood *** reduce total cholesterol and triglyceride levels and increase high-density lipoprotein *** also promote the abundance of beneficial gut ***,patients with diabetes and dyslipidemia can consume dates to reduce their blood glucose,cholesterol,and triglycerides.

关键词： Dates Lipid profile Blood glucose Diabetes mellitus Microbial contamination

Diabetes distress,the mediator of the poor glycemic control and depression:A meta-analysis

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World Journal of Meta-Analysis 2024年第4期12卷 20-31页

作者： hyder o.mirghani Department of Internal Medicine University of TabukTabuk 51941Tabuk ProvinceSaudi Arabia

BACKGRoUND Diabetes-related distress(DRD)is a common psychological disorder specifically associated with diabetes,its cross-talk with depression,and glycated hemoglobin(HbA1c)was discussed *** addressing DRD were shown to improve ***,the primary concern is to investigate the association of DRD with glycemic *** meta-analyses have compared the effects of depression and diabetes distress on *** To assess the relationship between DRD,depression,and glycemic *** We systematically searched PubMed MEDLINE,Google Scholar,and Cochrane Library from inception up to May *** keywords diabetes distress,depression,psychopathology,glycemic control,HbA1c,glycated hemoglobin,fasting,and postprandial blood glucose were used.A datasheet was used to extract the author’s name year and country of publication,diabetes distress,depression,and HbA1c among patients with DRD,depression,and control *** out of the 2046 studies retrieved,55 full texts were screened and 22 studies were included in the final *** distress was associated with poor glycemic control,odd ratio=0.42,95%confidence interval(CI):0.17-0.67,and P valueodd ratio=0.52,95%CI:0.38-0.72,and P valueobserved between depression and DRD regarding the impact on HbA1c,odd ratio=0.13,95%CI:0.15-0.41,P value=0.37,I2 for heterogeneity=76%.However,when heterogeneity was eliminated,diabetes distress influenced the HbA1c more compared to depression,odd ratio=0.29,95%CI:0.17-0.41,and P valueontrol more than *** studies using more specific measures(ecological momentary assessment)to assess DRD are recommended.

关键词： Diabetes-related distress Depression Glycemic control Glycated hemoglobin Diabetes

Vitamin D deficiency among outpatients and hospitalized patients with diabetic foot ulcers:A systematic review and meta-analysis

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World Journal of Meta-Analysis 2023年第5期11卷 218-227页

作者： hyder osman mirghani Department of Internal Medicine Faculty of MedicineUniversity of TabukSaudi ArabiaTabuk 3378Saudi Arabia

BACKGRoUND The definition of diabetic foot syndrome(DFS)varies depending on the location and *** classifications are available according to the *** ulcers and vitamin D deficiency are common diseases among patients with *** literature has shown an association between DF ulcer(DFU)and vitamin D ***,the available meta-0analysis was limited by substantial *** To investigate the association between DFUs and vitamin D *** We searched PubMed,MEDLINE,and Cochrane Library,EBSCo,and Google Scholar for studies comparing vitamin D levels and *** keywords DFU,DFS,diabetic septic foot,vitamin D level,25-hydroxy vitamin D,vitamin D status,and vitamin D deficiency were *** search engine was set for articles published during the period from inception to october 2022.A predetermined table was used to collect the study *** Vitamin D level was lower among patients with DFU compared to their counterparts[odds ratio(oR):-5.77;95%confidence interval(CI):-7.87 to-3.66;χ2 was 84.62,mean difference,9;I2 for heterogeneity,89%;Por overall effectobust for hospitalized patients(oR:-6.3295%CI:-11.66 to-0.97;χ2 was 19.39;mean difference,2;I2 for heterogeneity,90%;P=0.02).CoNCLUSIoN Vitamin D was lower among outpatients and hospitalized patients with *** larger randomized controlled trials are needed.

关键词： Vitamin D deficiency Diabetic foot ulcer outpatient Hospitalized patients Diabetic foot syndrome