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World Journal of Transplantation 2016年第1期6卷 165-173页

作者： Volker Assfalg Norbert hüser Department of Surgery Klinikum rechts der Isar der Technischen Universit?t München

Exposure to heparin is associated with a high incidence of immunization against platelet factor 4(PF4)/heparin complexes. A subgroup of immunized patients is at risk of developing heparin-induced thrombocytopenia(hIT), an immune mediated prothrombotic adverse drug effect. Transplant recipients are frequently exposed to heparin either due to the underlying end-stage disease, which leads to listing and transplantation or during the transplant procedure and the perioperative period. To review the current scientific knowledge on antiheparin/PF4 antibodies and hIT in transplant recipients a systematic Pub med literature search on articles in English language was performed. The definition of hIT is inconsistent amongst the publications. Overall, six studies and 15 case reports have been published on hIT before or after heart, liver, kidney, and lung transplantation, respectively. The frequency of seroconversion for anti-PF4/heparin antibodies ranged between 1.9% and 57.9%. however, different methods to detect anti-PF4/heparin antibodies were applied. In none of the studies hIT-associated thromboembolic events or fatalities were observed. More importantly, in patients with a history of hIT, reexposure to heparin during transplantation was not associated with thrombotic complications. Taken together, the overall incidence of hIT after solid organ transplantation seems to be very low. however, according to the current knowledge, cardiac transplant recipients may have the highest risk to develop hIT. Different alternative suggestions for heparin-free anticoagulation have been reported for recipients with suspected hIT albeit no official recommendations on management have been published for this special collective so far.

关键词： heparin-induced thrombocytopenia heparininduced thrombocytopenia heparin Organ Transplantation

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脂肪干细胞诱导分化的现状及前景

中国组织工程研究 2015年第6期19卷 969-974页

作者：赵娜中国医科大学基础医学院病原生物学教研室辽宁省沈阳市110001

背景:脂肪干细胞是由中胚层发育而来的多能干细胞,在特殊的生长因子和环境等诱导培养条件下,可以向不同的谱系分化。目的:详细阐述脂肪干细胞诱导分化的条件及鉴定方法。方法:应用计算机检索万方数据库及PubM ed数据库2005至2014年10年... 详细信息

背景:脂肪干细胞是由中胚层发育而来的多能干细胞,在特殊的生长因子和环境等诱导培养条件下,可以向不同的谱系分化。目的:详细阐述脂肪干细胞诱导分化的条件及鉴定方法。方法:应用计算机检索万方数据库及PubM ed数据库2005至2014年10年间的文献,中文检索词为"脂肪干细胞,诱导,分化";英文检索词为"adipose derived stem cells,differentiation"。依据纳入排除标准选择37篇文献进行归纳总结。结果与结论:脂肪干细胞在抗坏血酸、胰岛素、地塞米松、转化生长因子β作用下可向软骨细胞分化;成脂诱导液的配方包括3-异丁基-1-甲基黄嘌呤(IBMX)、胰岛素、地塞米松、吲哚美辛;成骨分化常用的诱导剂包含地塞米松或维生素D3、抗坏血酸,β-甘油磷酸钠;碱性成纤维细胞生长因子、表皮生长因子及维生素B27可联合应用诱导脂肪干细胞成神经分化;向心肌细胞分化普遍应用的诱导因子是5-氮杂胞苷;血管内皮生长因子和碱性成纤维细胞生长因子共同作用可以诱导脂肪干细胞向血管内皮细胞分化。随着分子生物学和细胞生物学的迅速发展,脂肪干细胞的分化研究也会更加深入,在目前对脂肪干细胞诱导分化现象观察的基础上,应加强对其内在的分子机制及调控脂肪干细胞可塑性的基因和蛋白的研究。

关键词：干细胞细胞分化脂细胞成体干细胞脂肪干细胞诱导脂肪细胞软骨细胞骨细胞心肌细胞血管内皮细胞神经细胞

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Efficacy of immediate instillation combined with regular instillations of pirarubicin for Ta and T1 transitional cell bladder cancer after transurethral resection： a prospective, randomized, multicenter study

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Chinese medical Journal 2013年第15期126卷 2805-2809页

作者： Li Ning-chen YE ZhANG-qun na Yan-qun CUA ThP Peking Univ Shougang Hosp Wujieping Urol Ctr Beijing 100144 Peoples R China huazhong Univ Sci & Technol Tongji Hosp Tongji Med Coll Dept Urol Wuhan 430030 Hunan Peoples R China

Background Immediate intravesical instillation of chemotherapeutic agents after transurethral resection （TUR） of non- muscle invasive transitional cell bladder cancer has recently been suggested and has been proven to decrease the tumor recurrence rate significantly. This study is to evaluate the efficacy and safety of immediate intravesical instillation combined with regular instillations of Pirarubicin （ThP~） as prophylaxis compared to regular instillations only after TUR operation. Methods This was a prospective, randomized, multi-center, clinical study. Patients diagnosed with non-muscle invasive bladder cancer （Ta and T1） pathologically and suitable for TUR were enrolled randomly into two groups. In the study group, the patients received intravesical instillation within 24-hour post TURBT, followed by regular intravesical therapy using 30 mg/50 ml of ThP~ once a week for 8 weeks, and then once a month to 1 year postoperatively Among the patients. In the control group, patients received regular instillation only. Results A total of 403 patients were enrolled into this study from 26 institutions in China. Among the potients, 210 were enrolled into the study group and 193 were enrolled into the control group. At the median follow-up of 18 months, the recurrence rate was 7.8% in the study group, significantly lower than that in the control group （14.3%; P=0.042）. Subgroup analysis showed that the recurrence rate in low and intermediate-risk patients was significantly lower in the study group （6.8%） than in the control group （14.0%; P=0.047）, although no significant differences were found in high-risk patients. Conclusion One immediate dose of ThP 30 mg after TURBT followed by regular intravesical therapy appears well tolerated and more effective than regular intravesical therapy for preventing tumor recurrence, especially in low and intermediate-risk patients.

关键词： pirarubicin instillation therapy non-muscle-invasive bladder cancer randomized clinical trial

Vitrectomy with internal limiting membrane peeling versus its flap insertion for macular hole in high myopia: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 141-148页

作者： Ya-Jun Wu Jie Rao Kang-Rui Wu na Wu Yi Cheng Xiao-Xuan Xu Li Yan Yi Shao Yu Tian Xiao-Rong Wu Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the Second Xiangya HospitalCentral South UniversityChangsha 410008Hunan ProvinceChina

AIM: To compare the anatomic and functional outcomes between vitrectomy with internal limiting membrane(ILM) peeling and internal ILM flap insertion technique for high myopia macular hole(Mh).METhODS: Pub med, Cochrane Library, EMBASE, and CNKI were systematically searched, and all studies involved Mh were included. The closure rate of Mh and the postoperative best-corrected visual acuity(BCVA) at 6 mo after the initial surgery were the primary measures. All statistical tests were performed in Review Manager ***: Five studies that included 151 eyes of 151 patients were finally included, all of which were retrospectively comparative studies. Between the pars plana vitrectomy(PPV) with ILM peeling surgery and the ILM insertion technique, the latter had significantly better efficacy with respect to the closure rate of Mh(OR=21.32, 95%CI=7.25-62.67, Phowever, regarding BCVA at 6 mo after the initial surgery in Mh, there was no statistical significance between the groups(OR=-0.04, 95%CI=-0.22-0.14, P=0.66). In addition, regarding the rate of retinal reattachment after the initial surgery, the two different methods were not significantly different(OR=2.22, 95%CI=0.34-14.32, P=0.4).CONCLUSION: Both ILM peeling and ILM insertion technique could significantly improve anatomic outcomes of Mh in high myopia with or without retinal detachment(RD), and anatomic outcomes are more effective. however, there is no statistical significance in BCVA at 6 mo after the initial surgery in Mh, or in the rate of retinal reattachment after the first surgery, between the two methods.

关键词： macular hole high myopia best-corrected visual acuity retinal attachment Meta-analysis

Red meat intake and the risk of endometrial cancer:Metaanalysis of observational studies

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World Journal of Meta-Analysis 2015年第2期3卷 125-132页

作者： Woong Ju na na Keum Dong hoon Lee Yun hwan Kim Seung Cheol Kim Eric L Ding Eunyoung Cho Department of Obstetrics and Gynecology Medical Research InstituteCollege of MedicineEwha Womans University Department of Epidemiology Harvard School of Public Health Department of Nutritron Harvard School of Public Health Department of Dermatology the Warren Alpert Medical School of Brown University

AIM:To evaluate whether red meat intake is related to the risk of endometrial cancer(EC) using ***:We searched Pub med,EMBASE,and the Cochrane Library up to June 2013,using common keywords related to red meat and ***-control studies and cohort studies comparing the risk of endometrial cancer among categories by the amount of intake were *** case-control studies and five cohort studies met our *** performed a conventional and a dose-response meta-analysis of case-control studies using the Der Simonian-Laird method for *** cohort studies we performed a conventional *** bias was evaluated using Egger's ***:In the meta-analysis of 11 case-control studies including 5419 cases and 12654 controls,higher red meat consumption was associated with an increased risk of EC [summary relative risk(SRR) = 1.43,95%CI:1.15-1.79;I2 = 73.3% comparing extreme intake categories).In a dose-response analysis,for red meat intake of 100 g/d,SRR was 1.84(95%CI:1.64-2.05).In contrast,in the meta-analysis of five prospective studies including a total of 2549 cases among 247746 participants,no significant association between red meat intake and EC risk(SRR = 0.97,95%CI:0.85-1.11;I2 = 4.9% comparing extreme intake categories) was ***:Our meta-analysis found a significantlinear association between red meat intake and EC risk based on case-control studies but this was not confirmed in prospective studies.

关键词： Red meat Endometrial cancer Doseresponse Meta-analysis Observational studies

Role of adjuvant(chemo)radiotherapy for resected extrahepatic cholangiocarcinoma:a meta-analysis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第7期21卷 549-559页

作者： Xin-qi ShI Jing-yu ZhANG hua TIAN Ling-na TANG Ai-lin LI Department of Radiation Oncology the First Hospital of China Medical UniversityShenyang 110001China

Background:Adjuvant(chemo)radiotherapy(A(C)RT)may be an important supplement to surgery for extrahepatic cholangiocarcinoma(EhCC).however,whether all patients would achieve benefits from A(C)RT and which adjuvant regimen,adjuvant radiotherapy(ART)or adjuvant chemoradiotherapy(ACRT),would be preferred,are still *** low incidence of EhCC makes it difficult to carry out randomized controlled trials(RCTs);therefore,almost all clinical studies on radiotherapy are *** have conducted a meta-analysis of these retrospective ***:We conducted a meta-analysis of current retrospective studies using Pubmed,Embase,and ClinicalTrials *** studies published in English that were related to A(C)RT and which analyzed overall survival(OS),disease-free survival(DFS),or locoregional recurrence-free survival(LRFS)were *** hazard ratios(hRs)were calculated for OS,DFS,and ***:Data from eight studies including 685 patients were *** analysis showed that A(C)RT significantly improved OS(hR 0.69,95%confidence interval(CI)0.48–0.97,P=0.03),DFS(hR 0.60,95%CI 0.47–0.76,PhR 0.27,95%CI 0.17–0.41,PhCC *** subgroups,patients with microscopically positive resection margin(R1)could achieve a benefit from A(C)RT(hR 0.44,95%CI 0.27–0.72,P=0.001).No statistically OS difference was observed in negative resection margin(R0)subgroup(hR 0.98,95%CI 0.30–3.19,P=0.98).Significant OS benefit was found in patients who received concurrent ACRT(hR 0.40,95%CI 0.26–0.62,Phile the result of ART without chemotherapy showed no significant benefit(hR 1.14,95%CI 0.29–4.50,P=0.85).In the distal cholangiocarcinoma subgroup,no significant difference was seen when ACRT and ART were included(hR 0.61,95%CI 0.14–2.72,P=0.52),but a significant difference was seen ewOshSpe,enDc iaFanlSla,yl yianzn iddn igsL ttRahlF ep Sca iotinne cEnuthrsr.C eCnt pAaCtieRnTt so,nelys p(ehcRi a0 ll.y2 i9 n,t9 h5 o%s eC Iw i0

关键词： Adjuvant(chemo)radiotherapy Extrahepatic cholangiocarcinoma Meta-analysis Disease-free survival Overall survival

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Bio-inspired chiral self-assemblies promoted neuronal differentiation of retinal progenitor cells through activation of metabolic pathway

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Bioactive Materials 2021年第4期6卷 990-997页

作者： na Sun Xiaoqiu Dou Zhimin Tang Dandan Zhang Ni Ni Jiajing Wang huiqin Gao Yahan Ju Xiaochan Dai Changli Zhao Ping Gu Jing Ji Chuanliang Feng Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Department of OphthalmologyNinth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai200011China State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiaotong UniversityDongchuan Road 800200240ShanghaiChina

Retinal degeneration is a main class of ocular *** far,retinal progenitor cell(RPC)transplantation has been the most potential therapy for it,in which promoting RPCs neuronal differentiation remains an unmet *** address this issue,innovatively designed L/D-phenylalanine based chiral nanofibers(LPG and DPG)are employed and it finds that chirality of fibers can efficiently regulate RPCs ***,western blot,and immunofluorescence analysis show that right-handed helical DPG nanofibers significantly promote RPCs neuronal differentiation,whereas left-handed LPG nanofibers decrease this *** effects are mainly ascribed to the stereoselective interaction between chiral helical nanofibers and retinol-binding protein 4(RBP4,a key protein in the retinoic acid(RA)metabolic pathway).The findings of chirality-dependent neuronal differentiation provide new strategies for treatment of neurodegenerative diseases via optimizing differentiation of transplanted stem cells on chiral nanofibers.

关键词： Chiral structures Self-assembly nanofibers Retinal progenitor cell Neuronal differentiation

Detection of the short-term preseizure changes in EEG recordings using complexity and synchrony analysis

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Progress in natural Science:Materials International 2006年第7期16卷 691-700页

作者： JIA Wenyan, KONG na, MA Jun, LIU hesheng, GAO Xiaorong, GAO Shangkai and YANG Fusheng (Department of Biomedical Engineering, School of medicine, Tsinghua University, Beijing 100084, China) Tsing hua Univ Sch Med Dept Biomed Engn Beijing 100084 Peoples R China

An important consideration in epileptic seizure prediction is proving the existence of a pre-seizure state that can be detected using various signal processing algorithms. In the analyses of intracranial electroencephalographic (EEG)recordings of four epilepsy patients, the short-term changes in the measures of complexity and synchrony were detected before the majority of seizure events across the sample patient population. A decrease in complexity and increase in phase synchrony appeared several minutes before seizure onset and the changes were more pronounced in the focal region than in the remote region. This result was also validated statistically using a surrogate data method.

关键词： EEG epileptic seizure prediction second-order complexity synchrony.

The ratio of superior mesenteric artery diameter to superior mesenteric vein diameter based on non-enhanced computed tomography in the early diagnosis of spontaneous isolated superior mesenteric artery dissection

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World Journal of Emergency medicine 2022年第3期13卷 202-207页

作者： Yuan-li Lei Wen-xing Song Yi Lin hui-ping Li he-ping Lyu Jiao-zhen Chen Zhang-ping Li Jia-na Yin Ji-ke Xue Shou-quan Chen Department of Emergency medicine the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Radiology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Gastroenterology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Vascular Surgery the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Department of Electrocardiogram Wenzhou People's HospitalWenzhou 325000China

BACKGROUND:Spontaneous isolated superior mesenteric artery(SMA)dissection(SISMAD)is a rare cause of abdominal *** aim of the study is to investigate the role of a new parameter,the ratio of the SMA diameter to the superior mesenteric vein(SMV)diameter(SMA/SMV)based on non-enhanced computed tomography(CT),in the early diagnosis of ***:In a registry study from December 2013 to June 2021,97 abdominal pain SISMAD patients(SISMAD group)admitted to our hospital were ***,the matched sex and age abdominal pain non-SISMAD patients at 1:2 were collected in reverse chronological order as the control ***’s t-test,Wilcoxon rank-sum test,and Chi-square test were used to compare differences between the SISMAD and control *** Calc was used to generate receiver operating characteristic(ROC)***:A total of 291 abdominal pain patients,including 97 SISMAD patients and 194 nonSISMAD patients,were included in the current *** maximum SMA diameter,perivascular exudation,and SMA/SMV based on non-enhanced CT were significant between the two groups(all Phowed that for the maximum SMA diameter,the area under the curve(AUC),cut-off,sensitivity,and specificity were 0.926,9.80,93.8%,and 79.4%,*** SMA/SMV,its AUC,cut-off,sensitivity,and specificity were 0.956,0.83,88.7%,and 92.3%,*** diagnostic efficiency of SMA/SMV was better than that of the maximum SMA diameter(Phe combined parameters of SMA/SMV and maximum SMA diameter had the best diagnostic efficiency(AUC=0.970).CONCLUSION:SMA/SMV may be a potential marker for SISMAD.

关键词： Abdominal pain Spontaneous isolated superior mesenteric artery dissection Computed tomography Receiver operating characteristic curve

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