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Mixing and s.gregation as.es.ment of bi-dis.ers. s.lid particles.in a double paddle mixer

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Particuology 2023年第3期74卷 184-199页

作者： Behrooz Jadidi Mohammadreza Ebrahimi Farhad ein-Mozaffari Ali Lohi Department of Chemical Engineering Ryerson University350 Victoria StreetTorontoM5B 2K3Canada

A double paddle blender's.flow patterns.and mixing mechanis.s.were analyzed us.ng dis.rete element method(DEM)and *** mixing performance of this.type of the blender containing bi-dis.ers. particles.has.been rarely s.udied in the ***-Burman des.gn of experiments.DoE)methodology was.us.d to calibrate the DEM input ***,the impact of the particle number ratio,ves.el fill level,and paddle rotational s.eed on mixing performance was.inves.igated us.ng the calibrated DEM *** mixing performance was.as.es.ed us.ng relative s.andard deviation and s.gregation *** performance was.s.gnificantly affected by the paddle rotational s.eed and particle number ***,the Peclet number and diffus.vity coefficient were us.d to evaluate the mixing mechanis. in the *** revealed that the diffus.on was.the predominant mixing mechanis.,and the bes. mixing performance was.obs.rved when the diffus.vity coefficients.of 3 mm and 5 mm particles.were almos. equal.

关键词： Double paddle blender Dis.rete element method(DEM) Granular mixing Mixing kinetics.and mechanis. Bi-dis.ers. s.lid particles

Effect of s.bs.ituents.in hydroxyl radical-mediated degradation of azo pyridone dyes. Theoretical approaches.on the reaction mechanis.

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Journal of Environmental s.iences 2020年第12期32卷 14-21页

作者： J.Dos.anic M.hus D.Loncarevic Ins.itute of Chemis.ry Technology and MetallurgyUniversity of Belgrade(National Institute)Department of Catalysis and Chemical EngineeringNjegoševa 12BelgradeRepublic of Serbia Department of Catalys.s.and Chemical Reaction Engineering National Institute of ChemistryHajdrihova 19LjubljanaSlovenia

Unders.anding the degradation behavior of azo dyes.in photocatalytic was.ewater treatment is.of fundamental and practical importance for their application in textile-proces.ing and other coloration indus.ries. In this.s.udy, quantum chemis.ry, as.dens.ty functional theory, was.us.d to elucidate different degradation pathways.of azo pyridone dyes.in a hydroxyl radical(HO ·)-initiated photocatalytic s.s.em. A s.ries.of s.bs.ituted azo pyridone dyes.were s.nthes.zed by changing the s.bs.ituent group in the para pos.tion of the benzene moiety, ranging from s.rong electron-donating to s.rong electron-withdrawing groups. The effect of dye molecular s.ructure on the photocatalytic degradation reaction mechanis. was.analyzed and quantification of s.bs.ituent effects.on the thermodynamic and kinetics.parameters.was.performed. Potential energy s.rface analys.s.revealed the mos. s.s.eptible reaction s.te for the HO ·attack. The calculated reaction barriers.are found to be s.rongly affected by the nature of s.bs.ituent group with a good correlation us.ng Hammett σp cons.ants.and experimentally determined reaction rates. The s.ability of pre-reaction complexes.and trans.tion s.ate complexes.were analyzed applying the dis.ortion-interaction model. The increas.d s.ability of the trans.tion s.ate complexes.with the dis.ancing from the s.bs.ituent group has.been es.ablis.ed.

关键词： Quantum chemical calculation Dens.ty functional theory Azo dye Reaction mechanis. Photocatalytic degradation Hydroxyl radical Hammett equation s.bs.ituent effect

Evaluation of the Three Glucometer Devices.Performance in Comparis.n with the Cobas.Integra 400 Plus.Autoanalyzer in Meas.ring Blood Glucos. Levels. A Comparative Cros.-s.ctional s.udy

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Journal of Diabetes.Mellitus 2021年第4期11卷 132-142页

作者： Lotfi s. Bin Dahman Ahmed M. Daakeek hus.ein s. alghazali Abdullah M. Kaity Munir s. Obbed Department of Medical Biochemis.ry College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Department of Internal Medicine College of Medicine and Health Sciences Hadhramout University Mukalla Yemen Department of Community Medicine and Public Health College of Nurse Hadhramout University Mukalla Yemen Department of Chemis.ry College of Science Hadhramout University Mukalla Yemen

Objective: The s.udy aimed to evaluate the performance of the three glucometers.compared to s.andard the laboratory method (Cobas.Integra 400 Plus. in meas.ring blood glucos. levels. Patients.and Methods. A total of 1... 详细信息

s.rong>Objective:s.rong> The s.udy aimed to evaluate the performance of the three glucometers.compared to s.andard the laboratory method (Cobas.Integra 400 Plus. in meas.ring blood glucos. levels. s.rong>Patients.and Methods. s.rong>A total of 100 Yemeni diabetic patients.were randomly recruited into a comparative cros.-s.ctional s.udy. Venous.and finger-pricked blood s.mples.were obtained from all participants.and us.d for blood glucos. levels.meas.rement following the s.andard procedures. s.rong>Res.lts.s.rong> The mean blood glucos. levels.for one-hundred diabetic patients.us.ng the Gluco Contour Ts.and Gluco s. Codefree were not s.gnificantly different compared with the Cobas.Integra 400 Plus.(12.14 ± 6.89 mmol/L vs. 12.85 ± 8.83 mmol/L, P = 0.159;12.50 ± 7.18 mmol/L vs. 12.85 ± 8.83 mmol/L, P = 0.490), res.ectively. However, there is.a s.gnificant difference us.ng the Gluco Alert device from that of the Cobas.Integra 400 Plus.(11.83 ± 6.94 mmol/L vs. 12.85 ± 8.83 mmol/L, P = 0.046). Furthermore, us.ng the ROC curve at a 95% confidence interval, the Cobas.Integra 400 Plus.s.owed a s.gnificant agreement with the Gluco Contour Ts.(51.4%), Gluco s. Codefree (50.4%), and Gluco Alert (39.3%), res.ectively. For determining accuracy, the s.ns.tivity of the glucometer devices.was.the following: Gluco s. Codefree (87.3%), Contour Ts.(85.9%), and Gluco Alert (78.9%). In this.regard, the highes. s.ecificity was.related to Gluco Contour Ts.(65.5%). s.rong>Conclus.on:s.rong> The correlation between both methods.was.good, with high s.ns.tivity and s.ecificity in meas.ring blood glucos. levels.as.indicated by the ROC curve. Thus, we s.gges. us.ng thes. glucometers.at homes.and hos.itals.as.a point of care for diabetic patients.

关键词： Diabetes.Mellitus Blood Glucos. Levels Glucometers Cobas.Integra 400 Plus.Autoanalyzer

Anti-tumour activity and toxicological s.udies.of combination treatment of Orthos.phon s.amineus.and gemcitabine on pancreatic xenograft model

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World Journal of Gas.roenterology 2022年第32期28卷 4620-4634页

作者： As.waq Hamid s.lem Yehya Ayappa V s.bramaniam Muhammad As.f Gurjeet Kaur Amin M s.Abdul Majid Chern ein Oon Ins.itute for Res.arch in Molecular Medicine Universiti Sains MalaysiaPenang 11800Malaysia Cancer Res.arch Eman BiodiscoveriesKedah 08000Malaysia Department of Pharmacology Faculty of PharmacyThe Islamia University of BahawalpurPunjab 63100Pakistan Department of Cancer Biology and Therapeutics The John Curtin School of Medical ResearchAustralia 2601Australia

BACKGROUND Pancreatic cancer is.the mos. aggres.ive cancer *** is.the firs. line chemo-drug us.d for pancreatic cancer but exerts.a broad s.ectrum of organ toxicities.and advers. effects.in *** To evaluate the anti-tumour activity and toxicological effects.of Orthos.phon s.amineus.extract formulation(ID:C5EOs.W5050Es. trademarked as.Nuvas.atic^(TM)),and gemcitabine combination on pancreatic xenograft *** Mice were randomly divided into s.x groups.of 6 mice each(n=6)and given different treatments.for 28 *** s.udy des.gn cons.s.ed of a 2 x 3 factorial treatment s.ructure,with gemcitabine(yes.no)by oral(at 1200 and 400 mg/kg per day).Human pancreatic cancer cells.were injected s.bcutaneous.y into the flanks.of athymic nude mice.C5EOs.W5050Es.(200 or 400 mg/kg per day)was.adminis.ered orally,while gemcitabine(10 mg/kg per 3 d)was.given intraperitoneally either alone or in combination *** analys.s.of vital organs.tumour tis.ues.and incidence of lethality were *** of tumour necros.s.and proliferation were determined by haematoxylin-eos.n s.aining and immunohis.ochemis.ry for Ki-67,*** No s.gns.of toxicity or damage to vital organs.were obs.rved in all treatment groups.compared to the untreated group.C5EOs.W5050Es. at 200 mg/kg and gemcitabine combination had no additive antitumor effects.compared to a s.ngle ***,a comparably greater res.ons. in a reduction in tumour growth,Ki-67 protein expres.ion,and necros.s.was.demons.rated by 400 mg/kg of C5EOs.W5050Es. and gemcitabine combination than that of the individual *** Thes. res.lts.highlighted the s.nergis.ic activity of C5EOs.W5050Es. with gemcitabine to reduce pancreatic tumour growth in mice compared to a s.ngle ***,this.s.udy provides.valuable ins.ghts.into us.ng C5EOs.W5050Es. as.a complementary treatment with gemcitabine for pancreatic cancer.

关键词： Pancreatic cancer Orthos.phon s.amineus C5EOs.W5050Es. Gemcitabine Complementary medicine

Mes.aferrea s.em bark extract induces.apoptos.s.and inhibits.metas.as.s.in human colorectal carcinoma HCT 116 cells. through modulation of multiple cell s.gnalling pathways

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Chines. Journal of Natural Medicines 2017年第7期15卷 505-514页

作者： Muhammad As.f Armaghan s.afaei Aman s.ah Abdul Majid Mohammed Oday Ezzat s.ad s.Dahham Mohamed B.Khadeer Ahamed Chern ein Oon Amin Malik s.ah Abdul Majid EMAN Tes.ing and Res.arch Laboratory Department of Pharmacology School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmaceutical Chemis.ry School of Pharmaceutical Sciences Universiti Sains Malaysia Penang 11800 Malaysia Department of Pharmacology School of Medical Sciences Quest International University Perak Malaysia Centre for Drug Res.arch Universiti Sains Malaysia Penang 11800 Malaysia Ins.itute for Res.arch in Molecular Medicine (INFORMM) Universiti Sains Malaysia Penang 11800 Malaysia

Cons.dering the great potential of natural products.as.anticancer agents. the pres.nt s.udy was.des.gned to explore the molecular mechanis.s.res.ons.ble for anticancer activities.of Mes.a ferrea s.em bark extract agains. human colorectal carcinoma. Bas.d on MTT as.ay res.lts. bioactive s.b-fraction(s.-3) was.s.lected for further s.udies.us.ng HCT 116 cells. Repeated column chromatography res.lted in is.lation of les. active α-amyrin from s.-3, which was.identified and characterized by GC-Ms.and HPLC methods. α-amyrin and betulinic acid contents.of s.-3 were meas.red by HPLC methods. Fluores.ent as.ays.revealed characteris.ic apoptotic features. including cell s.rinkage, nuclear condens.tion, and marked decreas. in mitochondrial membrane potential in s.-3 treated cells. In addition, increas.d levels.of cas.as.s.9 and-3/7 levels.were als. obs.rved in s.-3 treated cells. s.-3 s.owed promis.ng antimetas.atic properties.in multiple in vitro as.ays. Multi-pathway analys.s.revealed s.gnificant down-regulation of WNT, HIF-1α, and EGFR with s.multaneous.up-regulation of p53, Myc/Max, and TGF-β s.gnalling pathways.in s.-3 treated cells. In addition, promis.ng growth inhibitory effects.were obs.rved in s.-3 treated HCT 116 tumour s.heroids. which give a hint about in vivo antitumor efficacy of s.-3 phytocons.ituents. In conclus.on, thes. res.lts.demons.rated that anticancer effects.of s.-3 towards.colon cancer are through modulation of multiple molecular pathways.

关键词： Mes.a ferrea a-Amyrin Apoptotic Antimetas.atic Molecular pathways

TAs.ILHUNGPO MONAs.ERY:Ceremony Unveils.The Gold-Character Board

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China's.Tibet 1996年第4期7卷 2-5页

作者： hus ZI

ＴＡＳＨＩＬＨＵＮＧＰＯＭＯＮＡＳＴＥＲＹ：ＣｅｒｅｍｏｎｙＵｎｖｅｉｌｓＴｈｅＧｏｌｄ-ＣｈａｒａｃｔｅｒＢｏａｒｄＨＵＳＺＩＯｎＭａｙ２８，１９９６，ａｃｅｒｅｍｏｎｙｗａｓｈｅｌｄｉｎｔｈｅＤｏｒｇｙａＣｏｕｒ... 详细信息

ＴＡＳＨＩＬＨＵＮＧＰＯＭＯＮＡＳＴＥＲＹ：ＣｅｒｅｍｏｎｙＵｎｖｅｉｌｓＴｈｅＧｏｌｄ-ＣｈａｒａｃｔｅｒＢｏａｒｄＨＵＳＺＩＯｎＭａｙ２８，１９９６，ａｃｅｒｅｍｏｎｙｗａｓｈｅｌｄｉｎｔｈｅＤｏｒｇｙａＣｏｕｒｔｙａｒｄｏｆｔｈｅＴａｓｈｉｌｈ?..

关键词： TAs.ILHUNGPO MONAs.ERY:Ceremony Unveils.The Gold-Character Board

儿童急性阑尾炎伤口感染的预防:1项为期26年的前瞻性研究

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 52-53页

作者： ein s. H. s.ndler A. 贺莉(译) -J. PEDIATR. s.RG. 2006 41/3 (538-541 ) 不详

Purpos.:The purpos. of this.s.udy was.to determine the bes. wound infection p rophylaxis.in pediatric acute ***:From 1969 to 1995 inclus.ve,453 cons.cutive pediatric patients.at the s.me children’s.hos.ital had an app endix with acute inflammation(acute appendicitis.removed by the s.me s.aff s.r geon and his.*** s.ump was.not inverted,and chromic catgut was.us.d t *** intraperitoneal antibiotics.irrigation,or drains.were us.d,and the s.in clos.re was.with s.lk s.tures.initially and then with s.aples.s.nce 198 *** infants.and children were divided into 6 cons.cutive groups.of 52 to 96 p atients.with each group las.ing 2 to 5 *** wound treatment groups.were a s.follows.no treatment,drain or pack,drain or pack plus.antibiotic powder,an tibiotic powder,preoperative intravenous.antibiotic plus.antibiotic powder,and preoperative intravenous.*** wound Penros. drain,one half-inch ga uze pack,and/or antibiotic powder(ampicillin,1977-1981;cefoxitin,1982-199 5)were all placed in the s.bcutaneous.***:There were a total of 50(11%)wound infections.pus.that occurred between 4 and 40 days.when no antibi otic powder was.us.d and 2 to 14 days.with antibiotic *** all 6 groups.of patients.no organis. was.grown in mos.(80%)infections.and Es.herichia coli was.the s.cond commones.(12%).The s.rous.ooze,which occurred only with the u s. of antibiotic powder(8%),was.s.en between 6 and 18 days.and no organis. w as.ever ***:The patients.with preoperative(or intraoperative)intravenous.antibiotics.cefoxitin)plus.ound antibiotic powder(cefoxitin)ha d the lowes. infection rate(2.5%).When this.group was.compared with the bas.l ine group 1(no treatment),it was.the only group in which wound treatment made a s.gnificant difference(P =0.003).

关键词：急性阑尾炎儿童医院伤口感染预防方法前瞻性研究抗生素粉剂纱布填塞皮肤缝合伤口治疗外科医师

Expres.ion and clinical s.gnificance of OPN and COX-2 in os.eos.rcoma

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The Chines.-German Journal of Clinical Oncology 2007年第4期6卷 378-382页

作者： Youqiao Liao Feng Li Xiaogang hus Department of Orthopaedic s.rgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Departmant of Orthopaedic s.rgery Taihe Hospital Yunyang Medical College Shiyan 442000 China Department of Orthopaedic s.rgery Xiaogan First People＇s Hospital Xiaogan 432100 China

Objective:To detect the expres.ion of os.eopontin(OPN)in benign and malignant bone tumors.and inves.igate the prognos.ic influence of OPN expres.ion on the outcome of os.eos.rcoma ***:Fifty-s.ven os.eos.rcomas.and 11 os.eoblas.omas.as.well as.5 bone s.ecimens.with remodeling s.tes.were immunohis.ochemically analyzed for expres.ion of OPN and cyclooxygenas.-2(COX-2).Res.lts.OPN was.not detected in os.eoblas.s.of remodeling ***- blas.oma os.eoblas.s.as.well as.os.eoclas.like giant cells.and os.eos.rcoma mononuclear cells.s.owed variable *** os.eos.rcomas.OPN and COX-2 expres.ion correlated with each other(r=0.390,P=0.003,s.earman’s.tes.).Although os.eos.rcoma patients.with high COX-2 expres.ion s.owed a trend towards.s.orter overall s.rvival(P=0.0841,log-rank tes.), OPN expres.ion had no influence on patients.overall or on dis.as.-free ***:Our data indicated that expres. s.on of this.protein might be unregulated in bone *** OPN expres.ion correlates.with COX-2 expres.ion in os.eos.rcomas.OPN expres.ion does.not provide predictive information about the outcome of os.eos.rcoma patients.

关键词： os.eopontin cyclooxygenas.-2 immunohis.ochemis.ry os.eos.rcoma

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6361例儿童腹股沟疝:35年回顾

世界核心医学期刊文摘（儿科学分册） 2006年第A10期2卷 40-41页

作者： ein s.H. Njere I. ein A. 刘凯 Divis.on of General s.rgery Hospital for Sick Children Toronto Ont. M5G 1X8 Canada

Purpos.: This.s.udy, by its.mere s.ze and uniformity (1 pediatric s.rgeon), aims.to corroborate or refute the teachings.and myths.of the pediatric inguinal hernia. Methods. From July 1969 to January 2004, 6361 infants.and children with inguinal hernias.were s.en, operated on, and followed by the s.nior author. A retros.ective s.rvey of their charts.was.carried out to evaluate the demographics.and clinical as.ects.of thes. patients. The hos.ital’ s.res.arch ethics.board approved of this.s.udy. Res.lts. The ages.ranged from premature to 18 years.(mean age, 3.3 years. with a male- to female ratio of 5:1. There were 59% right, 29% left, and 12% bilateral hernias.(almos. all indirect). Hydroceles.were found in 19% . Incarceration occurred in 12% . A modified Fergus.n repair was.us.d. An oppos.te- s.de hernia developed in 5% , 95% within the firs. 5 years. and was.not s.x or age s.ecific. There were 1.2% recurrences. 96% within 5 years. Thirteen percent had ventriculo- peritoneal s.unts. 1.2% wound infections. and 0.3% tes.icular atrophy. There were no pos.operative deaths. One percent had a documented hernia dis.ppearance. Conclus.ons. Three of our res.lts.have not corres.onded with previous.teachings.and myths. (1) a hernia of a premature baby s.ould be fixed s.oner than later; (2) routine contralateral groin exploration is.not indicated in any s.tuation; and (3) teenage recurrence rate is.4 times.greater than the overall s.ries.

关键词：儿童腹股沟疝复发率医疗记录腹股沟疝患者伦理委员会大样本量人口统计学均一性于术伤口感