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Protective effect of Tetracera scandens *** extract against CCl_4-induced acute liver injury in rats

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Asian Pacific Journal of Tropical Biomedicine 2015年第3期5卷 221-227页

作者： Tung Bui Thanh Hai Nguyen Thanh Hue Pham thi Minh huong le-thi-Thu huong Duong thi Ly Loi Vu Duc School of Medicine and Pharmacy Vietnam National University Hanoi University of Pharmacy

Objective:To investigate the protective potential of ethanolic extracts of Tetracera scandens L.(***) against CCl_4 induced oxidative stress in liver ***:Dried leaf powder of *** was extracted with ethanol and concentrated to yield a dry *** were administered with 100 mg/kg of ethanolic extracts orally once daily for one *** were subsequently administered with a single dose of CCl_4(I mL/kg body weight,intraperitoneal injection).Various assays,such as serum levels of alanine aminotransferase,aspartate aminotransferase,lipid peroxidation,protein oxidation(carbonyl protein group),tumor necrosis factor alpha,catalase,superoxide dismutase,and glutathione peroxidase,were used to assess damage caused by CCl_4 and the protective effects of the ethanol extract on liver ***:Hepatotoxicity induced by CCl_4 was evidenced by a significant increase in serum aspartate aminotransferase and alanine aminotransferase level,lipid peroxidation,protein carbonyl group,and tumor necrosis factor alpha,as well as decreased activity of the hepatic antioxidant enzymes(*** *** glutathione peroxidase).Treatment with ethanolic *** extracts prevented all of these typically observed changes in CCl_4-treated ***:Our findings indicate that *** has a significant protective effect against CCl_4 induced hepatotoxicity in *** may be due to its antioxidant properties.

关键词： Tetracera scandens L Antioxidant Carbon tetrachloride Liver toxicity Lipid peroxidation

Assessment of the Quality of Frozen-Thawed Semen or Epididymal Sperm in Three Native Vietnamese Pig Breeds

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Open Journal of Animal Sciences 2023年第3期13卷 283-297页

作者： Van Khanh Nguyen huong Thu thi Vu huong le thi Nguyen huong thi Nguyen Au thi Hoang Dat Van le Nhung Tuyet thi Nguyen Hieu Trung Phan Yen Kim thi Pham Son Phan le Quynh Anh le Quynh Anh le Lan Doan Pham Minh Quang Luu Muoi thi Nguyen Key Laboratory of Animal Cell Biotechnology National Institute of Animal Science Hanoi Vietnam National Institute of Animal Science Hanoi Vietnam Ministry of Science and Technology Hanoi Vietnam Animal Experiments and Domestic Animal Conservation Center National Institute of Animal Science Hanoi Vietnam

Our aim was to evaluate the quality of ejaculated and epididymal frozen-thawed pig sperm of endangered Vietnam native pig breeds. Ejaculated sperm was collected from live boars and epididymal sperm was collected from slaughtered boars of the MuongTe, Kieng Sat and Co BinhThuan breeds and frozen in 0.25 ml straws using a protocol established earlier for modern pig breeds. We evaluated the sperm quality after thawing in terms of motility and rates of viable and abnormal spermatozoa. Our results revealed that the sperm motility and rates of viable and abnormal frozen-thawed sperm were >30%, >44%, and leavage, blastocyst and hatching rates than did the epididymal sperm (60.11% vs 56.02%, 17.23% vs 14.31%, 3.78% vs 2.34%, respectively, P leavage rate, blastocyst formation rate and the average number of cells/blastocysts, the hatching blastocyst rate was different between the breeds (P > 0.05). In the Co BinhThuan breed, the rate of pregnancy of ejaculated groups was similar to that of the epididymal group. In conclusion, the ejaculated and epididymal sperm of native Vietnamese pigs were successfully frozen. We succeeded in creating embryos in vitro and pregnant pigs after artificial insemination from frozen-thawed semen in three native Vietnamese pig breeds for the first time. The use of the ejaculated sperm improved the production of native pig embryos in vitro efficiency.

关键词： Native Vietnamese Pig In Vitro Porcine Embryo Epididymal Ejaculate Artificial Insemination

Overweight, obesity and associated factors among secondary school students in a northern city of Vietnam in 2011

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Health 2013年第1期5卷 24-29页

作者： huong thi le Nga thi Thu Vu Doan thi Thu Huyen Nguyen Van Toan Bac Giang Secondary School of Nursing No1 Hanoi Vietnam Institute for Preventive medicine and Public Health Hanoi Medical University Hanoi Vietnam

Overweight and obesity is an emerging public health problem among school-aged children in Bac Giang city in the Northen part of Vietnam recently. this study aims to identify overweight-obesity prevalence of secondary school children in this city and it’s associated factors. The study was a nested case control in a cross-sectional study design in 1528 secondary students selected from 4 secondary schools in 2 inner communes and 2 suburban communes of Bac Giang city, Vietnam. Result: Overweight prevalence among secondary school students in Bac Giang was 6.7%, the prevalence of obesity was 2.0%. Overweight and obesity is more prevalence in male students, inner communes and students from family have higher income and higher food expense. Overweight and obesity was associated with higher energy intake, more fat consumption, having supplement meals and bedtimemeal, increased physical activities and increased sleep duration. Conclusion: Education campaign targeting reducing overweight and obesity should target both parents about dietary adequacy and balance and children about more physical activities.

关键词： Overweight Obesity Secondary

Optimization of Nanocomposite TiO2/Hydroxyl Apatite for the Photocatalytic Paint

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材料科学与工程（中英文A版） 2013年第5期3卷 329-333页

作者： Nguyen thi Mai huong le thi Thu huong Hoang Chung Hieu Tran thi Duc Nguyen Trong Tinh lntitute of Applied Physics and Scientific Instruments Viet Nam Academy of Science and Technology Cau Giay District HanoiVietnam

Changes of Food Expenditure and Food Consumption of People Living in Ba Vi District, Hanoi, Vietnam from 1999 to 2013

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Health 2015年第12期7卷 1696-1702页

作者： huong le thi Phuong le Hong Thanh Nguyen Hoang Giang Nguyen Thu Xuan le thi Thanh Chuc Nguyen thi Kim Nga thi Thu Vu Institute for Preventive Medicine and Public Health Hanoi Medical University Hanoi Vietnam

Background: During the nutrition transition period which began in the early 1990s in Vietnam, dietary intake had been changed significantly because of changes in lifestyle and living standard. Objectives: this paper aims to describe the trend for food expenditure and the frequency of meat consumption in households in Ba Vi district, Hanoi, Vietnam from 1999 to 2013. Methods: this is a longitudinal study conducted in Ba Vi district, Hanoi. Semi-annual, face-to face interviews were conducted by well-trained interviewers with 11,922 households to collect data of the household’s income, spending for food and meat consumption. Chi-square test for trend was performed to evaluate the changes of food expenditure over the years. P-value under 0.05 was considered statistically significant. Results: There were ten times increase in household’s mean income and five times increase in mean food expenditure from 1999 to 2013. The percentage of household food expenditure per total family expenditure was really high (55% in 2013). The percentage of rice expenditure per total food expenditure decreased dramatically from 59.9% in 1999 to 33.1% in 2013 while spending for other animal-based, high-protein food was an upward trend, particularly meat (10.7% in 1999 to 24.2% in 2013). The percentage of rice expenditure in well-off households was lower than poor households (55% vs. 61.8% in 1999 and 31.4% vs. 36.5% in 2013). However, the percentage of spending for meat in well-off households were much higher than that of poor households (>10%). Conclusion: Our finding indicated that mean income and food expenditure, particularly meat intake, of households had increased dramatically from 1999 to 2013. The increase of meat intake requires reallocation and direction of Vietnam public health funding and strategy.

关键词： Vietnam Income Food Expenditure Meat Consumption

Nutritional status of Vietnamese infants assessed by Fenton growth chart and related factors:A cross-sectional study

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Pediatric Investigation 2023年第4期7卷 254-262页

作者： Lieu Thu thi Nguyen Cuong Danh Tran Ha Thu thi Nguyen Hai Thanh Phan Linh Thuy Nguyen huong Lan thi Nguyen Anh Hoai thi Ta Chau Quynh thi Pho Khanh Nam Do Anh Kim Dang huong thi le School of Preventive Medicine and Public Health Hanoi Medical UniversityHanoiVietnam Department of Nutrition National Hospital of Obstetrics and GynecologyHanoiVietnam Department of General Obstetrics National Hospital of Obstetrics and GynecologyHanoiVietnam Department of Nutrition and Dietetics Hanoi Medical University HospitalHanoiVietnam Queensland Alliance for Environmental Health Sciences(QAEHS) The University of QueenslandBrisbaneAustralia

Importance:Nutritional status of infants,measured by birth weight and length,is an essential factor in neonatal *** in newborns may lead to a higher risk of mortality,neurological and cognitive impairment,and poor language ***:this study aims to assess the nutritional status of infants and related factors regarding maternal anthropometric characteristics and medical ***:A cross-sectional study was conducted at the National Hospital of Obstetrics and Gynecology,Vietnam from May 2021 to May 2022 on 340 infants and *** birth weight was defined following the Intergrowth-21 *** was evaluated using the Fenton growth chart when the length was below the 10%percentile line of the gestational *** regression models were applied to identify factors associated with the nutritional status of ***:We found that 12.4%and 14.1%of infants in our study fell into stunted and underweight categories,*** of mothers over 35 years old,having a height lower than 150 cm or experiencing anemia during pregnancy were more likely to be stunted or have low birth *** albumin deficiency during pregnancy was strongly associated with the infant being underweight(odds ratio[OR]=2.8,95%confidence interval[95%CI]1.1–7.3).Newborns were more likely to be stunted if their mothers had a history of preterm birth(OR=3.3,95%CI 1.1–10.2).Interpretation:Maternal nutritional status is closely related to infant malnutrition,particularly in preterm *** the understanding of mothers regarding prenatal care,reproductive healthcare,adequate nutritional diet,and multi-micronutrient supplements during pregnancy is therefore important.

关键词： Fenton chart Infant Low birth weight Stunting Underweight

<i>Bordetella bronchiseptica</i>pneumonia in a woman with lymphoma: A case report

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Open Journal of Internal Medicine 2012年第2期2卷 50-52页

作者： Aurélien Delluc Baptiste Hervier thi-huong-Du le Boutin Alain le Coustumier Vincent Jarlier Zahir Amoura Florence Brossier Internal Medicine and Pneumology Cavale Blanche Hospital Brest France Internal Medicine Pitié-Salpêtrière Hospital Paris France Laboratory of Bacteriology Pitié-Salpêtrière Hospital Paris France National Reference Center for Whooping Cough and Other Bordetellosis Pasteur Institute Paris France

A 62-year-old woman with splenic marginal zone lymphoma presented with fever, cough and bilateral pneumonia 11 days after chemotherapy. A bronchoalveolar lavage showed numerous leukocytes and Gramnegative bacilli that were identified as Bordetella bronchiseptica in culture. An antibiotherapy with minocycline and ciprofloxacin helped her to stop coughing. this unusual micro-organism, which has mainly an animal reservoir, is a rarely cause of human infection, almost always in immunocompromised patients. The main problems in B. bronchiseptica infection are the difficulties of identification of this micro-organism and the recurrence of infection, which are a challenge for microbiologists and practitionners.

关键词： Bordetella bronchiseptica Pneumonia Lymphoma Case Report

Prediction of Shear Bond Strength of Asphalt Concrete Pavement Using Machine learning Models and Grid Search Optimization Technique

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 691-712页

作者： Quynh-Anh thi Bui Dam Duc Nguyen Hiep Van le Indra Prakash Binh Thai Pham Civil Engineering Department University of Transport Technology54 Trieu KhucThanh XuanHanoi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India

Determination of Shear Bond strength(SBS)at interlayer of double-layer asphalt concrete is crucial in flexible pavement *** study used three Machine learning(ML)models,including K-Nearest Neighbors(KNN),Extra Trees(ET),and Light Gradient Boosting Machine(LGBM),to predict SBS based on easily determinable input ***,the Grid Search technique was employed for hyper-parameter tuning of the ML models,and cross-validation and learning curve analysis were used for training the *** models were built on a database of 240 experimental results and three input variables:temperature,normal pressure,and tack coat *** validation was performed using three statistical criteria:the coefficient of determination(R2),the Root Mean Square Error(RMSE),and the mean absolute error(MAE).Additionally,SHAP analysis was also used to validate the importance of the input variables in the prediction of the *** show that these models accurately predict SBS,with LGBM providing outstanding ***(Shapley Additive explanation)analysis for LGBM indicates that temperature is the most influential factor on ***,the proposed ML models can quickly and accurately predict SBS between two layers of asphalt concrete,serving practical applications in flexible pavement structure design.

关键词： Shear bond asphalt pavement grid search optimization machine learning

Synthesis and characterization of NaYF4:Yb3+,Er3+@silica-N=folic acid nanocomplex for bioimaginable detecting MCF-7 breast cancer cells

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Journal of Rare Earths 2019年第11期37卷 1183-1187页

作者： Ha thi Phuong Tran Thu huong le thi Vinh Hoang thi Khuyen Do thi Thao Nguyen Thanh huong Pham thi Lien le Quoc Minh Institute of Materials Science Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoiViet Nam Graduate University of Science and Technology-Vietnam Academy of Science and Technology 18 Hoang Quoc VietCau GiayHanoiViet Nam Department of Chemistry Hanoi Medical University1-Ton That TungDong DaHanoiViet Nam Department of Chemistry Hanoi University of Mining and Geology18-Pho LienBac Tu LiemHanoiViet Nam Institute of Biotechnology Vietnam Academy of Science and Technology18-Hoang Quoc VietCau GiayHanoiViet Nam Duy Tan University K7/25 Quang TrungDa NangViet Nam

Upconversion nanophosphors are new promising nanomaterials to be used as biolabels for detection and imaging of cancer *** nanophosphors absorb long-wavelength excitation radiation in the infrared or near infrared region and emit shorter wavelength,higher energy radiation from ultraviolet to *** this paper,we studied the hydrothermal method and optical properties of the functionalized NaYF4:Yb^3+,Er^3+for biomedical *** synthesis,these NaYF4:Yb^3+,Er^3+nanophosphors were functionalized with aminosilanes and folic *** acid binds to the folate receptor on the surface of MCF-7 breast cancer cells and this binding promotes internalization of the nanophosphors via *** sizes of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA(folic acid)nanophosphors can be controlled with length of the rod about 300-800 nm and diameter of the rod about 100-200 *** structure of NaYF4:Yb^3+,Er^3+is in hexagonal crystal *** photo luminescence(PL)spectra of the functionalized NaYF4:Yb^3+,Er^3+@silica-N=FA nanophosphors were *** nanophosphors emit in red color with the strongest band at 650 nm under 980 nm *** result can provide NaYF4:Er^3+,Yb^3+@silica-N=FA complex for developing fluorescence label and image tool in cancer biology and medicine.

关键词： Upconversion luminescence NaYF4:Yb^3+,Er^3+ Nanophosphors Bioimaging Cancer cell Rare earths