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Interindividual Age-Independent Differences in Human CX43 Impact Ventricular Arrhythmic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María Pérez-Zabalza Antoni Oliver-Gelabert JoséMaría Vallejo-Gil Javier fañanás-Mastral Manuel Vázquez-Sancho Javier AndréBellido-Morales Alexánder Sebastián Vaca-núñez Carlos Ballester-Cuenca Emiliano Diez Laura Ordovás Esther Pueyo Biomedical Signal Interpretation and Computational Simulation group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Centro Universitario de la Defensa(CUD) Zaragoza 50090Spain. Department of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Institute of Experimental Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Investigación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research networking Center in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of the major components of gap junctions, the structures responsible for the intercellular communication and transmission of the electrical impulse in the left ventricle. There is limited information on the histological changes of CX43 with age and their effect on electrophysiology, especially in humans. Here, we analyzed left ventricular biopsies from living donors starting at midlife to characterize age-related CX43 remodeling. We assessed its quantity, degree of lateralization, and spatial heterogeneity together with fibrotic deposition. We observed no significant age-related remodeling of CX43. Only spatial heterogeneity increased slightly with age, and this increase was better explained by biological age than by chronological age. Importantly, we found that CX43 features varied considerably among individuals in our population with no relevant relationship to age or fibrosis content, in contrast to animal species. We used our experimental results to feed computational models of human ventricular electrophysiology and to assess the effects of interindividual differences in specific features of CX43 and fibrosis on conduction velocity, action potential duration, and arrhythmogenicity. We found that larger amounts of fibrosis were associated with the highest arrhythmic risk, with this risk being increased when fibrosis deposition was combined with a reduction in CX43 amount and/or with an increase in CX43 spatial heterogeneity. These mechanisms underlying high arrhythmic risk in some individuals were not associated with age in our study population. In conclusion, our data rule out CX43 remodeling as an age-related arrhythmic substrate in the population beyond midlife, but highlight its potential as a proarrhythmic factor at the individual level, especially when combined with increased fibrosis.

关键词： CX43 rhythm Independent

Highly crystallization-induced emissive luminophores with mechanoluminescent features for two-photon harvesting fluorescence imaging and latent fingerprint identification

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nano Research 2024年第7期17卷 6475-6482页

作者： Jian Lu Juan Gao Rui-Xuan Qian Shuai-Hua Wang fa-Kun Zheng Guo-Cong Guo Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Fluorescence imaging can be employed in fields of medical treatment,astronomical exploration,and national defense *** fluorescence imaging often takes the single-photon techniques,which is vulnerable to background interference and ***,two-photon fluorescence imaging can achieve much higher-resolution fluorescence imaging for reducing scattering and deeper ***,by assembling the tetraphenylethylene backbones with nontoxic and non-noble K^(+)ions,compound 1([(Hdma)K(H_(2)ettc)]_(n),H_(4)ettc=4',4''',4''''',4'''''''-(ethene-1,1,2,2-tetrayl)tetrakis(([1,1'-biphenyl]-4-carboxylic acid)))with the crystallization-induced emissions exhibited charming fluorescence imaging under two-photon excitation microscopy(TPEM).Besides,luminescent powders based on compound 1 can achieve high-resolution fingerprint recognition,providing secure access control and identification for a novel authentication *** with the commercial fluorescent dyes coumarin-6,the as-synthesized compound 1 showed great solvent stability,indicating its durability against harsh ***,compound 1 shows mechanoluminescent properties for the perturbation of weak supramolecular interactions within ordered arrangements of the H_(2)ettc^(2−)*** novel compound has provided an important insight to the development of twophoton fluorescence imaging and advanced external-stimuli responsive materials.

关键词： crystallization-induced emission fluorescence imaging two-photon absorption fingerprint recognition mechanoluminescence

Generating electron spin qubit in metal-organic frameworks via spontaneous hydrolysis

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Chinese Chemical Letters 2024年第7期35卷 529-533页

作者： Xian-fa Jiang Chongyun Shao Zhongwen Ouyang Zhao-Bo Hu Zhenxing Wang You Song State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Wuhan national High Magnetic Field Center&School of Physics Huazhong University of Science and TechnologyWuhan 430074China Chaotic Matter Science Research Center Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000China Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

Qubit,as the basic unit of quantum operations,has at least two quantum states for *** itself has no superimposable quantum states,but after injecting n atoms,the resulted nitrogenvacancy centers form excellent-performance *** the same purpose,we can also obtain qubits by modifying the matrix without effective quantum ***-1({Cu_(3)(BTC)_(2)(H_(2)O)_(3)},BTC=1,3,5-benzene-tricarboxylate)with S=0 ground state is electron paramagnetic resonance(EPR)silent,so it is not a qubit ***,the spontaneously hydrolyzed HKUST-1 produces dilute uncoupled Cu^(Ⅱ)ions with S=1/*** this paper,we utilized the hydrolysis products of HKUST-1 to obtain qubits and assembled a core-shell structural HKUST-1@ZIF-8 by ZIF-8({Zn(mim)_(2)},mim=2-methylimidazole)coated over HKUST-1 for controlling the *** experimental results clearly show that the qubits come from hydrolyzed Cu^(Ⅱ)***,the dilute uncoupled Cu^(Ⅱ)ions in this assembly can effectively reduce the decoherence of *** EPR studies show that the T_(2) of this compound is 1067 ns at 10 K.

关键词： Hydrolysis Qubit Decoherent times Metal-organic framework Core-shell structure

Efficiency and safety of laparoscopic left hemihepatectomy: A study of intrathecal vs extrathecal Glissonean pedicle techniques

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2612-2619页

作者： Li-Min Kang Lei Xu Fu-Wei Zhang fa-Kun Yu Li Lang Department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina Department of Outpatient Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKGROUnD Selective hemihepatic vascular occlusion is utilized in both right and left hemihepatectomies to preserve blood supply to the intact lobe,maintain hemo-dynamic stability,and mitigate surgical *** this technique encompasses both intrathecal and extrathecal Glissonean pedicle transection methods,there is a lack of systematic comparative reports on these two *** To retrospectively analyze the clinical data of patients with hepatocellular carcinoma(HCC)undergoing laparoscopic anatomical hepatectomy in our hospital to explore the feasibility,safety,and short-and long-term efficacy of extrathecal and intrathecal Glissonean pedicle transection methods in laparo-scopic left *** A retrospective study was performed to analyze the clinical data of 49 HCC patients who underwent laparoscopic left hemihepatectomy from January 2019 to December 2022 in our *** patients were divided into extrathecal Glissonean pedicle transection(EGP)group(n=24)and intrathecal Glissonean pedicle transection(IGP)group(n=25)according to the different approaches used for selective hemihepatic vascular *** perioperative indicators,liver function indexes,complications,and follow-up findings were compared between these two *** The surgeries were smooth in both groups,and no perioperative death was *** hepatic pedicle transection time and the operation time were(16.1±2.3)minutes and(129.6±19.0)minutes,respectively,in the EGP group,which were significantly shorter than those in the IGP group[(25.5±2.4)minutes and(184.8±26.0)minutes,respectively],both Pno significant differences in intraoperative blood loss,time to anal exhaust,hospital stay,drain indwelling time,and postoperative liver function between the two groups(all P>0.05).The incidence of postoperative complications showed no significant difference[16.67%(4/24)vs 16.0%(4/25),P>0.05].All the 49 HCC patients were followed up after surgery(range:11.2

关键词： Hepatocellular carcinoma Laparoscopy Extra-Glissonian approach Intra-Glissonian approach Surgical efficiency Surgical safety

Spatial construction of ultrasmall Pt-decorated 3D spinel oxidemodified n-doped graphene nanoarchitectures as high-efficiency methanol oxidation electrocatalysts

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Rare Metals 2024年第1期43卷 186-197页

作者： Qi Zhang Min-Min Yan Wen-fa Du Chen-Yu Yin Jian Zhang Lu Yang Yun-Qing Kang Hai-Yan He Hua-Jie Huang College of Mechanics and Materials Hohai UniversityNanjing 210098China new Energy Technology Engineering Lab of Jiangsu Province College of ScienceNanjing University of Posts&Telecommunications(NUPT)Nanjing 210023China International Center for Materials nanoarchitectonics(WPIMAnA) National Institute for Materials ScienceTsukuba 305-0044IbarakiJapan

Direct methanol fuel cell technology recently becomes the focus of both academic and engineering circles,which stimulates the exploitation and utilization of advanced electrode catalysts with high activity and long ***,we demonstrate a robust bottom-up approach to the spatial construction of three-dimensional(3D) spinel manganese-cobalt oxide-modified n-doped graphene nanoarchitectures decorated with ultrasmall Pt nanoparticles(Pt/MnCo_(2)O_(4)-nG) via a controllable selfassembly *** incorporation of MnCo_(2)O_(4)nanocrystals provides abundant hydroxyl sources to promote the oxidative removal of CO-like byproducts on Pt sites,while the existence of 3D porous n-doped graphene networks facilitates the transportation of both ions and electrons in the hybrid system,thus giving rise to remarkable synergetic coupling effects during the methanol oxidation ***,the optimized Pt/MnCo_(2)O_(4)-nG nano architecture expres ses exceptional electrocatalytic properties with a large electrochemically active surface area of 99.5 m^(2)·g^(-1),a high mass activity of1508.3 mA·mg^(-1),strong toxicity resistance and reliable long-term durability,which have obvious competitive advantages over those of conventional Pt/carbon black,Pt/carbon nano tube,Pt/graphene,and Pt/n-doped graphene catalysts with the same Pt usage.

关键词： Platinum MnCo_(2)O_(4) 3D graphene Electrocatalysts Methanol oxidation

Heavy neutral leptons in gauged U(1)Lμ-Lτ at muon collider

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Chinese Physics C 2024年第9期48卷 36-49页

作者： Ru-Yi He Jia-Qi Huang Jin-Yuan Xu fa-Xin Yang Zhi-Long Han Feng-Lan Shao School of Physics and Technology University of JinanJinan 250022China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

Heavy neutral leptons n are the most appealing candidates to generate tiny neutrino *** studied the signature of heavy neutral leptons in gauged U(1)Lμ-Lτ at a muon *** under the U(1)Lμ-Lτ symmetry,the heavy neutral leptons can be pair produced via the new gauge boson Z' at the muon collider as μ^(+)μ^(-)→Z′*→nn AnD μ^(+)μ^(-)→Z′(*)γ→nnγ.We then performed a detailed analysis on the lepton number violation signature μ^(+)μ^(-)→nn→μ^(±)μ^(±)W■W■ and μ^(+)μ^(-)→nn→μ^(±)μ^(±)W■W■γ at the 3 TeV muon collider,where the hadronic decays of W boson are treated as fat-jets *** lepton number violation signatures have quite clean backgrounds at the muon *** simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon *** instance,with new gauge coupling g'=0.6 and an integrated luminosity of 1000 fb^(-1),the μ^(±)μ^(±)JJ signal could probe m_(Z′)■13 ***,if the gauge boson mass satisfies 2m_(n)nature would be more promising than the μ^(±)μ^(±)JJ signature.

关键词： heavy neutral leptons gauged U(1)_(Lμ-Lτ) muon collider lepton number violation

Perioperative outcomes of transvaginal specimen extraction laparoscopic total gastrectomy and conventional laparoscopicassisted total gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1527-1536页

作者： Zhi-Cao Zhang Wen-Sheng Wang Jiang-Hong Chen Yuan-Hang Ma Qi-fa Luo Yun-Bo Li Yang Yang Dan Ma Department of General Surgery Xinqiao Hospital of Army Medical UniversityChongqing 400037China

BACKGROUnD natural orifice specimen extraction surgery(nOSES)has emerged as a promising alternative compared to conventional laparoscopic-assisted total gastrectomy(LATG)for treating gastric cancer(GC).However,evidence regarding the efficacy and safety of nOSES for GC surgery is *** study aimed to compare the safety and feasibility,in addition to postoperative complications of nOSES and *** Dual circular staplers were used in Roux-en-Y digestive tract reconstruction for transvaginal specimen extraction LATG,and its outcomes were compared with LATG in a cohort of 51 GC patients with tumor size≤5 *** study was conducted from May 2018 to September 2020,and patients were categorized into the nOSES group(n=22)and LATG group(n=29).Perioperative parameters were compared and analyzed,including patient and tumor characteristics,postoperative outcomes,and anastomosis-related complications,postoperative hospital stay,the length of abdominal incision,difference in tumor type,postoperative complications,and postoperative *** Postoperative exhaust time,operation duration,mean postoperative hospital stay,length of abdominal incision,number of specific staplers used,and Brief Illness Perception Questionnaire score were significant in both groups(Pn the nOSES group,the postoperative time to first flatus,mean postoperative hospital stay,and length of abdominal incision were significantly shorter than those in the LATG *** in the nOSES group had faster postoperative recovery,and achieved abdominal minimally invasive incision that met aesthetic *** were no significant differences in gender,age,tumor type,postoperative complications,and postoperative survival between the two *** The application of dual circular staplers in Roux-en-Y digestive tract reconstruction combined with nOSES gastrectomy is safe and *** approach offers better short-term outcomes compared to LATG,while long-term survival

关键词： Gastric cancer Circular stapler natural orifice specimen extraction surgery Laparoscopic-assisted total gastrectomy

Exploring the shadow of a rotating charged ModMax black hole

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Communications in Theoretical Physics 2024年第2期76卷 89-101页

作者： Khurshid Karshiboev farruh Atamurotov Ahmadjon Abdujabbarov Ali Övgün Anvar Reyimberganov Institute of Theoretical Physics National University of UzbekistanTashkent 100174Uzbekistan new Uzbekistan University Movarounnahr Street 1Tashkent 100000Uzbekistan Central Asian University Milliy Bog'Street 264Tashkent 111221Uzbekistan University of Tashkent for Applied Sciences Str.Gavhar 1Tashkent 100149Uzbekistan Tashkent State Technical University Tashkent 100095Uzbekistan Ulugh Beg Astronomical Institute Astronomy Street 33Tashkent 100052Uzbekistan Institute of Fundamental and Applied Research National Research University TIIAMEKori Niyoziy 39Tashkent 100000Uzbekistan Physics Department Eastern Mediterranean UniversityFamagusta99628 North Cyprusvia Mersin 10Turkey Urgench State University Urgench 220100Uzbekistan

The research presented in this paper discusses the impact that the parameters of charge(Q)and screening factor(γ)have on properties of the horizon and silhouette of rotating charged Mod Max black holes which were reviewed in[***.J.C(2022)82:1155]recently,building upon previous findings in the ***,the study explores the behavior of null geodesics,which can help us better understand the apparent shape of the black hole’s silhouette,as well as the distortion parameter and approximate radii of the silhouette that are influenced by the aforementioned parameters,and there are some values of parameter Q which corresponds to data from the Event Horizon Telescope(EHT).notably,we explore the distortion parameter and approximate radii of the silhouette,revealing that while an increase inγleads to a growth in silhouette radius(Rs),it simultaneously reduces the distortion rate(δs).Conversely,heightened Q charge results in a reduction of Rsaccompanied by an increase inδ***,the paper analyzes the effects of the black hole’s parameters on the effective potential and energy emission:the peak value of the energy emission rate experiences a decrease as the screening factor(γ)increases,while it increases with higher values of the charge parameter(Q).

关键词： black hole ModMax gravity rotating black hole black hole shadow

英语二语情绪标签名词与负载名词认知神经模型研究

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外语导刊 2024年第4期47卷 82-91,160页

作者：陈士法顾晓岚中国海洋大学外国语学院山东青岛266100

本研究采用情绪归类任务,通过考察英语二语情绪标签名词和负载名词诱发的脑电变化,探究了两类情绪名词的认知神经模型。研究发现:1)两类情绪名词均比中性名词诱发更大的n100;2)积极标签名词比中性名词诱发更大的EEPn和更小的n400,消极... 详细信息

本研究采用情绪归类任务,通过考察英语二语情绪标签名词和负载名词诱发的脑电变化,探究了两类情绪名词的认知神经模型。研究发现:1)两类情绪名词均比中性名词诱发更大的n100;2)积极标签名词比中性名词诱发更大的EEPn和更小的n400,消极标签名词和负载名词比中性名词诱发更大的LEPn;3)积极标签名词和积极负载名词均比中性名词诱发更大的LPC。据此构建了英语二语情绪名词的三阶段加工模型:早期为感知觉加工阶段,情绪表征促进词形识别;中期为情绪和概念意义加工阶段,标签名词的意义通达早于负载名词且受效价调节;晚期为语境整合阶段,两者均受效价调节。

关键词：情绪标签名词情绪负载名词情绪效应认知神经模型