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Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas

World Journal of Gastroenterology 2011年第14期17卷 1866-1873页

作者： Young Jin Jun Se Min jang Hu lin Han Ki-Seok jang Seung Sam Paik Kang Hong Lee Department of Pathology College of Medicine Hanyang University Seoul 133-792 South Korea Department of Surgery College of Medicine Hanyang University Seoul 133-792 South Korea

AIM:To investigate the role of glucose transporter 1 (GLUT1) expression in colorectal carcinogenesis and evaluate the correlation with clinicopathological parameters and apoptosis-activating factor-1 (Apaf-1) expression in colorectal adenocarcinomas. METHODS:We used tissue microarrays consisting of 26 normal mucosa,50 adenomas,515 adenocarcinomas,and 127 metastatic lesions. Medical records were reviewed and clinicopathological analysis was performed. RESULTS:GLUT1 expression was absent in normal mucosa and low or moderately apparent in 19 cases (38.0%) of 50 adenomas. However,GLUT1 expression was detected in 423 (82.1%) of 515 adenocarcinomas and in 96 (75.6%) of 127 metastatic lesions. GLUT1 expression was significantly correlated with female gender (P = 0.009),non-mucinous tumor type (P = 0.045),poorer differentiation (P = 0.001),lymph node metastasis (P < 0.001),higher AJCC and Dukes stage (P < 0.001 and P < 0.001,respectively). There was a significant inverse correlation between GLUT1 expression and Apaf-1 expression (P = 0.001). In univariate survival analysis,patients with GLUT1 expression demonstrated poor overall survival and disease-free survival (P = 0.047 and P = 0.021,respectively,log-rank test). CONCLUSION:GLUT1 expression was frequently increased in adenocarcinomas and metastatic lesions. GLUT1 expression was significantly correlated with poorer clinicopathologic phenotypes and survival of patients with colorectal adenocarcinomas.

关键词： Adenocarcinoma Colorectum Glucose transporter 1 Apoptosis-activating factor-1 Prognosis Survival

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Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells

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Cancer Communications 2022年第8期42卷 716-749页

作者： jang Hee Han Yong Keon Kim Hakhyun Kim Jooyoung Lee Myung Joon Oh Sang bum Kim Minjee Kim Kook Hwan Kim hyun Ju Yoon Myung-Shik Lee John D.Minna Michael A.White hyun Seok Kim Severance Biomedical Science Institute Yonsei University College of MedicineSeoul 03722Korea Department of Medical Science Yonsei University Graduate SchoolSeoul 03722Korea Department of Urology Seoul National University HospitalSeoul 03722Korea Checkmate Therapeutics Inc. Seoul 07207Korea Hamon Center for Therapeutic Oncology Research University of Texas Southwestern Medical CenterDallasTexas 75390USA Department of Cell Biology University of Texas Southwestern Medical CenterDallasTexas 75390USA Graduate School of Medical Science Brain Korea 21 ProjectYonsei University College of MedicineSeoul 03722Korea

Background: Autophagy is elevated in metastatic tumors and is often associatedwith active epithelial-to-mesenchymal transition (EMT). However, the extent towhich EMT is dependent on autophagy is largely unknown. This study aimed toidentify the mechanisms by which autophagy facilitates ***: We employed a liquid chromatography-based metabolomic approachwith kirsten rat sarcoma viral oncogene (KRAS) and liver kinase B1 (LKB1)gene co-mutated (KL) cells that represent an autophagy/EMT-coactivatedinvasive lung cancer subtype for the identification of metabolites linked to autophagy-driven EMT activation. Molecular mechanisms of autophagy-drivenEMT activation were further investigated by quantitative real-time polymerasechain reaction (qRT-PCR), Western blotting analysis, immunoprecipitation,immunofluorescence staining, and metabolite assays. The effects of chemicaland genetic perturbations on autophagic flux were assessed by two orthogonalapproaches: microtubule-associated protein 1A/1B-light chain 3 (LC3) turnoveranalysis by Western blotting and monomeric red fluorescent protein-greenfluorescent protein (mRFP-GFP)-LC3 tandem fluorescent protein quenchingassay. Transcription factor EB (TFEB) activity was measured by coordinatedlysosomal expression and regulation (CLEAR) motif-driven luciferase reporterassay. Experimental metastasis (tail vein injection) mouse models were used toevaluate the impact of calcium/calmodulin-dependent protein kinase kinase 2(CAMKK2) or ATP citrate lyase (ACLY) inhibitors on lung metastasis using IVISluciferase imaging ***: We found that autophagy in KL cancer cells increased acetyl-coenzymeA (acetyl-CoA), which facilitated the acetylation and stabilization of theEMT-inducing transcription factor Snail. The autophagy/acetyl-CoA/acetylSnail axis was further validated in tumor tissues and in autophagy-activatedpancreatic cancer cells. TFEB acetylation in KL cancer cells sustained prometastatic autophagy in a mammalian target o

关键词： snail autophagy acetyl-coenzyme A epithelial-to-mesenchymal transition non-small-cell lung cancer CAMKK2 acetyl-snail pancreatic cancer KRAS inhibitor metastasis ACLY

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Sex disparity in viral load, inflammation and liver damage in transgenic mice carrying full hepatitis B virus genome with the W4P mutation in the preS1 region

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World Journal of Gastroenterology 2018年第10期24卷 1084-1092页

作者： Seoung-Ae Lee So-Young Lee Yu-Min Choi Hong Kim bum-Joon Kim Department of Microbiology and Immunology Biomedical Sciences Liver Research Institute and Cancer Research Institute Seoul National University College of Medicine

AIM To study sex disparity in susceptibility to hepatocellular carcinoma(HCC), we created a transgenic mouse model that expressed the full hepatitis B virus(HBV) genome with the W4P *** Transgenic mice were generated by transferring the p hy92-1.1 x-HBV-full genome plasmid(genotype A2) into C57 Bl/6 N mice. We compared serum levels of hepatitis B surface antigen(HBs Ag), interleukin(IL)-6, and the liver enzymes alanine aminotransferase(ALT) and aspartate transaminase(AST), as well as liver histopathological features in male and female transgenic(W4PTG) mice and in nontransgenic littermates of 10 mo of age. RESULTS W4PTG males exhibited more pronounced hepatomegaly, significantly increased granule generation in liver tissue, elevated HBs Ag expression in the liver and serum, and higher serum ALT and IL-6 levels compared to W4PTG females or littermate control groups. CONCLUSION Together, our data indicate that the W4 P mutation in pre S1 may contribute to sex disparity in susceptibility to HCC by causing increased HBV virion replication and enhanced IL-6-mediated inflammation in male individuals. Additionally, our transgenic mouse model that expresses full HBV genome with the W4 P mutation in pre S1 could be effectively used for the studies of the progression of liver diseases, including HCC.

关键词： Hepatitis B virus W4P mutation of preS1 transgenic mice Hepatocellular carcinoma

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Cancer stem cell markers CD133 and CD24 correlate with invasiveness and differentiation in colorectal adenocarcinoma

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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho Choi hyo Won Lee Kyung Yul Hur Jae Joon Kim Gyeong-Sin Park Si-hyong jang Young Soo Song Ki-Seok jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

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开发用于小型功率逆变器系统的MOSFET模块

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电子与电脑 2006年第2期6卷 65-68页

作者： Yo-Chan Son Ki-Young jang bum-Seok Suh 飞兆半导体公司(韩国富川) 飞兆半导体公司(韩国富川) 飞兆半导体公司(韩国富川)

　　近年来,市场对于高性能和高效率的逆变器驱动设备需求飞速增长.今天,直流无刷(BLDC)电机已用于许多消费电子设备中,如:变频空调、洗衣机和风扇电机等,使它们较采用开关控制的交流感应电机速度更快、噪声更低及能效更高.这个进步得...

　　近年来,市场对于高性能和高效率的逆变器驱动设备需求飞速增长.今天,直流无刷(BLDC)电机已用于许多消费电子设备中,如:变频空调、洗衣机和风扇电机等,使它们较采用开关控制的交流感应电机速度更快、噪声更低及能效更高.这个进步得以实现的关键之一,在于采用了逆变技术,特别是集成功率模块.目前,集成功率开关及其门驱动电路的功率模块能提供紧凑、可靠和具成本效益的逆变器解决方案,而市场对这类功率模块的需求正急剧上升.SPM(智能功率模组)系列遂应运而生,能支持消费市场的设计需求,提供更高性能.……

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开发用于小型功率逆变器系统的MOSFET模块

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电子与电脑 2006年第1期6卷 65-68页

作者： Yo-Chan Son Ki-Young jang bum-Seok Suh 飞兆半导体公司

近年来，市场对于高性能和高效率的逆变器驱动设备需求飞速增长。今天，直流无刷（BLDC）电机已用于许多消费电子设备中，如：变频空调、洗衣机和风扇电机等，使它们较采用开关控制的交流感应电机速度更快、噪声更低及能效更高。这个进... 详细信息

近年来，市场对于高性能和高效率的逆变器驱动设备需求飞速增长。今天，直流无刷（BLDC）电机已用于许多消费电子设备中，如：变频空调、洗衣机和风扇电机等，使它们较采用开关控制的交流感应电机速度更快、噪声更低及能效更高。这个进步得以实现的关键之一，在于采用了逆变技术，特别是集成功率模块。目前，集成功率开关及其门驱动电路的功率模块能提供紧凑、可靠和具成本效益的逆变器解决方案，而市场对这类功率模块的需求正急剧上升。SPM（智能功率模组）系列遂应运而生，能支持消费市场的设计需求，提供更高性能。

关键词：集成功率模块功率逆变器 MOSFET 消费市场系统开发集成功率开关设备需求风扇电机驱动电路

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已发表抗疟药试验的系统评估

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中华卫生杀虫药械 2004年第4期10卷 231-233页

作者： Myint hy 周钧姜志宽南京军区军事医学研究所江苏南京210002

1引言抗疟药是抗感染剂中临床试验的首选评估药物.20世纪初,奎宁的剂量在预期的试验中曾被评估.随着1926年系统抗疟药的应用,临床研究开始注意这些化合物的可靠性和有效性.这些研究主要被用于伴有精神梅毒的接受疟疾治疗病人或者是部队... 详细信息

1引言抗疟药是抗感染剂中临床试验的首选评估药物.20世纪初,奎宁的剂量在预期的试验中曾被评估.随着1926年系统抗疟药的应用,临床研究开始注意这些化合物的可靠性和有效性.这些研究主要被用于伴有精神梅毒的接受疟疾治疗病人或者是部队军人.

关键词：抗疟药系统评估药理试验青蒿素氯喹 4一氨基喹啉

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满足低功率空调应用PSP提供前端整流器理想方案

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电子测试（新电子） 2005年第9期 44-48页

作者： Ki-Young jang Yo-Chan Son Man-KeeKim Sung-IlYong bum-SeokSuh 飞兆半导体公司

低功率空调领域中对外形紧凑、可靠性高和出色的散热及电性能均有着强劲需求。使用部分转换功率因数校正电路(PSP)的集成式功率模块可满足上述要求。该模块整合了2个绝缘栅双极晶体管(IGBT)和整流二极管,以及1个门驱动低压集成电路(LVIC... 详细信息

低功率空调领域中对外形紧凑、可靠性高和出色的散热及电性能均有着强劲需求。使用部分转换功率因数校正电路(PSP)的集成式功率模块可满足上述要求。该模块整合了2个绝缘栅双极晶体管(IGBT)和整流二极管,以及1个门驱动低压集成电路(LVIC)和1个热敏电阻,集成在基于直接铜键合(DBC)的移模封装中。

关键词：低功率理想方案空调整流器功率因数校正电路前端应用低压集成电路功率模块

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Inhibition of CD82 improves colitis by increasing NLRP3 deubiquitination by BRCC3

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Cellular & Molecular Immunology 2023年第2期20卷 189-200页

作者： Jae-Sung Kim hyo Keun Kim Joongho Lee Sein jang Euni Cho Seok-Jun Mun Seokhyun Yoon Chul-Su Yang Department of Bionano Technology Hanyang UniversitySeoul04673Korea Institute of Natural Science&Technology Hanyang UniversityAnsan15588Korea Department of Molecular and Life Science Hanyang UniversityAnsan15588Korea Center for Bionano Intelligence Education and Research Ansan15588Korea Department of Computer Science College of SW ConvergenceDankook UniversityYongin16890Korea Department of Electronics&Electrical Engineering College of EngineeringDankook UniversityYongin16890Korea

CD82 is a transmembrane protein that is involved in cancer suppression and activates immune cells;however, information on the NLRP3 inflammasome is limited. Herein, we show that although CD82 suppressed the activation of the NLRP3 inflammasome in vivo and in vitro, CD82 deficiency decreased the severity of colitis in mice. Furthermore, two binding partners of CD82, NLRP3 and BRCC3, were identified. CD82 binding to these partners increased the degradation of NLRP3 by blocking BRCC3-dependent K63-specific deubiquitination. Previous studies have shown that CD82-specific bacteria in the colon microbiota called Bacteroides vulgatus (B. vulgatus) regulated the expression of CD82 and promoted the activation of the NLRP3 inflammasome. Accordingly, we observed that B. vulgatus administration increased mouse survival by mediating CD82 expression and activating NLRP3 in mice with colitis. Overall, this study showed that CD82 suppression reduced the pathogenesis of colitis by elevating the activation of the NLRP3 inflammasome through BRCC3-dependent K63 deubiquitination. Based on our findings, we propose that B. vulgatus is a novel therapeutic candidate for colitis.

关键词： CD82 NLRP3 BRCC3 Colitis Inflammation

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Surface-functionalized cellulose nanocrystals(CNC)and synergisms with surfactant for enhanced oil recovery in low-permeability reservoirs

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Petroleum Science 2023年第3期20卷 1572-1583页

作者： Zhe Li Wan-Li Kang Meng-Lan Li Hong-Bin Yang Tong-Yu Zhu Ying-Qi He Hai-Zhuang jang Bo-Bo Zhou Ji-Ting Hao Key Laboratory of Unconventional Oil&Gas Development China University of Petroleum(East China)Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Nanocellulose,a natural polymeric nanomaterial,has attracted significant attention in enhanced oil recovery(EOR)applications due to its abundance,nanoscale,high oil-water interfacial adsorption *** this study,surface-functionalized cellulose nanocrystals(SF-CNCs)were prepared via hy-drochloric acid hydrolysis and chemical modification,with adaptable nanosize and considerable dispersion stability in low-permeability *** SF-CNCs were structurally characterized by FT-IR,Cryo-TEM,which have a diameter of 5-10 nm and a length of 100-200 *** SF-CNC dispersions possessed higher stability and stronger salt-tolerance than those of corresponding CNC dispersions,due to the strong hydrophilicity of the sulfonic acid *** was synergistically used with a non-ionic surfactant(APG1214)to formulate a combined flooding system(0.1 wt%SF-CNC+0.2 wt%APG1214).The combined flooding system exhibits strong emulsification stability,low oil-water interfacial tension of o.03 mN/m,and the ability to alter the wettability for oil-wetting ***,the combined system was_able to provide an optimum EOR efficiency of 20.2%in low-permeability cores with 30.13×10^(-3)μm^(2).*** can enlarge the sweep volume and increase the displacement efficiency ***,the newly formulated nanocellulose/surfactant combined system exhibits a remarkable EoR performance in low-permeability reservoirs.

关键词： Low-permeability reservoirs Enhanced oil recovery Cellulose nanocrystals(CNC) Surfactant Dispersion stability

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