检索结果-南通市图书馆

Comparison of the efficacy and safety of sedation between dexmedetomidine-remifentanil and propofol-remifentanil during endoscopic submucosal dissection

引用

World Journal of Gastroenterology 2015年第12期21卷 3671-3678页

作者： Namo kim Young-Chul Yoo Sang Kil Lee Hyunzu kim hyang Mi Ju Kyeong Tae Min Department of Anesthesiology and Pain Medicine Severance Hospital Yonsei University College of Medicine Department of Internal Medicine Yonsei University College of Medicine Department of Anesthesiology and Pain Medicine Kangdong Sacred Heart Hospital Hallym University College of Medicine

AIM: To compare the efficacy and safety of sedation protocols for endoscopic submucosal dissection(ESD) between dexmedetomidine-remifentanil and ***: Fifty-nine patients scheduled for ESD were randomly allocated into a dexmedetomidineremifentanil(DR) group or a propofol-remifentanil(PR) group. To control patient anxiety, dexmedetomidine or propofol was infused to maintain a score of 4-5 on the Modified Observer's Assessment of Alertness/Sedation scale. Remifentanil was infused continuously at a rate of 6 μg/kg per hour in both groups. The ease of advancing the scope into the throat, gastric motility grading, and satisfaction of the endoscopist and patient were assessed. Hemodynamic variables and hypoxemic events were compared to evaluate patient ***: Demographic data were comparable between the groups. The hemodynamic variables and pulse oximetry values were stable during the procedure in both groups despite a lower heart rate in the DR group. No oxygen desaturation events occurred in either group. Although advancing the scope into the throat was easier in the PR group("very easy" 24.1% vs 56.7%, P = 0.010), gastric motility was moresuppressed in the DR group("no + mild" 96.6% vs 73.3%, P = 0.013). The endoscopists felt that the procedure was more favorable in the DR group("very good + good" 100% vs 86.7%, P = 0.042), whereas patient satisfaction scores were comparable between the groups. En bloc resection was performed 100% of the time in both groups, and the complete resection rate was 94.4% in the DR group and 100% in the PR group(P = 0.477). CONCLUSION: The efficacy and safety of dexmedetomidine and remifentanil were comparable to propofol and remifentanil during ESD. However, the endoscopists favored dexmedetomidine perhaps due to lower gastric motility.

关键词： Dexmedetomidine Efficacy Peristalsis Safety Endosc

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Type I and II interferons enhance dendritic cell maturation and migration capacity by regulating CD38 and CD74 that have synergistic effects with TLR agonists

引用

Cellular & Molecular Immunology 2011年第4期8卷 341-347页

作者： Thanh-Nhan Nguyen-Pham Mi-Seon Lim Truc Anh Thi Nguyen Youn-Kyung Lee Chun-Ji Jin Hyun Ju Lee Cheol Yi Hong Jae-sook Ahn Deok-Hwan Yang Yeo-Kyeoung kim Ik-Joo Chung Byoung Chul Park Hyeoung-Joon kim Je-Jung Lee Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalJeollanamdoKorea Department of Hematology-Oncology Chonnam National UniversityGwangjuKorea The Brain Korea 21 Project Center for Biomedical Human Resources at Chonnam National UniversityGwangjuKorea Vaxcell-Bio Therapeutics JeollanamdoKorea Korea Research Institute of Bioscience and Biotechnology(KRIBB) DaejeonKorea

The major limitation for the maturation of dendritic cells(DCs)using Toll-like receptor(TLR)agonists is their decreased ability to migrate into lymph nodes compared with conventional ***38 can be used as a multifunctional marker to modulate migration,survival and Th1 responses of ***74 has been shown to negatively regulate DC *** goal of this study was to investigate the combinations of TLR agonists and interferons(IFNs)that most effectively regulate CD38 and CD74 expression on *** TLR agonist stimulation in combination with IFN-a and IFN-c was the best method for regulating CD38 and CD74 expression and inducing the highest secretion of *** in vitro migration assay showed that DCs treated with this combination had significantly enhanced migratory ability,similar to that observed in cells expressing CD38,CD74 and *** results of this study suggest that an alternative maturation protocol in which two TLR ligands are combined with type I and II IFNs generates potent DCs that have both a high migratory capacity and high IL-12p70 production.

关键词： CD38 CD74 dendritic cells interferon Toll-like receptor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A combination of immunoadjuvant nanocomplexes and dendritic cell vaccines in the presence of immune checkpoint blockade for effective cancer immunotherapy

引用

Cellular & Molecular Immunology 2021年第6期18卷 1599-1601页

作者： Manh-Cuong Vo Seo-Yeon Ahn Tan-Huy Chu Saji Uthaman Shammer Pillarisetti Tung Nguyen Thanh Uong Thangaraj Jaya Lakshmi Mihee kim Ga-Young Song Sung-Hoon Jung Deok-Hwan Yang Jae-sook Ahn Hyeoung-Joon kim In-Kyu Park Je-Jung Lee Institute of Research and Development Duy Tan UniversityDanangVietnam Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalHwasunJeollanamdoRepublic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolGwangjuRepublic of Korea Department of Polymer Science and Engineering Chungnam National UniversityDaejeonRepublic of Korea Department of Biomedical Science Chonnam National University Medical SchoolGwangjuRepublic of Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolGwangjuSouth Korea View author publications

Nanovaccines are used as delivery platforms for antigens and adjuvants, which activate antigen-presenting cells (APCs) and enhance anticancer immune responses.1,2 Researchers have recently developed a self-assembled nanocomplex using a polysorbitol-co-PEI (PSPEI) polymer complexed with poly(I:C) (PIC). By binding to different surface proteins, this nanocomplex enhances the intracellular delivery of cargos and induces potent anticancer immune responses against melanoma cells.3 We have previously demonstrated that PD-1/PD-L1 blockade enhanced the efficacy of DC-based cancer immunotherapy.4,5 Moreover, the combination of nanomedicines and PD-L1 blockade has been reported to enhance CD8+ T cell activation and inhibit immunosuppressive cells within the tumor microenvironment.6 In the present study, we investigated the therapeutic efficacy of a combinatorial treatment comprising the immunoadjuvant nanocomplex PSPEI-PIC, a DC vaccine, and PD-L1 blockade in a murine colon cancer model.

关键词： adjuvant vaccines immunotherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ECONOMIC EVALUATION OF LED OFFICE LIGHTING USING LCC METHOD

ECONOMIC EVALUATION OF LED OFFICE LIGHTING USING LCC METHOD

引用

4th Lighting Conference of China,Japan and Korea

作者： Lee,Min-Wook Cho,sook-Hyun kim,Hoon Department of Elecrical and Electronic Engineering Kangwon National University

Recently,LED lighting have often been used in indoor *** has become important to lighting designs for new buildings,to compare plans using several LED *** is also necessary to analyze installation expenses in early stage and operating expenses when conventional lighting installations are replaced with LED lighting as *** these situations,economic evaluations on several lighting designs are performed. As one example of an economic evaluation,the Life Cycle Cost(LCC) method evaluates total cost in each stage(production,use and disposal).This paper includes an economic evaluation on lighting design in several indoor offices and compares lighting installation design plans by lighting design,type of Iuminaires and operations.

关键词： LED office lighting economic evaluation life cycle cost method

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Superior gallstone dissolubility and safety of tert-amyl ethyl ether over methyl-tertiary butyl ether

引用

World Journal of Gastroenterology 2019年第39期25卷 5936-5952页

作者： Dong Do You Suk Joon Cho Ok-Hee kim Jin sook Song Kyu-Seok Hwang Sang Chul Lee Kee-Hwan kim Ho Joong Choi Ha-Eun Hong Haeyeon Seo Tae Ho Hong Jung Hyun Park Tae Yoon Lee Joseph Ahn Jae-Kyung Jung Kwan-Young Jung Say-June kim Department of Surgery St.Vincent's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247South Korea College of Pharmacy Chungbuk National UniversityCheongju 28644South Korea Department of Surgery Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Catholic Central Laboratory of Surgery Institute of Biomedical IndustryCollege of Medicinethe Catholic University of KoreaSeoul 06591South Korea Bio and Drug Discovery Division Korea Research Institute of Chemical TechnologyDaejeon 34114South Korea Department of Surgery Daejeon St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 34943South Korea Department of Surgery Uijeongbu St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoul 11765South Korea Department of Biomedicine and Health Science College of Medicinethe Catholic University of KoreaSeoul 06591South Korea Department of Surgery Eunpyeong St.Mary’s HospitalCollege of Medicinethe Catholic University of KoreaSeoul 03312South Korea Department of Medicinal Chemistry and Pharmacology University of Science and TechnologyDaejeon 34113South Korea

BACKGROUND The use of methyl-tertiary butyl ether(MTBE)to dissolve gallstones has been limited due to concerns over its toxicity and the widespread recognition of the safety of laparoscopic *** adverse effects of MTBE are largely attributed to its low boiling point,resulting in a tendency to ***,if there is a material with a higher boiling point and similar or higher dissolubility than MTBE,it is expected to be an attractive alternative to *** To determine whether tert-amyl ethyl ether(TAEE),an MTBE analogue with a relatively higher boiling point(102°C),could be used as an alternative to MTBE in terms of gallstone dissolubility and *** The in vitro dissolubility of MTBE and TAEE was determined by measuring the dry weights of human gallstones at predetermined time intervals after placing them in glass containers with either of the two *** in vivo dissolubility was determined by comparing the weights of solvent-treated gallstones and control(dimethyl sulfoxide)-treated gallstones,after the direct infusion of each solvent into the gallbladder in both hamster models with cholesterol and pigmented *** The in vitro results demonstrated a 24 h TAEE-dissolubility of 76.7%,56.5%and 38.75%for cholesterol,mixed,and pigmented gallstones,respectively,which represented a 1.2-,1.4-,and 1.3-fold increase in dissolubility compared to that of *** the in vitro experiment,the 24 h-dissolubility of TAEE was 71.7%and 63.0%for cholesterol and pigmented gallstones,respectively,which represented a 1.4-and 1.9-fold increase in dissolubility compared to that of *** addition,the results of the cell viability assay and western blot analysis indicated that TAEE had a lower toxicity towards gallbladder epithelial cells than *** We demonstrated that TAEE has higher gallstone dissolubility properties and safety than those of *** such,TAEE could present an attractive alternative to MTBE if our findings

关键词： Tert-amyl ethyl ether Gallstones Methyl-tert-butyl ether Contact litholytic agent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient and power-awareness query over sensor networks

引用

重庆邮电大学学报（自然科学版） 2007年第3期19卷 270-275页

作者： Sang-Hun Eo Ho-Seok kim sook-Kyoung Cho Hae-Young Bae Dept. of Computer Science & Information Engineering Inha University

Sensor networks consisted of low-cost, low-power, multifunctional miniature sensor devices have played an important role in our daily life. Light and humidity monitoring, seismic and animal activity detection, environment and habitat monitoring are the most common applications. However, due to the limited power supply, ordinary query methods and algorithms can not be applied on sensor networks. Queries over sensor networks should be power-aware to guarantee the maximum power savings. The minimal power consumption by avoiding the expensive communication of the redundant sensor nodes is concentrated on. A lot of work have been done to reduce the participated nodes, but none of them have considered the overlapping minimum bounded rectangle (MBR) of sensors which make them impossible to reach the optimization solution. The proposed OMSI-tree and OMR algorithm can efficiently solve this problem by executing a given query only on the sensors involved. Experiments show that there is an obvious improvement compared with TinyDB and other spatial index, adopting the proposed schema and algorithm.

关键词：传感器网络查询最小界矩形效率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aluminum nitride waveguide beam splitters for integrated quantum photonic circuits

引用

光子学研究:英文版 2023年第7期11卷 1196-1202页

作者： HYEONG-SOON JANG DONGHWA LEE HYUNGJUN HEO YONG-SU kim hyang-TAG LIM SEUNG-WOO JEON SUNG MOON SANGIN kim SANG-WOOK HAN HOJOONG JUNG Center for Quantum Information Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Electrical and Computer Engineering Ajou UniversitySuwon 16499Republic of Korea Division of Nano and Information Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea

We demonstrate integrated photonic circuits for quantum devices using sputtered polycrystalline aluminum nitride(Al N)on ***-chip Al N waveguide directional couplers,which are one of the most important components in quantum photonics,are fabricated and show the output power splitting ratios from 50:50 to 99:*** beam splitters with an extinction ratio of more than 10 d B are also realized from the Al N directional *** the fabricated Al N waveguide beam splitters,we observe Hong–Ou–Mandel interference with a visibility of 91.7%±5.66%.

关键词： waveguide quantum beam

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cyanidine-3-O-Galactoside Enriched <i>Aronia melanocarpa</i>Extract Inhibits Adipogenesis and Lipogenesis via Down-Regulation of Adipogenic Transcription Factors and Their Target Genes in 3T3-L1 Cells

引用

Food and Nutrition Sciences 2019年第2期10卷 128-147页

作者： Su-Min Lim Jae In Jung Nam Young kim Jung-Shik Bae Hyun sook Lee Eun Ji kim Center for Efficacy Assessment and Development of Functional Foods and Drugs Hallym UniversityChuncheonRepublic of Korea R&D Center Wellfine Co.Ltd.ChuncheonRepublic of Korea Department of Food Science&Nutrition Dongseo UniversityBusanRepublic of Korea

Aronia melamocarpa (AM) is a rich source of anthocyanins, which are known to help prevent obesity. The cyanidine-3-O-galactoside enriched AM extract (AM-Ex) containing more cyanidine-3-O-galactoside than conventional AM extract was recently developed. The objective of this study was to examine the effect of AM-Ex on adipogenesis and its action mechanisms in vitro using 3T3-L1 adipocytes. To examine the anti-obesity effect of AM-Ex, 3T3-L1 cells were induced adipocyte differentiation and incubated with various concentration of AM-Ex. Lipid accumulation, cellular triglyceride content, mRNA expression of transcription factors and adipogenic genes were analyzed. Treatment with 100 - 400 μg/mL of AM-Ex resulted in a dose-dependent decrease in adipocyte differentiation and triglyceride accumulation. mRNA expression of adipogenic transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer binding protein α, sterol regulatory element-binding protein 1 were decreased. The level of gene expression of adipogenesis and lipogenesis-related genes, such as adipocyte protein 2, lipoprotein lipase, acetyl-CoA carboxylase, ATP-citrate lyase and fatty acid synthase were decreased. These results suggest that AM-Ex alleviated risk factors related to obesity by modulating multiple pathways associated with adipogenesis.

关键词： Obesity Adipocyte Adipogenesis Lipogenesis Transcription Factor Adipocyte Protein 2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Multidrug-resistance reversing activity of Korean local citrus fruits against human acute myelogenous leukemia cell

Multidrug-resistance reversing activity of Korean local citr...

引用

The 3～(rd) International Conference on Natural Products :Natural Products -a Must for Human Survival ABSTRACTS

作者： sook Young Lee Sun Min kim Eun Ju Hwang Biology Research Center for Industrial Accelerators Dongshin University Postal address 880-4 Ahansanri Roanmyun Naju Jeonnam 502-811 Republic of Korea Dept.of Oriental Medicine Materials Dongshin University 252 Daehodong Naju Jeonnam 520-714 Korea Dept.of Oriental Medicine Materials Dongshin University 252 Daehodong Naju Jeonnam 520-714 Korea

This research has been undertaken to screen availability as a chemosensitizer resource of 14 local citrus spp. cultivating in Geju Island, Korea. We report that methanol extracts from fruits and flower have a chemosensitizing effect that can reverse P-glycoprotein(Pgp)-mediated multidrug-resistance(MDR). MDR reversing activity of citrus extracts using drug sensitive AML-2/WT and resistant AML-2/D100 of human acute myelogenous leukemia cells was more strong immature fruits than mature fruits and flower. In the several immature fruits with high MDR reversing activity, treatment of drug-resistant AML-2/D100 cells with its extracts increased remarkably their cytotoxicity to vincristine, resultantly causing high chemosensitizing index(CI). Immature Inchangkyool(C. ichangiensis) showed the most high CI of 14 citrus extracts. Also, Hongkyool(C. tachibana), Byungkyool(C. platymamma), Cheongkyool(C. nippokoreana), Jinkyool(C. sunki) of immature fruits strongly potentiated vincristine cytotoxicity in AML-2/D100 cells. In addition, peel extracts increased about 2 to 10 fold chemosensitizing effect as compared with whole fruit extract in mature Hongkyool(C. tachibana), Byungkyool(C. platymamma), Inchangkyool(C. ichangiensis). In the case of flower extracts, the mean IC50 value for extracts in AML-2/WT and AML-2/D100 without vincristine was up to 200 μg/ml whereas the range of its mean IC50 value in AML-2/D100 in the presence of vincristine was 18-200μg/ml. CI of flower extracts displayed higher than mature extracts but not immature fruits. This result indicates that immature citrus fruit of C. ichangiensis would contian the active principles which do not exert their activity solely by cytotoxicity. In particular, Inchangkyool(C. ichangiensis), Byungkyool(C. platymamma), and Cheongkyool(C. nippokoreana of 14 local citrus suggest that possibility as effective resources for chemosensitizing compounds isolation by further investigation.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

PDTC inhibits NF - κB activation by inhibiting proteasome activity through the mediation of zinc

PDTC inhibits NF - κB activation by inhibiting proteasome a...

引用

中国药理学会第八次全国代表大会

作者： Chul Hoon kim In sook kim Jinu LEE Shin Young KANG Joo Hee kim Hyun Soo kim Young Soo AHNBrain Korea 21 Project for Medical Sciences Brain Research Institute and Department of PharmacologyYonsei University College of Medicine Seoul 120 - 752 Korea

Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF-κB).We have previously reported that the effects of pyrrolidine dithiocarbamate (PDTC) on cell death and NF-κB inhibition are zinc dependent (kim et al,FEBS Lett.449, 28-32,1999, kim,et al,J. Neurochem.72, 1586-1592,1999),not through its antioxidant *** the present study, we sought to characterize the molecular mechanism of PDTC inhibition of NF-κB

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：