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Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

Asian Journal of Andrology 2008年第2期10卷 259-265页

作者： Bekir S. Parlaktas Birsen ozyurt huseyin ozyurt Ayten T. Tunc Ali Akbas Department of Urology Gaziosmanpasa University School of Medicine Tokat 60100 Turkey Department of Anatomy Gaziosmanpasa University School of Medicine Tokat 60100 Turkey Department of Biochemistry Gaziosmanpasa University School of Medicine Tokat 60100 Turkey Department of Histology and Embryology Gaziosmanpasa University School of Medicine Tokat 60100 Turkey

Aim： To evaluate the effects of melatonin on antioxidant enzyme levels and histopathologic changes in dizocilpine （MK-801）-induced psychosis model rat testis. Methods： A total of 24 adult male Wistar-Albino rats were divided into three groups with 8 in each. Group I was used as control. Rats in Group II were injected with MK-801 （0.5 mg/kg body weight i.p. for 5 days）. In addition to MK-801, melatonin （50 mg/kg body weight i.p. once a day for 5 days） was injected into the rats in Group Ⅲ. The testes were harvested bilaterally for biochemical and histopathological examinations. Antioxidant enzyme activities, malondialdehyde, protein carbonyl and nitric oxide （NO） levels in testicular tissues were analyzed using spectrophotometric analysis methods. Histopathological examinations of the testes were also performed. Results： MK-801 induced testicular damage, which resulted in significant oxidative stress （OS） by increasing the levels of antioxidant enzymes. The malondialdehyde, protein carbonyl and NO levels were increased in testicular tissues of rats. Treatment with melatonin led to significant decrease in oxidative injury. Administration of melatonin also reduced the detrimental histopathologic effects caused by MK-801. Conclusion： The results of the present study showed that MK-801 cause OS in testicular tissues of rats and treatment with melatonin can reduce the harmful effects＇of MK-801. （Asian JAndro12008 Mar; 10： 259-265）

关键词： testis dizocilpine psychosis oxidative stress melatonin antioxidant enzymes

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The biochemical effects of ischemia-reperfusion injury in the ipsilateral and contralateral testes of rats and the protective role of melatonin

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Asian Journal of Andrology 2014年第2期16卷 314-318,I0012页

作者： Bekir S Parlaktas Dogan Atilgan huseyin ozyurt Yusuf Gencten Ali Akbas Fikret Erdemir Nihat Uluocak Department of Urology Gaziosmanpasa University Faculty of Medicine Tokat Turkey Department of Biochemistry Gaziosmanpasa University Faculty of Medicine Tokat Turkey.

Testicular torsion （TT） is a serious urologic emergency that is observed in adolescent males and that can lead to infertility if left untreated. The ischemia-reperfusion （I/R） injury due to TT has been implicated in the pathogenesis of testicular damage. We investigated the effects of melatonin on oxidative damage in the ipsUateral and contralateral testes of rats induced by unilateral TT. A total of 21 prepubertal male Wistar albino rats were divided into three groups, each consisting of seven rats, In Group 1 （SHAM group）： a sham operation to the left testis and bilateral orchiectomy were performed. In Group 2 （I/R group）： I/R injury was created by rotating the left testis 720° in a clockwise direction for 2 h and detorsing the testis after 2 h. Group 3 （I/R ＋ MEL group）： rats were subjected to I/R injury and one-shot melatonin injection （50mgkg-1, intraperitoneal （i.p.））. The testes of the rats were excised bilaterally in all groups. The testicular tissue activities of antioxidant catalase （CAT）, superoxide dismutase （SOD） and glutathione peroxidase enzymes （GSH-Px）, and the tissue levels of malondialdehyde （MDA）, protein carbonyl （PC） and nitric oxide （NO） were determined. Administration of melatonin caused a significant decrease in lipid peroxidation and enzyme activities in the ipsilateral testis when compared with the control group （P 〈 0.05）. All of the changes in the enzyme activities of the contralateral testis were insignificant （P 〉 0.05）. MDA levels were significantly altered in the contralateral testis （P = 0.009）, Melatonin administration decreased the deleterious effects of I/R injury in the ipsilateral torted testes of the rats. The contralateral testes were slightly affected by unilateral TT.

关键词： antioxidant enzymes ischemia-reperfusion (I/R) lipid peroxidation melatonin testicular torsion {TT)

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Evaluation of the Lower Urinary Tract before Renal Transplantation: To Which Patients? How?

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Open Journal of Urology 2012年第3期2卷 127-130页

作者： Adnan Simsir Hamad Dheir Rashad Mammadov Cuneyt Hoscoskun huseyin Toz Ercan Ok Ceyhun ozyurt Department of General Surgery Ege University School of Medicine Izmir Turkey Department of Urology Ege University School of Medicine Izmir Turkey Division of Nephrology Ege University School of Medicine Izmir Turkey

Purpose: The evaluation of lower urinary tract (LUT) before transplantation is not required, except in patients with a history of LUT disfunction (LUTD). In this study, we adressed the necessity for lower urinary system evaluation in transplantation candidates classified according to their etiology. Materials and Methods: Sixty-two patients were prospectively evaluated. The patients were evaluated at 2 months preoperatively and at 6 months post transplantation using questionnaires, bladder diary and urodynamic studies. The end stage renal disease (ESRD) etiologies of the patients were divided into three groups as follows: patients with a parenchymal disease, patients with LUTD and those with unknown etiology and the obtained results were evaluated accordingly. Results: The evaluation of 50 patients revealed significant differences in ICIQ-SF (p < 0.001), IPSS (p < 0.001), daily urine volumes (p = 0.05), maximum urinary flow rate (p = 0.03), PVR, the number of patients with VUR and all cystometric parameters between the patient groups divided according to the etiology. The comparison of the groups to each other revealed no statistically significant differences in all parameters between the LUTD group and the patient groups with unknown etiology. Considering that the results from questionnaires of patients with a single voided volume of 100 cc or greater on the bladder diary would be scientifically more significant, they were evaluated separately. Thus, even though the results from questionnaires did not differ between the group with unknown etiology and the LUTD group, there were significant differences when compared to patients who developed ESRD due to a parenchymal disease. Similar findings were found between the results of urodynamic study. Conclusions: The evaluation of lower urinary tract in patients with a history of LUTD and in those with unknown etiology should be initially evaluated by noninvasive methods such as questionnaires and uroflowmetry.

关键词： Renal Transplantation Lower Urinary Tract Evaluation Urodynamics

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Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants

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World Journal of Gastroenterology 2015年第4期21卷 1222-1233页

作者： Sevgi Ozden Zerrin Ozgen Hazan ozyurt Cengiz Gemici Gokhan Yaprak huseyin Tepetam Alpaslan Mayadagli Radiation Oncology Dr. Lutfi Kirdar Kartal Training and Research Hospital34890IstanbulTurkey Faculty of Medicine Bezmialem Vakif University34093 IstanbulTurkey

AIM: To evaluate survival data in patients with gastric cancer in relation to postoperative adjuvant therapy and survival determinantsMETHODS: A total of 201 patients(mean ± SD age: 56.0 ± 11.9 years, 69.7% were males) with gastric carcinoma who were operated and followed up at Lutfi Kirdar Kartal Training and Research Hospital between 1998 and 2010 were included in this retrospective study. Follow up was evaluated divided into two consecutive periods(before 2008 and 2008-2010, respectively) based on introduction of 3-D conformal technique in radiotherapy at our clinic in 2008. Data on patient demographics, clinical and histopathological characteristics of gastric carcinoma and the type of treatment applied after surgery [postoperative adjuvant treatment protocols including chemoradiotherapy(CRT) and chemotherapy(CT), supportive therapy or follow up without any treatment] were recorded. The median duration and determinants of local recurrence free(LRF) survival, distant metastasis free(DMF) survival and overall survival were evaluated in the overall population as well as with respect to follow up years [1998-2008(n = 127) vs 2008-2010(n = 74)].RESULTS: Median duration for LRF survival, DMF survival and overall survival were 31.9, 24.1 and 31.9 mo, respectively in patients with postoperative adjuvant CRT. No significant difference was noted in median duration for LRF survival, DMF survival and overall survival with respect to treatment protocols in the overall population and also with respect to followed up periods. In the overall population, CT protocols FUFA [5-fluorouracil(400 mg/m2) and leucovorin-folinic acid(FA, 20 mg/m2)](29.9 mo) and UFT + Antre [a fixed combination of the oral FU prodrug tegafur(flouroprymidine, FT, 300 mg/m2 per day) with FA(Antrex?), 15 mg tablet, two times a day](42.5 mo) was significantly associated with longer LRF survival times than other CT protocols(P = 0.036), while no difference was noted between CT protocols in terms of DMF surviv

关键词： Gastric carcinoma Local recurrence free survival D

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Evaluation of the Lower Urinary Tract before Renal Transplantation: To Which Patients? How?

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Open Journal of Urology（泌尿学期刊） 2012年第3期

作者： Adnan Simsir Hamad Dheir Rashad Mammadov Cuneyt Hoscoskun huseyin Toz Ercan Ok Ceyhun ozyurt

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