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超声内镜微探头进行术前结肠直肠癌分期:能否改进手术治疗方法?

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世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 24-25页

作者： hurlstone d.p. Brown S. Cross S.S. 尹勇 Gastroenterology and Liver Unit The Royal HallamshireHospitalGlossop Road Sheffield South Yorkshire S10 2JFUnited KingdomDr.

Background and study aims: Miniprobe ultrasound technology allows in-vivo luminal staging of colorectal cancer with a probe that passes directly through the colonoscope’s instrument port. Conventional rigid radial echoscopes are limited by the need for a second examination, an inability to image stenotic lesions, and the inaccessibility of proximal tumours. Since minimally invasive resection techniques are now possible, a sensitive preoperative staging tool is needed to optimize patient selection. The aim of this study was to examine the accuracy of miniprobe ultrasound imaging in the preoperative staging of colorectal cancer and to examine the value of the technique for management decisions. patients and methods: In a prospective study, a total of 131 consecutive patients with adenocarcinoma or broad-based.p.lyps of the colorectum underwent 12.5-MHz miniprobe ultrasonography examinations conducted by a single endoscopist. Staging criteria for d.p.h of tumour infiltration and nodal status were determined. Nodal disease was defined as the presence of a hypoechoic, round, defined boundary lesion larger than 10 mm in diameter. T0-T1N0 lesions were resected using endoscopic mucosal resection, and.p.tients with lesions staged as T2N1 were referred for surgical resection. Tumour staging using endoscopic ultrasonography was then compared with the histopathological specimens. Results: The accuracy of T staging using endoscopic ultrasonography was 96% in comparison with the histopathological specimen. Five lesions (4% ) were incorrectly overstaged as T3 - pathology stage T2. Understaging occurred in three lesions (endosco-pic ultrasound stage T3 - pathology stage T4). The overall accuracy of nodal staging using endoscopic ultrasonography was 87% (sensitivity 0.95, specificity 0.71, positive predictive value 0.87, negative predictive value 0.88). Conclusions: Miniprobe ultrasonography has a high overall accuracy for both T staging and N staging of colorectal cancer andmay hav

关键词：结肠直肠癌超声内镜超声成像术前分期广基息肉病理学分期结肠直肠腺癌淋巴结病变操作孔切除技术

20兆赫高频超声内镜下黏膜切除治疗结肠直肠黏膜下层病变:一项前瞻性分析

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 39-40页

作者： hurlstone d.p. Cross S.S. Sandersd.S. 纪泛扑 17 Alexandra Gardens Nether Edge Sheffield S11 9DQ United Kingdom Dr.

Goals: To prospectively assess the safety and efficacy of high- frequency ultrasound assisted mini- probe endoscopic mucosal resection for the treatment of colorectal submucosal tumors. primary endpoints were tumor free vertical/horizontal resection margins and.p.sitive histopathologic diagnosis. Outcome data over a 24- month period were assessed. Background: A 20- MHz high- frequency mini- probe ultrasound is an accurate modality for the diagnosis of stage T1m and T1 colorectal lesions. Few studies have addressed the safety and efficacy of this technology as applicable to submucosal lesions of the colorectum. Methods: Thirty patients underwent high- frequency mini- probe ultrasound- guided endoscopic mucosal resection of 30 lesions (diameter) using the inject and cut technique. Repeat endoscopy and ultrasound was performed at 3, 6, and 12 months post- “ index" resection. Results: A total of 27 lesions (90% ) underwent complete resection with negative histologic margin status (median diameter, 8 mm; range, 3- 20 mm). No statistical difference (p >0.1 ) was observed between submucosal lesion position and histologic resection margin negativity. Three rectal lesions (10% ) within the submucosal layer 3 failed to separate from the muscularis and underwent transanal excision of tumor. Bleeding occurred in 1 patient (3% ). No recurrence was evident at the resection site in 27 cases (median follow- up, 9 months; range, 4- 18 months). Conclusions: High- frequency mini- probe ultrasound- guided endoscopic mucosal resection is a safe and effective therapeutic modality for submucosal lesions of the colorectum. The technique offers a single- stage diagnostic and therapeutic technique for selected submucosal lesions and may offer an alternative to surgical resection.

关键词：黏膜下层高频超声结肠直肠超声复查病灶位置组织学检查外科切除切缘阴性结果病理学诊断

老年人结肠镜检安全且诊断价值高:一项2000例患者的前瞻性对比研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 24-25页

作者： Karajeh M.A. Sanders d.S. hurlstone d.p. 孟欣颖 The Gastroenterology and Liver Unit Royal Hallamshire HospitalSheffield S10 2JF South YorkshireUnited Kingdom

Background and Study Aims:Optical colonoscopy is considered the gold standard for colorectal examination and has the advantage of allowing biopsies and ***,the data on its safety and effectiveness in the elderly population are limited and somewhat *** prospectively assessed whether there are differences in completion rates,diagnostic yield,complication rates and 30-day mortality between patients aged ≥65 years and.p.tients aged dergoing colonoscopy at our *** and Methods:data were collected.p.ospectively on 2000 colonoscopies performed over a 2-year period(January 2002 to January 2004).We compared 1000 consecutive colonoscopies in patients aged≥65 with 1000 consecutive colonoscopies in patients aged p).data were collected on sedation;on completion rates,both crude and adjusted to discount failures due to obstructive disease;on diagnostic yield;complications,and on 30-day ***:The median age was 75 years(51%women)for the elderly group and 54 years(59%women)for *** proportion of patients who received sedation was similar for both groups(59%vs.62%,p=0.97)but the mean dose of midazolam was lower in the elderly group(3.8 mg vs.4.5 mg,p de completion rate was lower for the elderly group(81.8%vs.86.5%,p=0.004),but the adjusted rate was similar for both groups(88.1%elderly vs.87.6%control,p=0.18).The overall diagnostic yield was higher in the elderly group(65%vs.45%,p detected(7.1%vs.1.3%,pplication rate was low(0.2%per group).Conclusions:Colonoscopy in the elderly is safe and effective with a high diagnostic *** may now be the imaging modality of choice in the elderly population.

关键词：结肠镜检查诊断价值其安全性老年人群并发症发生率检查结果前瞻性评价梗阻性病变

胃肠病患者自行使用口服补充和替代治疗的概率

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 49-50页

作者： Kong S.C. hurlstone d.p. pocock C.Y. d.S. Sanders 陈瑜 Royal Hallamshire Hospital Glossop Road Sheffield S102JF United Kingdom Dr.

Goals: To assess the incidence of oral complementary and alternative medicine (CAM) usage by gastroenterology patients at a single university center and comp are against controls. Background: The public awareness and usage of CAM have inc reased. The use of CAM has been described in patients with functional bowel diso rders; however, their role in patients with gastrointestinal disease is less cle ar. Study: patients attending luminal gastroenterology clinics and customers at local supermarkets completed a 30- point, structured questionnaire assessing th eir use of CAM. Results: A total of 1,409 subjects were recruited. The incidence of CAM use was 49.5% for inflammatory bowel disease, 50.9% for irritable bo wel syndrome, 20% for general gastrointestinal diseases, and 27% for control s. pearson’ s χ 2 tests showed that patients with inflammatory bowel disease ( IBd) or irritable bowel syndrome were more likely to use CAM than controls (p d that females were more likely to take CAM than men (p percentage of CAM users among patients with IBd is similar to those with a functional diagnosis. Increasing n umbers of IBd.p.tients are using CAM in addition to conventional therapy. Awaren ess of this may prevent adverse CAM and conventional drug interactions.

关键词：胃肠病肠易激综合征肠道功能紊乱问卷调查炎症性肠病评估单不良相互作用 pearson 性比

Numerical analysis of high‑speed railway slab tracks using calibrated and validated 3d time‑domain modelling

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Railway Engineering Science 2024年第1期32卷 36-58页

作者： A.F.Esen O.Laghrouche p.K.Woodward d.Medina‑pineda Q.Corbisez J.Y.Shih d.p.Connolly Institute for High‑Speed Rail and System Integration University of LeedsLeeds LS29JTUK Institute for Infrastructure and Environment Heriot-Watt UniversityEdinburgh EH144ASUK Alstom Transport Saint‑OuenFrance Birmingham Centre for Railway Research and Education University of BirminghamBirmingham B152TTUK

Concrete slabs are widely used in modern railways to increase the inherent resilient quality of the tracks,provide safe and smooth rides,and reduce the maintenance *** this paper,the elastic performance of a novel slab trackform for high-speed railways is investigated using three-dimensional finite element modelling in *** is then compared to the performance of a ballasted ***,slab and ballasted track models are developed to replicate the full-scale testing of track *** the models are calibrated with the experimental results,the novel slab model is developed and compared against the calibrated slab track *** slab and ballasted track models are then extended to create linear dynamic models,considering the track geodynamics,and simulating train passages at various speeds,for which the Ledsgard documented case was used to validate the *** travelling at low and high speeds are analysed to investigate the track deflections and the wave propagation in the soil,considering the issues associated with critical *** train loading methods are discussed,and the most practical approach is retained and ***,correlations are made between the geotechnical parameters of modern high-speed rail and conventional *** is found that considering the same ground condition,the slab track deflections are considerably smaller than those of the ballasted track at high speeds,while they show similar behaviour at low speeds.

关键词： High-speed railways Slab track New ballastless track Ballasted track Critical speeds Finite element modelling Calibration of numerical models

Solid-liquid extraction for yttrium recovery using porous polymeric resin(XAd-7) functionalized with d_(2)EHpA

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Journal of Rare Earths 2024年第9期42卷 1764-1773,I0005页

作者： p.A.Martínez-Montoya R.G.Sanchez-Alvarado d.Y.Medina-Velazquez M.L.Carrera-Jota p.Garnica-Chávez A.de J.Morales-Ramirez Higher School of Chemical Engineering and Extractive Industries ESIQIEIPNDepartment of Metallurgical EngineeringUPALM S/NCol.LindavistaGustavo A.Madero Cd.de MéxicoC.P07738Mexico Metropolitan Autonomous University Department of MaterialsBasic Sciences and EngineeringAv.San Pablo No.180Col.Reynosa TamaulipasCd.de MéxicoC.P02200Mexico Center for Research and Technological Innovation CIITECIPNCda.de CECATIs/nSanta CatarinaAzcapotzalcoC.P02250CDMXMexico

The recovery of yttrium is proposed by applying a solid-liquid extraction process using di-2-ethyl hexylphosphoric acid(d2EHpA) as extracting *** extracting agents were supported on a macro porous polymeric resin XAd-7(solid.p.ase).Yttrium ions extraction and discharge tests were performed,firstly from a synthetic aqueous solution of 100 mg/L Y(liquid.p.ase) at 25℃ with *** effects of pH of aqueous solutions bearing yttrium,volume fraction of extracting agents and the solid/liquid(S/L)ratio on the yttrium recovery were *** most favorable conditions for yttrium ions extraction are;20 vol% d_(2)EHpA functionalized resin,pH=1.5 and an S/L ratio of 10 mg/mL The discharge of yttrium ions was done under the same conditions of extraction stage,using a 2 mol/L [H_(2)SO_(4)] as stripping *** to 80% yttrium is extracted,while 75% yttrium is recovered in the striping *** all experiments,the reaction equilibrium is reached after 20 min,and the kinetics for the extraction stage was determined as a second-order ***,experiments were carried out to discharge the yttriumloaded resins,and it has been determined that the best pH value to strip the Y ions is *** tests of extraction and discharge for yttrium ions show that the functionalized resin can work at least five cycles without decreasing its ***,the proposed.p.ocess was tested in a real solution with Y ions fro m a waste fluorescent la mp powder leached in H_(2)SO_(4),demonstrating the ability to effectively recover yttrium,separating it from various metals from the studied residue.

关键词： Yttrium recovery Rare earth solid-liquid extraction XAd-7 resin Fluorescent lamps recycling Solid-liquid kinetics extraction

Enantioselective iridium-catalyzed allylic substitution with a Reformatsky reagent: direct construction of β-stereogenic homoallylic esters

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Science China Chemistry 2024年第11期67卷 3791-3797页

作者： debasis pal Kirana d.Veeranna Yuk Fai Wong p.Andrew Evans d.p.rtment of Chemistry Queen's University Xiangya School of pharmaceutical Sciences Central South University

The Reformatsky reagent derived from ethyl bromoacetate circumvents the challenge associated with the direct regio-and enantioselective iridium-catalyzed allylic alkylation with an unstabilized aliphatic ester enolate. Notably, this work represents the first example of using a Reformatsky reagent in a metal-allyl reaction, which permits the direct construction of enantioenriched β-stereogenic homoallylic esters without preactivation of the pronucleophile or post-reaction modification of the product(e.g., thermal decarboxylation of a 1,3-dicarbonyl). Moreover, the process allows the coupling of a broad range of sterically and electronically diverse electrophiles bearing aryl, heteroaryl and alkenyl derivatives, including the significantly more challenging alkyl-substituted allylic carbonates. The versatility of the ester product is exemplified by a series of functional group manipulations and the development of a concise and efficient enantioselective total synthesis of the natural product,(+)-descurainolide A. Finally, mechanistic studies indicate that the zinc enolate behaves as a soft nucleophile that undergoes outer-sphere alkylation.

关键词： allylic substitution asymmetric catalysis mechanistic studies natural product synthesis Reformatsky reagent

precipitation transformation pathway and mechanical behavior of nanoprecipitation strengthened Fe-Mn-Al-C-Ni austenitic low-density steel

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Journal of Materials Science & Technology 2024年第7期174卷 157-167页

作者： Y.F.An X.p.Chen L.Mei p.Ren d.Wei W.Q.Cao College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Guangxi Engineering Research Center for Characteristic Metallic powder Materials School of Electronic EngineeringGuangxi University of Science and TechnologyLiuzhou 545006China Central Iron&Steel Research Institute Beijing 100081China

precipitation strengthening has been widely ad.p.ed in austenitic low-density steel owing to excellent hardened *** approach generally employs the coherentκ′carbides and non-coherent B2 *** the precipitation transformation pathway is decisive for further optimizing the microstructures under specific engineering ***,the detailed.p.ecipitation sequence of Fe-28Mn-11Al-1C-5Ni(wt%)austenitic low-density steel as well as its influence on mechanical prop-erties during aging process is systematically *** results reveal that nano-sizedκ′carbides domains(2 nm)exist in the solution-treated *** aging at 500℃for 1 h,the cuboidalκ′carbides(15-20 nm)uniformly disperse in austenite ***,after aging at 700℃for 15 min,the coarsenκ′carbides(30-35 nm)inhomogeneously distribute and align preferentially along the〈100〉***,extending the aging time to 60 min,the needle-type B2 particles replace theκ′carbides due to the enrichment of Ni elements at the phase boundaries among the austenite andκ′*** aging at 900℃,κ′carbides entirely dissolve into the austenite matrix,and the intragranular B2 particles are the sole precipitates in the austenite matrix and follow the K-S orientation relationship with *** work hardening capability seriously deteriorates due to the shearing ofκ′carbides by gliding *** the intragranular B2 particles preserve excellent work hardening rate by dislocations bow-out *** present work is meaningful for guiding the design of new generation dual-nano precipitation austenitic lightweight steel.

关键词： Lightweight steel κ′-carbides B2 particles Work hardening capability

paper Analytical device for the Colourimetric detection of Alkaline phosphatase in Serum and Saliva

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Journal of Analysis and Testing 2024年第3期8卷 385-394页

作者： d.Alageswari A.Lakshmidevi p.E.Resmi p.V.Suneesh Aarathipradeep T.G.SatheeshBabu d.p.rtment of Chemistry Amrita School of Physical Sciences Coimbatore Amrita Vishwa Vidyapeetham Amrita Biosensor Research Lab Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham Amrita Biomedical Engineering Centre Amrita School of Engineering Coimbatore Amrita Vishwa Vidyapeetham

A paper analytical device (pAd) was developed for the colourimetric estimation of alkaline phosphatase (ALp). ALp catalyzes the hydrolysis of disodium phenyl phosphate (d.p.) to phenol, which then undergoes oxidative coupling with4-aminoantipyrine (4-AAp) producing a reddish brown-coloured quinone imine. The colourimetric reaction tested in solution has been translated onto a pAd for the point of care (poC) testing of ALp. A uniform colour was obtained in 25 min with the introduction of ALp onto the reagent drop cast paper device. The images obtained by scanning the pAd were processed using ImageJ software. The colour intensity obtained by image processing was proportional to the concentration of ALp present in the sample. ALp in serum and saliva samples were tested using the pAd in the range of 0 to 528 U/L and0 to 187 U/L, respectively. The interference studies revealed that the pAd was selective to ALp in the presence of other biomolecules. The pAd exhibited a limit of detection (LOd) of 3.3 U/L and a sensitivity of 48.36 a.u/Log(U/L) for serum ALp and LOd of 1.69 U/L and a sensitivity of 28.5 a.u/Log (U/L) for salivary ALp. The pAd showed good agreement with the clinical methods for real samples.

关键词： Alkaline phosphatase Colourimetry ImageJ paper analytical device point of care testing