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Nano Research 2022年第6期15卷 5545-5555页

作者： Hyejin kwon Carson.J.Bruns Paul M.Rady Department of Mechanical Engineering University of ColoradoBoulder427 UCB1111 Engineering DriveBoulderCO 80309USA ATLAS Institute 112518th St.320 UCBBoulderCO 80309USA

Polycyclic aromatic hydrocarbons(PAHs)are promising nanocarbon materials with diverse optoelectronic properties,yet they also pose concerning environmental and health *** the ubiquity of PAHs in the environment(crude oil,emissions,and biomass),most supermolecules rely on heteroatoms for *** discovered and characterized a family of all-hydrocarbon,all-π-conjugated[n]cycloparaphenylene-PAH host–guest *** built a theoretical framework to rapidly select these complexes and predict their stabilities,driven exclusively by CH–π*** than a dozen complexes were confirmed experimentally and assembled directly from commercially available *** motif offers a versatile way to combine the advantageous properties of organic semiconductors with the rich dynamic,stereochemical,stimulus-responsive,and stressdissipative behavior of host–guest complexes,while creating new opportunities for bespoke PAH separation or remediation materials.

关键词： cycloparaphenylenes density functional calculations host−guest systems hydrocarbons polycycles self-assembly supramolecular chemistry

Blockchain Consistency Check Protocol for Improved Reliability

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Computer Systems Science & Engineering 2021年第2期36卷 281-292页

作者： Mohammed Alwabel Youngmi kwon Department of Radio and Information Communications Engineering Chungnam National UniversityDaejeonKorea

Blockchain is a technology that provides security features that can be used for more than just *** achieves security by saving the information of one block in the next *** the information of one block will require changes to all the next block in order for that change to take *** makes it unfeasible for such an attack to ***,the structure of how blockchain works makes the last block always vulnerable for attacks,given that its information is not saved yet in any *** allows malicious node to change the information of the last block and generate a new block and broadcast it to the *** that the nodes always follow the longer chain wins rule,the malicious node will win given that it has the longest chain in the *** paper suggests a solution to this issue by making the nodes send consistency check messages before broadcasting a *** the nodes manage to successfully verify that the node that generated a new block hasn’t tampered with the blockchain than that block will be *** results of the simulation show suggested protocol provided better security compared to the regular blockchain.

关键词： Blockchain security forking blockchain consistency check(BCC) protocol

Adaptive Consistent Management to Prevent System Collapse on Shared Object Manipulation in Mixed Reality

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Computers, Materials & Continua 2023年第4期75卷 2025-2042页

作者： Jun Lee Hyun kwon Department of Game Software Hoseo UniversityAsan-siKorea Department of Artificial Intelligence and Data Science Korea Military AcademySeoulKorea

A concurrency control mechanism for collaborative work is akey element in a mixed reality environment. However, conventional lockingmechanisms restrict potential tasks or the support of non-owners, thusincreasing the working time because of waiting to avoid conflicts. Herein, wepropose an adaptive concurrency control approach that can reduce conflictsand work time. We classify shared object manipulation in mixed reality intodetailed goals and tasks. Then, we model the relationships among goal,task, and ownership. As the collaborative work progresses, the proposedsystem adapts the different concurrency control mechanisms of shared objectmanipulation according to the modeling of goal–task–ownership. With theproposed concurrency control scheme, users can hold shared objects andmove and rotate together in a mixed reality environment similar to realindustrial sites. Additionally, this system provides MS Hololens and Myosensors to recognize inputs from a user and provides results in a mixed realityenvironment. The proposed method is applied to install an air conditioneras a case study. Experimental results and user studies show that, comparedwith the conventional approach, the proposed method reduced the number ofconflicts, waiting time, and total working time.

关键词： Mixed reality upper body motion recognition shared object manipulation adaptive task concurrency control

New Spam Filtering Method with Hadoop Tuning-Based MapReduce Naïve Bayes

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Computer Systems Science & Engineering 2023年第4期45卷 201-214页

作者： Keungyeup Ji Youngmi kwon Department of Radio and Information Communications Engineering Chungnam National UniversityDaejeon34134Korea

As the importance of email increases,the amount of malicious email is also increasing,so the need for malicious email filtering is *** it is more economical to combine commodity hardware consisting of a medium server or PC with a virtual environment to use as a single server resource and filter malicious email using machine learning techniques,we used a Hadoop MapReduce framework and Naïve Bayes among machine learning methods for malicious email ***ïve Bayes was selected because it is one of the top machine learning methods(Support Vector Machine(SVM),Naïve Bayes,K-Nearest Neighbor(KNN),and Decision Tree)in terms of execution time and *** email was filtered with MapReduce programming using the Naïve Bayes technique,which is a supervised machine learning method,in a Hadoop framework with optimized performance and also with the Python program technique with the Naïve Bayes technique applied in a bare metal server environment with the Hadoop environment not *** to the results of a comparison of the accuracy and predictive error rates of the two methods,the Hadoop MapReduce Naïve Bayes method improved the accuracy of spam and ham email identification 1.11 times and the prediction error rate 14.13 times compared to the non-Hadoop Python Naïve Bayes method.

关键词： Hadoop hadoop distributed file system(HDFS) MapReduce configuration parameter malicious email filtering Naïve Bayes

Application of artificial intelligence to rock mechanics:An overview

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第1期13卷 248-266页

作者： Abiodun Ismail Lawal Sangki kwon Department of Energy Resources Engineering Inha UniversityYong-Hyun DongNam KuIncheonSouth Korea Department of Mining Engineering Federal University of TechnologyAkureNigeria

Different artificial intelligence(AI)methods have been applied to various aspects of rock mechanics,but the fact that none of these methods have been used as a standard implies that doubt as to their generality and validity still *** this,a literature review of application of AI to the field of rock mechanics is *** studies of the researches published in the top journals relative to the fields of rock mechanics,computer applications in engineering,and the textbooks were *** performances of the AI methods that have been used in rock mechanics applications were *** literature review shows that AI methods have successfully been used to solve various problems in the rock mechanics field and they performed better than the traditional empirical,mathematical or statistical ***,their practical applicability is still an issue of concern as many of the existing AI models require some level of expertise before they can be used,because they are not in the form of tractable mathematical *** some advanced AI methods are still yet to be *** limited availability of dataset for the AI simulations is also identified as a major *** solutions to the identified problems and the possible future research focus were proposed in the study subsequently.

关键词： Artificial intelligence(AI) Rock mechanics Literature review Statistical method

Development of mathematically motivated hybrid soft computing models for improved predictions of ultimate bearing capacity of shallow foundations

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 747-759页

作者： Abiodun Ismail Lawal Sangki kwon Department of Energy Resources Engineering Inha UniversityIncheonSouth Korea Department of Mining Engineering Federal University of TechnologyAkureNigeria

Ultimate bearing capacity(UBC)is a key subject in geotechnical/foundation engineering as it determines the limit of loads imposed on the *** most reliable means of determining UBC is through experiment,but it is costly and time-consuming which has led to the development of various models based on the simplified *** outcomes of the models are usually validated with the experimental results,but a large gap usually exists between ***,a model that can give a close prediction of the experimental results is *** study proposes a grasshopper optimization algorithm(GOA)and salp swarm algorithm(SSA)to optimize artificial neural networks(ANNs)using the existing UBC experimental *** performances of the proposed models are evaluated using various statistical *** obtained results are compared with the existing *** proposed models outperformed the existing *** proposed hybrid GOA-ANN and SSA-ANN models are then transformed into mathematical forms that can be incorporated into geotechnical/foundation engineering design codes for accurate UBC measurements.

关键词： Ultimate bearing capacity(UBC) Geotechnics Grasshopper optimization algorithm(GOA) Salp swarm algorithm(SSA) Soft computing(SC)method

The two faces of IL-2: a key driver of CD8^(+)T-cell exhaustion

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Cellular & Molecular Immunology 2021年第7期18卷 1641-1643页

作者： Byungsuk kwon School of Biological Sciences University of UlsanUlsanRepublic of Korea

The body undergoes abnormal,pathological immune responses when antigens are present at too great an excess for the immune system to handle or the body is persistently exposed to *** etiology of many types of chronic diseases is partially related to such conditions;thus,understanding the pathophysiological processes of these chronic diseases is of paramount importance for therapeutic purposes.A recent paper published in Nature Immunology revealed the unexpected involvement of the T cell-activating cytokine interleukin(IL)-2 in counteracting the immune attack on tumors,a finding that will provide new options for cancer therapy.

关键词： involvement diseases Immunology

Regulatory roles of dermal type 2 innate lymphoid cells

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Cellular & Molecular Immunology 2013年第6期10卷 453-455页

作者： Byungsuk kwon School of Biological Sciences University of Ulsan Ulsan Korea

Type 2 immune immunity evolved a unique system to protect against noxious xenobiotics at the epithelial bar- rier） Recently, epithelial cell-derived cytokines IL-25, IL-33 and TSLP have been shown to be critical in producing Th2 cytokines, including IL-4, IL-5, IL- 9 and IL-13, eby type 2 innate lymphoid cells （ILC2s） as well as Th2 cells.

关键词： Th2细胞白细胞介素13 白细胞介素4 白细胞介素5 淋巴细胞淋巴细胞亚群细胞因子类血气分析

Appendectomy in patient with suspected COVID-19 with negative COVID-19 results: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1944-1949页

作者： Changho Kim Jong Kun Kim In hwan Yeo Jae Young Choe Jeong Eun Lee So Jeong Kang Chan Sub Park Ki Tae kwon Soyoon hwang Department of Emergency Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Surgery School of MedicineKyungpook National UniversityKyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine School of MedicineKyungpook National UniversityDaeguKoreaDepartment of Infection ControlKyungpook National University Chilgok HospitalDaegu 41944South Korea

BACKGROUND Even at present,we are in the middle of the novel coronavirus disease 2019(COVID-19)pandemic and are facing challenges in trial and ***,emergency surgery for patients with suspected COVID-19 is burdensome not only for patients but also for healthcare ***,we established a surveillance system in the emergency room and established principles for managing patients suspected of COVID-19 who require emergency *** SUMMARY A 67-year-old man was diagnosed with appendicitis in March *** wife was diagnosed with COVID-1910 d earlier,and the patient was in close contact with *** patient tested negative twice on an upper respiratory COVID-19 reverse transcription–polymerase chain reaction screening test,but chest X-ray and chest computed tomography revealed patchy ground-glass opacity in both upper lobes of the patient’s *** same emergency surgery procedure for patients with confirmed COVID-19 was applied to this patient suspected of having the disease to ensure that surgery was not delayed while waiting for the reverse transcription–polymerase chain reaction results.A few hours after surgery,the upper respiratory tract specimen taken in the emergency room was negative for COVID-19 but the lower respiratory tract specimen was found to be positive for the *** When COVID-19 is suspected,emergency surgery should be performed as for confirmed COVID-19 without delay.

关键词： COVID-19 Appendicitis Appendectomy Emergency room Infection control Case report

LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer

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Genomics, Proteomics & Bioinformatics 2023年第1期21卷 177-189页

作者： Oh Kwang kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao Sam Seok Cho Sung hwan Ki Youngshik Choe Jun Nyung Lee Yun-Sok Ha Eun Ju Bae Tae Gyun kwon Byung-Hyun Park Sangkyu Lee BK21 Plus KNU Multi-Omics Based Creative Drug Research Team College of PharmacyResearch Institute of Pharmaceutical SciencesKyungpook National UniversityDaegu 41566Republic of Korea Department of Biochemistry and Molecular Biology Chonbuk National University Medical SchoolJeonjuJeonbuk 54896Republic of Korea College of Pharmacy Chosun UniversityGwangju 61452Republic of Korea Korea Brain Research Institute Daegu 41068Republic of Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41566Republic of Korea Department of Urology Kyungpook National University HospitalDaegu 41566Republic of Korea College of Pharmacy Chonbuk UniversityJeonjuJeonbuk 54896Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men *** 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival *** great efforts,the detailed mechanisms underlying castration-resistant PCa(CRPC)remain *** 5(SIRT5),an NAD+-dependent desuccinylase,is hypothesized to be a key regulator of various ***,compared to other SIRTs,the role of SIRT5 in cancer has not been extensively ***,we revealed significantly decreased SIRT5 levels in aggressive PCa cells relative to the PCa *** correlation between the decrease in the SIRT5 level and the patient’s reduced survival rate was also *** quantitative global succinylome analysis,we characterized a significant increase in the succinylation at lysine 118(K118su)of lactate dehydrogenase A(LDHA),which plays a role in increasing LDH *** a substrate of SIRT5,LDHA-K118su significantly increased the migration and invasion of PCa cells and LDH activity in PCa *** study reveals the reduction of SIRT5 protein expression and LDHA-K118su as a novel mechanism involved in PCa progression,which could serve as a new target to prevent CPRC progression for PCa treatment.

关键词： Sirtuin 5 Lactate dehydrogenase A Lysine succinylation PCa progression