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PD-YOLO:Colon Polyp Detection Model Based on Enhanced Small-Target Feature Extraction

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Computers, Materials & Continua 2025年第1期82卷 913-928页

作者： Yicong Yu Kaixin Lin Jiajun Hong Rong-Guei tsai Yuanzhi Huang New Engineering Industry College Putian UniversityPutian351100China Engineering Research Center of Big Data Application in Private Health Medicine(Putian University) Fujian Province UniversityPutian351100China Computer College Guangdong University of Science&TechnologyDongguan523668China

In recent years,the number of patientswith colon disease has increased *** polyps are the precursor lesions of colon *** not diagnosed in time,they can easily develop into colon cancer,posing a serious threat to patients’lives and health.A colonoscopy is an important means of detecting colon ***,in polyp imaging,due to the large differences and diverse types of polyps in size,shape,color,etc.,traditional detection methods face the problem of high false positive rates,which creates problems for doctors during the diagnosis *** order to improve the accuracy and efficiency of colon polyp detection,this question proposes a network model suitable for colon polyp detection(PD-YOLO).This method introduces the self-attention mechanism CBAM(Convolutional Block Attention Module)in the backbone layer based on YOLOv7,allowing themodel to adaptively focus on key information and ignore the unimportant *** help themodel do a better job of polyp localization and bounding box regression,add the SPD-Conv(Symmetric Positive Definite Convolution)module to the neck layer and use deconvolution instead of *** results indicate that the PD-YOLO algorithm demonstrates strong robustness in colon polyp *** to the original YOLOv7,on the Kvasir-SEG dataset,PD-YOLO has shown an increase of 5.44 percentage points in AP@0.5,showcasing significant advantages over other mainstream methods.

关键词： Polyp detection YOLOv7 SPD-Conv CBAM deconvolution

Functional Design of A Series of Submerged Breakwaters for Coastal Protection Against Waves

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China Ocean Engineering 2010年第3期24卷 553-564页

作者： Li-hung tsai Chih-Chung WEN Center of Harbor and Marine Technology Institute of TransportationMinistry of Transportation and Communications Department of Safety Health and Environmental EngineeringHungkuang University

The purpose of this paper is to develop a functional method for designing a series of submerged breakwaters on practical topography. The method is used to verify the feasibility and effectiveness of Bragg breakwaters for coastal protection by using field topography. The first part of this paper provides definitions and procedures needed in the design process for applying the mechanism of Bragg reflection. Next, Bragg breakwaters are designed on the basis of the cross-sectional topography and then on the plane topography of the Mi-Tuo coast by following the proposed process and procedure. Numerical modeling （Hsu et al., 2003; Wen and tsai, 2008） was used as a design and assessment tool. Finally, the effectiveness and feasibility of a Bragg breakwater was assessed by practical cases. Based on the mechanism of Bragg reflection, an optimum layout for a series of submerged breakwaters is proposed to protect the Mi-Tuo coast. The results indicate that the proper layout of a series of submerged creakwaters can achieve the objective of beach protection.

关键词： a series of submerged breakwaters Bragg reflection coastal protection

Numerical Simulation of Bragg Reflection Based on Linear Waves Propagation over A Series of Rectangular Seabed

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China Ocean Engineering 2008年第1期22卷 71-86页

作者： Chih-Chung WEN Li-hung tsai Department of Environmental Engineering Hungkuang University Center of Harbor and Marine Technology Institute of TransportationMinistry of Transportation and Communications

A numerical model, Evolution Equation of Mild-Slope Equation （EEMSE） developed by Hsu et al. （2003）, was applied to study the Bragg reflection of water waves over a series of rectangular seabed. Three key parameters of the Bragg reflection including the peak coefficient of primary Bragg reflection, its corresponding relative wavelength, and the bandwidth, have shown to be effective in describing the characteristics of the primary Bragg reflection. The characteristics of the Bragg reflection were investigated under the various conditions comprising number, height, and spacing interval of a series of rectangular seabed. The results reveal that the peak of Bragg reflection increases with the increase of rectangular seabed height and number, the bandwidth and the shift value of the Bragg reflection depend on the increase of the rectangular seabed height as well as the decrease of rectangular seabed number, and the relative rectangular seabed spacing in the rang of 3 and 4 could produce higher Bragg reflection. Finally, a correlative and regressive analysis is performed by use of the calculated data. Based on the results of the analysis, empirical equations were established. Our study results can provide an appropriate choice of a series of rectangular seabed field for a practical design.

关键词： Bragg reflection mild-slope equation rectangular seabed bandwidth of the Bragg reflection rapidly varying component

Human hepatitis viruses-associated cutaneous and systemic vasculitis

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World Journal of Gastroenterology 2021年第1期27卷 19-36页

作者： Chrong-Reen Wang hung-Wen tsai Department of Internal Medicine National Cheng Kung University HospitalTainan 70403Taiwan Department of Pathology National Cheng Kung University HospitalTainan 70403Taiwan

Human hepatitis viruses(HHVs)include hepatitis A virus,hepatitis B virus(HBV),hepatitis C virus(HCV),hepatitis delta virus,and hepatitis E virus and can cause liver inflammation in their common human ***,HHV is rapidly cleared by the immune system,following acute HHV *** morbidities associated with hepatitis A virus and hepatitis E virus infection occur shortly after their intrusion,in the acute ***,the viral infectious process can persist for a long period of time,especially in HBV and HCV infection,leading to chronic hepatitis and further progressing to hepatic cirrhosis and liver *** infection brings about complications in other organs,and both acute and chronic hepatitis have been associated with clinical presentations outside the *** involvement with cutaneous and systemic vasculitis is a well-known extrahepatic presentation;moreover,there is growing evidence for a possible causal relationship between viral pathogens and *** for hepatitis delta virus,other HHVs have participated in the etiopathogenesis of cutaneous and systemic vasculitis via different mechanisms,including direct viral invasion of vascular endothelial cells,immune complex-mediated vessel wall damage,and autoimmune responses with stimulation of autoreactive B-cells and impaired regulatory *** vasculitis and polyarteritis nodosa are recognized for their association with chronic HHV *** therapeutic guidelines for HHV-associated vasculitis have not yet been established,antiviral therapy should be initiated in HBV and HCV-related systemic vasculitis in addition to the use of *** exchange and/or combined cyclophosphamide and corticosteroid therapy can be considered in patients with severe life-threatening vasculitis manifestations.

关键词： Human hepatitis viruses Hepatitis B virus Hepatitis C virus Cryogobulinemic vasculitis Polyarteritis nodosa Antiviral therapy

Autoimmune liver diseases in systemic rheumatic diseases

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World Journal of Gastroenterology 2022年第23期28卷 2527-2545页

Systemic rheumatic diseases(SRDs)are chronic,inflammatory,autoimmune disorders with the presence of autoantibodies that may affect any organ or *** dysfunction in SRDs can be associated with prescribed drugs,viral hepatitis,alternative hepatic comorbidities and coexisting autoimmune liver diseases(AILDs),requiring an exclusion of secondary conditions before considering liver *** patterns of overlap diseases depend predominantly on genetic determinants with common susceptible loci widely distributing in both *** AILDs,it is important to identify the overlapping SRDs at an early stage since such a coexistence may influence the disease course and *** co-occurring SRDs in AILDs are Sjögren syndrome(SS),rheumatoid arthritis(RA)or systemic lupus erythematosus(SLE)in autoimmune hepatitis(AIH),and SS,RA or systemic sclerosis in primary biliary *** to different disease complications and therapies,it is imperative to differentiate between SLE liver involvement and SLE-AIH overlap *** options can be personalized to control coexisting conditions of liver autoimmunity and rheumatic manifestations in AILD-SRD overlap *** collaboration between hepatologists and rheumatologists can lead to significant advances in managing such a complex *** this review,we provide a comprehensive overview on coexisting AILDs in different SRDs and the therapeutic approach in managing these overlap diseases.

关键词： Autoimmune liver disease Systemic rheumatic disease Overlap disease Liver function test Drug-induced liver injury Viral hepatitis

Immediate-release tofacitinib reduces insulin resistance in nondiabetic active rheumatoid arthritis patients:A single-center retrospective study

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World Journal of Diabetes 2022年第6期13卷 454-465页

BACKGROUND An increased risk of insulin resistance(IR)has been identified in rheumatoid arthritis(RA),a chronic inflammatory disorder with elevated levels of pathogenic *** targeting proinflammatory cytokines can control the disease and improve insulin sensitivity in *** Janus kinase(JAK)signaling can regulate cytokine receptors and participate in RA pathogenesis,it remains to be elucidated whether there is a reduction of IR in such patients under JAK inhibitor(JAKi)*** To study the effect of JAKi treatment on the reduction of IR in RA patients with active *** A retrospective study was carried out from April 1,2017 to March 31,2021 in a population of non-diabetic patients with active RA who were undergoing tofacitinib(TOF)therapy with 5 mg twice-daily immediate-release *** Fifty-six RA patients,aged 30 years to 75 years(mean±SD:52.3±11.1)with disease activity score 28 values ranging from 4.54 to 7.37(5.82±0.74),were classified into high-IR(>2.0)and low-IR(≤2.0)groups based on their baseline homeostatic model assessment(HOMA)-IR *** had no previous exposure to JAKi,and received TOF therapy for no less than 6 *** 30 patients who were naïve to biologics,after a 24-week therapeutic period,the high-IR group showed reduced HOMA-IR levels (3.331 ± 1.036 vs 2.292 ± 0.707, P < 0.001). In another 26patients who were exposed to tumor necrosis factor-α or interleukin-6 blockers, the high-IR group,despite having achieved a decrease but with lower magnitude than in naïve patients, showedreduced HOMA-IR levels (2.924 ± 0.790 vs 2.545 ± 1.080, P = 0.018).CONCLUSIONIn this retrospective study, reduced IR was achieved in non-diabetic active RA patients following24 wk of TOF therapy.

关键词： Insulin resistance Rheumatoid arthritis Diabetes mellitus Tofacitinib Janus kinase inhibitor

Anti-and non-tumor necrosis factor-α-targeted therapies effects on insulin resistance in rheumatoid arthritis,psoriatic arthritis and ankylosing spondylitis

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World Journal of Diabetes 2021年第3期12卷 238-260页

In addition toβ-cell failure with inadequate insulin secretion,the crucial mechanism leading to establishment of diabetes mellitus(DM)is the resistance of target cells to insulin,*** resistance(IR),indicating a requirement of beyond-normal insulin concentrations to maintain euglycemic status and an ineffective strength of transduction signaling from the receptor,downstream to the substrates of insulin *** is a common feature of most metabolic disorders,particularly type II DM as well as some cases of type I DM.A variety of human inammatory disorders with increased levels of proinflammatory cytokines,including tumor necrosis factor(TNF)-α,interleukin(IL)-6 and IL-1β,have been reported to be associated with an increased risk of *** arthritis conditions,including rheumatoid arthritis(RA),psoriatic arthritis(PsA)and ankylosing spondylitis(AS),with the involvement of proinflammatory cytokines as their central pathogenesis,have been demonstrated to be associated with IR,especially during the active disease *** is an increasing trend towards using biologic agents and small molecule-targeted drugs to treat such *** this review,we focus on the effects of anti-TNF-α-and non-TNF-α-targeted therapies on IR in patients with RA,PsA and ***-TNF-αtherapy,IL-1 blockade,IL-6 antagonist,Janus kinase inhibitor and phosphodiesterase type 4 blocker can reduce IR and improve diabetic hyper-glycemia in autoimmune-mediated arthritis.

关键词： Insulin resistance Diabetes mellitus Tumor necrosis factor-α-targeted therapy Non-tumor necrosis factor-α-targeted therapy Rheumatoid arthritis Psoriatic arthritis

Diffusion characteristics of HTO and 99TcO_4^- in compacted Gaomiaozi(GMZ) bentonite

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Nuclear Science and Techniques 2017年第5期28卷 60-67页

作者： Tsuey-Lin tsai Shih-Chin tsai Yu-hung Shih Liang-Cheng Chen Chuan-Pin Lee Te-Yen Su Chemistry Division Institute of Nuclear Energy ResearchNo. 1000 Wenhua Rd. Jiaan Village Longtan DistrictTaoyuan China Nuclear Science and Technology Development Center National Tsing Hua University Hsinchu China Department of Earth Sciences National Cheng Kung University No. 1 University Road Tainan China

The characteristics of diffusion are essential to the transport of radionuclides through buffer/backfill materials, such as bentonite, which are commonly found in waste repositories. This study used through-diffusion techniques to investigate the diffusion behavior of HTO and ^(99)TcO_4^- on GMZ bentonite of various densities. Diffusion rates were calculated by measuring the diffusion coefficients(De, Da), plotting breakthrough curves and interpreting experiment data. The apparent and effective diffusion coefficients of HTO ranged from(1.68 ± 0.40) 9 × 10^(-11) to(2.80 ± 0.62) 9 × 10^(-11) m^2/s and from(4.61 ±1.28) 9 × 10^(-12) to (16.2 ± 2.50) 9 × 10^(-12) m^2/s, *** apparent and effective diffusion coefficients of^(99)TcO_4^-ranged from(5.26 ± 0.16) 9 × 10^-12to(7.78 ± 0.43) 9× 10^-12m^2/s and from(1.49 ± 0.002) 9 × 10^(-12) to(4.16 ±0.07) 9 × 10^(-12) m^2/s, respectively. The distribution coefficients of HTO and^(99)TcO_4^-ranged from(0.70 ± 0.12) 9× 10^(-2) to(1.36 ± 0.53) 9 × 10^(-2) mL/g and from(1.12 ±0.06) 9 × 10^(-2) to(5.79 ± 2.22) 9 × 10^(-2) mL/g, *** Deand Kdvalues were shown to decrease with an increase in the bulk dry density of compacted bentonite. Our results show that HTO and ^(99)Tc could be considered nonsorbent radionuclides. The data obtained in this studyprovide a valuable reference for the safety assessment of waste repositories.

关键词： Distribution coefficient Apparent diffusion coefficient Effective diffusion coefficient Compacted bentonite Through-diffusion

Characterization of solid particles sampled from condensates in boiling water reactor

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Nuclear Science and Techniques 2016年第2期27卷 141-148页

作者： Yu-hung Shih Tung-Jen Wen Liang-Cheng Chen Tsuey-Lin tsai Chemistry Division Institute of Nuclear Energy Research

The growth, activation and deposition of corrosion products are the primary sources of radiation buildup on the surface of out-of-core piping in nuclear power plants. The buildup of radiation can have negative effects on the performance of the facility and cause harm to staff during maintenance outages for refueling. This paper reports on the crystalline and amorphous structures of corrosion products sampled in the boiling water reactors in nuclear power plants of Kuo-Sheng and identified using an acid dissolving technique. X-ray diffraction, scanning electron microprobe and inductively coupled plasmaatomic emission spectroscopy were used to analyze the samples. The results indicate that the quantity of amorphous iron oxide at inlet of the condensate demineralizer in Unit 2 is higher than that in Unit 1. The proportion of crystalline to amorphous corrosion products can affect the efficiency of removal. Thus, these results can be used to explain the difference in removal efficiency of condensate demineralizers in different units. Moreover, the iron oxide structures with various properties were observed in different operational periods. It is probable that the higher proportion of amorphous structures with a smaller particle size would reduce efficiency in the removal of condensate demineralization in Unit 2.

关键词：沸水反应堆电感耦合等离子体原子发射光谱法固体颗粒采样无定形结构表征凝聚腐蚀产物