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Survival Analysis of Stage Ⅳ Metastatic Gastric Cancer Patients Treated with HangAm-Plus

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Chinese Journal of Integrative Medicine 2014年第1期20卷 49-55页

作者： Jae-Woo Park Jeungwon yoon Chong-Kwan Cho Yeon-Weol Lee hwa-seung yoo East-West Cancer Center Dunsan Oriental Hospital of Daejeon University

Objective：To evaluate the efficacy of HangAm-Plus（HAP）on stageⅣmetastatic gastric cancer by analyzing the treated patients’overall survival ***：Following the study eligibility,overall survival and one year survival rate of 44 stageⅣmetastatic gastric cancer patients who visited EastWest Cancer Center（EWCC）were *** study consisted of two arms：HAP treatment only（n=18）and combined treatment of concurrent conventional chemotherapy and HAP（n=26）.Patient characteristics by gender,age,surgical intervention,Eastern Cooperative Oncology Group（ECOG）score,treatment duration（〈4 weeks or≥4 weeks）,and lines of the chemotherapy received were *** related side effects were also ***：The median survival of combined group was longer（10.0 months）than that of HAP group（5.1 months）.One-year survival rate of combined treatment group and HAP group was 38.5%±9.5%and 33.3%±11.1%,respectively（P〉0.05）.One-year survival rate of those received more and less than 4-week treatment was 57.1%±18.7%and 8.3%±8.0%,respectively（P=0.001）.Conclusions：The study supports the safety and potential efficacy of HAP treatment in prevention of chemo-related side effects for stageⅣmetastatic gastric cancer treated with conventional *** studies are needed to investigate and confirm the results before applying the treatment in clinical settings.

关键词： advanced gastric cancer supportive care Chinese materia medica Oriental medicine

Effects of Cordyceps militaris extract on angiogenesis and tumor growth

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Acta Pharmacologica Sinica 2004年第5期25卷 115-123页

作者： hwa-seung yoo,Jang-woo SHIN,Jung-hyo CHO,Chang-gue SON,Yeon-weol LEE,Sang-yong PARK,Chong-kwan CHO Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine Daejeon University Daejeon 301-724 Department of East-West Cancer Center R&D Lab of Bulrolife Co Ltd Daejeon Korea College of Oriental Medicine Daejeon University Daejeon 301-724 Institute ofTraditional Medicine and Bioscience Daejeon University Daejeon 301-724 Department of East-West Cancer Center College of Oriental Medicine

AIM: To evaluate the effects of Cordyceps militaris extract (CME) on angiogenesis and tumor growth. METHODS:Human umbilical vein endothelial cells (HUVEC), HT1080, and B16-F10 cells were used. DNA fragment, angio-genic related gene expressions (MMPs, bFGF, VEGF, etc), capillary tube formation, wound healing in vitro, tumorgrowth in vivo were measured. RESULTS: CME inhibited growth of HUVECs and HT1080 (P<0.01). CME 100and 200 mg/L reduced MMP-2 gene expression in HT1080 cells by 6.0 % and 22.9 % after 3-h and 14.9 % and32.8 % after 6-h treatment. CME did not affect MMP-9 gene expression in B16-F10 melanoma cells. CME 100 and200 mg/L also reduced bFGF gene expression in HUVECs by 22.2 % and 41.3 %. CME inhibited tube formation ofendothelial cells in vitro and in vivo. CME repressed the growth of B16-F10 melanoma cells in mice compared withcontrol group (P<0.05). CONCLUSION: CME has antiangiogenetic properties.

关键词： Cordyceps militaris angiogenesis human umbilical vein endothelial cells HT1080 cells B16-F10cells matrix metalloproteinases basic fibroblast growth factor

Effect of Meridian Massage for Cancer Related Fatigue

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世界科学技术-中医药现代化 2008年第4期10卷 136-143,116页

作者： In sook Jeoung hwa-seung yoo Graduate School of Health and Sports Daejeon University East-West Cancer Center Dunsan Oriental Hospital of Daejeon University

Objectives:The purpose of this study is to investigate the effectiveness of meridian massage in lessening the fatigue and improving both physical and mental quality of life of cancer *** and design:This study was conducted at the East-West Cancer Center at Daejeon University;Using a single-arm,waiting list and non-treatment control research de- sign,we compared the results of control group and to that of the experimental *** and methods:From July 2,2007 to July 28,2007,eighteen eligible cancer patients were recruited to participate in the *** Chalder Fatigue Scale(CFS),Visual Analogue Scale(VAS)and active oxygen level were measured before and after treatment for both control and experimental *** on their back or stomach inside a room with a temperature of 18-22℃,the pa- tients received 30 minutes of meridian massages mainly around the trapezius muscles 5 times a week. Statistical analysis used:Data analysis was carried out using independent t-test,paired t-test and One-way ANOVA. Results:Data analysis of modified CFS showed statistically significant results for all groups between before and after treat- *** CFS,results of physical and psychological analysis showed significant results for all groups except before and after no treatment and secondary *** the analysis of VAS,the experimental group showed a greater decrease in score compared to that of the control group and the average difference was statistically significant(P0.05),active oxygen levels for the control group showed little difference before and after no treatment(331.11 and 330.78,respectively)while the experimental group observed a decrease in active oxygen level before and after treatment(327.28 and 314.11,respectively).Conclusion:In conclusion,patients who received meridian massage showed decreased cancer related fatigue scores compared to the *** results sugge

关键词：癌症疲劳治疗方法临床分析

Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

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Acta Pharmacologica Sinica 2007年第6期28卷 901-907页

作者： Myung-hyun YIM Jang-woo SHIN Jin-young SON Se-mi OH seung-hyun HAN Jung-hyo CHO Chong-kwan CHO hwa-seung yoo Yeon-weol LEE Chang-gue SON East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea

Aim:To investigate the immunoregulatory functions of water extracts of Hericiumerinaceum （WEHE） focusing on natural killer （NK） cell-based anticancer ***:Mouse splenocytes or purely isolated NK ceils were stimulated with1-100 mg/L WEHE for 24 h followed by co-culture with51Cr-labled Yac-1 cells for4 h,then NK cell-derived cytolytic activity was measured using a *** antibodies against mouse interleukin-12 （IL-12） were addedinto the WEHE-stimulated splenocytes,thereafter,cytotoxicity was measured toexamine the involvement of ***-PCR and ELISA analyses were performed toconfirm the induction of transcription and the translation of IL-12 and interferon-gamma （IFN-gamma） in the WEHE-treated ***:WEHE enhancedthe cytolytic activity of total splenocytes towards Yac-1 ceils in a ***,this activation was not observed when the NK cells isolatedfrom the splenocytes were treated with ***,the treatment withantibodies against IL-12 abolished the effect of WEHE on splenocyte-derivedcytolytic ***-PCR and ELISA analyses showed the induction of IL-12 andIFN-gamma in the WEHE-treated ***:WEHE indirectlyactivates the cytolytic ability of NK cells via the induction of IL-12 in totalsplenocytes,and possibly via other immuno-mediators or cellular components.

关键词： Hericium erinaceum NK cells interleukin-12

Anti-Proliferative Effects of Ginsenosides Extracted from Mountain Ginseng on Lung Cancer

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Chinese Journal of Integrative Medicine 2016年第5期22卷 344-352页

作者： Dong Gyu Lee Sung-ll Jang Young-Rang Kim Kyeong Eun Yang So Jung yoon Zee-Won Lee Hyun Joo An Ik-Soon Jang Jong-Soon Choi hwa-seung yoo Division of Life Science Korea Basic Science InstituteDaejeon 305-333Korea East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea Graduate School of Analytical Science and Technology Chungnam National UniversityDaejeon 305-764Korea

Objective： To investigate the effect of three major ginsenosides from mountain ginseng as anti- cancer substance and explore the underlying mechanism involved in lung cancer. Methods： The inhibitory proliferation of lung cancer by major five ginsenosides （Rbl, Rb2, Rgl, Rc, and Re） was examined using 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyl tetrazolium bromide assay. Calculated 50% inhibition （IC50） values of five ginsenosides were determined and compared each other. Apoptosis by the treatment of single ginsenoside was performed by fluorescence-assisted cytometric spectroscopy. The alterations of apoptosis-related proteins were evaluated by Western blot analysis. Results： The abundance of ginsenosides in butanol extract of mountain ginseng （BX-MG） was revealed in the order of Rbl, Rgl, Re, Rc and Rb2. Among them, Rbl was the most effective to lung cancer cell, followed by Rb2 and Rgl on the basis of relative IC50 values of IMR90 versus A549 cell. The alterations of apoptotic proteins were confirmed in lung cancer A549 cells according to the administration of Rbl, Rb2 and Rgl. The expression levels of caspase-3 and caspase-8 were increased upon the treatment of three ginsenosides, however, the levels of caspase-9 and anti-apoptotic protein Bax were not changed. Conclusion： Major ginsenosides such as Rbl, Rb2 and Rgl comprising BX-MG induced apoptosis in lung cancer cells via extrinsic apoptotic pathway rather than intrinsic mitochondrial pathway.

关键词： Butanol extract of mountain ginseng ginsenoside lung cancer apoptosis

An herbal formula,CGX,exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats

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World Journal of Gastroenterology 2006年第38期12卷 6142-6148页

作者： Jang-Woo Shin Jin-Young Son Se-Mi Oh seung-Hyun Han Jing-Hua Wang Jung-Hyo Cho Chong-Kwan Cho hwa-seung yoo Yeon-Weol Lee Myong-Min Lee Xiao Ping Hu Chang-Gue Son East-West Cancer Center Dunsan Oriental Hospitalof Orientai medical College of Daejeon University 1136 Dunsan-dong Seo-gu Daejeon 302-122 South Korea Department of Oromaxillofacial Infection and Immunity and Dental Research Institute School of Dentistry Seoul National University 28 Yongon-Dong Chongno-Gu Seoul 110-749 South Korea

AIM： To evaluate the therapeutic effect of Chunggan extract （CGX）, a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine （DMN）-induced chronic liver injury model in rats. METHODS： Liver injuries were induced in Wistar rats by injection of DMN （ip, 10 mg/mL per kg） for 3 consecutive days per week for 4 wk. The rats were administered with CGX Coo, 100 or 200 mg/kg per day） or distilled water as a control daily for 4 wk starting from the 15^th d of the DMN treatment. Biochemical parameters （serum albumin, bilirubin, ALP, AST and ALT）, lipid peroxides, hydroxyproline, as well as histological changes in liver tissues were analyzed. In addition, gene expression of TNF-α, TGF-β, TIMP-1, TIMP-2, PDGF-β, and MMP-2, all of which are known to be associated with liver fibrosis, were analyzed using real-time PCR. RESULTS： CGX administration restored the spleen weight to normal alter having been increased by DMN treatment. Biochemical analysis of the serum demonstrated that CGX significantly decreased the serum level of ALP （P 〈 0.05）, ALT （P 〈 0.02）, and AST （P 〈 0.02） that had been elevated by DMN treatment. CGX administration moderately lowered lipid peroxide production and markedly lowered hydroxyproline generation caused by DMN treatment in accordance with histopathological examination. DMN treatment induced a highly upregulated expression of TNF-α, TGF-β,TIMP-1, TIMP-2, PDGF-β, and MMP-2. Of these, the gene expression encoding PDGF-β and MMP-2 was still further enhanced 2 wk after secession of the 4-wk DMN treatment, and was remarkably ameliorated by CGX administration. CONCLUSION： CGX exhibits hepatotherapeutic properties against chronic hepatocellular destruction and consequential liver fibrosis.

关键词： Dimethylnitrosamine Hepatotherapeutic Herbal medicine PDGF-β Chunggan extract

Toxicological study of the hepatotherapeutic herbal formula,Chunggan extract,in beagle dogs

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World Journal of Gastroenterology 2006年第46期12卷 7497-7502页

作者： Woo-Jin Choi Jang-Woo Shin Jin-Young Son Dong-Seok Seo Hark-Soo Park seung-Hyun Han Ha-lung Sung Jung-Hyo Cho Chong-Kwan Cho hwa-seung yoo Yeon-Weol Lee Chang-Gue Son East-West Cancer Center Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University 1136Dunsan-dong Seo-gu Daejeon 302-122 South Korea Safety Assess-ment Center Korea Testing and Research Institute for Chemical Industry 7-6 Gomak-ri Wolgot-myeon Gimpo-si Kyonggi-doKorea Department of Oromaxillofacial Infection & Immunity and Dental Research Institute School of DentistrySeoul National University 28 Yongon-Dong Chongno-Gu Seoul110-749 South Korea

AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis. RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopa- thology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug. CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

关键词： Hepatotherapeutics Herbal remedy Chung-gan extract Safety Toxicological study

Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression

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中医杂志:英文版 2023年第4期43卷 686-694页

作者： Dong-Wook Kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae Lee Taehee Kim Suk-Yun Kang Yeonhee Ryu hwa seung yoo Jin Sun Lee Jin Bong Park Sang Do Lee Hyun-Woo Kim Department of Physiology and Medical Science College of Medicine and Brain Research InstituteChungnam National UniversityDaejeon 35015Republic of Korea KM Fundamental Research Division Korea Institute of Oriental Medicine Daejeon 34054Republic of Korea East-West Cancer Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon 35234Republic of Korea Department of Surgery Chungnam National University HospitalDaejeon 35015Republic of Korea Laboratory of Veterinary Pharmacology College of Veterinary Medicine and Research Institute for Veterinary ScienceSeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea

OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable *** study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in ***:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR *** was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind *** blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal ***:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF.

关键词： analgesia brain-derived neurotrophic factor chemotherapy-induced peripheral neuropathy docetaxel nerve stimulation

N, P co-doped 3D porous carbon with self-assembled morphological control via template-free method for potassiumion battery anodes

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Rare Metals 2024年第9期43卷 4243-4252页

作者： Jeehoon Yu Dae Kyom Kim Hong Geun Oh seung-Keun Park Youngjae yoo Department of Advanced Materials Engineering Chung-Ang University

The larger ionic radius of potassium ions than that of lithium ions significantly limits the accomplishment of rapid diffusion kinetics in graphite electrodes for potassium-ion batteries （PIBs）,resulting in comparatively poor rate performance and cycle ***,we report a high-rate performance and cycling stability amorphous carbon electrode achieved through nitrogen and phosphorous *** as-prepared N,P co-doped carbon electrodes have distinct 3D structures with large surface areas,hierarchical pore architectures,and increased interlayer spaces resulting from the direct pyrolysis of supramolecular self-assembled aggregates without *** obtained electrode N3P1 exhibits a reversible specific capacity of 258 m Ah·g-1at a current density of 0.1A·g-1and a good long-term cycle performance (96.1%capacity retention after 800 cycles at 0.5 A·g-1).Kinetic investigations show that the N3P1 electrode with the welldeveloped porous structure and large number of surface defects exhibits capacitive-driven behavior at all scan rates,which may be attributed by N and P ***-situ transmission electron microscopy analyses in the fully discharged and charged states demonstrate structural stability and reversibility owing to the expanded interlayer *** suggested synthesis approach is simple and effective for producing heteroatom-doped carbon materials for PIBs and other advanced electrochemical energy storage materials.

关键词： 3D porous structures Amorphous carbons Nitrogen and phosphorous co-doping Potassium-ion batteries