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N-acetyl cysteine therapy in acute viral hepatitis

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World Journal of Gastroenterology 2003年第12期9卷 2698-2700页

作者： huseyin Gunduz Oguz Karabay Ali Tamer Resat zaras Ali Mert mer Fehmi Tabak Department of Internal Medicine and Cordiology Izzet Baysal Medical FacultyIzzet Baysal University/BoluTurkey Department of Infectious Diseases and Clinical Microbiology Izzet Baysal Medical FacultyIzzet Baysal University/BoluTurkey Department of Internal Medicine Izzet Baysal Medical FacultyIzzet Baysal University/BoluTurkey Department of Infectious Diseases and Clinical Microbiology Cerrahpasa Medical FacultyIstanbul UniversityFindikzade/lstanbulTurkey

AIM: To investigate the effect of N-acetyl cysteine (NAC)on acute viral hepatitis (AVH).METHODS: We administered 200 mg oral NAC three times daily (600 mg/day) to the study group and placebo capsules to the control group. All patients were hospitalized and diagnosed as AVH. Blood total and direct bilirubin, ALT, AST,alkaline phosphatese, albumin and globulin levels of each patient were measured twice weekly until total bilirubin level dropped under 2 mg/dl, ALT level under 100 U/L, follow up was continued and then the patients were ***: A total of 41(13 female and 28 male) AVH patients were included in our study. The period for normalization of ALT and total bilirubin in the study group was 19.7±6.9 days and 13.7±8.5 days respectively. In the control group it was 20.4±6.5 days and 16.9±7.8 days respectively (P＞0.05).CONCLUSION: NAC administration effected neither the time necessary for normalization of ALT and total bilirubin values nor duration of hospitalization, so we could not suggest NAC for the treatment of icteric AVH cases. However, our results have shown that this drug is not harmful to patients with AVH.

关键词： Acetylcysteine Acute Disease Adolescent Adult Alanine Transaminase Antiviral Agents Aspartate Aminotransferases Bilirubin Comparative Study Female Hepatitis A Hepatitis B Humans Liver Function Tests Male Middle Aged Reference Values

Effectiveness of Saccharomyces boulardii in a rat model of colitis

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World Journal of Gastroenterology 2012年第44期18卷 6452-6460页

作者： Mujde Soyturk Saba Mukaddes Saygili huseyin Baskin Ozgul Sagol Osman Yilmaz Fatih Saygili Hale Akpinar Department of Gastroenterology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Internal Medicine Mediguven HospitalSalihli 45300ManisaTurkey Department of Clinical Microbiology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Pathology Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Laboratory Animal Science Dokuz Eylul University School of MedicineInciraltiIzmir 35340Turkey Department of Gastroenterology Pamukkale University School of MedicineDenizli 20070Turkey

AIM:To investigate the effects of Saccharomyces boulardii(***) in an experimental rat model of trinitrobenzene sulfonic acid(TNBS)-induced ***:Thirty-two Wistar albino female rats were categorized into five *** the first day of the study,50 mg TNBS was administered via a rectal catheter in order to induce colitis in all rats,except those in the control *** 14 d,the rats were fed a standard diet,without the administration of any additional supplements to either the control or TNBS groups,in addition to 1 mg/kg per day *** to the *** group,1 mg/kg per day methyl prednisolone(MP) to the MP *** animals in the *** + MP group were coadministered these doses of *** and *** the study,weight loss,stool consistency,and the presence of obvious blood in the stool were evaluated,and the disease activity index(DAI) for colitis was *** intestines were examined and colitis was macro-and microscopically *** serum and tissue levels of tumor necrosis factor-α(TNF-α) and nitric oxide(NO) were determined,and fungemia was evaluated in the blood ***:The mean DAI scores for the MP and *** + MP groups was significantly lower than the TNBS group(3.69 ± 0.61 vs 4.46 ± 0.34,P = 0.018 and 3.77 ± 0.73 vs 4.46 ± 0.34,P = 0.025,respectively).While no significant differences between the TNBS and the *** or MP groups could be determined in terms of serum NO levels,the level of serum NO in the *** + MP group was significantly higher than in the TNBS and *** groups(8.12 ± 4.25 μmol/L vs 3.18 ± 1.19 μmol/L,P = 0.013;8.12 ± 4.25 μmol/L vs 3.47 ± 1.66 μmol/L,P = 0.012,respectively).The tissue NO levels in the ***,MP and *** + MP groups were significantly lower than the TNBS group(16.62 ± 2.27 μmol/L vs 29.72 ± 6.10 μmol/L,P = 0.002;14.66 ± 5.18 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.003;11.95 ± 2.34 μmol/Lvs 29.72 ± 6.10 μmol/L,P = 0.002,respectively).The tis

关键词： Saccharomyces boulardii Rat Trinitroben-zene sulfonic acid Tumor necrOsis factor-m Nitric ox-ide Fungemia

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内共振系统的范式计算

振动工程学报 2001年第1期14卷 65-67页

作者：张伟亿叶敏 Kancay huseyin 天津大学力学系天津300072 Department of Systems DesignEng. University

提出了一种简便的、适合于符号推导运算的范式分析过程。借助于符号运算。

关键词：内共振系统范式计算高维非线性振动系统

H pylori iceA alleles are disease-specific virulence factors

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World Journal of Gastroenterology 2007年第18期13卷 2581-2585页

作者： Vildan Caner Mustafa Yilmaz Nadir Yonetci Sevil Zencir Nedim Karagenc Ilknur Kaleli huseyin Bagci Department of Medical Biology School of Medicine Pamukkale University 20020 Kinikli Denizli Turkey Department of Gastroenterology School of Medicine Pamukkale University 20020 Kinikli Denizli Turkey Department of Microbiology and Clinical Microbiology School of Medicine Pamukkale University 20020 Kinikli Denizli Turkey

AIM： To characterize and compare genotype profiles of H pylori strains isolated from patients with chronic gastritis and duodenal ulcer in western part of Turkey. METHODS： A total of 46 patients [30 chronic gastritis （CG） and 16 duodenal ulcer （DU）] who had undergone endoscopy because of dyspeptic complaints were studied. The antral biopsy specimens were evaluated for the presence of Hpylori by rapid urease test and culture, and the genotype profiles were determined by real-time PCR. RESULTS： The cagA gene was observed in 43 （93.5%） isolates. The vacA s1m2 genotype was the predominant subtype, found in 63.3% and 68.7% of isolates in patients with CG and DU, respectively. Twenty （66.6%） isolates from patients with CG were iceA2 positive while the iceA1 was predominant in those with DU （68.8%）. In terms of the association of the ice,4 alleles to other genes, both alleles were significantly associated with the cagA vacA slm2 genotype. CONCLUSION： The prevalent circulating genotypes in CG and DU were cagA vacA slm2 iceA2 and cagA vacA slm2 iceA1 genotype, respectively. It was found that cagA vacA slm2 genotype seems to be common virulence factors in both CG and DU while iceA alleles show specificity for gastroduodenal pathologies in this study.

关键词： Hpylori Virulence genes Culture Real-timePCR

Constraints on unconsolidated pyroclastic flow sediments related REE enrichments originated from potassic-alkaline Gölcük stratovolcano: Darıdere-Direkli-Yakaören (DDY) table 4deposits, southwestern Anatolia of Turkey

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Acta Geochimica 2021年第6期40卷 926-944页

作者： Murat Budakoglu Ali Tugcan Unluer Zeynep Doner huseyin Kocaturk Mustafa Kaya Mustafa Kumral M.Sezai Kirikoglu Department of Geological Engineering Faculty of MinesIstanbul Technical UniversityIstanbulTurkey

In the last five decades,Rare Earth Elements(REE)are mostly produced from carbonatite complexes and alkaline magmatic *** this respect,pyroclastic flows produced by the potassic-alkaline Gölcük volcanism in the Isparta(SW,Turkey)angle stand out as an important target area where REE enrichments can be *** study focuses on the REE potential,geochemical and mineralogical characteristics of REE-bearing minerals as well as formation modeling of unconsolidated pyroclastic flows in Darıdere-Direkli-Yakaören(DDY)deposits in ***-bearing minerals of DDY deposits which contain abundant trachytic-trachyandesitic rock fragments were determined as fluorapatite,britholite,and chevkinite by using XRD and SEM–EDX *** to the geochemical analysis,the vast majority of RREE(up to 996 ppm)content is LREE such as La,Ce and ***ıdere is the most REE enriched region followed by Yakaören and Direkli regions in terms of LREE(574.9 ppm),relative to MREE(38.5 ppm)and HREE(5.28 ppm)*** results are also on par with subduction-related Italian extrusive carbonatites such as Polino,Cupaello and San *** DDY deposits can also be comparable with intraplate extrusive REE deposits in terms of LREE enrichments,however,HREE,Nb,Th and Zr values are generally *** RREE concentrations tend to rise with the increasing contents of alkaline elements(Na and K),HFSE(such as Nb and U),as well as LILE(Ba,Sr and Rb)and are negatively affected by sedimentary carbonate *** economic value of the DDY deposits can gain importance due to the increasing global demand for LREE’s.

关键词： Pyroclastic flows Rare Earth Elements(REE) Apatite Britholite Chevkinite Alkaline-Ultrapotasic magmatism

Pseudoxantoma elasticum,as a repetitive upper gastrointestinal hemorrhage cause in a pregnant woman

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World Journal of Gastroenterology 2007年第28期13卷 3897-3899页

作者： Vedat Goral Dogan Demir Yekta Tuzun Ugur Keklikci huseyin Buyukbayram Kadim Bayan Asur Uyar Department of Gastroenterology Dicle University School of MedicineDiyarbakirTurkey Department of Family Medicine Dicle University School of MedicineDiyarbakirTurkey Department of Ophtalmology Dicle University School of MedicineDiyarbakirTurkey Department of Pathology Dicle University School of MedicineDiyarbakirTurkey Department of Radiology Dicle University School of MedicineDiyarbakirTurkey

Pseudoxantoma elasticum is a rare, hereditary, multisystemic disease affecting the skin, eye, and cardiovascular system. A twenty-eight-year-old female has presented to emergency unit with the complaint of gastrointestinal hemorrhage. This patient, who had been monitored in the gastroenterology clinic more than 10 times in the past 8 years, noted a repetitive hemorrhage during her previous pregnancy in her history. The examination of the patient revealed the following signs and symptoms： atrophy in the epithelium of the retina pigment; typical angioid streaks and peau d＇orange finding in the fundus; thinning of the retinal nerve fiber in OCT （optic coherence tomography）; bilateral and reticular papillary lesions with yellowish- color in the neck region （plucked chicken appearance）; presence of bleeding loci in fundus, and nephrocalcinosis in kidneys. In light of these symptoms, the patient was diagnosed with pseudoxantoma elasticum. Skin biopsy confirmed the pseudoxantoma elasticum diagnose. PXE is an uncommon, hereditary disease. Early diagnosis of pseudoxantoma elasticum cases, is important for minimalizing systemic complications and informing the other family members through genetic counseling.

关键词： Pseudoxantoma elasticum Upper gastrointestinal hemorrhage

The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin

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Asian Journal of Andrology 2014年第2期16卷 314-318,I0012页

作者： Bekir S Parlaktas Dogan Atilgan huseyin Ozyurt Yusuf Gencten Ali Akbas Fikret Erdemir Nihat Uluocak Department of Urology Gaziosmanpasa University Faculty of Medicine Tokat Turkey Department of Biochemistry Gaziosmanpasa University Faculty of Medicine Tokat Turkey.

Testicular torsion （TT） is a serious urologic emergency that is observed in adolescent males and that can lead to infertility if left untreated. The ischemia-reperfusion （I/R） injury due to TT has been implicated in the pathogenesis of testicular damage. We investigated the effects of melatonin on oxidative damage in the ipsUateral and contralateral testes of rats induced by unilateral TT. A total of 21 prepubertal male Wistar albino rats were divided into three groups, each consisting of seven rats, In Group 1 （SHAM group）： a sham operation to the left testis and bilateral orchiectomy were performed. In Group 2 （I/R group）： I/R injury was created by rotating the left testis 720° in a clockwise direction for 2 h and detorsing the testis after 2 h. Group 3 （I/R ＋ MEL group）： rats were subjected to I/R injury and one-shot melatonin injection （50mgkg-1, intraperitoneal （i.p.））. The testes of the rats were excised bilaterally in all groups. The testicular tissue activities of antioxidant catalase （CAT）, superoxide dismutase （SOD） and glutathione peroxidase enzymes （GSH-Px）, and the tissue levels of malondialdehyde （MDA）, protein carbonyl （PC） and nitric oxide （NO） were determined. Administration of melatonin caused a significant decrease in lipid peroxidation and enzyme activities in the ipsilateral testis when compared with the control group （P 〈 0.05）. All of the changes in the enzyme activities of the contralateral testis were insignificant （P 〉 0.05）. MDA levels were significantly altered in the contralateral testis （P = 0.009）, Melatonin administration decreased the deleterious effects of I/R injury in the ipsilateral torted testes of the rats. The contralateral testes were slightly affected by unilateral TT.

关键词： antioxidant enzymes ischemia-reperfusion (I/R) lipid peroxidation melatonin testicular torsion {TT)

Impact of admission blood glucose levels on prognosis of elderly patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

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Journal of Geriatric Cardiology 2013年第4期10卷 310-316页

作者： Ahmet Ekmekci Mahmut Uluganyan Fatif Tufan huseyin Uyarel Gurkan Karaca Seref Kul Barl(s) Gungor Department of Cardiology Dr.Siyami Ersek Thoracic and Cardiovascular Surgery Center Training and Research Hospital Tibbiye Caddesi 34000 Istanbul Turkey Department of Cardiology Kadirli State Hospital Toki Caddesi 8075 Osmaniye Turkey Department of Geriatric Istanbul University Medical Hospital Vatan Cadddessi 34000 Istanbul Turkey Department of Cardiology Bezmialem Vakif University Medical Hospital Vatan Caddesi 34000 Istanbul Turkey

OBJECTIVE:Admission hyperglycemia in acute myocardial infarction (MI) is related with increased in-hospital and long term mortality and major cardiac adverse events。 We aimed to investigate how admission hyperglycemia affects the short and long term outcomes in elderly patients >65 years) after primary percutaneous coronary intervention for ST elevation myocardial infarction。 METHODS:We retrospectively analyzed 677 consecutive elderly patients (mean age 72.2 ±5.4)。 Patients were divided into two groups according to admission blood glucose levels。 Group : low glucose group (LLG), glucose 168 mg/dL。 RESULTS:In-hospital, long term mortality and in-hospital major adverse cardiac events were higher in the high admission blood glucose group (P 1, post-thrombolysis in MI <3 and admission blood glucose levels were independent predictors of in-hospital adverse cardiac events (P <0.001)。 CONCLUSIONS:Admission hyperglycemia in elderly patients presented with ST elevation myocardial infarction is an independent predictor of in-hospital major adverse cardiac events and is associated with in-hospital and long term mortality。

关键词： Admission hyperglycemia Elderly patients In-hospital mortality Long-term mortality Major adverse cardiac events

Encapsulated black garlic: Comparison with black garlic extract in terms of physicochemical properties, biological activities, production efficiency and storage stability

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Food Bioscience 2022年第6期50卷 127-138页

作者： Aycan Cinar Seda Altuntas huseyin Demircan Ayse Neslihan Dundar Gokce Taner Rasim Alper Oral Bursa Technical University Faculty of Engineering and Natural SciencesDepartment of Food Engineering16330BursaTurkey Bursa Technical University Faculty of Engineering and Natural SciencesDepartment of Bioengineering16330BursaTurkey

In this paper, the convenience of encapsulation technique was investigated in terms of characterization of capsule, changing the volatile compounds and preservation biological activity throughout six months for black garlic (BG) by comparison with the aqueous extract which prepared from BG (stored at 4 °C) each analysis period. Besides, the genotoxic and antigenotoxic aspects of aqueous black garlic extract (BGE) and black garlic capsule (BGC) developed as a novel promising product were also researched. The S-allyl-L-cysteine (SAC) content, which is mostly known to be responsible for biological activity, was preserved in BGC during six months. The variety of volatile compound of BGC (2 compounds) was significantly reduced compared to BG (17 compounds) and BGE (7 compounds), which indicates that the extraction and encapsulation traps the undesirable odor. A significant decrease was observed for total phenolic content and antioxidant capacity (performed with DPPH and CUPric Reducing Antioxidant Capacity (CUPRAC)) of BGC with storage like BGE. In contrast, the values obtained with the ABTS method remained constant with storage. The antimicrobial activity (carried out on five Gram-positive bacteria, three Gram-negative bacteria and three yeasts) of BGC was preserved better than BGE. The treatment concentrations (50, 100, 200 μg/mL) of both BGE and BGC did not have a genotoxic effect and moreover they have antigenotoxic effects against mitomycin C on human lymphocyte cells. All these results implied that BGC can be good a candidate to increase the consumption of BG providing health benefits and functional supplement for food.

关键词： Black garlic Encapsulation Volatile compounds Biological activities Preservation technique Storage