检索结果-南通市图书馆

An Intramolecular Charge Transfer and Aggregation Induced Emission Enhancement Fluorescent Probe Based on 2-Phenyl-1,2,3-triazole for Highly Selective and Sensitive Detection of Homocysteine and Its Application in Living Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2019年第12期37卷 1216-1222页

作者： Yicheng Chu Zhengfeng Xie Daijiao Zhuang Yongshuang Yue Yuhua Yue Wei shi shun Feng Oil&Gas Field Applied Chemistry Key Laboratory of Sichuan Province College of Chemistry and Chemical EngineeringSouthwest Petroleum University8 Xindu RoadXinduChengduSichuan 610500China School of Life Science and Engineering Southwest Jiaotong UniversityChengduSichuan 610031China

Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocysteine(Hcy).Moreover,APTC has excellent optical properties such as intramolecular charge transfer(ICT)and aggregation induced emission enhancement(AIEE)characteristics,indicating its extensive application ***'s more,APTC displayed rapid,high selectivity and specificity towards homocysteine over cysteine/*** detection limit of APTC for Hcy was as low as 2.198×10^-8 mol·L^-1,and the response time was only 5 *** has been successfully applied to detect Hcy in silica gel plates and living cells,which indicates that APTC has good stability and biocompatibility as a selective probe for ***,the mechanism was studied using 1H NMR titration experiments and mass spectrometry.

关键词： specificity Probe Highly

Comprehensive Evaluation of Tobacco Ecological Suitability of Henan Province Based on GIS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Agricultural Sciences in China 2010年第4期9卷 583-592页

作者： CHEN Hai-sheng LIU Guo-shun YANG Yong-feng YE Xie-feng shi Zhou National Tobacco Cultivation and Physiological and Biochemical Center Henan Agricultural University Zhengzhou 450002 P.R. China Zhejiang Tongji Science and Technology Vocational College Hangzhou 311231 P.R.China Institute of Agricultural Remote Sensing and Information Technology College of Environment and Resource Science Zhejiang University Hangzhou 310029 P.R.China

The growth of tobacco is sensitive to environment conditions. The tobacco production is strictly restricted by regional cultivated land. Based on the principal of hiberarchy analysis and fuzzy mathematics and the technique of geographic information system （GIS）, the comprehensive evaluation of tobacco ecology suitability were studied according to the actual circumstances of the whole Henan tobacco planting regions, China. The evaluation index system of tobacco ecology suitability of Henan tobacco planting regions was established by choosing 17 evaluation indexes from 3 respects of climate, soil and landform with Delphi method. Furthermore, the membership function was set up according to the effects of each ecology factors on the growth and quality of tobacco suitability. And the analytical hierarchy process （AHP） was used to determine the weight of indexes by using quantitative analysis. Then the tobacco ecology suitability map of Henan tobacco plantation was drawn with GIS software mapGIS. It is found that the most areas of the western and southern parts of Henan Province, China, are the highly suitable regions, accounting for 22.52% of Henan tobacco planting areas. It is because that there are medium air temperature, sunshine and rainfall, medium soil pH value, and high contents of soil organic matter in the regions. Moreover, the topography is hill and massif, and the height above sea level is between 150-800 m there. Some areas of the southern and middle parts of Henan Province are the suitable ones, accounting for 34.99% of Henan tobacco planting areas. It is because that there are enough rainfall, medium air temperature, high contents of available N and available K in the soil in these regions. There are less suitable regions in the northern and eastern parts of the investigated regions because of drought, too high pH value and CI in the soil and irrigation water, accounting for 35.54% of the whole areas. It can be conducted rapidly and correctly by combining

关键词： GIS flue-cured tobacco evaluation factors AHP ecology suitability

Natural consolidation characteristics of viscous debris flow deposition

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2016年第10期13卷 1723-1734页

作者： HE Song-Tang WANG Dao-Jie CHEN shun ZHANG Shu-Juan CHANG shi-Qiu Key Laboratory of Mountain Hazards and Earth Surface Processes Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of Science&Ministry of Water ConservancyChengdu 510041China University of Chinese Academy of Sciences Beijing 100049China

Pore water pressure and water content are important indicators to both deposition and consolidation of debris flows, enabling a direct assessment of consolidation degree. This article gained a more comprehensive understanding about the entire consolidation process and focused on exploring pore water pressure and volumetric water content variations of the deposit body during natural consolidation under different conditions taking the viscous debris flow mass as a study subject and by flume experiments. The results indicate that, as the color of the debris changed from initial dark green to grayish-white color, the initial deposit thickness declined by 3% and 2.8% over a permeable and impermeable sand bed, respectively. A positive correlation was observed between pore water pressure and depth in the deposit for both scenarios, with deeper depths being related to greater pore water pressure. For the permeable environment, the average dissipation rate of pore water pressure measured at depths of 0.10 m and 0.05 m were 0.0172 Pa/d and 0.0144 Pa/d, respectively, showing a positivechanging trend with increasing depth. Under impermeable conditions, the average dissipation rates at different depths were similar, while the volumetric water content in the deposit had a positive correlation with depth. The reduction of water content in the deposit accelerated with depth under impermeable sand bed boundary conditions, but was not considerably correlated with depth under permeable sand bed boundary conditions. However, the amount of discharged water from the deposit was greater and consolidation occurred faster in permeable conditions. This indicates that the permeability of the boundary sand bed has a significant impact on the progress of consolidation. This research demonstrates that pore water and pressure dissipations are present during the entire viscous debris consolidation process. Contrasting with dilute flows, pore pressure dissipation in viscous flows cannot be complete

关键词： Viscous debris flow Natural consolidation Dissipation of pore water pressure Volumetric Water content Flume experiment

TP53BP2:Roles in suppressing tumorigenesis and therapeutic opportunities

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2023年第5期10卷 1982-1993页

作者： Yunfei huo Ke Cao Buxin Kou Mengyin Chai Shuangshuang Dou Dexi Chen Ying shi Xiaoni Liu Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical UniversityBeijing 100069China

Malignant tumor is still a major problem *** tumorigenesis or tumor development,tumor suppressor p53-binding protein 2(TP53BP2),also known as apoptosis stimulating protein 2 of p53(ASPP2),plays a critical role in p53 dependent and independent *** of TP53BP2 is highly correlated with the prognosis and survival rate of malignant tumor ***53BP2 can interact with p53,NF-κB p65,Bcl-2,HCV core protein,PP1,YAP,CagA,RAS,PAR3,and other proteins to regulate cell ***,TP53BP2 can also regulate the proliferation,apoptosis,autophagy,migration,EMT and drug resistance of tumor cells through downstream signaling pathways,such as NF-κB,RAS/MAPK,mevalonate,TGF-β1,PI3K/AKT,aPKC-ι/GLI1 and autophagy *** a potential therapeutic target,TP53BP2 has been attracted more *** review the role of TP53BP2 in tumorigenesis or tumor development and the signal pathway involved in TP53BP2,which may provide more deep insight and strategies for tumor treatment.

关键词： Binding proteins Signaling pathways TP53 TP53BP2 Tumorigenesis Tumor development

ESRFuzzer:an enhanced fuzzing framework for physical SOHO router devices to discover multi-Type vulnerabilities

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cybersecurity 2021年第1期4卷 364-385页

作者： Yu Zhang Wei huo Kunpeng Jian Ji shi Longquan Liu Yanyan Zou Chao Zhang Baoxu Liu Institute of Information Engineering Chinese Academy of SciencesBeijingChina School of Cyber Security University of Chinese Academy of SciencesBeijingChina Key Laboratory of Network Assessment Technology Chinese Academy of SciencesBeijingChina Beijing Key Laboratory of Network Security and Protection Technology BeijingChina Institute for Network Science and Cyberspace Tsinghua UniversityBeijingChina Beijing National Research Center for Information Science and Technology BeijingChina

SOHO(small office/home office)routers provide services for end devices to connect to the Internet,playing an important role in ***,security vulnerabilities pervasively exist in these routers,especially in the web server modules,greatly endangering end *** discover these vulnerabilities,fuzzing web server modules of SOHO routers is the most popular ***,its effectiveness is limited due to the lack of input specification,lack of routers’internal running states,and lack of testing environment recovery ***,existing works for device fuzzing are more likely to detect memory corruption *** this paper,we propose a solution ESRFuzzer to address these *** is a fully automated fuzzing framework for testing physical SOHO *** continuously and effectively generates test cases by leveraging two input semantic models,i.e.,KEY-VALUE data model and CONF-READ communication model,and automatically recovers the testing environment with power *** also coordinates diversified mutation rules with multiple monitoring mechanisms to trigger multi-type *** the guidance of the two semantic models,ESRFuzzer can work in two ways:general mode fuzzing and D-CONF mode *** mode fuzzing can discover both issues which occur in the CONF and READ operation,while D-CONF mode fuzzing focus on the READ-op issues especially missed by general mode *** ran ESRFuzzer on 10 popular routers across five *** total,it discovered 136 unique issues,120 of which have been confirmed as 0-day vulnerabilities we *** an improvement of SRFuzzer,ESRFuzzer have discovered 35 previous undiscovered READ-op issues that belong to three vulnerability types,and 23 of them have been confirmed as 0-day vulnerabilities by *** experimental results show that ESRFuzzer outperforms state-of-the-art solutions in terms of types and number of vulnerabilities found.

关键词： Fuzzing IoT Automatic vulnerability detection

Scaling Properties of the Period-Adding Sequences in a Multiple Devil’s Staircase

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 1998年第4期15卷 246-248页

作者： WU Cai-yun QU shi-xian WU shun-guang HE Da-ren Department of Physics Teachers CollegeYangzhou UniversityYangzhou 225002 Department of Basic Courses Xi'an Petroleum InstituteXi'an 710065 Department of Physics Northwestern UniversityXi'an 710069 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100080

In this letter the scaling properties of the period-adding sequences in a so-called“multiple Devil’s staircase”are *** is certified both analytically and numerically that the width of the i-th phase-locked plateau in a sequence scales as In|Δe(i)|∝i,and the position of the plateau scales as In|e_(∞)-e_(i)|∝*** properties are qualitatively different from those of the period-adding sequences in conventional Devil’s staircases.

关键词： adding letter sequences

Expression and antioxidation of Nrf2/ARE pathway in traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2013年第4期6卷 305-310页

作者： Zhen-Guo Cheng Guo-Dong Zhang Peng-Qiang shi Bao-shun Du Second Department of Neurosurgery Xinxiang Central Hospital

Objective:To explore the expression of Nrf2/ARE pathway in hindbrain tissue after the traumatic brain injury（TBI） and its anli-oxidative stress effect in the secondary nerve ***: The mice with Nrf2 gene knockout were used for the establishment of brain injury *** experimental animals were divided into four groups:(Nrf2+/+) sham-operation group,(Nrf2+/+) brain injury group,（Nrf2T） sham-operation group and(Nrf2-/-) brain injury *** specimen 24 h after cerebral trauma was *** RT-PCR method was adopted to detect the expression of Nrf2 mRNA in brain;Western blotting method was adopted to detect the levels of Nrf2,HO-1 and NQO1 proteins in brain;EUSA method was adopted to detect the oxidative stress indicators: protein carbonyls,4-hydroxy-2-nonenal（4-HNE） and 8-hydroxy-2’-deoxyguanosine（8-OHdG）. ResuHs:The Nrf2 mRNA and protein of Nrf2-/- mice were not expressed,and the diflerence of the relative amount of Nrf2 mRNA between Nrf2+/+ TBI group and Nrf2+/+ sham-operation group was not statistically significant（P>0.05）;the level of Nrf2 protein in Nrf2+/+ TBI group increased significantly compared with the Nrf2+/+ sham-operation group（P-/- mice decreased obviously compared with the Nrf2+/+ mice（P+/+ mice increased obviously compared with the corresponding sham-operation group（P-/- mice in TBI group had no obvious change compared with the corresponding sham-operation group（P>0.05）;there was only a little amount of expression of protein carbonyls,4-HNE and 8-OHdG proteins in brain tissues in the Nrf2-/+ and Nrf2-/- shamoperation groups,and the difference was not statistically signif

关键词： Traumatic brain injury Nrf2/ARE pathway Gene expression Anti-oxidative stress

Novel mutation in a Chinese patient with progressive familial intrahepatic cholestasis type 3

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第2期21卷 699-703页

作者： Hao-Zhe Sun Hong shi shun-Cai Zhang Xi-Zhong Shen Department of Gastroenterology and Hepatology Zhongshan HospitalFudan University Shanghai Medical College Fudan University

Genotyping is conclusive for the diagnosis of progressive familial intrahepatic cholestasis type 3(PFIC3). Here we report a Chinese patient of PFIC3 with compound mutations in the ABCB4 gene. Liver biopsy was performed on a 17-year-old male patient with intrahepatic cholestasis of unknown etiology. Liver histology findings are indicative of intrahepatic cholestasis with extensive fibrosis. Genotyping revealed c.175C>T(p.L59L) mutation in exon 4, c.504C>T(p.N168N) mutation in exon 6, c.711A>T(p.I237I) mutation in exon 8, c.874A>T(p.K292X) in exon 9 and a novel mutation, c.1804G>T(p.G602W) in exon 15. Based on these findings, the patient was diagnosed with PFIC3. The novel mutation p.G602 W in exon 15 was predicted as probably damaging by Poly Phen-2 with a score of 0.986(sensitivity: 0.54; specificity: 0.94) and was predicted to affect protein function with a SIFT score of 0.01.

关键词： Liver disease Cholestasis Progressive familial int

Scattering from Rough Surfaces Using the"Shooting and Bouncing Rays" Technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 1999年第3期4卷 319-321页

作者： Gao huo-tao Ke Heng-yu Hou Jie-chang Wu shi-cai Wuhan Univ China

The “shooting and bouncing rays” (SBR) technique is used to analyze the electromagnetic scattering characters of ocean rough surfaces varying with time. Some numerical results are presented and compared with the method of moments, and some factors, such as the incident angle, polarization and frequency are investigated which influence on electromagnetic scattering characters of ocean rough surfaces.

关键词： “shooting and bouncing rays” technique electromagnetic scattering characters ocean rough surfaces