检索结果-南通市图书馆

Experience on Treatment of Infantile Asthma by Acupuncture plus Herbal Medicine

在线全文

学校读者我要写书评

暂无评论

Journal of Acupuncture and Tuina Science 2013年第1期11卷 19-21页

作者： Yang Guo-xiu huang Guo-qi Department of Acupuncture Jiangsu Provincial Hospital of Traditional Chinese Medicine

Asflmla is commonly termed ＂roaring disease＂, referring to gurgling wilh slmtum in tile throat, characterized by difficult and rapid breaflling. Infantile asfluna belongs to a kind of ronchitis, and would occur repeatedly and become a chronic disease. Because the defending function of the respiratoo＇ systeln in children has not been complete and tile imnmne system of the respiratoD tract has not been matured, file hyperactive inflammatoxy reaction would happen, if stinmlated by inducing thctors of se alle.gen, infection or emotional depression, so as to develop dyspnea, increased secretion of phlegm, and spasm of bronclfial smooth nmscle, hindering the normal ventilation of air and resulting in asthma, manifested by the clinical symptolns of dyspnea, shortness of breath, unsmooth expectoration, and wheezing. In severe cases, patients may also present with cyanosis of the lips, facial puffiness and breathing an open mouth and raised shoulders. Before each seizure, SOlne indicating signs would occur in some patients with asthma, such as itching sensation in the nose, itching sensation in tile eyelids, sneezing, lacrimation, dry cough, and sore throat, etc., caused by infection of the respiratory tract. If induced by alle.to food, there are oen symptoms of vomiting, abdominal pain and urticaria. At this moment, tilt physical examinations should find pale and edema in nasal mucus, slight congestion in the tonsil, mad wheezing, and slight flatulence by abdominal percussion. At this moment, if propel treaUnent is given, the symptolns can be relieved. I treated infantile asthma patients according to flir seizure and remission phases. Now, the report is given as follows.

关键词： Acupuncture-moxibustion Therapy Acupuncture Medication Combined Cupping Therapy Asthma Child

How Will China Achieve Its Poverty alle.iation Targets?

在线全文

学校读者我要写书评

暂无评论

China Today 2018年第9期67卷 59-61页

作者： huang CHENGWEI the national publicity and education center for poverty alle.iation under the State Council Leading Group Office of Poverty alle.iation and Development

huang CHENGWEI is director of the national publicity and education center for poverty alle.viation under the State Council Leading Group Office of Poverty alle.iation and Development.

关键词： How Will China Achieve Its Poverty alle.iation Targets

Reversal of hyperglycemia by protein transduction of NeuroD in vivo

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2007年第8期28卷 1181-1188页

作者： Yin huang Jing CHEN Ge LI Tian-yue CHENG Ming-hong JIANG Shu-yu ZHANG Jun LU Shi YAN Wei-wei FAN Da-ru LU~1 State Key Laboratory of Genetic Engineering,Institute of Genetics,School of Life Science,Fudan University,Shanghai 200433,China State Key Laboratory of Genetic Engineering Institute of Genetics School of Life Science Fudan University Shanghai China

Aim:To test whether the neurogenic differentiation(NeuroD)protein could alle.viate symptoms of diabetes mellitus by its transduction activity in ***:Type 1 diabetes mellitus in mice was induced by ip(intraperitoneal)injection ofstreptozotocin(150 mg/kg).One group of diabetic mice were intravenouslyinjected with the NeuroD-EGFP(Enhanced Green Fluorescent Protein)(5 mg/kg,n=6)and the other group with EGFP(5 mg/kg,n=5).After the transduction ofNeuroD-EGFP,the distribution of the protein was examined by means of frozensection under fluorescent microscope *** conducted RT-PCR andReal-time quantitative PCR to measure the transcription levels of insulin *** was utilized to detect the insulin ***-noassay was conducted to determine the serum insulin *** glucoselevels and body weights were regularly recorded after the protein ***:The NeuroD protein can be transduced into cells in vivo with a highefficiency of nearly 100%.Insulin mRNA was highly expressed in NeuroD-treateddiabetic mice,38-fold higher than that of control group(Palle.viation of hyperglycemia after NeuroD administration(P<0.01,t-test,n=6).Conclusion:In vivo-transduced NeuroD in the small intestine remained function-ally active and could ameliorate the non-fasting glucose levels of streptozotocin-induced,diabetic mice by inducing enteric insulin expression.

关键词： neurogenic differentiation 1 type 1 diabetes mellitus intestines insulin

土地精准扶贫路径探索——以全生命周期为视角

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

教学与研究 2017年第11期 45-52页

作者：黄燕芬夏方舟中国人民大学公共管理学院

针对当前扶贫中往往面临扶贫主体差异显著、对接能力不足、普惠式扶贫政策瞄准困难,扶贫过程中资源传递内耗过大、资源边际效益递减、良性循环基础薄弱、返贫问题难以解决等诸多问题,本文在"人"和"物"全生命周期的视角下,以土地这一农... 详细信息

针对当前扶贫中往往面临扶贫主体差异显著、对接能力不足、普惠式扶贫政策瞄准困难,扶贫过程中资源传递内耗过大、资源边际效益递减、良性循环基础薄弱、返贫问题难以解决等诸多问题,本文在"人"和"物"全生命周期的视角下,以土地这一农民根本资源为研究对象,探究土地精准扶贫的可能路径与作用,以期为进一步促进瞄准扶贫工作对象、择优扶贫方式、稳健扶贫效果提供理论参考与实践建议。

关键词：精准扶贫全生命周期扶贫路径土地扶贫

在线全文

学校读者我要写书评

暂无评论

加强技术风险管理确保地铁工程建设安全

城乡建设 2005年第9期 8-9+4页

作者：黄卫

Todevelop urban rail transportation such as subway plays an important role in alle.viatingpublic transport pressure in mega- cities and promotingsound development of ur-ban economy and society. However, in China as well as other countries, due to the lackof necessary analysis and demonstration on potential technology risk, ignorance of theobjective law and mismanagement, grave economic loss occurred during subway con-struction as a result of varying degrees of engineering accidents. So far, the technologyrisk management duringsubwayconstruction has been attached great importance.

关键词：地铁建设项目地铁工程技术风险管理建设安全工程风险管理建设工程质量保险风险控制建设部

中国汉族人群ENPP1基因K121Q多态与2型糖尿病的关联及Meta分析

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

遗传 2010年第8期32卷 808-816页

作者：王敏彭婵屈亚莉黄青阳华中师范大学生命科学学院遗传调控与整合生物学湖北省重点实验室武汉430079 武汉医疗救治中心武汉430022

多个欧洲白人的Meta分析表明核苷酸焦磷酸酶1（Ectonucleotide pyrophosphatase/phosphodiesterase 1,ENPP1）基因K121Q多态与2型糖尿病相关联,但在日本人、韩国人和中国台湾人的研究中没有发现相关性,而在中国大陆人群中二者的关联研... 详细信息

多个欧洲白人的Meta分析表明核苷酸焦磷酸酶1（Ectonucleotide pyrophosphatase/phosphodiesterase 1,ENPP1）基因K121Q多态与2型糖尿病相关联,但在日本人、韩国人和中国台湾人的研究中没有发现相关性,而在中国大陆人群中二者的关联研究结果不尽一致。文章调查了湖北地区539例2型糖尿病患者和404名正常人ENPP1基因K121Q多态性。基因型及等位基因频率在病例组和对照组间没有显著差异（P〉0.05）,但经性别、年龄和体重指数调整后的Logistic回归分析揭示XQ基因型与2型糖尿病显著相关（OR=1.5,95%CI：1.39~1.62,P〈0.001）。对性别进行的亚组分析显示,女性病例组Q等位基因和XQ基因型的频率显著高于对照组（Q：12.4%vs.6.1%,P=0.001;XQ：23.7%vs.11.7%,P=0.001）。结果表明ENPP1基因K121Q多态与湖北汉族人2型糖尿病的关联存在性别差异,在女性中更明显。文章是对中国大陆人群进行的第一个Meta分析,结果显示Q等位基因增加2型糖尿病的发病风险（OR=1.42,P=0.042）。

关键词： ENPP1基因 K121Q 2型糖尿病多态性 Meta分析

LAC-DGLU:基于CNN和注意力机制的命名实体识别模型

在线全文

学校读者我要写书评

暂无评论

计算机科学 2020年第11期47卷 212-219页

作者：赵丰黄健张中杰国防科技大学智能科学学院长沙410073

对文本进行分词和词嵌入通常是中文命名实体识别的第一步,但中文的词与词之间没有明确的分界符,专业词及生僻词等未收录词(Out of Vocabulary,OOV)严重干扰了词向量的计算,基于词向量嵌入的模型性能极易受到分词效果的影响。同时现有模... 详细信息

对文本进行分词和词嵌入通常是中文命名实体识别的第一步,但中文的词与词之间没有明确的分界符,专业词及生僻词等未收录词(Out of Vocabulary,OOV)严重干扰了词向量的计算,基于词向量嵌入的模型性能极易受到分词效果的影响。同时现有模型大多使用循环神经网络,计算速度较慢,很难达到工业应用的要求。针对上述问题,构建了一个基于注意力机制和卷积神经网络的命名实体识别模型,即LAC-DGLU。针对分词依赖的问题,提出了一种基于局部注意力卷积(Local Attention Convolution,LAC)的字嵌入算法,减轻了模型对分词效果的依赖。针对计算速度较慢的问题,使用了一种带门结构的卷积神经网络,即膨胀门控线性单元(Dilated Gated Linear Unit,DGLU),提高了模型的计算速度。在多个数据集上的实验结果显示,该模型相比现有最优模型F1值提高了0.2%~2%,训练速度可以达到现有最优模型的1.4~1.9倍。

关键词：字嵌入局部注意力卷积膨胀卷积门控线性单元残差结构

Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2008年第5期35卷 267-271页

作者： Yu Zhang a, Xiaoping huang a, Jun Qi b, Cai Yan a, Xin Xu a, Yaling Han a, Mingrong Wang a, * a State Key Laboratory of Molecular Oncology, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China b Clinical Laboratory, Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China State Key Laboratory of Molecular Oncology Cancer Institute/Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100021 China Clinical Laboratory Cancer Institute/Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 100021 China

Androgen-induced proliferation shutoff gene AS3, also known as APRIN, is a growth inhibitory gene that is initially implicated in prostate cancer. This gene is required for androgen-dependent growth arrest and is a primary target for 1,25(OH)2D3 and androgens. alle. lic loss at AS3 locus has been linked to a variety of cancers. However, the correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma (ESCC) is not well established. In this study, the genomic and expression alterations of AS3 in ESCC and their clinical significance are evaluated. Loss of heterozygosity (LOH) analysis using an AS3 intragenic microsatellite marker D13S171 revealed 72% alle.ic loss at AS3 locus in ESCC, which is significantly correlated with higher pathological grade (P=0.042). RT-PCR examination showed that AS3 mRNA obviously decreased in 44% tumors and its down-regulation was correlated with the sex of patients (P=0.03). Furthermore, the correlation between genomic and expression alterations of AS3 gene was analyzed in 18 ESCC specimens, which indicated that the consistency between alle.ic loss and decreased mRNA expression of AS3 was relatively poor. The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC.

关键词： esophageal squamous cell carcinoma AS3/APRIN loss of heterozygosity down-regulation hormone

阿片类物质依赖损伤的Wnt/β-Catenin通路异常及戒毒药物的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

海南医学院学报 2015年第10期21卷 1425-1427页

作者：徐世超黄鹏广州市脑科医院(广州市惠爱医院广州市医科大学附属脑科医院) 广东广州510370

目的:本研究对阿片类物质依赖损伤的Wnt/β-Catenin通路异常及戒毒药物的影响进行研究,为相关临床治疗提供参考。方法:本文对本院收治的80例阿片类物质依赖的患者进行分析,比较患者治疗前和采用戒毒药物美沙酮治疗后患者Wnt/β-Catenin... 详细信息

目的:本研究对阿片类物质依赖损伤的Wnt/β-Catenin通路异常及戒毒药物的影响进行研究,为相关临床治疗提供参考。方法:本文对本院收治的80例阿片类物质依赖的患者进行分析,比较患者治疗前和采用戒毒药物美沙酮治疗后患者Wnt/β-Catenin通路关键蛋白及TNFα和IL2/4的表达,以同期健康体检者为对照组。结果:阿片类物质依赖性患者Wnt4和β-Catenin及TNFα和IL2/4蛋白表达明显高于健康体检者,美沙酮药物治疗后上述异常蛋白表达得到明显恢复。结论:阿片类物质损伤机体主要通过激活Wnt/β-Catenin通路、上调TNFα和IL2/4蛋白实现,美沙酮主要通过抑制上述蛋白的异常表达减轻机体损伤。

关键词：阿片类物质美沙酮 Wnt/β-Catenin通路戒毒药物