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Virtual vibration test rig for fatigue analysis of dozer push arms

International Journal of Mechanical System Dynamics 2024年第3期4卷 278-291页

作者： Lei Hou Weibin Li Wenyan Gu Zizheng Sun Xiangqian Zhu jin-hwan choi Key Laboratory of High-Efficiency and Clean Mechanical Manufacture of MOE National Demonstration Center for Experimental Mechanical EngineeringSchool of Mechanical EngineeringShandong UniversityJinanChina Rizhao Research Institute of Shandong University RizhaoChina School of Aerospace Engineering Xiamen UniversityXiamenChina School of Qilu Transportation Shandong UniversityJinanChina Department of Mechanical Engineering Kyunghee UniversitySeoulSouth Korea

To obtain accurate fatigue life results for construction machinery components,acquiring load spectra is crucial,as their authenticity and validity directly determine the precision of the *** working conditions,component attitudes change continuously,but they remain static on the vibration test rig(VTR),so the acquired target signals should match with the actual component attitudes in the driving signal *** paper proposes an efficient and economical simulation-based virtual VTR for fatigue analysis of ***,the relationship between the push arm rotation angle and the cylinder stroke is established,since the cylinder strokes can be measured easily in data acquisition ***,load decomposition is used to determine the attitude relationship between virtual VTR conditions and actual conditions,and target signals are calculated based on this attitude relationship and measured *** to the system's frequency response function,the driving signals are iterated until the system's response signals converge with the target ***,the iteratively obtained load spectra are utilized for fatigue life *** results show that the virtual VTR can effectively and accurately obtain the results of fatigue analysis and has engineering application significance.

关键词： virtual vibration test rig driving signal generation component attitudes fatigue analysis dozer push arm

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Wear characteristics of Ⅴ shape diamond tool for micro prism pattern with Al alloys

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中国有色金属学会会刊：英文版 2012年第S3期22卷 769-774页

作者： Eun-Suk PARK Tae-jin JE hwan-jin choi Eun-Chae JEON Myung-Chang KANG Nano-Mechatronics University of Science & Technology Division of Nano-Mechanical Systems Korea Institute of Machinery and Materials National Core Research Center for Hybrid Materials Solution Pusan National University

The ultra-precision machining process using a single crystal diamond tool has been mainly used for machining molds of optical *** the micro patterns of various shapes having excellent surface roughness can be machined by using ultra-precision machine tools,the micro pattern on a large light guide plate (LGP) is mainly machined using a diamond *** tool wear occurs due to long machining distances and time while machining a large-area LGP *** deformation and dimensional error of micro pattern are caused by tool wear,as a result,the light efficiency of LGP *** characteristics of tool wear should be analyzed in order to precisely machine large-area LGP mold from all sorts of *** experiments were performed in order to compare wear characteristics of a V90° diamond tool using Al3003,5052,6061 and *** prism pattern of depth 10 μm was machined in order to analyze characteristics of tool wear according to machining distances (0.5,1 and 1.5 km).The effects of tool wear on pattern shape were analyzed by applying overlapped cutting depths (Rough machining is (10+8+7) μm and Finish machining is (5+3+2+1) μm) by continuously machining a prism pattern of W shape of 25 μm in depth.

关键词： diamond tool wear Al alloys micro prism pattern planer

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Machine Learning for QoS Optimization and Energy-Efficient in Routing Clustering Wireless Sensors

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Computers, Materials & Continua 2025年第1期82卷 327-343页

作者： Rahma Gantassi Zaki Masood Yonghoon choi Department of Electrical Engineering Chonnam National University Gwangju61186Republic of Korea

Wireless sensor network(WSN)technologies have advanced significantly in recent *** in WSNs,machine learning algorithms are crucial in selecting cluster heads(CHs)based on various quality of service(QoS)*** paper proposes a new clustering routing protocol employing the Traveling Salesman Problem(TSP)to locate the optimal path traversed by the Mobile Data Collector(MDC),in terms of energy and QoS *** bemore specific,to minimize energy consumption in the CH election stage,we have developed the M-T protocol using the K-Means and the grid clustering *** addition,to improve the transmission phase of the Low Energy Adaptive Clustering-Grid-KMeans(LEACH-G-K)protocol,the MDC is employed as an intermediary between the CH and the sink to improve the wireless sensor network(WSN)*** results of the experiment demonstrate that the M-T protocol enhances various Low Energy Adaptive Clustering protocol(LEACH)improvements such as the LEACH-G-K,LEACH-C,Threshold sensitive Energy Efficient Sensor Networks(TEEN),MDC maximum residual energy leach protocol.

关键词： LEACH-G-K MDC TSP QoS K-Means

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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1555-1564页

作者： Eunhee Kim Rudolph ETanzi Se Hoon choi Genetics and Aging Research Unit MassGeneral Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMAUSA McCance Center for Brain Health Massachusetts General HospitalBostonMAUSA

Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关键词： Alzheimer's disease exercise fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan choi Soo-Ho choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan Ping Yu Emily choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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Image-guided conservative management of right colonic diverticulitis

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World Journal of Gastroenterology 2009年第46期15卷 5838-5842页

作者： Sun jin Park Sung II choi Suk hwan Lee Kil Yeon Lee Department of Surgery Kyung Hee University School of Medicine

AIM： To study the clinical outcomes of medical therapy in patients with right colonic diverticulitis. METHODS： The records of 189 patients with right colonic diverticulitis which was finally diagnosed by computed tomography, ultrasonography, or operative findings were retrospectively reviewed. RESULTS： Of the 189 patients hospitalized for right colonic diverticulitis, the stages of diverticulitis by a modified Hinchey classification were 26 patients （13.8%） in stage 0, 139 patients （73.5%） in stage I a, 23 patients （12.2%） in stage I b, and 1 patient （0.5%） in stage Ⅲ. Medical therapy was undertaken in 185 of 189 patients （97.9%）. One hundred and eighty three of 185 patients were successfully treated with bowel rest and antibiotics. Two patients in stage I b required a resection or surgical drainage because of an inadequate response to conservative treatment. Recurrent diverticulitis developed in 15 of 183 patients （8.2%） who responded to medical therapy. All 15 patients who suffered a second attack had uncomplicated diverticulitis, and were successfully treated with medical ***： Our results indicate that right colonic diverticulitis is essentially benign and image-guided conservative treatment is primarily required.

关键词： Ascending colon Cecum Medical therapy Colonic diverticulitis

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Single port laparoscopic right hemicolectomy with D3 dissection for advanced colon cancer

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World Journal of Gastroenterology 2010年第2期16卷 275-278页

作者： Sung Il choi Kil Yeon Lee Sun jin Park Suk-hwan Lee Department of Surgery School of MedicineKyung Hee University#1 Hoegi-dong Dongdaemun-guSeoul 130-702 South Korea

We report the first case of single port laparoscopic right hemicolectomy for advanced colon *** abdominal 3 cm length incision was made via the umbilicus.A small wound retractor and a surgical glove were used as a single *** soft tissue anterior to the superior mesenteric vein was completely removed and D3 lymph node dissection was *** total operative time was 180 min with minimal blood loss (<50 mL).The size of the tumor was 5 cm×3 cm and its tumor stage was ***-nine lymph nodes were harvested and none were *** believe that single port surgery for colon cancer is a feasible and safe procedure with surgical results comparable to conventional laparoscopic procedures.

关键词： Single port laparoscopic surgery Colon cancer D3 lymph node dissection

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Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： Hae jin Park Hee jin Lee Tae Kyung Kim Sung hwan Hong Wei-Min Wang Taek Jib choi Ki Buem Kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

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