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The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model

Traditional Medicine Research 2024年第2期9卷 8-17页

作者： Ao Qier Naren Mandula Qiburi Qiburi Manda Manda Tegexi Baiyin Xilinqiqige Bao huricha baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang Pharmaceutical Laboratory Inner Mongolia International Mongolian HospitalHohhot 010065China College of Mongolian Medicine Inner Mongolia Medical UniversityHohhot 010110China Medical Innovation Center for Nationalities Inner Mongolia Medical UniversityHohhot 010110China Institute of Mongolian Medicinal Chemistry School of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot 010021China School of Life Sciences Inner Mongolia UniversityHohhot 010021China

Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass ***,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine ***:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 *** the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine ***-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior *** sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal ***:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass *** discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology ***“compound-target-disease”network contained 163 intersection targets with the migraine *** Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,*** Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,*** predictions were further demonstrated via in vivo animal model *** RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreat

关键词： Horcha-6 bio-active components rat migraine model inflammation hormone metabolism neurotransmitter

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Study of the anti-inflammatory effect of the Traditional Mongolian Medicine Hohgardi-9 in acute lung injury

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Traditional Medicine Research 2023年第11期8卷 23-33页

作者： Aodeng Qimuge Tegexi Baiyin Bilige Bilige Temuqile Temuqile Sha-Na Chen Ying-Chun Bai Wuhan Qimuge Siqin Siqin Hugejile Hang Chang-Shan Wang huricha baigued De-Zhi Yang Pharmaceutical Laboratory Inner Mongolia International Mongolian HospitalHohhot 010065China Experimental Center Inner Mongolia Traditional Chinese&Mongolian Medical Research InstituteHohhot 010010China School of Life Sciences Inner Mongolia UniversityHohhot 010021China Inner Mongolia Key Laboraotry of Mongolian Medicinal Chemistry Inner Mongolia UniversityHohhot 010021China.

Background:Hohgardi-9 is a well-known traditional Mongolian drug that relieves cough and removes *** it is widely used to treat lung diseases clinically,Hohgardi-9’s bioactive constituents and mechanism of action are *** this study,we explored the bioactive compounds in Hohgardi-9 and the mechanism underlying its therapeutic effect against acute lung injury(ALI).Methods:We obtained the main components of Hohgardi-9 and analyzed the targets related to ALI by searching the traditional Chinese medicine systems pharmacology database and existing ***,we constructed the compound-target network using Cytoscape 3.8.0 software to obtain the bioactive compounds in Hohgardi-9 against *** used a string database to investigate the interaction between the possible protein targets of *** also performed Gene Ontology function annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to predict its anti-ALI ***,to verify the therapeutical effects of Hohgardi-9,we used an ALI rat model and analyzed the components of Hohgardi-9 found in the rat plasma using ultra-high-performance liquid chromatography coupled with Q-Exactive mass ***:The network pharmacology and plasma component analysis showed that Hohgardi-9 contained 31 potentially bioactive components,including quercetin,herbacetin,izoteolin,and columbinetin acetate,which affected the NF-κB,TLR,and TNF signaling pathways via key targets,such as RELA(p65)and *** in vivo experiments using hematoxylin and eosin staining revealed that Hohgardi-9 significantly improved lung tissue injury and pulmonary edema in ALI ***,Hohgardi-9 significantly reduced the expression levels of genes encoding inflammatory factors,such as TRL4,TNF-α,IL-1β,and ICAM1,in the lungs of ALI ***:Hohgardi-9 alleviated ALI by inhibiting inflammation-related gene expression through its active ingredients,such as quercetin and herbaceti

关键词： Hhohgardi-9 acute lung injury active components anti-inflammation

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