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A novel polyherbal formulation containing thymoquinone attenuates carbon tetrachloride-induced hepatorenal injury in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2020年第4期10卷 147-155页

作者： Aftab Ahmad Mohammed F.Abuzinadah Huda M.Alkreathy hussam i.kutbi Noor Ahmad Shaik Varish Ahmad Shakir Saleem Asif Husain Health information Technology Department Faculty of Applied StudiesKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia Department of Medical Laboratory Technology Faculty of Applied Medical SciencesKing Abdulaziz UniversityP.O.Box 80402 Jeddah-21589JeddahKingdom of Saudi Arabia Department of Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Pharmacy Practice Faculty of PharmacyKing Abdulaziz UniversityJeddahSaudi Arabia Department of Genetic Medicine Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Public Health College of Health SciencesSaudi Electronic UniversityRiyadhKingdom of Saudi Arabia Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi110062India

Objective:To evaluate a novel polyherbal formulation(BSVT)containing the standardized extracts from the leaves of Boerhavia diffusa,Solidago virgaurea,Vitex negundo,and thymoquinone in CCl4 induced hepatorenal toxicity in ***:A total of 36 rats were divided into six groups including normal control,CCl4(2 mL/kg,i.p.),CCl4(2 mL/kg,i.p.)+Cystone?(750 mg/kg p.o.),CCl4(2 mL/kg,i.p.)+BSVT(25 mg/kg,p.o.),CCl4(2 mL/kg,i.p.)+BSVT(50 mg/kg,p.o.),and CCl4(2 mL/kg,i.p.)+BSVT(100 mg/kg,p.o.).All treatments were given for four *** levels of aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,total protein,serum urea,blood urea nitrogen and creatinine were *** dismutase,malondialdehyde,and glutathione peroxidase were evaluated in tissue *** histopathological study of liver and kidney tissues was also ***:Aspartate transaminase,alanine transaminase,alkaline phosphatase,cholesterol,serum urea,blood urea nitrogen and creatinine were significantly elevated(Pile total protein was considerably reduced in the CCl4 group as compared to the normal control(Pich indicated hepatorenal *** addition,superoxide dismutase and glutathione peroxidase activities were significantly decreased(Pile malondialdehyde levels were increased markedly(Pith BSVT formulation recovered these parameters towards a normal level in a dose-dependent ***:BSVT formulation ameliorates the hepatorenal toxicity in a dose-dependent ***,clinical studies are required to confirm its efficacy.

关键词： Boerhavia diffusa Solidago virgaurea Vitex negundo Thymoquinone Cystone^(█) Carbon tetrachloride Hepatorenal

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Smart Energy Management System Using Machine Learning

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Computers, Materials & Continua 2024年第1期78卷 959-973页

作者： Ali Sheraz Akram Sagheer Abbas Muhammad Adnan Khan Atifa Athar Taher M.Ghazal hussam Al Hamadi School of Computer Science National College of Business Administration&EconomicsLahore54000Pakistan Riphah School of Computing&innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Pattern Recognition and Machine Learning Lab Department of SoftwareGachon UniversitySeongnamGyeonggido13120Korea Department of Computer Science COMSATS University IslamabadLahore CampusLahore54000Pakistan School of information Technology Skyline University CollegeSharjah1797United Arab Emirates Network and Communication Technology Lab Center for Cyber SecurityFaculty of Information Science and TechnologyUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia College of Engineering and iT University of DubaiDubaiUnited Arab Emirates

Energy management is an inspiring domain in developing of renewable energy ***,the growth of decentralized energy production is revealing an increased complexity for power grid managers,inferring more quality and reliability to regulate electricity flows and less imbalance between electricity production and *** major objective of an energy management system is to achieve optimum energy procurement and utilization throughout the organization,minimize energy costs without affecting production,and minimize environmental *** energy management is an essential and complex subject because of the excessive consumption in residential buildings,which necessitates energy optimization and increased user *** address the issue of energy management,many researchers have developed various frameworks;while the objective of each framework was to sustain a balance between user comfort and energy consumption,this problem hasn’t been fully solved because of how difficult it is to solve *** inclusive and intelligent Energy Management System(iEMS)aims to provide overall energy efficiency regarding increased power generation,increase flexibility,increase renewable generation systems,improve energy consumption,reduce carbon dioxide emissions,improve stability,and reduce energy *** Learning(ML)is an emerging approach that may be beneficial to predict energy efficiency in a better way with the assistance of the internet of Energy(ioE)*** ioE network is playing a vital role in the energy sector for collecting effective data and usage,resulting in smart resource *** this research work,an iEMS is proposed for Smart Cities(SC)using the ML technique to better resolve the energy management *** proposed system minimized the energy consumption with its intelligent nature and provided better outcomes than the previous approaches in terms of 92.11% accuracy,and 7.89% miss-rate.

关键词： intelligent energy management system smart cities machine learning

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The future of competitive advantage in Oman: integrating green product innovation, Al, and intellectual capital in business strategies

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international Journal of innovation Studies 2024年第2期8卷 154-171页

作者： Fadi Abdelfattah Mohammed Salah Khalid Dahleez Riyad Darwazeh hussam Al Halbusi Modern College of Business and Science(MCBS) MuscatOman Dean College of Business Administration A'Sharqiyah UniversityIbraOman Head of Accounting Department Business SchoolAl-Ahliya Amman UniversityAmmanJordan Management Department Ahmed Bin Mohammed Military College(ABMMC)DohaQatar

This study delves into the dynamics of green product innovation,artificial intelligence(Al)adaption,and intellectual capital,investigating their impact on the competitiveness of firms in *** emphasizes the crucial role of government intervention and R&D investments in this *** on the responses of 214 top managers in Oman,the research employs structural equation modeling to analyze the intricate relationships between these *** findings underscore a significant positive correlation between green innovation,Al implementation,and intellectual capital,with government involvement and R&D investments as vital *** study provides a novel perspective on the synergy of technology,innovation,and intellectual capital in developing *** offers essential insights for business leaders,policymakers,and scholars,highlighting the necessity of integrating advanced technologies and sustainable practices in business strategies to achieve competitive *** research adds to the existing body of knowledge on innovation and *** offers practical implications for enhancing firm performance in Oman and similar emerging markets.

关键词： Green product innovation R&D investments Ai adoption intellectual capital Government involvement Knowledge-driven culture Oman

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Taxonomy,distribution,and contemporary exposure of terrestrial mammals to floods and human pressure across different areas for biodiversity conservation in China

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integrative Zoology 2024年第3期19卷 458-467页

作者： Roman SHARNUUD Eric i.AMECA MOE Key Laboratory for Biodiversity Science&Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijingChina Climate Change Specialist Group Species Survival CommissionInternational Union for Conservation of NatureGlandSwitzerland

A significant research focus is placed on identifying animal species and areas at future risk to human-induced alterations of the environment and long-term changes in climatic ***,the extent to which exposure to extreme climatic events and intense human pressure can increase the risk of harmful impacts on species remains poorly *** on terrestrial mammals in China,one of the world’s megadiverse countries,we investigated patterns of contemporary exposure to floods and human pressures and determined their taxonomic representation and distribution across three major area-based conservation schemes,namely,national nature reserves(NNRs),priority areas for biodiversity conservation(PABCs),and key biodiversity areas(KBAs).Among the 440 species assessed with moderate or high exposure to floods,327(∼75%)also qualified as moderate or high in exposure to intense human *** species mainly belong to the orders Chiroptera,Eulipotyphla,and ***,there were 305,311,and 311 species with moderate or high exposure to flood and intense human pressure represented across NNRs,PABCs,and KBAs,*** findings support the prioritization of KBAs for expansion of site-based protection efforts such as NNRs in China,considering threats to species from exposure to adverse effects from both extreme climate and human pressure.

关键词： conservation floods human pressure mammals taxonomy

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Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1517-1522页

作者： işın Kaya Medical Genetics Bakırçay UniversityÇiğli Education ve Training Hospitalİzmir 35620Turkey

BACKGROUND Nonallelic homologous recombination(NAHR)of segmental duplications or low copy repeats(LCRs)result in DNA gain/loss and play an important role in the origin of genomic *** SUMMARY A 3-year-old boy was referred for genetic *** genomic hybrid-ization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal *** Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.

关键词： Wolf-Hirschhorn syndrome Silver-Russell syndrome Recurrent rearrangements Case report

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Using fracture-based continuum modeling of coupled geomechanical-hydrological processes for numerical simulation of hydraulic fracturing

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1582-1599页

作者： Goodluck i.Ofoegbu GNO Modeling Research LLC. San AntonioTX78253USA

This paper describes numerical simulation of hydraulic fracturing using fracture-based continuum modeling(FBCM)of coupled geomechanical-hydrological processes to evaluate a technique for high-density fracturing and fracture *** simulations are innovative because of modeling discrete fractures explicitly in continuum analysis.A key advantage of FBCM is that fracture initiation and propagation are modeled explicitly without changing the domain grid(*** re-meshing).Further,multiple realizations of a preexisting fracture distribution can be analyzed using the same domain *** simulated hydraulic fracturing technique consists of pressurizing multiple wells simultaneously:initially without permeating fluids into the rock,to seed fractures uniformly and at high density in the wall rock of the wells;followed by fluid injection to propagate the seeded fracture density *** combines the ease of continuum modeling with the potential accuracy of modeling discrete fractures and fracturing *** are modeled as piecewise planar based on intersections with domain elements;fracture geometry stored as continuum properties is used to calculate parameters needed to model individual fractures;and rock behavior is modeled through tensorial aggregation of the behavior of discrete fractures and unfractured *** are presented for previously unfractured rock and for rock with preexisting fractures of horizontal,shallow-dipping,steeply dipping,or vertical *** of a single-well model are used to determine the pattern and spacing for a multiple-well *** results illustrate high-density fracturing and fracture caging through simultaneous fluid injection in multiple wells:for previously unfractured rock or rock with preexisting shallow-dipping or horizontal fractures,and in situ vertical compressive stress greater than *** preexisting fractures are steeply dipping or vertical,and considering the same in situ

关键词： Discrete fracture Fracture-based continuum modeling Fracture caging High-density fracturing Hydraulic fracturing Preexisting fracture

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High-temperature tribological performance of functionally graded Stellite 6/WC metal matrix composite coatings manufactured by laser-directed energy deposition

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Friction 2024年第3期12卷 522-538页

作者： Marta OSTOLAZA Alaitz ZABALA Jon inaki ARRiZUBiETA iñigo LLAVORi Nagore OTEGi Aitzol LAMiKiZ Department of Mechanical Engineering University of the Basque Country UPV/EHUPlaza Torres Quevedo 1Bilbo 48013Spain Faculty of Engineering Mechanics and Industrial ProductionMondragon UnibertsitateaLoramendi 4Mondragon 20500Spain

Wear-driven tool failure is one of the main hurdles in the *** issue can be addressed through surface coating with ceramic-reinforced metal matrix ***,the maximum ceramic content is limited by *** this work,the tribological behaviour of the functionally graded WC-ceramic-particlereinforced Stellite 6 coatings is *** that end,the wear resistance at room temperature and 400°C is ***,the tribological analysis is supported by crack sensitivity and hardness evaluation,which is of utmost importance in the processing of composite materials with *** indicate that functionally graded materials can be employed to increase the maximum admissible WC content,hence improving the tribological behaviour,most notably at high ***,a shift from abrasive to oxidative wear is observed in high-temperature wear testing.

关键词： friction coating metal matrix composite functionally graded materials high temperature laserdirected energy deposition

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Are population cycles recovering?

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integrative Zoology 2024年第3期19卷 538-547页

作者： Vasily D.YAKUSHOV Boris i.SHEFTEL A.N.Severtsov institute of Ecology and Evolution of the Russian Academy of Sciences MoscowRussia

The dynamics of populations of small mammals of Central Siberia was *** studies were carried out at the Yenisei ecological station“Mirnoye”of the *** institute of Ecology and Evolution,Russian Academy of *** time series analysis was performed by the wavelet transform using the statistical data processing language *** the 20th century,the dynamics of the population of the community and some of its constituent species(Sorex araneus;***;***;***;***;Craseomys rufocanus;Clethrionomys rutilus;Microtus oeconomus;***)were characterized by a 4-year *** type of dynamics changed to noncyclic by the nineties,but by 2022,four species(***,***,***,and ***)and the community as a whole showed a tendency toward recovery of population *** remaining species were characterized by consistently low numbers with irregular low amplitude fluctuations.

关键词： population cycles small mammals time-series analysis wavelet transform

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Quantum algorithms for matrix operations and linear systems of equations

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Communications in Theoretical Physics 2024年第3期76卷 100-112页

作者： Wentao Qi Alexandr i Zenchuk Asutosh Kumar Junde Wu School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS ChernogolovkaRussia P.G.Department of Physics Gaya CollegeMagadh UniversityRampurGaya 823001India Harish-Chandra Research institute HBNIChhatnag RoadJhunsiPrayagraj 211019India Vaidic and Modern Physics Research Centre Bhagal BhimBhinmalJalore 343029India

Fundamental matrix operations and solving linear systems of equations are ubiquitous in scientific *** the‘sender-receiver’model,we propose quantum algorithms for matrix operations such as matrix-vector product,matrix-matrix product,the sum of two matrices,and the calculation of determinant and inverse *** encode the matrix entries into the probability amplitudes of the pure initial states of *** applying proper unitary transformation to the complete quantum system,the desired result can be found in certain blocks of the receiver’s density *** quantum protocols can be used as subroutines in other quantum ***,we present an alternative quantum algorithm for solving linear systems of equations.

关键词： matrix operation systems of linear equations ‘sender-receiver’quantum computation model quantum algorithm

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Near resonance vibration isolation on a levered-dual response(LEDAR)Coulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.i.TOLUWALOJU C.K.THEiN D.HALiM Department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence Research and innovation institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEDAR)Coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEDAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio Coulomb damping preload tension/compression isolation band/depth offset potential

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