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Secondary craniofacial necrotizing fasciitis from a distant septic emboli: A case report

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World Journal of Clinical Cases 2022年第31期10卷 11630-11637页

作者： Da-Woon Lee Si-Hyun Kwak hwan-jun choi Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Institute of Tissue Regeneration College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea

BACKGROUND Craniofacial necrotizing fasciitis(CNF)is an uncommon but fatal infection that can spread rapidly through the subfascial planes in the head and neck *** usually progress rapidly,and early management is necessary to optimize *** SUMMARY A 43-year-old man visited our hospital with left hemifacial swelling involving the buccal and submandibular *** patient had fever for approximately 10 d before visiting the hospital,but did not report any other systemic *** tomography scan demonstrated an abscess with gas *** surgical drainage of the facial abscess,the patient’s systemic condition worsened and progressed to septic *** examination revealed pulmonary and renal *** percutaneous catheter drainage was performed at the renal abscess site,which caused improvement of *** patient showed no evidence of systemic complications during the 4-mo post-operative follow-up *** As the patient did not improve with conventional CNF treatment and symptoms only resolved after controlling the infection,the final diagnosis was secondary CNF with septic *** surgical decompression is important for CNF ***,if symptoms worsen despite early diagnosis and management,such as pus drainage and surgical intervention,clinicians should consider the possibility of a secondary abscess from internal organs.

关键词： Craniofacial necrotizing fasciitis Septic emboli Klebsiella pneumoniae Secondary Case report

Recurrent intramuscular lipoma at extensor pollicis brevis:A case report

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World Journal of Clinical Cases 2023年第3期11卷 684-691页

作者： Je Yeon Byeon Yong Seon hwang Ji Hye Lee hwan jun choi Plastic and Reconstructive Surgery Soonchunhyang University HospitalCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea

BACKGROUND This report describes and discusses recurrent intramuscular lipoma(IML)of the extensor pollicis brevis(EPB).An IML usually occurs in a large muscle of the limb or *** of IML is *** IMLs,especially those with unclear boundaries,necessitate complete *** cases of IML in the hand have been ***,recurrent IML appearing along the muscle and tendon of EPB on wrist and forearm has not been reported *** SUMMARY In this report,the authors describe clinical and histopathological features of recurrent IML at EPB.A 42-year-old Asian woman presented with a slowgrowing lump in her right forearm and wrist area six months *** patient had a history of surgery for a lipoma of the right forearm one year ago with a scar of 6cm on the right *** resonance imaging confirmed that the lipomatous mass,which had attenuation similar to subcutaneous fat,had invaded the muscle layer of *** and biopsy were performed under general *** histological examination,it was identified as an IML showing mature adipocytes and skeletal muscle ***,surgery was terminated without further *** recurrence occurred during a follow-up of five years after *** Recurrent IML in the wrist must be examined to differentiate it from *** to surrounding tissues should be minimized during excision.

关键词： Intramuscular Lipoma Recurrence Wrist Case report

Expression rates of p16,p53 in head and neck cutaneous squamous cell carcinoma based on human-papillomavirus positivity

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World Journal of Clinical Cases 2025年第9期13卷 13-23页

作者： Ha-Jong Nam Heongrae Ryu Da-Woon Lee Je Yeon Byeon jun Hyuk Kim Ji Hye Lee Soomin Lim hwan jun choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea Department of Pathology Soonchunhyang University HospitalCheonan-si 31151South Korea Bachelor of Medicine and Bachelor of Surgery University College LondonMedical SchoolLondon WC1E 6DEUnited Kingdom

BACKGROUND The high prevalence of human papillomavirus(HPV)infection in oropharyngeal squamous cell carcinoma(SCC)is well established,and p16 expression is a strong ***-related tumors exhibit unique mechanisms that target p16 and p53 ***,research on HPV prevalence and the combined predictive value of p16 and p53 expression in head and neck cutaneous SCC(HNCSCC),particularly in Asian populations,remains *** retrospective study surveyed 62 patients with HNSCC(2011-2020),excluding those with facial warts or other skin *** To explore the prevalence of HPV and the predictive value of p16 and p53 expression in HNCSCC in Asian *** All patients underwent wide excision and *** staining for HPV,p16,and p53 yielded positive and negative *** relevance of each marker was investigated by categorizing the tumor locations into high-risk and middle-risk zones based on recurrence *** Of the 62 patients,20(32.26%)were male,with an average age of 82.27 years(range 26-103 years).High-risk included 19 cases(30.65%),with the eyelid and lip being the most common sites(five cases,8.06%).Middle-risk included 43 cases(69.35%),with the cheek being the most common(29 cases,46.77%).The p16 expression was detected in 24 patients(38.71%),p53 expression in 42 patients(72.58%),and HPV in five patients(8.06%).No significant association was found between p16 expression and the presence of HPV(P>0.99),with a positive predictive value of 8.33%.CONCLUSION This study revealed that p16,a surrogate HPV marker in oropharyngeal SCC,is not reliable in HNCSCC,providing valuable insights for further research in Asian populations.

关键词： Squamous cell carcinoma Oropharyngeal Non-oropharyngeal Human papillomavirus The p16 The p53

Removal of unexpected schwannoma with superficial parotidectomy using modified-Blair incision and superficial musculoaponeurotic system folding: A case report

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World Journal of Clinical Cases 2023年第18期11卷 4438-4445页

作者： Ha-Jong Nam hwan jun choi Je-Yeon Byeon Syeo-Young Wee Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371Gyeonsangbuk-doSouth Korea Department of Plastic and Reconstructive Surgery Soonchunhyang University Cheonan HospitalCheonan-si 31151Chungcheongnam-doSouth Korea

BACKGROUND When a firm facial mass in the cheek region is associated with a high index of clinical suspicion of its being of parotid gland origin,preventive parotidectomy is invariably *** report a rare case of a schwannoma that was suspected to be of parotid gland origin in a patient,who underwent successful surgical management using a modified-Blair incision and superficial musculoaponeurotic system(SMAS)layer folding *** SUMMARY A 27-year-old woman presented to the hospital for evaluation of a firm,fixed,non-tender mass(2.5 cm×3.5 cm),located anterior to the right ear,of 1 year’s ***-enhanced facial computed tomography revealed a wellencapsulated,low-density mass adherent to the superficial lobe of the right parotid gland,with a high index of clinical suspicion of an accessory parotid gland *** patient was scheduled to undergo resection of the mass and superficial *** underwent surgery using a modified-Blair incision,and the SMAS layer was folded posteriorly to reconstruct the *** examination confirmed the diagnosis of a schwannoma.,and we observed no postoperative complications such as hematoma,infection,or abnormal facial *** incision scar was unnoticeable 2 mo postoperatively,and the facial contour was maintained without any differences between the affected and unaffected *** We used a modified-Blair incision and SMAS layer folding method to achieve aesthetically good results following resection of a rare schwannoma with superficial parotidectomy in the cheek region.

关键词： Schwannoma Parotid gland Superficial musculoaponeurotic system Case report

Does the advantage of transcutaneous oximetry measurements in diabetic foot ulcer apply equally to free flap reconstruction?

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World Journal of Clinical Cases 2023年第31期11卷 7570-7582页

作者： Da Woon Lee Yong Seon hwang Je Yeon Byeon jun Hyuk Kim hwan jun choi Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-si 31151South Korea

BACKGROUND Transcutaneous oxygen pressure(TcpO2)is a precise method for determining oxygen perfusion in wounded *** device uses either electrochemical or optical *** To evaluate the usefulness of TcpO2 measurements on free flaps(FFs)in diabetic foot ulcers(DFUs).METHODS TcpO2 was measured in 17 patients with DFUs who underwent anterolateral thigh(ALT)-FF surgery and compared with 30 patients with DFU without FF *** Significant differences were observed in the ankle-brachial index;duration of diabetes;and haemoglobin,creatinine,and C-reactive protein levels between the two ***2 values were similar between two groups except on postoperative days 30 and 60 when the values in the ALT-FF group remained50 *** Even if the flap is clinically stable,sympathectomy due to adventitia stripping during anastomosis and arteriovenous shunt progression due to diabetic polyneuropathy could lead to low TcpO2 values in the ALT-FF owing to its thick fat tissues,which is supported by the slow recovery of the sympathetic tone following ***,TcpO2 measurements in patients with DFU who underwent FF reconstruction may be less accurate than in those who did not.

关键词： Arteriovenous shunt Surgical Diabetic neuropathies Free tissue flaps Sympathectomy Blood gas monitoring Transcutaneous Diabetic angiopathies

Effectiveness of out-fracture of the inferior turbinate with reduction nasal bone fracture

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World Journal of Clinical Cases 2023年第27期11卷 6374-6382页

作者： Se-Young Kim Ha-Jong Nam Je-Yeon Byeon hwan jun choi Department of Plastic and Reconstructive Surgery Soonchunhyang University Gumi HospitalGumi-si 39371South Korea Department of Plastic and Reconstructive Surgery Soonchunhyang University Cheonan HospitalCheonan-si 31151South Korea

BACKGROUND The nasal bone,being the most protruding bone in the center of the facial bones,is particularly susceptible to *** bone fractures can often result in secondary deformation and dysfunction of the nose,including septal *** on functional or intra-nasal complications have been rarely reported after nasal bone fracture *** To evaluate the severity of nasal obstruction and its improvement following nasal bone fracture reduction using inferior *** We conducted a retrospective review of data from 50 patients with symptomatic nasal obstruction between January to December *** patients underwent preoperative Computed tomography evaluation,and symptom changes and nasal cavity volume were analyzed using a visual analog scale and acoustic rhinometry before and after *** reduction and out-fracture of both inferior turbinates performed by the same *** outcomes were assessed by comparing changes in the nasal airway volume measured using acoustic rhinometry before and after *** minimal cross-sectional area(MCA)was also analyzed based on the Stranc *** Before reduction,the mean MCA for all cases was 0.59±0.06 cm^(2),which represented an 11%decrease compared to the average size of a Korean adult(0.65±0.03 cm^(2)).The MCA for frontal impact was 0.60±0.02 cm^(2) and for lateral impact,it was 0.58±0.03 cm^(2).After reduction via inferior turbinoplasty,the MCA improved to 0.64±0.04 cm^(2).CONCLUSION This study suggests that turbinoplasty is helpful in addressing nasal ***-fracture of the inferior turbinate is an effective and durable technique that can be easily performed to enlarge the nasal airway with minimal morbidity.

关键词： Acoustic rhinometry Nasal bone Fracture Turbinate

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum jun Kim Seungyon Koh Hyo Jin Cho Xuelian Jin Byung Gon Kim jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Analysis of optical emission spectroscopy data during silicon etching in SF_(6)/O_(2)/Ar plasma

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Plasma Science and Technology 2021年第12期23卷 117-127页

作者： Dong hwan KIM Jeong Eun choi Sang Jeen HONG Department of Electronics Engineering Myongji University116 Myongji-roYongin-siGyeonggi-doRepublic of Korea

Silicon etching is an essential process in various applications,and a major challenge for etching process is anisotropic high aspect ratio etching *** etch profile is determined by the plasma parameters and process *** this study,the plasma state with each process parameters were analyzed through the optical emission spectroscopy(OES)plasma diagnostic sensor by both chemical and physical *** temperature and electron density were additionally acquired using the corona model with OES data that provides chemical species information,and the etch profile was evaluated through scanning electron microscope measurement *** results include changes in profile with gas ratio,bias power,and *** figure out that factors like ion energy and ion angular distribution as well as chemical reaction affect the anisotropic profile.

关键词： silicon etching profile optical emission spectroscopy plasma in-formation corona model

Black esophagus with concomitant candidiasis developed after diabetic ketoacidosis

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World Journal of Gastroenterology 2007年第42期13卷 5662-5663页

作者： Yong hwan Kim Si Young choi Department of Thoracic and Cardiovascular Surgery Uijeongbu St. Mary's Hospital The Catholic University of Korea College of Medicine Seoul 480-821 Korea Department of Thoracic and Cardiovascular Surgery Uijeongbu St. Mary’s Hospital The Catholic University of Korea College of Medicine Seoul 480-821 Korea

Black esophagus is a very rare disease and its pathogenesis has been *** esophagus developed concomitantly with candidiasis after diabetic ketoacidosis has not been reported *** report a case who developed esophageal stricture after the treatment of black esophagus and thus balloon dilatation was performed several times but failed,hence,surgical treatment was performed.

关键词： Esophagus Candidiasis Diabetic ketoacidosis Surgery