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Liquid Metal Grid Patterned Thin Film Devices Toward Absorption‑Dominant and Strain‑Tunable Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 541-553页

作者： Yuwen Wei Priyanuj Bhuyan Suk Jin Kwon Sihyun Kim Yejin Bae Mukesh Singh Duy Thanh Tran Minjeong ha Kwang‑Un Jeong Xing Ma Byeongjin Park Sungjune Park Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Composites Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and TechnologyGwangju 61005Republic of Korea School of Materials Science and Engineering and Sauvage Laboratory for Smart MaterialsHarbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055People’s Republic of China

The demand of high-performance thin-film-shaped deformable electromagnetic interference(EMI)shielding devices is increasing for the next generation of wearable and miniaturized soft *** highly reflective conductive materials can effectively shield EMI,they prevent deformation of the devices owing to rigidity and generate secondary electromagnetic pollution ***,soft and stretchable EMI shielding thin film devices with absorption-dominant EMI shielding behavior is *** devices consist of liquid metal(LM)layer and LM grid-patterned layer separated by a thin elastomeric film,fabricated by leveraging superior adhesion of aerosol-deposited LM on *** devices demonstrate high electromagnetic shielding effectiveness(SE)(SE_(T) of up to 75 dB)with low reflectance(SER of 1.5 dB at the resonant frequency)owing to EMI absorption induced by multiple internal reflection generated in the LM grid ***,the excellent stretchability of the LM-based devices facilitates tunable EMI shielding abilities through grid space adjustment upon strain(resonant frequency shift from 81.3 to 71.3 GHz@33%strain)and is also capable of retaining shielding effectiveness even after multiple strain *** newly explored device presents an advanced paradigm for powerful EMI shielding performance for next-generation smart electronics.

关键词： Absorption-dominant electromagnetic interference shielding Liquid metals Soft and stretchable electronics Thin film devices Tunable electromagnetic interference shielding

M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： ha Eun Shin Jun-Hyeok han Seungyong Shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

Efficacy of fexuprazan compared with rebamipide in Korean patients with gastritis:A matching-adjusted indirect comparison

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World Journal of Clinical Cases 2024年第19期12卷 3890-3897页

作者： Gwang ha Kim hang Lak Lee Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea

BACKGROUND Gastritis is one of the most frequently diagnosed diseases requiring medical treatment in South ***,a novel potassium-competitive acid blocker,has been approved for treating gastritis and erosive ***,rebamipide is the most commonly used mucoprotective agent for acute and chronic gastritis in real-world settings in South ***,there have been no studies comparing the efficacy of these two drugs *** To compare the efficacy of fexuprazan with that of rebamipide for acute and chronic *** This was a matching-adjusted indirect *** patient data from a phase III study of fexuprazan(10 mg BID)were compared with cumulative data from two matching studies of rebamipide(100 mg TID).Erosion improvement and healing rates were compared between two weeks of fexurapan,two weeks of rebamipide,and four weeks of *** two main outcome variables were presented as percentages,and the risk differences(RD)and 95%confidence intervals(CI)were calculated for the relative treatment *** In the primary analysis,the erosion improvement and healing rates after a twoweek treatment with fexuprazan were 64.5%and 53.2%,respectively,while a twoweek treatment with rebamipide resulted in erosion improvement and healing rates of 43.6%(RD:21.0%;95%CI:9.6-32.3;P<0.01)and 35.6%(RD:17.6%;95%CI:6.1-29.2;P=0.003),*** the additional analysis,the erosion improvement and healing rates for the two-week fexuprazan treatment(64.2%and 51.2%,respectively)were similar to those obtained during a four-week treatment with rebamipide(60.6%;RD:3.6%;95%CI:-9.8,17.0;P=0.600 and 53.5%;RD:-2.3%;95%CI:-16.1,11.5;P=0.744,respectively).CONCLUSION The two-week fexuprazan treatment was superior to the two-week rebamipide treatment and similar to the fourweek rebamipide treatment for patients with gastritis.

关键词： Gastritis Erosive gastritis Fexuprazan Rebamipide Matching-adjusted indirect comparison Indirect treatment comparison

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乾隆朝清厘僧道停颁牒照档案(下)

历史档案 2024年第3期 4-18页

作者：哈恩忠中国第一历史档案馆

广西巡抚臣杨锡绂谨奏,为奏明事。乾隆八年四月十二日准兵部加封递到大学士鄂等字寄内开,乾隆八年三月初七日奉上谕:二氏之教由来已久,其遵守戒律闭户焚修者固于民无害,即寻常僧道,或因无力营生,藉此以免饥寒,亦难尽行沙汰。但游手之徒... 详细信息

广西巡抚臣杨锡绂谨奏,为奏明事。乾隆八年四月十二日准兵部加封递到大学士鄂等字寄内开,乾隆八年三月初七日奉上谕:二氏之教由来已久,其遵守戒律闭户焚修者固于民无害,即寻常僧道,或因无力营生,藉此以免饥寒,亦难尽行沙汰。但游手之徒借名出家,耗民财而妨民俗,自不可听其引而日盛不为清厘。

关键词：广西巡抚乾隆朝僧道八年民俗杨锡绂

CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer

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Genes & Diseases 2024年第4期11卷 381-399页

作者： Ming Shao Qingfei Pan haiyan Tan Jing Wu ha Won Lee Andrew D.Huber William C.Wright Ji-Hoon Cho Jiyang Yu Junmin Peng Taosheng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105USA Center for Proteomics and Metabolomics St.Jude Children's Research HospitalMemphisTN 38105USA Department of Structural Biology St.Jude Children's Research HospitalMemphisTN 38105USA Department of Developmental Neurobiology St.Jude Children's Research HospitalMemphisTN 38105USA

CYP3A5 is a cytochrome P450(CYP)enzyme that metabolizes drugs and contributes to drug resistance in ***,it remains unclear whether CYP3A5 directly influences cancer *** this report,we demonstrate that CYP3A5 regulates glucose metabolism in pancreatic ductal ***-omics analysis showed that CYP3A5 knockdown re-sults in a decrease in various glucose-related metabolites through its effect on glucose trans-port.A mechanistic study revealed that CYP3A5 enriches the glucose transporter GLUT1 at the plasma membrane by restricting the translation of TXNIP,a negative regulator of ***,CYP3A5-generated reactive oxygen species were proved to be responsible for atten-uating the AKT-4EBP1-TXNIP signaling ***3A5 contributes to cell migration by maintaining high glucose uptake in pancreatic *** together,our results,for the first time,reveal a role of CYP3A5 in glucose metabolism in pancreatic ductal adenocarcinoma and identify a novel mechanism that is a potential therapeutic target.

关键词： Cell migration CYP3A5 Glucose metabolism GLUT1 Pancreatic cancer TXNIP

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乾隆朝清厘僧道停颁牒照档案(上)

历史档案 2024年第2期 4-20页

作者：无哈恩忠中国第一历史档案馆不详

度牒是官方颁发给出家僧道之合法身份证明。一般认为度牒始于北魏时期,唐代设立度牒制度,持有度牒的僧道可免除租税徭役、云游各处。清初依然沿袭度牒制度,康熙初年停止。乾隆帝登基后,为管理和控制僧道数量,予以恢复。由于度牒的特殊作... 详细信息

度牒是官方颁发给出家僧道之合法身份证明。一般认为度牒始于北魏时期,唐代设立度牒制度,持有度牒的僧道可免除租税徭役、云游各处。清初依然沿袭度牒制度,康熙初年停止。乾隆帝登基后,为管理和控制僧道数量,予以恢复。由于度牒的特殊作用,致遁入空门的僧道人数众多,“若辈不耕而食,不织而衣,且甘食美衣,公然以为分所应得”,其中鱼龙混杂,不免有“无赖游手”,甚至混入获罪逃匿者。加之度牒买卖转让,管理人员乘机借端需索,亦有害吏治。鉴于种种原因,乾隆三十九年(1774)六月颁布上谕:“所有礼部奏请给发牒照之处,着永远停止。”实行千年的度牒制度终被废除。档案中所称牒照亦指度牒。本组档案史料选编自中国第一历史档案馆藏内阁题本、宫中朱批奏折、军机处录副奏折及上谕档等,涉及乾隆中期以前清廷清厘僧道停颁度牒的系列内容,可供研究参考。

关键词：度牒录副奏折僧道身份证明乾隆朝北魏时期管理人员档案

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越南学生汉语动物成语习得偏误分析

越南学生汉语动物成语习得偏误分析

作者： TRUONG LE ha NHU 重庆交通大学

学位级别：硕士

汉语成语一直被认为是中华文化的精华,是汉语学习过程中不可忽视的一部分。现在学习汉语的越南人越来越多。对越南学生来说,仅会简单说一点汉语是不够的,他们希望了解更多成语,更深层次地了解汉语成语背后的文化,提高汉语运用能力。但... 详细信息

汉语成语一直被认为是中华文化的精华,是汉语学习过程中不可忽视的一部分。现在学习汉语的越南人越来越多。对越南学生来说,仅会简单说一点汉语是不够的,他们希望了解更多成语,更深层次地了解汉语成语背后的文化,提高汉语运用能力。但由于动物成语的丰富性、结构的稳定性、意义的整体性和语法功能的多样性以及汉语文化背景、风俗习惯的多元性,再加上两国的地理环境及国家的民族思维方式存在差异,两国人民对同一种动物的联想在认知和理解上也存在很多差异。这导致越南学生很难掌握动物成语知识,在应用成语中常常出现偏误。因此,笔者作为越南学生,为了帮助越南学生更深入地学习和理解汉语动物成语,拟研究越南学生在汉语动物成语习得过程中遇到的偏误,归纳偏误类型,分析偏误原因并提出针对性的学习策略。本研究通过深入分析汉语与越南语动物成语的构词特点和文化内涵差异,揭示了语言结构和文化背景理解不足是导致越南学生在学习汉语动物成语时产生偏误的主要原因。通过设计并实施调查问卷,详细分析了越南学生在汉语动物成语学习中的具体偏误类型,包括语义偏误、语法偏误和语用偏误。调查结果显示,这些偏误不仅影响了学生运用语言的准确性,也限制了他们对汉语文化深层次的理解。针对发现的问题,本文提出了相应的对策,旨在帮助越南学生克服学习障碍,深化对汉语动物成语及其背后文化的理解。这些对策包括加强文化背景知识学习、采用成语分类和归纳法,以及通过多样化的学习活动和资源创造丰富的学习环境。研究强调通过多媒体资源、实践互动和中越文化交流活动等手段,激发学生的学习兴趣,提高其汉语成语的实际应用能力。本研究对于汉语作为第二语言的教学实践具有重要意义。通过实施本研究提出的学习对策,不仅可以有效减少越南学生在汉语成语学习中的偏误,还可以促进中越文化的交流与理解,为越南学生提供一条深入学习汉语、提升跨文化交际能力的有效途径。

关键词：越南学生动物成语偏误分析学习策略

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中华民族共同体学话语体系的创新

中南民族大学学报（人文社会科学版） 2024年第9期44卷 41-43页

作者：哈正利大连民族大学

2023年12月,国家民族事务委员会组织编写的《中华民族共同体概论》(以下简称《概论》)教材正式出版。该教材以习近平总书记关于加强和改进民族工作的重要思想为根本遵循。总体看来,《概论》教材成功建构了一个新的中华民族共同体叙事体... 详细信息

2023年12月,国家民族事务委员会组织编写的《中华民族共同体概论》(以下简称《概论》)教材正式出版。该教材以习近平总书记关于加强和改进民族工作的重要思想为根本遵循。总体看来,《概论》教材成功建构了一个新的中华民族共同体叙事体系和话语体系。中华民族史的研究肇始于近代中国。近代以来,陆续出版过一些中华民族史整体叙事的著作。

关键词：中华民族史《概论》中华民族共同体话语体系根本遵循教材习近平总书记叙事

Non-surgical treatment of diabetic foot ulcers on the dorsum of the foot with polydeoxyribonucleotide injection:Two case reports

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World Journal of Clinical Cases 2024年第20期12卷 4446-4451页

作者： Yooseok ha Jeong-Hee Kim Jiyoung Kim Hyeokjae Kwon Department of Plastic and Reconstructive Surgery Chungnam National University HospitalDaejeon 35015South Korea College of Nursing Woosuk UniversityWanju-gun 55338South Korea

BACKGROUND Diabetic foot ulcers are caused by a variety of factors,including peripheral neuropathy,peripheral arterial disease,impaired wound healing mechanisms,and repetitive *** with diabetic foot ulcer on the dorsum of the foot are often treated ***,the right non-surgical therapy must be chosen if surgical choices are contraindicated or if the patient prefers conservative treatment over *** SUMMARY The purpose of this case report is to highlight the efficacy of polydeoxyribonucleotide(PDRN)injection as a non-surgical treatment option for diabetic foot ulcers on the dorsum of the foot,particularly in patients who choose against surgical *** case report presents two cases of diabetic foot ulcers located on the dorsum of the foot that were successfully treated with PDRN injection as a non-surgical *** If the patient declines surgery for diabetic ulcers with Wagner grade II or below,PDRN injection can be effective if necrotic tissue is removed and the wound bed kept clean.

关键词： Diabetic foot Wound healing Regenerative medicine Polydeoxyribonucleotides Case report