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Extracellular nucleoprotein exacerbates influenza viruspathogenesis by activating Toll-like receptor 4 and the NLRP3inflammasome

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Cellular & Molecular Immunology 2022年第6期19卷 715-725页

作者： Chang-ung Kim Yu-Jin Jeong Pureum Lee Moo-Seung Lee Jong-Hwan Park Young-Sang Kim Doo-Jin Kim Infectious Disease Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)DaejeonSouth Korea Department of Biochemistry Chungnam National UniversityDaejeonSouth Korea Environmental Diseases Research Center Korea Research Institute of Bioscience and Biotechnology(KRIBB)DaejeonSouth Korea University of Science and Technology(UST) DaejeonSouth Korea College of Veterinary Medicine Chonnam National UniversityGwangjuSouth Korea

Host immune responses, such as those initiated by pattern recognition receptor (PRR) activation, are important for viralclearance and pathogenesis. However, little is known about the interactions of viral proteins with surface PRRs or, moreimportantly, the association of innate immune activation with viral pathogenesis. In this study, we showed that internalinfluenza virus proteins were released from infected cells. Among these proteins, nucleoprotein (NP) played a critical role inviral pathogenesis by stimulating neighboring cells through toll-like receptor (TLR)2, TLR4, and the NLR family pyrin domaincontaining 3 (NLRP3) inflammasome. Through the activation of these PRRs, NP induced the production of interleukin (IL)-1β andIL-6, which subsequently led to the induction of trypsin. Trypsin induced by NP increased the infectivity of influenza virus,leading to increases in viral replication and pathology upon subsequent viral infection. These results reveal the role of releasedNP in influenza pathogenesis and highlight the importance of the interactions of internal viral proteins with PRRs in theextracellular compartment during viral pathogenesis.

关键词： Influenza virus Viral protein release Nucleoprotein Toll-like receptor Cyotkine-trypsin cycle

Differential diagnoses of magnetic resonance imaging for suspected acute appendicitis in pregnant patients

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World Journal of Emergency Medicine 2018年第1期9卷 26-32页

作者： Ji Yong Jung Ji ung Na Sang Kuk Han Pil Cho Choi Jang Hee LEE Dong Hyuk Shin Department of Emergency Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

BACKGROUND: Accurate and timely diagnosis of acute surgical disease in pregnant patient is chal enging. Although magnetic resonance imaging(MRI) is the most accurate modality to diagnose acute appendicitis in pregnant patients, it is often used as a last resort because of high cost and long scan time. We performed this study to analyze differential diagnoses of appendix MRI and to investigate if there are any blood tests that can predict surgical condition in pregnant ***: A retrospective, cross-sectional study was conducted on 46 pregnant patients who underwent non-enhanced appendix MRI in suspicion of acute appendicitis from 2010 to 2016. Differential diagnoses of appendix MRI were analyzed and blood tests were compared between those who had surgical and non-surgical ***: Appendix MRI differentiated two surgical disease; acute appendicitis and ovarian torsion; and various non-surgical conditions such as uterine myoma, hydronephrosis, ureterolithiasis and diverticulitis among clinically suspected acute appendicitis in pregnancy. The diagnostic accuracy of MRI for acute appendicitis in this study was 93.5%. Patients who had surgical disease showed significantly higher WBC count(≥11,000/mm^3), proportion of neutrophils in the WBC(≥79.9%), neutrophil-to-lymphocyte ratio(NLR≥6.4), levels of C-reactive protein(CRP≥1.82 mg/dL) and bilirubin(≥0.66 mg/dL) than those who had non-surgical ***: MRI can reliably differentiate surgical conditions and several blood tests(WBC, proportion of neutrophils in the WBC, NLR, CRP, bilirubin) can help anticipate acute surgical condition among pregnant patients suspected to have acute appendicitis.

关键词： Appendicitis Magnetic resonance imaging Pregnancy Neutrophils

Metal−Organic Frameworks as a Subnanometer Platform for Ion−Ion Selectivity

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Accounts of Materials Research 2022年第7期3卷 735-747页

作者： Jun Lu Xiaoyi Hu Kevin M.ung Yinlong Zhu Xiwang Zhang Huanting Wang Department of Chemical and Biological Engineering Monash Centre for Membrane InnovationMonash UniversityClaytonVictoria 3800Australia Department of Chemical and Biological Engineering Monash UniversityClaytonVictoria 3800Australia Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210016China School of Chemical Engineering Dow Centre for Sustainable Engineering InnovationThe University of QueenslandSt LuciaQueensland 4072Australia

CONSPECTUS:Selective ion transport in nanoporous membranes has become a research hot spot in the fields of both nanofluidics and membrane separation because of its wide potential applications,such as ion separation,energy harvesting and conversion,and ion *** nanofluidic devices or membranes with nanoconfined to subnanoconfined space is the core part of nanofluidic studies because the materials used to construct nanofluidic devices determine the exploration potential of the ion-transport performance.

关键词： separation harvesting confined

TOWARD THE REALIZATION OF THE ULTRASONIC INVERSE SCATTERING COMPUTED TOMOGRAPHY BASED ON THE LIMITED VIEW REFLECTION AND TRANSMISSION OBSERVATION DATA

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TOWARD THE REALIZATION OF THE ULTRASONIC INVERSE SCATTERING ...

Iodized oil uptake assessment with cone-beam CT in chemoembolization of small hepatocellular carcinomas

2002中国—日本声学学术会议

作者： ung-Soon Kim Akira Yamada Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Koganei Tokyo 184-8588 Japan Graduate School of Bio-Applications and Systems Engineering Tokyo University of Agriculture and Technology Koganei Tokyo 184-8588 Japan

A method of ultrasonic inverse scattering computed tomography was presented using the multi-frequency scattered data received by the fixed array elements on the sector semicircular positions. The vali

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World Journal of Gastroenterology 2009年第46期15卷 5833-5837页

作者： ung Bae Jeon Jun Woo Lee Ki Seok Choo Chang Won Kim Suk Kim Tae Hong Lee Yeon Joo Jeong Dae Hwan Kang Department of Radiology Pusan National University Yangsan Hospital Department of Radiology Pusan National University Hospital Department of Internal Medicine Pusan National University Yangsan Hospital

AIM:To evaluate the utility of assessing iodized oil uptake with cone-beam computed tomography(CT)in transarterial chemoembolization(TACE)for small he-patocellular carcinoma(HCC).METHODS:Cone-beam CT provided by a biplane flat-panel detector angiography suite was performed on eighteen patients(sixteen men and two women;41-76 years;mean age,58.9 years)directly after TACE for small HCC(26 nodules under 30 mm;mean diam-eter,11.9 mm;range,5-28 mm).The pre-procedural locations of the tumors were evaluated using tripha-sic multi-detector row helical computed tomography(MDCT).The tumor locations on MDCT and the iodized oil uptake by the tumors were analyzed on cone-beam CT and on spot image directly after the ***:All lesions on preprocedural MDCT were de-tected using iodized oil uptake in the lesions on cone-beam CT(sensitivity 100%,26/26).Spot image depictediodized oil uptake in 22 of the lesions(sensitivity 85%).The degree of iodized oil uptake was overestimated(9%,2/22)or underestimated(14%,3/22)on spot image in f ive nodules compared with that of cone-beam ***:Cone-beam CT is a useful and conve-nient tool for assessing the iodized oil uptake of small hepatic tumors(< 3 cm)directly after TACE.

关键词： Chemoembolization Computed tomography Hepatocellular carcinoma Liver

Canopy Net Photosynthesis Rate of a Mongolian Oak (<i>Quercus mongolica</i>) Forest Estimated by Field Experimental Data

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American Journal of Plant Sciences 2017年第3期8卷 390-411页

作者： Seung Jin Joo Soon-ung Park Center for Atmospheric and Environmental Modeling Seoul Korea

The canopy net photosynthesis rate of Mongolian oak (Quercus mongolica) tree species that are dominant in East Asia and Korea is estimated with empirical models derived from field experimental data obtained from the Nam-San site in Seoul, Korea for the growing period from early May to late October in 2010. The empirical models include the attenuation function of photosynthetic photon flux density (PPFD) (r2 = 0.98-0.99, p r2 = 0.99, p < 0.001) derived from the measured data at several levels within the canopy. The incident PPFD at each level within canopy significantly varies diurnally and seasonally due to the seasonal variation of the total plant area index (TPAI = leaf area index + wood silhouette area index) and the light shielding effect of light path-length through the canopy in association with the variation of solar elevation angle. Consequently, a remarkable seasonal variation of the total canopy net photosynthesis rate of Q. mongolica forest stand is found for its growing period. The PPFD exceeding 1000 μmol m-2·s-1 is found to cause the decrease of net photosynthesis rate due to the thermal stress in the early (May) and late (September) growing period. During the whole growing season, the estimated total canopy net photosynthesis rate is found to be about 3.3 kg CO2 m-2.

关键词： Mongolian Oak (Quercus mongolica) Canopy Net Photosynthesis Rate PPFD TPAI Solar Elevation Angle

Research on flexible display at Ulsan National Institute of Science and Technology

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npj Flexible Electronics 2017年第1期1卷 47-59页

作者： Jihun Park Sanghyun Heo Kibog Park Myoung Hoon Song Ju-Young Kim Gyouhyung Kyung Rodney Scott Ruoff Jang-ung Park Franklin Bien School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea School of Electrical and Computer Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea Department of Physics Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea School of Design and Human Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea Center for Multidimensional Carbon Materials Institute for Basic Science(IBS)Ulsan 44919Republic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Displays represent information visually,so they have become the fundamental building block to visualize the data of current electronics including ***,electronics have been advanced toward flexible and wearable electronics that can be bent,folded,or stretched while maintaining their performance under various ***,recent advances in research to demonstrate flexible and wearable displays are *** introduce these results by dividing them into several categories according to the components of the display:active-matrix backplane,touch screen panel,light sources,integrated circuit for fingerprint touch screen panel,and characterization tests;and we also present mechanical tests in nano-meter scale and visual ergonomics research.

关键词： dividing electronics panel

PROGRESS AND PROSPECT OF RICE ALLOLOPATHY RESEARCH

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PROGRESS AND PROSPECT OF RICE ALLOLOPATHY RESEARCH

HAUSTORIUM INDUCTION OF PARASITIC PLANTS AS A NEW BIOASSAY METHOD

中国第三届植物化感作用学术研讨会、第八届全国杂草科学大会、联合国粮农组织——中国“水稻化感作用论坛”

作者： Kil-ung KIM Dong-Hyun SHIN Department of Agronomy College of Agriculture and Life SciencesKyungpook National UniversityDaegu(Taegu) 702-701Korea(South)

An improvement in allelopathic potential in rice will have a great impact on both low-input and high-input management *** alone is not likely to replace other weed control practices,but it surely functions as a component of integrated weed management *** reduced use of herbicide over time will provide significant economical benefits to farmers and will also reduce adverse effects on the environment.

关键词： PROGRESS AND PROSPECT OF RICE ALLOLOPATHY RESEARCH

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HAUSTORIUM INDUCTION OF PARASITIC PLANTS AS A NEW BIOASSAY M...