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Effect of supplementing layer hen diet with phytogenic feed additives on laying performance, egg quality, egg lipid peroxidation and blood biochemical constituents

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Animal Nutrition 2018年第4期4卷 394-400页

作者： Reham abou-Elkhair Shaimaa Selim Eman hussein Department of Nutrition and Clinical Nutrition Faculty of Veterinary Medicine University of Sadat City Department of Nutrition and Clinical Nutrition Faculty of Veterinary Medicine University of Menoufia Department of Poultry Production Faculty of Agriculture University of Menoufia

This study was conducted to evaluate the effects of supplementing laying hen diet with phytogenic additives on laying performance, egg quality, blood constituents and egg lipid peroxidation. Two hundred Lohmann Brown Lite laying hens were randomly allotted to 4 dietary treatments: control(without phytogenic additive), fennel seeds(5 g/kg), black cumin seeds(5 g/kg) and hot red pepper(5 g/kg).Each of the 4 diets was fed to 5 replicates of 10 hens for 8 weeks. No significant differences were observed in body weight or feed intake between the groups. Dietary inclusion of fennel followed by red pepper improved(P < 0.05) egg weight, egg production, egg mass and feed conversion ratio compared with control. Higher yolk shape index, shell and albumen weight percentages and Haugh unit(P < 0.05)were recorded in the fennel supplemented group compared with control. The egg yolk color score increased by the addition of fennel or hot red pepper in laying hen diets compared with control. The inclusion of black cumin or hot red pepper decreased serum and egg yolk cholesterol and malondialdehyde concentrations(P < 0.05) compared with control. Serum aspartate aminotransferase concentration was lower in black cumin group(P < 0.05) than in other treatments. In conclusion, the best laying performance and egg quality were obtained by dietary inclusion of fennel, followed by hot red pepper and black cumin. Dietary supplementation of black cumin or red pepper may lead to the development of low-cholesterol concentration and better antioxidant capacity of eggs.

关键词： Phytogenic additives Egg quality Hepatoprotective activity Lipid peroxidation Cholesterol Laying hens

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Multiclass Classification for Cyber Threats Detection on Twitter

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Computers, Materials & Continua 2023年第12期77卷 3853-3866页

作者： Adnan hussein Abdulwahab Ali Almazroi College of Computer Science and Engineering Department of Computer ScienceAL-Ahgaff UniversityMukallaYemen College of Computing and Information Technology at Khulais Department of Information TechnologyUniversity of JeddahJeddahSaudi Arabia

The advances in technology increase the number of internet systems *** a result,cybersecurity issues have become more *** threats are one of the main problems in the area of ***,detecting cybersecurity threats is not a trivial task and thus is the center of focus for many researchers due to its *** study aims to analyze Twitter data to detect cyber threats using a multiclass classification *** data is passed through different tasks to prepare it for the *** Frequency and Inverse Document Frequency(TFIDF)features are extracted to vectorize the cleaned data and several machine learning algorithms are used to classify the Twitter posts into multiple classes of cyber *** results are evaluated using different metrics including precision,recall,F-score,and *** work contributes to the cyber security research *** experiments revealed the promised results of the analysis using the Random Forest(RF)algorithm with(F-score=81%).This result outperformed the existing studies in the field of cyber threat detection and showed the importance of detecting cyber threats in social media *** is a need for more investigation in the field of multiclass classification to achieve more accurate *** the future,this study suggests applying different data representations for the feature extraction other than TF-IDF such as Word2Vec,and adding a new phase for feature selection to select the optimum features subset to achieve higher accuracy of the detection process.

关键词： Cybersecurity cyber threat detection artificial intelligence machine learning Twitter

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Impact of rotavirus vaccine implementation on Israeli children:a comparison between pre-and post-vaccination era

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World Journal of Pediatrics 2022年第6期18卷 417-425页

作者： hussein Zaitoon Shaden Hanna Ellen Bamberger Department of Pediatrics Bnai Zion Medical CenterThe Ruth and Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of Technology47 Golomb St.31048HaifaIsrael The Ruth and Bruce Rappaport Faculty of Medicine Technion-Israel Institute of TechnologyHaifaIsrael

Background Worldwide rotavirus vaccination has resulted in a substantial decrease in rotavirus-induced severe gastroenteritis and related hospitalizations among ***,the characterization of patients warranting hospitalization needs to be further *** purpose of the study is to compare the clinical and laboratory features of children hospitalized with acute rotavirus infection before and after the introduction of routine *** This is a retrospective observational *** were pediatric patients who presented to the Bnai Zion Medical Center pediatric emergency department and were diagnosed with rotavirus acute gastroenteritis between 2017 and *** During the pre-vaccination period(2007–2009),114 infants and young children(median age:14 months,range:1–72 months;59 male,55 female)were hospitalized for rotavirus-induced acute gastroenteritis with a rate of 11.71 positive rotavirus tests per 1000 emergency room *** the post-vaccination period(2012–2019),168 infants and young children(median age:17 months,range:0–84 months;90 male,78 female)were hospitalized with a rate of 4.18 positive rotavirus tests per 1000 emergency room *** were no statistical differences between the two groups in gender,breast-feeding rates and sibling(s).The proportion of cases with moderate-to-severe dehydration was higher in the post-vaccination children than in the pre-vaccination *** Rates of rotavirus-attributed acute gastroenteritis hospitalizations declined from the pre-to the post-vaccination *** rates of dehydration were found in the post-vaccination *** surveillance is warranted to better understand the implications of the vaccine.

关键词： Acute gastroenteritis Booster dose Hospitalization Rotavirus Vaccination

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Proteomic profiling reveals engineered chitosan nanoparticles mediated cellular crosstalk and immunomodulation for therapeutic application in apical periodontitis

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Bioactive Materials 2022年第5期7卷 77-89页

作者： Hebatullah hussein Anil Kishen The Kishen Lab Dental Research InstituteUniversity of TorontoTorontoON M5G 1G6Canada Faculty of Dentistry University of TorontoTorontoON M5G 1G6Canada Faculty of Dentistry Ain Shams UniversityEndodontics DepartmentCairoEgypt School of Graduate Studies University of TorontoTorontoON M5G 1G6Canada Department of Dentistry Mount Sinai Health SystemMount Sinai HospitalTorontoON M5G 1X5Canada

Macrophages(MQ)are major constituents of chronically inflamed periapical tissues in apical *** study aimed to investigate the immunomodulatory effect of engineered bioactive chitosan-based nanoparticles(CSnp)antibiofilm medication on MQ cocultured with periodontal ligament fibroblasts(PdLF).Cells viability,spreading,PdLF migration,and intracellular CSnp uptake were *** Mass Tag-based proteomics was applied to analyze MQ global protein expression profiles after interaction with Enterococcus faecalis biofilm,CSnp-treated biofilm,and *** inflammatory mediators were *** bioinformatics analyses,candidate proteins were validated via targeted *** maintained cells viability,increased MQ spreading,and PdLF migration(p1.5-folds,p1.5-folds,p<0.05)was ***-treated biofilm reduced pro-inflammatory IL-1β and nitric oxide but enhanced anti-inflammatory IL-10 and TGF-β1(p<0.05).Internalized engineered bioactive CSnp reprogrammed MQ proteomic and cytokine profiles to modulate biofilm-mediated inflammation,and prompted PdLF migration,emphasizing its potential to regulate healing process in the treatment of apical periodontitis.

关键词： Chitosan-based nanoparticles Macrophages Immunomodulation Tandem mass tags Mass spectrometry Endodontics

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Securing Copyright Using 3D Objects Blind Watermarking Scheme

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Computers, Materials & Continua 2022年第9期72卷 5969-5983页

作者： hussein Abulkasim Mona Jamjoom Safia Abbas Faculty of Science New Valley UniversityEl-Kharga 72511Egypt Department of Computer Sciences College of Computer and Information SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia

Recently,securing Copyright has become a hot research topic due to rapidly advancing information *** a host cover,watermarking methods are used to conceal or embed sensitive information messages in such a manner that it was undetectable to a human observer in contemporary *** media covers may often take any form,including audio,video,photos,even DNA data *** this work,we present a new methodology for watermarking to hide secret data into 3-D *** technique of blind extraction based on reversing the steps of the data embedding process is *** implemented technique uses the features of the 3-D object vertex’discrete cosine transform to embed a grayscale image with high *** coefficient of vertex and the encrypted picture pixels are used in the watermarking ***,the extraction approach is fully blind and is dependent on the backward steps of the encoding procedure to get the hidden *** distance,Euclidean distance,Manhattan distance,and the Cosine distance are used to evaluate and test the performance of the proposed *** visibility and imperceptibility of the proposed method are assessed to show the efficiency of our work compared to previous corresponding methods.

关键词： Discrete cosine transform 3-D object copyright watermarking

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Antioxidant Properties of Fermented Camel Milk Prepared Using Different Microbial Cultures

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Food and Nutrition Sciences 2022年第11期13卷 861-877页

作者： Nagwa hussein Ismail abou-Soliman Mahmoud Ibrahim El-Sayed Sameh Awad Department of Animal Breeding Animal and Poultry Production Division Desert Research Centre Cairo Egypt Department of Dairy Technology Research Food Technology Research Institute Agricultural Research Center Giza Egypt Department of Dairy Science and Technology Faculty of Agriculture Alexandria University Alexandria Egypt

This study investigated the effect of using different combinations of commercial starter culture and lactobacilli strains on the antioxidant properties of fermented camel milk for 14 days. The bacterial strains included Lb. casei subsp. casei B-1922, Lb. paracasei subsp. paracasei B-4560, Lb. rhamnosus B-442 and Lb. rhamnosus B-1445. The antioxidant activity of fermented milk was estimated using DPPH radical scavenging activity, ferrous ion chelating activity (FCA) and ferric reducing power assays. The total phenolic content (TPC), titratable acidity, proteolysis degree and sensory acceptability of samples were also evaluated. The results showed that all the studied parameters were affected by both the type of starter culture and storage. Samples containing the commercial starter and Lb. rhamnosus B-1445 had the highest DPPH radical scavenging activity and TPC throughout storage. Fermented milks prepared using the commercial starter and Lb. rhamnosus B-442 or Lb. paracasei retained their high FCA and reducing power throughout storage compared to the other samples. Fermented milk containing the commercial starter and Lb. casei showed the lowest antioxidant activity. The DPPH scavenging activity for all fermented milks decreased sharply during storage, while the change in FCA, reducing power and TPC differed among the samples during storage. The highest acidity was observed in the samples containing the commercial starter and Lb. paracasei, while fermented milk prepared using commercial starter and Lb. rhamnosus B-1445 had the lowest acidity. Samples containing the commercial starter and Lb. casei had the greatest proteolysis during the first week of storage, while samples containing the commercial starter and Lb. rhamnosus B-1445 had the highest proteolysis on day 14. Fermented milks with commercial starter and Lb. rhamnosus B-1445 or Lb. paracasei were the most acceptable products, while samples containing the commercial starter and Lb. casei were less acceptable.

关键词： Antioxidant Activity Fermented Camel Milk Lactobacilli

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Improved Multi-party Quantum Key Agreement with Four-qubit Cluster States

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Computers, Materials & Continua 2022年第10期73卷 225-232页

作者： hussein Abulkasim Eatedal Alabdulkreem Safwat Hamad Faculty of Science New Valley UniversityEl-Kharga&the Academy of Scientific Research and TechnologyCairoEgypt College of Computer and Information Sciences Princess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia Faculty of Computer and Information Sciences Ain Shams UniversityCairoEgypt

Quantum key agreement is a promising key establishing protocol that can play a significant role in securing 5G/6G communication ***,Liu et al.(Quantum Information Processing 18(8):1-10,2019)proposed a multi-party quantum key agreement protocol based on four-qubit cluster states was *** aim of their protocol is to agree on a shared secret key among multiple remote *** et *** four-qubit cluster states to be the quantum resources and the X operation to securely share a secret *** addition,Liu et al.’s protocol guarantees that each participant makes an equal contribution to the final *** authors also claimed that the proposed protocol is secure against participant attack and dishonest participants cannot generate the final shared key ***,we show here that Liu et *** is insecure against a collusive attack,where dishonest participants can retrieve the private inputs of a trustworthy participant without being ***,the corresponding modifications are presented to address these security flaws in Liu et al.’s protocol.

关键词： Quantum key agreement 5G/6G communication networks collusive attacks quantum cryptography

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Fast adaptive regression-based model predictive control

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Control Theory and Technology 2023年第4期21卷 555-570页

作者： Eslam Mostafa hussein A.Aly Ahmed Elliethy Electrical and Computer Engineering Military Technical CollegeCairo14627Egypt

Model predictive control(MPC)is an optimal control method that predicts the future states of the system being controlled and estimates the optimal control inputs that drive the predicted states to the required *** computations of the MPC are performed at pre-determined sample instances over a finite time *** number of sample instances and the horizon length determine the performance of the MPC and its computational cost.A long horizon with a large sample count allows the MPC to better estimate the inputs when the states have rapid changes over time,which results in better performance but at the expense of high computational ***,this long horizon is not always necessary,especially for slowly-varying *** this case,a short horizon with less sample count is preferable as the same MPC performance can be obtained but at a fraction of the computational *** this paper,we propose an adaptive regression-based MPC that predicts the best minimum horizon length and the sample count from several features extracted from the time-varying changes of the *** proposed technique builds a synthetic dataset using the system model and utilizes the dataset to train a support vector regressor that performs the *** proposed technique is experimentally compared with several state-of-the-art techniques on both linear and non-linear *** proposed technique shows a superior reduction in computational time with a reduction of about 35–65%compared with the other techniques without introducing a noticeable loss in performance.

关键词： Regression analysis MPC Control Parametrization Wavelet Support vector regression(SVR) Optimization

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Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models

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World Journal of Gastroenterology 2022年第33期28卷 4787-4811页

作者： Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim abou-Kheir Department of Biology American University of BeirutBeirut 1107-2020Lebanon Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Pathology and Laboratory Medicine American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Internal Medicine American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Biology and Center for Drug Discovery American University of BeirutBeirut 1107-2020Lebanon

BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related *** stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon ***, there is limited research on the effects of DIQ on eradicating CSCs in *** To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived *** Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid *** Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil *** This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation.

关键词： Diiminoquinone Anticancer activity Colorectal cancer Cancer stem cells Patient-derived organoids Colonospheres

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风力发电机组运维数字孪生系统设计

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工程机械 2024年第5期55卷 1-4+255页

作者：杨嘉龙王国庆苏东鹏张旭东覃波石振宇 Ebrahim Ahmed hussein Saad 长安大学工程机械学院

针对传统的风力发电机组运维管理存在被动运维、自动化程度低和劳动力需求高等问题，基于MBSE理论，提出建立风力发电机组运维数字孪生系统模型。介绍数字端模型构建过程，基于RPA流程自动化机器人技术的应用，以及基于风力发电机组运... 详细信息

针对传统的风力发电机组运维管理存在被动运维、自动化程度低和劳动力需求高等问题，基于MBSE理论，提出建立风力发电机组运维数字孪生系统模型。介绍数字端模型构建过程，基于RPA流程自动化机器人技术的应用，以及基于风力发电机组运维管理需求的运维系统引擎的设计方法，并开发了风力发电机组运维数字孪生系统原型软件。通过对风力发电机组运维数字孪生系统模型原型的开发，验证了建立风力发电机组运维数字孪生系统的可行性。

关键词： MBSE RPA 数字孪生仿真模型

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