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Associations between maternal vitamin D status and porcine litter characteristics throughout gestation

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Journal of Animal Science and Biotechnology 2023年第2期14卷 806-813页

作者： Claire Stenhouse Emma hurst Richard J.Mellanby Cheryl J.Ashworth Functional Genetics and Development Division The Roslin Institute and Royal(Dick)School of Veterinary StudiesUniversity of EdinburghMidlothian EH259RGUK Current Affiliation Department of Animal ScienceTexas A&M UniversityCollege StationTexas 77843‑2471USA Clinical Sciences Division The Roslin Institute and Royal(Dick)School of Veterinary StudiesUniversity of EdinburghMidlothian EH259RGUK.

Emerging evidence suggests an important role of vitamin D in the establishment and maintenance of pregnancy,and the regulation of foetal growth across mammalian ***,the temporal changes in maternal vitamin D sta-tus throughout gestation in the pig and the relationship between maternal vitamin D status and litter characteristics of interest across gestation remain poorly understood and *** abundance of 25(OH)D in maternal plasma was quantified by HPLC–MS/MS at gestational days(GD)18,30,45,60 and 90(n=5–11 gilts/GD).Maternal plasma 25(OH)D concentrations significantly increased between GD18 and GD30(P<0.05).The relationship between maternal vitamin D metabolite concentrations and litter characteristics of interest including gilt weight,ovulation rate,mean litter weight,number of live foetuses,percentage prenatal survival,and sex ratio of the litter was *** 25(OH)D(P=0.059)concentrations tended to be positively associated with percentage prenatal survival on *** GD90,maternal 25(OH)D(P<0.05)concentrations were inversely associated with gilt *** plasma 25(OH)D concentrations were inversely associated with the percentage of male foetuses in the litter on GD90(P<0.05).This study has provided novel insights into temporal changes in maternal vitamin D status throughout ges-tation and the relationship between maternal vitamin D status and the economically important litter characteristics of gilt weight,percentage prenatal survival and percentage of male foetuses in the *** the understanding of the role of vitamin D across important developmental timepoints in relation to foetal growth is essential to improve reproductive success in livestock species.

关键词： Porcine Pregnancy Vitamin D

Improving Interventions on Cardiovascular Disease and Diet: A Policy Incentive Analysis

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Health 2023年第6期15卷 569-621页

作者： Sandra hurst Keigwin School of Nursing Jacksonville University Jacksonville USA

Various Cardiovascular Diseases (CVDs) can be catastrophic and can lead to irreversible outcomes. Despite improved interventions for CVD prevention awareness, there continues to be discussion and research on diet-related CVD and mortality without addressing the problem. Instead of prioritizing public guidelines and policies, policymakers should understand CVD and address population barriers to adhering to a healthy diet that decreases CVD risk. Therefore, this project aims to analyze federal healthy food incentive policies to promote healthy diet behaviors that reduce CVD risk. The method used was existing data for a comparative policy analysis that included a policy proposal process: phases of progression, measures, and a policy model with data collection and requirements. This analysis compared a current federal food incentive program versus the proposed program. Results of the final analysis derived from the literature review and collected data stated consuming foods from the Mediterranean and other low-fat and low-salt diets reduced CVD risks that also reduced other risks secondary to CVD, such as obesity, diabetes, and Cerebrovascular Accident (CVA). Comparatively, combined healthy food incentives and disincentives were more effective for improving healthy behaviors than, in some cases, even after incentives were removed. Therefore, this policy analysis supports the indication for incentive policy change. However, the lack of federal stakeholders’ response to key policy changes upon proposal submission may require other methods of proposal dissemination. Nonetheless, focusing analysis on various Food Insecurity Nutrition Incentive (FINI) programs instead of one, multi-state program, which may have improved analysis outcomes, was the lesson learned.

关键词： CVD Risk Prevention Diets Dietary Guidelines American Stroke/Heart Association (ASA/AHA) CVA Federal Healthy Food Incentives

Coupled hydro-mechanical evolution of fracture permeability in sand injectite intrusions

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Journal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 742-751页

作者： Quan Gan Derek Elsworth Yixin Zhao Antonio Grippa Andrew hurst School of Geosciences University of AberdeenAberdeenUK State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyBeijingChina Department of Energy and Mineral Engineering EMS Energy Institute and G3 CenterPennsylvania State UniversityUniversity ParkPAUSA

Sandstone“injectite”intrusions are generally developed by the fluidization of weakly cemented sandstones and their subsequent injection into fractured *** this work,a continuum coupled hydromechanical model TOUGH-FLAC3D is applied to simulate the discrete fracture network in large-scale sand injectite complexes.A sand production constitutive model is incorporated to consider the formation of sand through plastic deformation and its influence on evolution of fracture *** in the fluidized sand slurry drives the injection with sand dikes intruded upwards,typically into previously low permeability“tight”mudstone *** contrast in poroelastic properties of the underlying weak sandstone and overlying injectite receptor directly affects the evolution of fracture aperture both during and after *** drainage into the unconsolidated matrix may reduce the extent of fracture aperture growth,through the formation of shear *** results of this work have broad implications related to the emplacement of sandstone intrusions and subsequent hydrocarbon accumulation,maturation and then production.

关键词： Sandstone intrusions Fracture permeability Sand fluidization Hydro-mechanical coupling

Additive manufacturing(3D printing)of electrically conductive polymers and polymer nanocomposites and their applications

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eScience 2022年第4期2卷 365-381页

作者： Kirstie R.Ryan Michael P.Down Nicholas J.hurst Edmund M.Keefe Craig E.Banks Faculty of Science and Engineering Manchester Metropolitan UniversityChester StreetManchesterM15GDUK

Additive manufacturing,or three-dimensional(3D)printing,offers a unique solution for fabricating complex geometries with high ***,many commercial additive manufacturing machines focus on the printing of polymers with limited ***,conductive polymers(CPs)can be processed to enable the additive manufacturing of conductive,low-density,and low-cost parts for a myriad of *** review summarizes the relevant achievements in the additive manufacturing of conductive polymers(CPs)and conductive polymer nanocomposites,with a discussion of the advantages and limitations of processing and printing these materials compared with alternative traditional manufacturing methods and their ***,the prospective applications of these additive manufacturing printed conductive materials are explored.

关键词： Conducting polymers Additive manufacturing Electrochemcial applications Supercapacitors Batteries

Recent Advances on Citrus yellow vein clearing virus in Citrus

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Horticultural Plant Journal 2020年第4期6卷 216-222页

作者： Cuihua Liu Hai Liu John hurst Michael P Timko Changyong Zhou Citrus Research Institute Southwest UniversityChongqing 400715China Department of Biology University of VirginiaCharlottesvilleVA 22904USA

Citrus yellow vein clearing virus(CYVCV)is the causal agent of yellow vein clearing disease,a significant and devastating disease of most citrus species including lemon and sour ***,a single-strand positive-sense RNA virus containing six ORFs(Open Reading Frames),represents a new species in the genus Mandarivirus of the Alphaflexiviridae *** virus can cause particularly serious damage,resulting in reduced tree vigor,lower yields,and decreased marketability of fruit production,and it has been found in India,Turkey,Pakistan,China and *** we described the geographical distribution of the virus,its transmission mode by grafting,mechanical inoculation,and insects,as well as currently available techniques for *** addition,we also discussed practical measures aimed at controlling the disease and provided theoretical guidance to prevent the acquisition and spread of the disease that is a significant step toward ensuring the health of the citrus industry.

关键词： Citrus yellow vein clearing virus geographical distribution viral detection practical management

Comparative Analysis of the Determinants of China's State-owned Outward Direct Investment in OECD and Non-OECD Countries

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China & World Economy 2011年第4期19卷 74-91页

作者： Luke hurst Crawford School of Economics and Government The Australian National University

Chinese outward direct investment （ODI） is expanding at an unprecedented rate. The present study augments the understanding of the determinants and drivers of Chinese ODI. It reviews the literature on Chinese 0191 and analyzes investment by state-owned enterprises （SOE） for the period 2003-2008, focusing specifically on the differences between the determinants of Chinese investment in developed （OECD） and developing （non-OECD） economies. In addition, the study assesses the appropriateness of the general framework used for investigating ODI determinants （Dunning＇s eclectic paradigm） to analyze the experience of Chinese SOE. The findings indicate that Dunning＇s eclectic paradigm provides an excellent theoretical framework for analyzing the determinants of Chinese SOE investment in developed countries, and provides a good starting point for analysis of Chinese investment in developing countries. However, Dunning＇s specification requires refinement for developing countries. This paper finds a distinct difference between the motivations for Chinese SOE investment in developed and developing countries.

关键词： China investment determinants outward direct investment state-owned enterprise

Re-expression of DIRAS3 and P53 induces apoptosis and impaired autophagy in head and neck squamous cell carcinoma

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Military Medical Research 2021年第2期8卷 148-161页

作者： Zhe Liu Douglas R.hurst Xing Qu Li-Guang Lu Chen-Zhou Wu Yu-Yu Li Yi Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Head and Neck Oncology West China Hospital of StomatologySichuan UniversityChengdu 610041China Department of Pathology University of Alabama at BirminghamBirminghamAL 35216USA Department of Evidence Based Stomatology West China Hospital of StomatologySichuan UniversityChengdu 610041China.

Background:p53 and DIRAS3 are tumor suppressors that are frequently silenced in *** this study,we sought to determine whether the concurrent re-expression of p53 and DIRAS3 could effectively induce head and neck squamous cell carcinoma(HNSCC)cell ***:CAL-27 and SCC-25 cells were treated with Ad-DIRAS3 and rAd-p53 to induce re-expression of DIRAS3 and p53 *** effects of DIRAS3 and p53 re-expression on the growth and apoptosis of HNSCC cells were examined by TUNEL assay,flow cytometric analysis and *** effects of DIRAS3 and p53 re-expression on Akt phosphorylation,oncogene expression,and the interaction of 4 E-BP1 with eIF4 E were determined by real-time PCR,Western blotting and immunoprecipitation *** ability of DIRAS3 and p53 re-expression to induce autophagy was evaluated by transmission electron microscopy,LC3 fluorescence microscopy and Western *** effects of DIRAS3 and p53 re-expression on HNSCC growth were evaluated by using an orthotopic xenograft mouse ***:TUNEL assay and flow cytometric analysis showed that the concurrent re-expression of DIRAS3 and p53 significantly induced apoptosis(P<0.001).MTT and flow cytometric analysis revealed that DIRAS3 and p53 reexpression significantly inhibited proliferation and induced cell cycle arrest(P<0.001).Mechanistically,the concurrent re-expression of DIRAS3 and p53 down-regulated signal transducer and activation of transcription 3(STAT3)and upregulated p21WAF1/CIP1 and Bax(P<0.001).DIRAS3 and p53 re-expression also inhibited Akt phosphorylation,increased the interaction of eIF4 E with 4 E-BP1,and reduced the expression of c-Myc,cyclin D1,vascular endothelial growth factor(VEGF),fibroblast growth factor(FGF),epidermal growth factor receptor(EGFR)and Bcl-2(P<0.001).Moreover,the concurrent re-expression of DIRAS3 and p53 increased the percentage of cells with GFP-LC3 puncta compared with that in cells treated with control adenovirus(50.00%±4.55%vs.4.67%±1.25%,P<

关键词： DIRAS3 p53 Apoptosis Autophagy Head and neck squamous cell carcinoma

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BP甩卖俄罗斯石油资产

商业周刊（中文版） 2022年第4期 50-51页

作者： Laura hurst 邵璐宁(译) 不详

今年2月8日,在发布了英国石油公司(BP Plc)十年来最高的季度利润后,首席执行官伯纳德·鲁尼(Bernard Looney)为公司与俄罗斯最大石油生产商之间的深厚关系进行了极力辩解。当时,俄罗斯坦克尚未开进乌克兰,但俄乌边境已陈兵13万人,紧张... 详细信息

今年2月8日,在发布了英国石油公司(BP Plc)十年来最高的季度利润后,首席执行官伯纳德·鲁尼(Bernard Looney)为公司与俄罗斯最大石油生产商之间的深厚关系进行了极力辩解。当时,俄罗斯坦克尚未开进乌克兰,但俄乌边境已陈兵13万人,紧张局势正在迅速升级,而英国石油在有官方背景的俄罗斯石油公司(Rosneft PJSC)持股20%,意味着这家总部位于伦敦的石油巨头与之利害攸关。

关键词：英国石油公司首席执行官利害攸关伯纳德 BP 俄罗斯甩卖乌克兰

A study of chlorophyll-like and phycobilin pigments in the C endosymbiont of the apple- snail Pomacea canaliculata

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BIOCELL 2012年第2期36卷 47-55页

作者： ISRAEL A.VEGA FEDERICO A.DELLAGNOLA JORGE A.hurst MARTÍN S.GODOY ALFREDO CASTRO-VAZQUEZ Laboratorio de Fisiologia(IHEM-CONICET) and Departamento de Morfología y Fisiología(Facultad de Ciencias MédicasUniversidad Nacional de Cuyo)Casilla de Correo 335500 MendozaArgentina Instituto de Ciencias Básicas-Universidad Nacional de Cuyo.Padre Jorge Contreras 1300.Parque Gral.San Martín 5500 Mendoza Departamento de Química Biológica.Facultad de Farmacia y Bioquímica Universidad de Buenos Aires.Present address:Instituto de Botánica Darwinion.Labardén 200B1642HYD Buenos Aires

Pigments present in the brown-greenish C morph of an intracellular endosymbiont of Pomacea canaliculata were *** extracts of the endosymbiotic corpuscles showed an absorption spectrum similar to that of *** fractions obtained from silica gel column chromatography of the acetone extracts(CI,CII and CIII),were studied by positive ion fast atom bombardment-mass spectrometry(FAB–MS)and hydrogen-nuclear magnetic resonance(H-NMR).Results indicated the presence of(1)a sterol in the yellow colored CI fraction;(2)a mixture of pheophorbides a and b in the major green fraction,CII;and(3)a modified pheophorbide a in the smaller green fraction,*** extracts of the C endosymbiont did not show evidence of the occurrence of C-phycocyanin,allophycocyanin or phycoerithrin(light absorption,fluorescence emission,and electrophoresis of the protein moieties)while cyanobacterial cells(Nostoc sp.)showed evidence of C-phycocyanin and *** possible phylogenetic and functional significance of the pigments present in the C endosymbiont is discussed.

关键词： symbiosis Cyanobacteria chloroplast photosynthetic pigments phylogeny