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不足额灌溉技术的实地考察报告

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节水灌溉 1988年第3期 61-61页

作者： English,M.j. james,L.d. hunsaker,d.j. Mckusick,R.j. 付元海河南省商丘地区水利局

本文试图论述不足额灌溉技术的实用性。一般来说,实行不足额灌溉能够增加农田的收益,特别在供水受限制或供水费用昂贵的地方,收益更高。但是,由于供水和作物产量之间的关系不好确定,

关键词：灌溉技术收益财政管理农场

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Intranuclear inclusions in a fragile X mosaic male

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Translational Neurodegeneration 2013年第1期2卷 59-67页

作者： dalyir I Pretto Michael R hunsaker Christopher L Cunningham Claudia M Greco Randi j Hagerman Stephen C Noctor deborah A Hall Paul j Hagerman Flora Tassone department of Biochemistry and Molecular Medicine School of MedicineUniversity of California at DavisOne Shields AvenueDavisCAUSA department of Psychiatry and Behavioral Sciences School of MedicineUniversity of California at DavisDavisCAUSA MINd Institute University of California Davis Medical CenterSacramentoCAUSA Neuroscience Graduate Program University of CaliforniaDavisDavisCAUSA department of Pathology School of MedicineUniversity of California at DavisDavisCAUSA department of Pediatrics School of MedicineUniversity of California at DavisDavisCAUSA department of Biochemistry Neurological SciencesRush UniversityChicagoILUSA

Lack of the fragile X mental retardation protein leads to Fragile X syndrome(FXS)while increased levels of FMR1 mRNA,as those observed in premutation carriers can lead to Fragile X-associated tremor ataxia syndrome(FXTAS).Until recently,FXTAS had been observed only in carriers of an FMR1 premutation(55–200 CGG repeats);however the disorder has now been described in individuals carriers of an intermediate allele(45–54 CGG repeats)as well as in a subject with a full mutation with ***,we report on molecular and clinical data of a male FMR1 mosaic individual with full and premutation *** analysis of FMR1 and FMRP expression in this subject is consistent with a FXS *** observed reduced expression of FMRP in both peripheral blood and brain leading to the FXS *** addition,a dramatic 90%depletion of both FMR1 mRNA and FMRP levels was observed in the blood,as normally observed in FXS cases,and an even greater depletion in the brain.A clinical report of this patient,at age 71,described neurodegenerative signs of parkinsonism that were likely,in retrospect,part of a FXTAS scenario as post-mortem examination shows the presence of intranuclear inclusions,the hallmark pathology of *** findings presented in this study indicate co-morbidity for both FXS and FXTAS in this individual carrying both full and premutation FMR1 *** addition,based on symptoms and pathological and molecular evidence,this report suggests the need to redefine the diagnostic criteria of FXTAS.

关键词： Intranuclear inclusions FXS FXTAS Premutation

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