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Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

Journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo Chen Kyra L.A.Cloosterman Sita M.A.Bierma-Zeinstra Marienke van middelkoop Robert-Jan de Vos Department of Orthopaedic Surgery and Sports Medicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a common problem among *** is only limited evidence for risk factors for AT,and most studies have not defined the AT *** study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered *** study aimed to assess incidence and risk factors of AT based on data from a large prospective *** secondary aim was to explore differences in risk factors between insertional and midportion ***:Participants were recruited from among registered runners at registration for running *** were completed at baseline,1 month before the event,1 week before the event,and 1 month after the *** concerning demographics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional *** primary outcome was the incidence of *** logistic regression analysis was applied to identify risk factors for the ***:We included 3379 participants with a mean follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

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Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue

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World Journal of Gastroenterology 2017年第6期23卷 1018-1029页

作者： Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde huub middelkoop Itamar Ronen Andrea van der Meulen-de Jong Department of Gastroenterology and Hepatology Leiden University Medical Center C.J.Gorter Center Leiden University Medical Center Department of Radiology Leiden University Medical Center Department of Medical Statistics Leiden University Medical Center Center for Inflammatory Bowel Diseases University of California Los Angeles Department of Gastroenterology and Hepatology University Medical Center Utrecht Department of Psychiatry Leiden University Medical Center Department of Rheumatology Leiden University Medical Center Department of Neuropsychology Leiden University Medical Center Department of Radiology Leiden University Medical CenterLeiden

AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study *** Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI *** This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls.

关键词：磁性的回声成像全身的发炎疲劳 Crohns 疾病认知

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黄芪多糖对HD11鸡巨噬细胞转录组和代谢组的影响

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畜牧兽医学报 2024年第3期55卷 1290-1301页

作者：陈富斌徐国伟王磊刘琴冯海鹏张康郭志廷韩松伟刘佳惠古雪艳张景艳李建喜 huub F.J.Savelkoul 中国农业科学院兰州畜牧与兽药研究所兰州730050 甘肃农业大学动物医学院兰州730070 荷兰瓦赫宁根大学细胞生物与免疫学教研组荷兰瓦赫宁根市

旨在通过分析黄芪多糖对鸡巨噬细胞HD11转录组和代谢组的作用,探讨黄芪多糖(Astragalus polysaccharide, APS)对鸡巨噬细胞HD11的免疫调节机制。设置空白对照组(CONT组)和APS处理组(A50组),其中,A50组用含50μg·mL^(-1)APS的完全培养... 详细信息

旨在通过分析黄芪多糖对鸡巨噬细胞HD11转录组和代谢组的作用,探讨黄芪多糖(Astragalus polysaccharide, APS)对鸡巨噬细胞HD11的免疫调节机制。设置空白对照组(CONT组)和APS处理组(A50组),其中,A50组用含50μg·mL^(-1)APS的完全培养液培养HD11细胞12 h;CONT组用完全培养液培养HD11细胞12 h。采用代谢组学与转录组学技术分析CONT组与A50处理组细胞中差异基因和差异代谢物,并进行2个组学的联合分析。结果显示:在A50处理组与CONT组的转录组分析比较中,共检测到差异基因845个,其中上调基因415个,下调基因430个;差异表达基因主要富集在细胞因子-细胞因子受体相互作用、Toll样受体信号通路、吞噬体、AGE-RAGE等信号通路,其中,细胞因子-细胞因子受体相互作用、Toll样受体信号2条通路最为显著性;在A50处理组与CONT组的代谢组分析比较中,共筛选出差异代谢物89个,其中,下调差异代谢物为70个,上调的差异代谢物为19个。在A50处理组与CONT组的转录与代谢组联合分析中共同富集到可信度排名前十的通路有嘌呤代谢、碳代谢、磷酸戊糖途径、谷胱甘肽代谢、组氨酸代谢、氨基糖和核苷酸糖代谢、α同亚麻酸代谢、ABC转运体、铁死亡和酪氨酸代谢。APS可能是通过TLR2受体信号通路、糖酵解和磷酸戊糖途径的代谢重编程,进而发挥对HD11细胞的免疫调节作用。

关键词：黄芪多糖巨噬细胞转录代谢

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Spatial distribution of archaeal and bacterial ammonia oxidizers in the littoral buffer zone of a nitrogen-rich lake

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Journal of Environmental Sciences 2012年第5期24卷 790-799页

作者： huub J. M. Op den Camp Department of Microbiology IWWR Radboud University Nijmegen

The spatial distribution and diversity of archaeal and bacterial ammonia oxidizers （AOA and AOB） were evaluated targeting amoA genes in the gradient of a littoral buffer zone which has been identified as a hot spot for N cycling. Here we found high spatial heterogeneity in the nitrification rate and abundance of ammonia oxidizers in the five sampling sites. The bacterial amoA gene was numerically dominant in most of the surface soil but decreased dramatically in deep layers. Higher nitrification potentials were detected in two sites near the land/water interface at 4.4–6.1 μg NO2-N/（g dry weight soil·hr）, while only 1.0–1.7 μg NO2-N/（g dry weight soil·hr） was measured at other sites. The potential nitrification rates were proportional to the amoA gene abundance for AOB, but with no significant correlation with AOA. The NH4＋ concentration was the most determinative parameter for the abundance of AOB and potential nitrification rates in this study. Higher richness in the surface layer was found in the analysis of biodiversity. Phylogenetic analysis revealed that most of the bacterial amoA sequences in surface soil were affiliated with the genus of Nitrosopira while the archaeal sequences were almost equally affiliated with Candidatus ‘Nitrososphaera gargensis’ and Candidatus ‘Nitrosocaldus yellowstonii’. The spatial distribution of AOA and AOB indicated that bacteria may play a more important role in nitrification in the littoral buffer zone of a N-rich lake.

关键词： littoral zone ammonia oxidation archaea bacteria heterogeneity abundance

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Tissue engineering in burn scar reconstruction

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Burns & Trauma 2015年第3期3卷 122-132页

作者： PPM van Zuijlen KLM Gardien MEH Jaspers EJ Bos DC Baas AJM van Trier E middelkoop Burn Center Red Cross HospitalBeverwijkThe Netherlands Department of Plastic Reconstructive and Hand SurgeryRed Cross HospitalBeverwijkThe Netherlands Association of Dutch Burn Centers BeverwijkThe Netherlands Department of Plastic Reconstructive and Hand SurgeryMOVE Research InstituteVU University Medical CenterAmsterdamThe Netherlands

Nowadays,most patients with severe burns will survive their *** evolution is accompanied by the challenge to cover a large percentage of total body surface area ***,more and more patients have to deal with the sequelae of burn scars and require(multiple)*** review provides a gross overview of developments in the field of tissue engineering for permanent burn wound coverage and reconstructive burn surgery,focusing on usage and clinical *** only skin substitutes will be discussed but also the replacement of subcutaneous fat tissue and cartilage.

关键词： Burns Tissue engineering Scar Contracture Substitute Subcutaneous fat tissue Cartilage Reconstruction

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Thermally stimulated exciton emission in Si nanocrystals

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Light(Science & Applications) 2017年第1期6卷 228-234页

作者： Elinore MLD de Jong huub Rutjes Jan Valenta M Tuan Trinh Alexander N Poddubny Irina N Yassievich Antonio Capretti Tom Gregorkiewicz Van der Waals-Zeeman Institute University of AmsterdamScience Park 9041098 XHAmsterdamThe Netherlands Department of Chemical Physics and Optics Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 312116 Prague 2Czech Republic Department of Electrical Engineering and Computer Science University of Michigan2200 Bonisteel BlvdAnn ArborMI 48109USA Ioffe Institute Russian Academy of Sciences26 Polytechnicheskaya194021 St PetersburgRussia

Increasing temperature is known to quench the excitonic emission of bulk silicon,which is due to thermally induced dissociation of ***,we demonstrate that the effect of temperature on the excitonic emission is reversed for quantumconfined silicon *** laser-induced heating of silicon nanocrystals embedded in SiO2,we achieved a more than threefold(4300%)increase in the radiative(photon)emission *** theoretically modeled the observed enhancement in terms of the thermally stimulated effect,taking into account the massive phonon production under intense *** results elucidate one more important advantage of silicon nanostructures,illustrating that their optical properties can be influenced by *** also provide an important insight into the mechanisms of energy conversion and dissipation in ensembles of silicon nanocrystals in solid *** practice,the radiative rate enhancement under strong continuous wave optical pumping is relevant for the possible application of silicon nanocrystals for spectral conversion layers in concentrator photovoltaics.

关键词： micro-photoluminescence nanocrystal optical spectroscopy silicon thermal

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Resource use efficiency, ecological intensification and sustainability of intercropping systems

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Journal of Integrative Agriculture 2015年第8期14卷 1542-1550页

作者： MAO Li-li ZHANG Li-zhen ZHANG Si-ping Jochem B Evers Wopke van der Werf WANG Jing-jing SUN Hong-quan SU Zhi-cheng huub Spiertz College of Agronomy and Biotechnology China Agricultural University College of Agricultural Resources and Environmental Sciences China Agricultural University Institute of Cotton Research Chinese Academy of Agricultural Sciences/State Key Laboratory of Cotton Biology Centre for Crop Systems Analysis (CSA) Department of Plant Sciences Wageningen University China Institute of Water Resources and Hydropower Research

The rapidly growing demand for food, feed and fuel requires further improvements of land and water management, crop productivity and resource-use *** field experimentation and crop growth modelling during the past five decades made a great leap forward in the understanding of factors that determine actual and potential yields of *** research field of production ecology developed concepts to integrate biological and biophysical processes with the aim to explore crop growth potential in contrasting *** understand the potential of more complex systems（multi-cropping and intercropping） we need an agro-ecosystem approach that integrates knowledge derived from various disciplines： agronomy, crop physiology, crop ecology, and environmental sciences（soil, water and climate）.Adaptation of cropping systems to climate change and a better tolerance to biotic and abiotic stresses by genetic improvement and by managing diverse cropping systems in a sustainable way will be of key importance in food *** accelerate sustainable intensification of agricultural production, it is required to develop intercropping systems that are highly productive and stable under conditions with abiotic constraints（water, nutrients and weather）.Strategies to achieve sustainable intensification include developing tools to evaluate crop growth potential under more extreme climatic conditions and introducing new crops and cropping systems that are more productive and robust under conditions with abiotic *** paper presents some examples of sustainable intensification management of intercropping systems that proved to be tolerant to extreme climate conditions.

关键词： abiotic stress farming systems over-yielding resource use efficiency sustainability

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Rhizobium Lipo-chitooligosaccharide Signaling Triggers Accumulation of Cytokinins in Medicago truncatula Roots

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Molecular Plant 2015年第8期8卷 1213-1226页

作者： Arjan van Zeijl Rik H.M. Op den Camp Eva E. Deinum Tatsiana Charnikhova Henk Franssen huub J.M. Op den Camp Harro Bouwmeester Wouter Kohlen Ton Bisseling Rene Geurts Department of Plant Sciences Laboratory of Molecular Biology Wageningen University Droevendaalsesteeg 16708 PB Wageningen The Netherlands Department of Systems Biophysics FOM institute AMOLF Science Park 104 1098 XG Amsterdam The Netherlands Department of Plant Sciences Laboratory of Plant Physiology Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen The Netherlands Department of Microbiology IWWR Radboud University Nijmegen Heyendaalseweg 135 6525 AJ Nijmegen The Netherlands College of Science King Saud University Post Office Box 2455 Riyadh 11451 Saudi Arabia

Legume rhizobium symbiosis is initiated upon perception of bacterial secreted lipo-chitooligosaccharides （LCOs）. Perception of these signals by the plant initiates a signaling cascade that leads to nodule formation. Several studies have implicated a function for cytokinin in this process. However, whether cytokinin accu- mulation and subsequent signaling are an integral part of rhizobium LCO signaling remains elusive. Here, we show that cytokinin signaling is required for the majority of transcriptional changes induced by rhizo- bium LCOs. In addition, we demonstrate that several cytokinins accumulate in the root susceptible zone 3 h after rhizobium LCO application, including the biologically most active cytokinins, trans-zeatin and iso- pentenyl adenine. These responses are dependent on calcium- and calmodulin-dependent protein kinase （CCaMK）, a key protein in rhizobial LCO-induced signaling. Analysis of the ethylene-insensitive Mtein21 Mtsickle mutant showed that LCO-induced cytokinin accumulation is negatively regulated by ethylene. Together with transcriptional induction of ethylene biosynthesis genes, it suggests a feedback loop negatively regulating LCO signaling and subsequent cytokinin accumulation. We argue that cytokinin accumulation is a key step in the pathway leading to nodule organogenesis and that this is tightly controlled by feedback loops.

关键词： Medicago truncatula cytokinin ethylene rhizobium lipo-chitooligosaccharides CRE1

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Risk factors for overuse injuries in short-and long-distance running: A systematic review

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Journal of Sport and Health Science 2021年第1期10卷 14-28,I0001页

作者： Dennis van Poppel Maarten van der Worp Anouk Slabbekoorn Sylvia S.P.van den Heuvel Marienke van middelkoop Bart W.Koes Arianne P.Verhagen Gwendolyne G.M.Scholten-Peeters Research Group Diagnostics Avans University of Applied SciencesBreda4818 CRthe Netherlands Stichting Academie Instituut Fysiotherapie PLUS Utrecht3581 MDthe Netherlands Nederlands Paramedisch Institute Amersfoort3818 LAthe Netherlands Department of General Practice Erasmus MC Medical University CenterRotterdam3015 CEthe Netherlands Center for Muscle and Joint Health University of Southern DenmarkOdense5230Denmark Discipline of Physiotherapy Graduate School of HealthUniversity of TechnologySydneyChippendale NSW 2008Australia Department of Human Movement Sciences Faculty of Behavioral and Movement SciencesVrije Universiteit AmsterdamAmsterdam1081 HVthe Netherlands

Purpose:The aim of this study was to review information about risk factors for lower extremity running injuries in both short-distance(mean running distance-20 km/week and-10 km/session)and long-distance runners(mean running distance>20 km/week and>10 km/session).Methods:Electronic databases were searched for articles published up to February *** cohort studies using multivariable analysis for the assessment of individual risk factors or risk models for the occurrence of lower extremity running injuries were *** reviewers independently selected studies for eligibility and assessed risk of bias with the Quality in Prognostic Studies *** GRADE approach was used to assess the quality of the ***:A total of 29 studies were included:17 studies focused on short-distance runners,11 studies focused on long-distance runners,and 1 study focused on both types of runners.A previous running-related injury was the strongest risk factor for an injury for long-distance runners,with moderate-quality *** injuries not attributed to running was the strongest risk factor for an injury for short-distance runners,with high-quality *** body mass index,higher age,sex(male),having no previous running experience,and lower running volume were strong risk factors,with moderate quality evidence,for short-distance ***-quality evidence was found for all risk models as predictors of runningrelated injuries among short-and long-distance ***:Several risk factors for lower extremity injuries have been identified among short-and long-distance runners,but the quality of evidence for these risk factors for running-related injuries is *** injuries seem to have a multifactorial origin both in short-and long-distance runners.

关键词： Musculoskeletal health Protective factors Running-related injury

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黄芪多糖对鸡巨噬细胞HD11的免疫调节作用研究

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中兽医医药杂志 2023年第4期42卷 1-7页

作者：刘琴王磊张康徐国伟郭志廷王学智张景艳 huub F.J.Savelkoul 中国农业科学院兰州畜牧与兽药研究所甘肃省中兽药工程技术研究中心甘肃兰州730050 中国农业科学院兰州兽医研究所甘肃兰州730046 荷兰瓦赫宁根大学细胞生物与免疫学教研组瓦赫宁根6700AH

调节巨噬细胞的活化是增强畜禽免疫力的有效方法。黄芪多糖(APS)作为免疫增强剂,在临床被广泛应用,但有关其对家禽巨噬细胞的调节作用机制鲜有报道。本研究用APS诱导鸡巨噬细胞HD1112 h,评价其对HD11细胞的免疫调节作用。通过CCK-8法检... 详细信息

调节巨噬细胞的活化是增强畜禽免疫力的有效方法。黄芪多糖(APS)作为免疫增强剂,在临床被广泛应用,但有关其对家禽巨噬细胞的调节作用机制鲜有报道。本研究用APS诱导鸡巨噬细胞HD1112 h,评价其对HD11细胞的免疫调节作用。通过CCK-8法检测细胞增殖活力;用台盼蓝检测细胞的活率;采用Griess试剂法检测细胞中NO含量;采用RT-PCR法检测细胞中细胞因子、TLRs和NF-κB p65的mRNA表达水平。结果表明,25~400μg/mL APS对鸡巨噬细胞HD11无毒性作用,能显著促进细胞增殖(P0.05)。CCK-8检测显示,50~200μg/mL APS能显著提高细胞中NO含量(P0.05)。此外,50~200μg/mL APS对TLR2基因表达有显著的抑制作用(P<0.05),100~200μg/mL APS对TLR4基因表达有显著的抑制作用(P<0.05),表明TLR2对APS更敏感,但200μg/mL APS能提高NF-κB p65的转录水平(P<0.05)。这些结果表明黄芪多糖作为一种免疫调节剂对鸡巨噬细胞有免疫增强作用,并表现出不同的剂量依赖效应。

关键词：黄芪多糖 HD11细胞炎性因子免疫增强

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