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A brief introduction to the Hematology Oncology Center of Beijing Children's Hospital

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Pediatric Investigation 2018年第4期2卷 207-208页

作者： huyong zheng Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of Pediatrics(Capital Medical University)Key Laboratory of Major Diseases in Children Ministry of Education Hematology Oncology CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

The Hematology Oncology Center of Beijing Children's Hospital, affiliated to Capital Medical University is a unique center that integrates clinical care, scientific research, teaching, and training. It is staffed by 269 doctors, nurses, and other health professionals, including one academician and 31 senior medical staff. In addition, 26 staff members are doctoral degree holders and 56 are master's degree holders. Dr. Yamei Hu and her team were the first to carry out clinical research on childhood leukemia in China from 1976.

关键词： the Hematology Oncology Center Beijing Children's Hospital integrates clinical care

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儿童慢性髓细胞性白血病的诊断与治疗

中华儿科杂志 2022年第10期60卷 967-969页

作者：郑胡镛国家儿童医学中心首都医科大学附属北京儿童医院血液病中心儿童血液病与肿瘤分子分型北京市重点实验室儿童血液病国家临床重点专科儿科学国家重点学科儿科重大疾病研究教育部重点实验室北京100045

儿童慢性髓细胞性白血病(CML)发病率低, 一直以来参考成人CML的标准诊治。尽管儿童CML的治疗已到达与成人CML治疗相似的效果, 但儿童CML治疗过程中更需重视长期服药对儿童生长发育及生存质量的影响。"儿童慢性髓细胞性白血病诊疗专家共... 详细信息

儿童慢性髓细胞性白血病(CML)发病率低, 一直以来参考成人CML的标准诊治。尽管儿童CML的治疗已到达与成人CML治疗相似的效果, 但儿童CML治疗过程中更需重视长期服药对儿童生长发育及生存质量的影响。"儿童慢性髓细胞性白血病诊疗专家共识"提出了针对中国儿童CML的诊断分期、酪氨酸激酶抑制剂(TKI)治疗的用药选择、移植适应证及追踪管理等建议, 对开展我国儿童CML的规范化诊治、提高整体救治水平、改善CML患儿生存质量等, 具有极其重要的理论指导和临床应用价值。

关键词：慢性髓细胞性白血病长期服药儿童生长发育规范化诊治生存质量追踪管理用药选择 CML

Treatment of childhood cancer in China:Current status and future direction

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Pediatric Investigation 2020年第3期4卷 153-156页

作者： Chi-kong Li Jingyan Tang huyong zheng Jianpei Fang XiaofeiSun Department of Paediatrics The Chinese University of Hong KongHong Kong Children’s HospitalHong KongChina Department of Hematology/Oncology Shanghai Children’s Medical CentreShanghai Jiao-Tong University School of MedicineNational Center for Children’s HealthChina Hematology Oncology Center Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthChina Department of Pediatrics Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Pediatric Oncology Sun Yat-Sen University Cancer CenterGuangzhouChina

Introduction China has a population of 1.3 billion and 16.6%of the population(212 million)is below age of 15 years according to the sixth national census in 2010.1 Chinese National Central Cancer Registry(NCCR)collected data from 219 cancer registries distributed in different parts of *** 2010 data from NCCR reported that childhood cancer comprised approximately 0.6%of all *** a recent study analyzed data from 145 cancer registries in China,the age-standardized incidence rate of childhood cancer was 87.1 per *** top five commonest childhood cancers were leukemia(35.6 per million),central nervous system(CNS)tumor(15.0 per million),lymphoma(6.4 per million),bone cancer(4.4 per million)and kidney cancer(3.7 per million).2 The incidence is lower than western countries but similar to those reported by other low-middle income *** reasons for lower incidence of childhood cancer may be related to incomplete data *** China,there is a large floating population,221 million,who were not permanent residents in locations they worked and might not be included in the city *** projected number of new cases of childhood cancer in 0-14 years is 22875,and new cases of leukemia projected to be 8943 in *** is important to have accurate data on incidence and survival that will help the government in policy making on health care delivery.

关键词： Neuroblastoma Pediatric Multidisciplinary care Prognosis

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中枢神经系统受累的郎格罕斯细胞组织细胞增生症诊治进展

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临床儿科杂志 2013年第4期31卷 389-392页

作者：张莉郑胡镛首都医科大学附属北京儿童医院血液病中心北京100045

胃郎格罕斯细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)是一种少见的单核巨噬系统疾病,临床表现多样,可有多脏器受累,但其中枢神经系统合并症相对少见。国内外对其诊断及治疗标准仍不统一。该文回顾及总结中枢神经系统受累... 详细信息

胃郎格罕斯细胞组织细胞增生症(Langerhans cell histiocytosis,LCH)是一种少见的单核巨噬系统疾病,临床表现多样,可有多脏器受累,但其中枢神经系统合并症相对少见。国内外对其诊断及治疗标准仍不统一。该文回顾及总结中枢神经系统受累LCH患者的磁共振成像(MRI)特点、神经病理学变化、临床表现、危险因素以及一些治疗经验,以提高临床医师对LCH患者中枢神经系统合并症的认识。

关键词：郎格罕斯细胞组织细胞增生症中枢神经系统儿童

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儿童中枢神经系统白血病研究进展

中华实用儿科临床杂志 2022年第2期37卷 146-149页

作者：魏昂郑胡镛王彬国家儿童医学中心首都医科大学附属北京儿童医院血液病中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室北京100045

急性白血病是儿童时期最常见的肿瘤,随着危险度分层治疗的不断完善,其完全缓解率有了明显提高。然而中枢神经系统白血病(CNSL)仍是白血病死亡和复发的主要原因之一。现就儿童CNSL的发病机制、诊断及治疗的研究进展进行综述,进一步提高... 详细信息

急性白血病是儿童时期最常见的肿瘤,随着危险度分层治疗的不断完善,其完全缓解率有了明显提高。然而中枢神经系统白血病(CNSL)仍是白血病死亡和复发的主要原因之一。现就儿童CNSL的发病机制、诊断及治疗的研究进展进行综述,进一步提高临床医师对该病的认识。

关键词：儿童中枢神经系统白血病发病机制诊断治疗

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儿童肿瘤溶解综合征高尿酸血症的诊治进展

首都医科大学学报 2019年第3期40卷 483-487页

作者：蒋理郑胡镛国家儿童医学中心首都医科大学附属北京儿童医院血液肿瘤中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室

高尿酸血症是肿瘤溶解综合征(tumor lysis syndrome,TLS)中的一种严重合并症。尿酸作为人体嘌呤代谢的终产物,在生理条件下主要的存在形式为尿酸盐。血液中的尿酸盐几乎全部被肾小球滤过,而TLS所引起的大量尿酸堆积超过了肾小球的滤过能... 详细信息

高尿酸血症是肿瘤溶解综合征(tumor lysis syndrome,TLS)中的一种严重合并症。尿酸作为人体嘌呤代谢的终产物,在生理条件下主要的存在形式为尿酸盐。血液中的尿酸盐几乎全部被肾小球滤过,而TLS所引起的大量尿酸堆积超过了肾小球的滤过能力,出现“高尿酸血症”。过剩的尿酸随血液到达人体的各个组织器官引起全身性疾病,患者可有恶心呕吐等症状,尿酸沉积在关节和肾脏中可产生关节疼痛及肾绞痛。若高尿酸血症引发急性尿酸盐肾病,则会出现严重的氮质血症和肾功能衰竭。既往只有别嘌呤醇可供临床医生选择用于高尿酸血症的预防,而对已经形成的高尿酸血症并无针对性的药物可以应用。近16年来由于尿酸氧化酶投入市场,临床医生对于预防与治疗TLS所致高尿酸血症的处理变得游刃有余。本文重点对高尿酸血症和尿酸氧化酶的临床应用进展做一综述。

关键词：肿瘤溶解综合征高尿酸血症尿酸氧化酶

Bacteremia tuberculosis among HIV-negative children in China

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Pediatric Investigation 2022年第3期6卷 197-206页

作者： Ping Chu Jin Shi Fang Dong Hui Yang Shunying Zhao Gang Liu huyong zheng Jinrong Liu Huimin Li Jie Lu Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryBeijing Pediatric Research InstituteBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang University&Capital Medical UniversityBeijingChina Department of Tuberculosis Beijing Tuberculosis and Thoracic Tumor Research InstituteBeijing Chest HospitalCapital Medical UniversityBeijingChina Department of Laboratory Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department 2 of Respiratory Medicine Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Infectious Disease Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Beijing Key Laboratory of Pediatric Hematology Oncology National Key Discipline of PediatricsMinistry of EducationKey Laboratory of Major Diseases in ChildrenMinistry of EducationHematology Oncology CenterBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Bacteremia tuberculosis(TB)is a severe form of extrapulmonary *** assessing bacteremia TB in children are limited,especially for HIV-negative ***:To explore the detailed clinical features of the bacteremia TB in children under 18 years of ***:We reviewed the clinical records of the patients retrospectively and collected the strains isolated from their blood *** used mycobacterial interspersed repetitive-unit-variable-number tandem-repeat(MIRU-VNTR)to characterize the bacterial genotypes and alamarBlue to determine their drug susceptibility *** chain reactions and DNA sequencing were used to identify drug-resistant ***:There were 13 pediatric bacteremia TB patients,10 of whom were diagnosed with Bacillus Calmette–Guérin(BCG)bacteremia *** patients aged from 0.30 to 11.58 years were enrolled,of whom 76.92%were *** had fevers before hospitalization,and 76.92%had respiratory *** had received BCG vaccinations,and 46.15%had adverse post-vaccination *** withMycobacterium tuberculosis,BCG bacteremia was more likely to appear in younger *** with BCG bacteremia had primary immunodeficiency diseases,and lower CD4,IgA,and IgE ***:Bacteremia TB was rapidly fatal in a large proportion of the immunodeficient *** classic findings may not be diagnostically specific,a high level of clinical suspicion is required,especially for patients with certain types of *** are needed to develop rapid diagnostic tests and to determine the value of empirical therapy in childhood bacteremia TB.

关键词： Bacteremia tuberculosis HIV negative Children China

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儿童血液肿瘤靶向治疗新进展

中华实用儿科临床杂志 2017年第3期32卷 161-167页

作者：陆继冉郑胡镛儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科教育部儿科重大疾病研究重点实验室首都医科大学附属北京儿童医院血液肿瘤中心100045

肿瘤靶向治疗是针对肿瘤细胞表达的某种生物标志物、采用相应的特异性药物结合靶点的治疗方法。近年来，随着医学科学技术的迅速发展，尤其随着对肿瘤分子生物学研究的深入，儿童血液肿瘤的治疗已由传统化疗、放疗的细胞攻击模式向靶向... 详细信息

肿瘤靶向治疗是针对肿瘤细胞表达的某种生物标志物、采用相应的特异性药物结合靶点的治疗方法。近年来，随着医学科学技术的迅速发展，尤其随着对肿瘤分子生物学研究的深入，儿童血液肿瘤的治疗已由传统化疗、放疗的细胞攻击模式向靶向性治疗模式转变。现重点针对细胞表面分子的单克隆抗体、针对特异融合基因的酪氨酸激酶抑制剂及嵌合抗原受体T淋巴细胞的免疫疗法等进行综述。

关键词：儿童血液恶性肿瘤靶向治疗

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青少年白血病的诊断与治疗进展

中华实用儿科临床杂志 2018年第3期33卷 161-165页

作者：郑胡镛于皎乐郑雪岭国家儿童医学中心首都医科大学附属北京儿童医院血液肿瘤中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室100045

青少年白血病是儿童白血病中的一个特殊群体，由于青少年白血病患儿一部分在儿童医院按“大儿童”白血病方案诊治，一部分在成人医院按“小大人”行成人方案诊治，均未得到充分重视，导致治疗效果和生存质量明显低于儿童白血病患儿。建... 详细信息

青少年白血病是儿童白血病中的一个特殊群体，由于青少年白血病患儿一部分在儿童医院按“大儿童”白血病方案诊治，一部分在成人医院按“小大人”行成人方案诊治，均未得到充分重视，导致治疗效果和生存质量明显低于儿童白血病患儿。建立由血液肿瘤学医师、护士、心理医师、内分泌医师、营养师及药剂师等组成的多学科团队，对青少年白血病患儿进行多学科的综合治疗，将有力于提高青少年白血病患儿的治疗效果和生存质量。

关键词：白血病青少年多学科团队