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A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 147-155页

作者： Aftab Ahmad Mohammed F.Abuzinadah Huda M.Alkreathy hussam i.kutbi Noor Ahmad Shaik Varish Ahmad Shakir Saleem Asif Husain Health information Technology Department Faculty of Applied StudiesKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityP.O.Box 80402 Jeddah-21589JeddahKingdom of Saudi Arabia Department of Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddahSaudi Arabia Department of Genetic Medicine Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Public Health College of Health SciencesSaudi Electronic UniversityRiyadhKingdom of Saudi Arabia Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi110062India

Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicity in ***:A total of 36 rats were divided into six groups including normal control,CCl4(2 mL/kg,i.p.),CCl4(2 mL/kg,i.p.)+Cystone?(750 mg/kg p.o.),CCl4(2 mL/kg,i.p.)+BSVT(25 mg/kg,p.o.),CCl4(2 mL/kg,i.p.)+BSVT(50 mg/kg,p.o.),and CCl4(2 mL/kg,i.p.)+BSVT(100 mg/kg,p.o.).All treatments were given for four *** levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,total protein,serum urea,blood urea nitrogen and creatinine were *** dismutase,malondialdehyde,and glutathione peroxidase were evaluated in tissue *** histopathological study of liver and kidney tissues was also ***:Aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,serum urea,blood urea nitrogen and creatinine were significantly elevated(Pile total protein was considerably reduced in the CCl4 group as compared to the normal control(Pich indicated hepatorenal *** addition,superoxide dismutase and glutathione peroxidase activities were significantly decreased(Pile malondialdehyde levels were increased markedly(Pith BSVT formulation recovered these parameters towards a normal level in a dose-dependent ***:BSVT formulation ameliorates the hepatorenal toxicity in a dose-dependent ***,clinical studies are required to confirm its efficacy.

关键词： Boerhavia diffusa Solidago virgaurea Vitex negundo Thymoquinone Cystone^(█) Carbon tetrachloride Hepatorenal

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Arctic sea-ice extent: No record minimum in 2023 or recent years

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 52-55页

作者： Ola M.Johannessen Tor i.Olaussen Nansen Scientific Society BergenNorway Nansen Environmental and Remote Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. On 11 September 2023 the minimum was 4.969 million square kilometers(***^(2)). This was not a record low, which occurred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. However, the ice extent had decreased by 0.432 ***^(2) compared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when considering the strong heat waves in the atmosphere and ocean, with record temperatures set around the world. in general, there is a high correlation between the long-term decrease in sea-ice extent and the increasing CO_(2) in the atmosphere, where the increase of CO_(2) in recent decades explains about 80% of the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic Minimum ice Climate

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Coarse to Fine: The Role of Severe Plastic Deformation in Advancing Titanium-Based Medical implants - A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan i Međo ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča institute of Nuclear Sci-ences-National institute of the Republic of Serbia University of Belgrade11001BeogradSerbia innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

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Speckle-interferometric Study of Close Visual Binary System HiP 11253(HD 14874)using Gaia(DR2 and EDR3)

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Research in Astronomy and Astrophysics 2023年第7期23卷 221-228页

作者： hussam Aljboor Ali Taani Department of Basic Scientific Sciences Prince Hussein Bin Abdullah Ⅱ Academy for Civil ProtectionAl Balqa Applied UniversityAmmanJordan Physics Department Faculty of ScienceAl Balqa Applied University19117 SaltJordan

We present a comprehensive set of physical and geometrical parameters for each of the components of the close visual binary system HiP 11253(HD 14874).We present an analysis for the binary and multiple stellar systems with the aim to obtain a match between the overall observational spectral energy distribution of the system and the spectral synthesis created from model atmospheres using Al-Wardat's method for analyzing binary and multiple stellar *** epoch positions are used to determine the orbital parameters and the total *** parameters of both components are derived as:T_(eff)^(a)=6025,T_(eff)^(b)=4710,logg_(a)=4.55,logg_(b)=4.60,R_(a)=1.125 R_(⊙),R_(b)=0.88R_(⊙),L_(a)=1.849 L_(⊙),L_(b)=0.342 L_(⊙).Our analysis shows that the spectral types of the components are F9 and *** combining the orbital solution with the parallax measurements of Gaia DR2 and EDR3,we estimate the individual masses using the H-R diagram as M_(a)=1.09 M_(⊙)and M_(b)=0.59 M_(⊙)for using Gaia DR2 parallax and M_(a)=1.10 M_(⊙)and M_(b)=0.61 M_(⊙)for using Gaia EDR3 ***,the location of both system's components on the stellar evolutionary tracks is presented.

关键词： (stars:)binaries:visual stars:kinematics and dynamics (stars:)binaries(including multiple):close techniques:interferometric techniques:spectroscopic

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Physical and orbital properties of the stellar system HiP 43766

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Research in Astronomy and Astrophysics 2021年第5期21卷 84-90页

作者： Hatem Widyan hussam Aljboor Department of Physics Al al-Bayt UniversityMafraq 25113Jordan

in this paper,we present the analysis of the stellar binary system HiP 43766 to determine its *** rely on dynamical modeling and atmospheric modeling with recent data to determine the orbital solution and the physical properties of the *** is a consistency between observed and synthetic photometry obtained using atmospheric *** calculated dynamical mass sum of the system ranged between 1.691 and 2.609 solar masses,while it ranges between 2.0 and 2.1 as estimated utilizing atmospheric *** could be due to inaccuracy in estimating the orbit,which could be modified with future observations with more relative positional *** parameters of the system and the position of the components on the evolutionary tracks show that the system consists of F5 and G5 subgiant stars,mostly formed by fragmentation.A dynamical mass sum is predicted for the system.

关键词： stars:binaries:close stars:binaries:visual stars:individual:HiP 43766

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Multisensory mechanisms of gait and balance in Parkinson’s disease:an integrative review

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Neural Regeneration Research 2025年第1期20卷 82-92页

作者： Stiven Roytman Rebecca Paalanen Giulia Carli Uros Marusic Prabesh Kanel Teus van Laar Nico i.Bohnen Department of Radiology University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morris K.Udall Center of Excellence for Parkinson’s Disease Research University of MichiganAnn ArborMIUSA institute for Kinesiology Research Science and Research Centre KoperKoperSlovenia Department of Health Sciences Alma Mater Europaea–ECMMariborSlovenia Parkinson’s Foundation Research Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology Service and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Understanding the neural underpinning of human gait and balance is one of the most pertinent challenges for 21st-century translational neuroscience due to the profound impact that falls and mobility disturbances have on our aging *** and gait control does not happen automatically,as previously believed,but rather requires continuous involvement of central nervous *** effectively exert control over the body,the brain must integrate multiple streams of sensory information,including visual,vestibular,and somatosensory *** mechanisms which underpin the integration of these multisensory signals are the principal topic of the present *** multisensory integration theories focus on how failure of cognitive processes thought to be involved in multisensory integration leads to falls in older *** emphasis,however,has been placed on specific contributions of individual sensory modalities to multisensory integration processes and cross-modal interactions that occur between the sensory modalities in relation to gait and *** the present work,we review the contributions of somatosensory,visual,and vestibular modalities,along with their multisensory intersections to gait and balance in older adults and patients with Parkinson’s *** also review evidence of vestibular contributions to multisensory temporal binding windows,previously shown to be highly pertinent to fall risk in older ***,we relate multisensory vestibular mechanisms to potential neural substrates,both at the level of neurobiology(concerning positron emission tomography imaging)and at the level of electrophysiology(concerning electroencephalography).We hope that this integrative review,drawing influence across multiple subdisciplines of neuroscience,paves the way for novel research directions and therapeutic neuromodulatory approaches,to improve the lives of older adults and patients with neurodegenerative diseases.

关键词： aging balance encephalography functional magnetic resonance imaging gait multisensory integration Parkinson’s disease positron emission tomography somatosensory vestibular visual

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Apolipoprotein A-i binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury i.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Synthesis of Poly(acrylic acid)-Grafted Carboxymethyl Cellulose for Efficient Removal of Copper ions

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Journal of Renewable Materials 2019年第12期7卷 1403-1414页

作者： Ying Lin Yihua Cao Qingping Song Jiangang Gao Puyou Jia Hamed Alsulami Marwan Amin kutbi College of Biological and Chemical Engineering Anhui Polytechnic UniversityWuhu241000China institute of Chemical industry of Forest Products Chinese Academy of Forestry(CAF)Nanjing210042China Department of Mathematics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia.

Biocompatible and high content grafted carboxymethyl cellulose-g-poly(acrylic acid)powder was successfully synthesized in an aqueous system,and used as adsorbents for the removal of Cu(ii)in aqueous *** copolymer was characterized by FT-iR and SEM *** copolymerization introduced a large number of carboxyl groups in the polymer and caused the micro-surface of the material to be *** fundamental adsorption behaviors of the material were *** adsorption kinetics was well fitted with pseudo-second order equation,while the adsorption isotherm preferred to be described the Langmuir *** maximum adsorption capacity obtained from the Langmuir model was 154.32 mg/g,indicating that the adsorption capacity of carboxymethyl cellulose was improved remarkably after grafting poly(acrylic acid).Moreover,Fourier transform infrared spectroscopy(FT-iR)has been used to investigate the adsorption mechanisms at molecular levels,which revealed that carboxyl groups are facile to form bidentate carboxylates with metal ***,this environment friendly copolymer will be a promising candidate for application in removal of heavy metal ions.

关键词： Carboxymethyl cellulose-g-acrylic acid grafting copolymerization adsorption copper ions

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Seismic Analysis of Reinforced Concrete Silos under Far-Field and Near-Fault Earthquakes

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Structural Durability & Health Monitoring 2022年第3期16卷 213-233页

作者： Anwer H.Hussein hussam K.Risan Department of Civil Engineering Al-Nahrain UniversityBaghdad10072Iraq

Silos are strategical structures used to stockpile various types of granular *** are highly vulnerable to earthquake excitation and have been frequently reported to fail at a higher rate than any other industrial *** seismic response of silos within the near-fault region will suffer a complex combination of loadings due to the unique characteristics of the near-fault ground motions;which are usually associated with a large amplitude pulse at the beginning of either the velocity or the displacement time *** study aims to numerically evaluate the seismic response of reinforced concrete cylindrical silos under near-fault ground motions(NFGM)and far-field ground motions(FFGM).The assessment investigates the impact of the slenderness ratio and the para-meters’influence on the seismic behavior of reinforced concrete *** validity of the Eurocode provisions in the structural safety of silos will also be *** nonlinear time history analysis is carried out through the finite element approach by examining four silos with different slenderness *** concrete damage plas-ticity model is assigned to the silo wall to simulate the nonlinear behavior of concrete in the plastic zone;while,the behavior of the stored material is represented by the Drucker-Prager plastic *** wall-granular material interaction is considered and defined by coulomb’s friction *** results of the near-fault records reveal a growth up to 72.8%in the hoop stress and 160.4%in the vertical stress compared to the far-field ***,the seismic response of reinforced concrete silos is highly sensitive to the type of ground motion,and slender silos tend to impose greater structural demand under the ***,The Eurocode-8 seismic provisions were adequate in the conventional far-field ground motions and less effective in the near-fault zone.

关键词： Silos seismic analysis near-fault earthquake far-field earthquake

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ioMT-Based Smart Healthcare of Elderly People Using Deep Extreme Learning Machine

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Computers, Materials & Continua 2023年第7期76卷 19-33页

作者： Muath Jarrah hussam Al Hamadi Ahmed Abu-Khadrah Taher M.Ghazal School of information Technology Skyline University CollegeUniversity City Sharjah1797SharjahUAE College of Computing and informatics Saudi Electronic UniversityRiyadh11673Saudi Arabia Center for Cyber Security Faculty of Information Science and TechnologyUniversity Kebangsaan Malaysia(UKM)43600BangiSelangorMalaysia Center for Cyber-Physical Systems Khalifa University127788Abu DhabiUAE

The internet of Medical Things(ioMT)enables digital devices to gather,infer,and broadcast health data via the cloud *** phenomenal growth of the ioMT is fueled by many factors,including the widespread and growing availability of wearables and the ever-decreasing cost of sensor-based *** is a growing interest in providing solutions for elderly people living assistance in a world where the population is rising *** ioMT is a novel reality transforming our daily *** can renovate modern healthcare by delivering a more personalized,protective,and collaborative approach to ***,the current healthcare system for outdoor senior citizens faces new *** healthcare systems are inefficient and lack user-friendly technologies and interfaces appropriate for elderly people in an outdoor ***,in this research work,a ioMT based Smart Healthcare of Elderly people using Deep Extreme Learning Machine(SH-EDELM)is proposed to monitor the senior citizens’*** performance of the proposed SH-EDELM technique gives better results in terms of 0.9301 accuracy and 0.0699 miss rate,respectively.

关键词： iCT ML FN DELM SH-EDELM

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