检索结果-南通市图书馆

鼻流量测试新语句材料的效度检验及鼻流量值的性别差异分析

在线全文

学校读者我要写书评

暂无评论

听力学及言语疾病杂志 2014年第5期22卷 471-474页

作者： Kim Ha-kyung hwang young-jin 曹艳静刘晓明黄昭鸣华东师范大学言语听觉科学教育部重点实验室上海200062 华东师范大学言语听觉康复科学系韩国LUTHER大学言语语言病理学系北京联合大学特殊教育学院

目的：检验鼻流量测试新语句材料的测试效度，并分析其测试结果的性别差异。方法应用本研究编制的鼻流量测试新语句材料和目前中国主要使用的鼻流量测试原语句材料，用NasalView 棆鼻流量测试仪测试102例年龄18～23岁的北京在校大学生... 详细信息

目的：检验鼻流量测试新语句材料的测试效度，并分析其测试结果的性别差异。方法应用本研究编制的鼻流量测试新语句材料和目前中国主要使用的鼻流量测试原语句材料，用NasalView 棆鼻流量测试仪测试102例年龄18～23岁的北京在校大学生的鼻流量值，男女各半，均在北京出生且居住18年以上，均以北京话为交流语言，比较其结果和男女差异。结果①新材料鼻腔句、口腔句和口鼻腔句测试的平均鼻流量值分别为56．58％±3．43％、33．86％±5．24％和49．49％±4．13％，原材料的测试结果分别为54．31％±4．43％、35．64％±5．90％和47．12％±4．96％，差异均有显著统计学意义，且女生较男生高（均为 P＜0．01）；②鼻流量测试新材料与原材料测试结果之间有相关关系，鼻腔句 r＝．899（ P＜0．01），口腔句 r＝0．850（ P＜0．01），口鼻腔句 r＝0．8510（ P＜0．01）；③新材料测试结果的标准误较原材料更小，差异有极显著统计学意义（P＜0．01）。结论鼻流量测试新语句材料具有较好的测试效度，与原语句材料之间存在较高的相关关系，利用新材料进行鼻流量测试时，其结果会更准确，可信度更高；正常青年女性鼻流量值较男性高。

关键词：鼻流量测试语句材料性别 NasalView

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan Choi Soo-Ho Choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

在线全文

学校读者我要写书评

暂无评论

失语症定义和失语症评估

中国听力语言康复科学杂志 2013年第1期11卷 62-65页

作者： KIM Ha-kyung hwang young-jin 刘巧云周谢玲华东师范大学言语听觉科学教育部重点实验室上海200062 华东师范大学言语听觉康复科学系上海200062 LUTHER大学言语语言病理学系韩国446—700

根据美国失语症协会定义，失语症是一种因大脑损伤引起的获得性语言障碍，患者主要表现为口语表达、听觉理解和阅读、书写能力损失。失语症多数由脑卒中或脑外伤引起，有时也可由脑肿瘤、阿尔兹海默症等其他中枢性神经损伤引起，在言语... 详细信息

根据美国失语症协会定义，失语症是一种因大脑损伤引起的获得性语言障碍，患者主要表现为口语表达、听觉理解和阅读、书写能力损失。失语症多数由脑卒中或脑外伤引起，有时也可由脑肿瘤、阿尔兹海默症等其他中枢性神经损伤引起，在言语语言治疗后会有一定程度的改善。本文主要介绍了失语症的定义和波士顿失语症诊断量表，西部失语症成套测验．明尼苏达失语症鉴别诊断测验．Porch交往能力指数测试4种标准化失语症评估量表。

关键词：失语症标准化失语症评估

Lightweight design of 45000r/min spindle using full factorial design and extreme vertices design methods

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第1期18卷 153-158页

作者： PARK Seong-jin LEE Choon-man hwang young-kug Department of Mechanical Design and Manufacturing Engineering Changwon National University

Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which satisfy the stiffimss and rotational speed required to the spindle. A general full factorial design method was used to verify some factors that affect the natural frequency of a spindle. It is verified that the shorter shaft length and bearing span length represent the higher natural frequency, and there are some effects according to the change in the levels of factors. The detailed spindle dimension is determined by applying an EVD method, which can define the optimal bearing position through considering the limiting condition. Based on the estimated regression model, the optimal spindle size and bearing distance that can improve the primary natural frequency are obtained, and the influence of design factors on the natural frequency is also analyzed.

关键词： high-speed spindle extreme vertices design natural frequency lightweight design full factorial design

Influence of potassium pyrophosphate in electrolyte on coated layer of AZ91 Mg alloy formed by plasma electrolytic oxidation

在线全文

学校读者我要写书评

暂无评论

中国有色金属学会会刊：英文版 2009年第4期19卷 824-828页

作者： jin-young CHO Duck-young hwang Dong-H eon LEE Bongyoung YOO Dong-Hyuk SHIN Department of Metallurgy and Materials Scienc e Hanyang University

The effect of potassium pyrophosphate in the electrolyte on plasma electrolytic oxidation(PEO) process for AZ91 Mg alloy was *** morphologies and chemical compositions of the coating layer on the AZ91 Mg alloy were evaluated and corrosion resistance was also estimated by potentiodynamic polarization *** coating layer on AZ91 Mg alloy coated from the Bath 2 containing 0.03 mol/L of potassium pyrophosphate for 360 s exhibited considerably dense structure and contained 11%-18%(mass fraction) of *** higher content of phosphorous of coating layer coated from Bath 2 could be detected at the bottom of oxide layer,which strongly implied that the phosphorous ion might be concentrated at the barrier *** potential of coating layer of AZ91 Mg alloy increased and corrosion current density decreased with increasing the concentration of potassium *** polarization resistance(Rp) of coating layer of AZ91 Mg alloy coated from Bath 2 was 4.65×107 Ω/cm2,which was higher than that(Rp=3.56×104 Ω/cm2) of the sample coated from electrolyte without potassium *** coating layer coated from Bath 2 containing 0.03 mol/L potassium pyrophosphate exhibited the best corrosion resistance.

关键词： AZ91镁合金合金涂层焦磷酸钾电解氧化等离子体电解质腐蚀电流密度耐腐蚀性

Beta-nerve growth factor gene therapy alleviates pyridoxine-induced neuropathic damage by increasing doublecortin and tyrosine kinase A in the dorsal root ganglion

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第1期15卷 162-168页

作者： Hyun-Kee Cho Woosuk Kim Kwon-young Lee jin-Ok Ahn Jung Hoon Choi In Koo hwang jin-young Chung Department of Veterinary Internal Medicine and Institute of Veterinary Science College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea Department of Anatomy and Cell Biology College of Veterinary MedicineResearch Institute for Veterinary ScienceSeoul National UniversitySeoulSouth Korea Department of Anatomy College of Veterinary MedicineKangwon National UniversityChuncheonKangwon-doSouth Korea

Beta-nerve growth factor(β-NGF) is known to be a major leading cause of neuronal plasticity. To identify the possible action mechanisms of β-NGF gene therapy for sciatic nerve recovery, experimental dogs were randomly divided into control, pyridoxine, and pyridoxine + β-NGF groups. We observed chronological changes of morphology in the dorsal root ganglia in response to pyridoxine toxicity based on cresyl violet staining. The number of large neurons positive for cresyl violet was dramatically decreased after pyridoxine intoxication for 7 days in the dorsal root ganglia and the neuron number was gradually increased after pyridoxine withdrawal. In addition, we also investigated the effects of β-NGF gene therapy on neuronal plasticity in pyridoxine-induced neuropathic dogs. To accomplish this, tyrosine kinase receptor A(TrkA), βIII-tubulin and doublecortin(DCX) immunohistochemical staining was performed at 3 days after the last pyridoxine treatment. TrkA-immunoreactive neurons were dramatically decreased in the pyridoxine group compared to the control group, but strong TrkA immunoreactivity was observed in the small-sized dorsal root ganglia in this group. TrkA immunoreactivity in the dorsal root ganglia was similar between β-NGF and control groups. The numbers of βIII-tubulin-and DCX-immunoreactive cells decreased significantly in the pyridoxine group compared to the control group. However, the reduction of βIII-tubulin-and DCX-immunoreactive cells in the dorsal root ganglia in the β-NGF group was significantly ameliorated than that in the pyridoxine group. These results indicate that β-NGF gene therapy is a powerful treatment of pyridoxine-induced neuropathic damage by increasing the TrkA and DCX levels in the dorsal root ganglia. The experimental protocol was approved by the Institutional Animal Care and Use Committee(IACUC) of Seoul National University, South Korea(approval No. SNU-060623-1, SNU-091009-1) on June 23, 2006 and October 9, 2009, respectively.

关键词： β-nerve growth factor βIII-tubulin doublecortin gene therapy neuron-glial antigen 2 neuropathy pyridoxine

Comparison Study and Forensic Analysis between Experiment and Coupled Dynamics Simulation for Submerged Floating Tunnel Segment with Free Ends under Wave Excitations

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2023年第10期137卷 155-174页

作者： Woo Chul Chung Chungkuk jin Moo Hyun Kim Ju-young hwang Division of Mechanical Engineering Korea Maritime&Ocean UniversityBusanSouth Korea Department of Ocean Engineering and Marine Sciences Florida Institute of TechnologyMelbourneFLUSA Department of Ocean Engineering Texas A&M UniversityCollege StationTXUSA Department of Civil Engineering Dong-Eui UniversityBusanSouth Korea

This paper presents dynamic-behavior comparisons and related forensic analyses of a submerged floating tunnel(SFT)between numerical simulation and physical experiment under regular and irregular *** experiments are conducted in the 3Dwave tank with 1:33.3 scale,and the corresponding coupled time-domain simulation tool is devised for *** entire SFT systemconsists of a long concrete tunnel and 12 tubular aluminummooring *** numerical simulation models,the Cummins equation with 3D potential theory including second-order wave-body interaction effects and the much simpler Morison-equation-based formula with the lumped-massbased line model,are designed and *** analyses for mooring-line adjustments in the simulation are carried out in view of the best representation of the physical *** that,the measured pre-tension distribution and systemstiffness of twelvemooring lines arewell reproduced in the ***,the dynamic responses and mooring tensions of the SFT are compared under regular and irregular *** measured and simulated results coincide reasonably well for both regular-and irregular-wave conditions.

关键词： Submerged floating tunnel comparative study forensic analysis mooring-line modeling dynamic response mooring tension

Monolayer Graphitic Carbon Nitride as Metal-Free Catalyst with Enhanced Performance in Photo- and Electro-Catalysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2022年第3期14卷 308-321页

作者： Huiyan Piao Goeun Choi Xiaoyan jin Seong‑Ju hwang young Jae Song Sung‑Pyo Cho jin‑Ho Choy Intelligent Nanohybrid Materials Laboratory(INML) Institute of Tissue Regeneration Engineering(ITREN)Dankook UniversityCheonan 31116Republic of Korea College of Science and Technology Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Materials Science and Engineering College of EngineeringYonsei UniversitySeoul 03722Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea National Center for Inter‑University Research Facilities(NCIRF) Seoul National UniversitySeoul 08826Republic of Korea Graphene Research Center Advanced Institute of Convergence TechnologySuwon 16229Republic of Korea Department of Pre‑Medical Course College of MedicineDankook UniversityCheonan 31116Republic of Korea Tokyo Tech World Research Hub Initiative(WRHI) Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226‑8503Japan

The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic *** has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics *** this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step *** atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic *** addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine *** to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction *** addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).

关键词： Graphitic carbon nitride Monolayer Atomic image Electro-and photo-catalysis