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Cigarette smoking and alcohol drinking and esophageal cancer risk in Taiwan Residents women

World Journal of Gastroenterology 2010年第12期16卷 1518-1521页

作者： I-Chen Wu Deng-Chyang Wu hung-ju su Hui-Jen Tsai Chien-Yu Lu Jang-Ming Lee Ming-Tsang Wu Division of Gastroenterology Department of Internal MedicineKaohsiung Medical University Hospital Faculty of Medicine College of MedicineKaohsiung Medical University Biomedical Engineering Research Laboratories Industrial Technology Research Institute Division of Hematology and Oncology Department of Internal MedicineKaohsiung Medical University Hospital Department of surgery National Taiwan University Hospital Department of Family Medicine Kaohsiung Medical University Hospital Graduate Institute of Occupational Safety & Health Kaohsiung Medical University

AIM:To investigate the etiology of esophageal cancer among Taiwan Residents ***:This is a multi-center,hospital-based,case-control *** patients consisted of women who were newly diagnosed and pathology-proven to have esophageal squamous cell carcinoma(ESCC) from three large medical centers(one from Northern and two from Southern Taiwan,respectively)between August 2000 and December *** ESCC patient was matched with 4 healthy women based on age(within 3 years)and hospital of origin,from the Department of Preventive Medicine in each hospital.A total of 51 case patients and 204 controls,all women,were ***:Frequencies of smokers and drinkers among ESCC patients were 19.6%and 21.6%,respectively,which were significantly higher than smokers(4.4%) and drinkers(4.4%)among controls(OR=4.07,95%CI:1.36-12.16,P=0.01;OR=3.55,95%CI:1.03-12.27,P=0.04).Women who drank an amount of alcohol more than 158 g per week had a 20.58-fold greater risk(95%CI:1.72-245.62,P=0.02)of ESCC than those who never drank alcohol after adjusting for other covariates,although the sample size was ***:Cigarette smoking and alcohol drinking,especially heavy drinking,are the major risks for developing ESCC in Taiwan Residents women.

关键词： Esophageal squamous cell carcinoma Taiwan Residents women Cigarette smoking Alcohol drinking

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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High cycle fatigue performance at 650℃and corresponding fracture behaviors of GH4169 joint produced by linear friction welding

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Chinese Journal of Aeronautics 2025年第1期38卷 622-637页

作者： Shitong MA Xiawei YANG Zhenguo GUO Yu su Xinyuan HE ju LI jun TAO Bo XIAO Wenya LI State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Friction Welding TechnologiesSchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Aeronautical Key Laboratory for Welding and Joining Technologies AVIC Manufacturing Technology InstituteBeijing 100024China Department of Mechanical Engineering City University of HongKongHongKongChina

GH4169 joints manufactured by Linear Friction Welding(LFW)are subjected to tensile test and stair-case method to evaluate the High Cycle Fatigue(HCF)performance at 650℃.The yield and ultimate tensile strengths are 582 MPa and 820 MPa,*** HCF strength of joint reaches 400 MPa,which is slightly lower than that of Base Metal(BM),indicating reliable quality of this type of *** microstructure observation results show that all cracks initiate at the inside of specimens and transfer into deeper region with decrease of external stress,and the crack initiation site is related with microhardness of *** Electron Backscattered Diffraction(EBSD)results of the observed regions with different distances to fracture show that plastic deformation plays a key role in HCF,and the Schmid factor of most grains near fracture exceeds *** addition,the generation of twins plays a vital role in strain concentration release and coordinating plastic deformation among grains.

关键词： High cycle fatigue GH4169 superalloy Linear friction welding Fracture mechanism Microstructure evolution

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珊瑚来源潜在降解对甲氧基肉桂酸辛酯的细菌物种多样性

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热带海洋学报 2025年第1期44卷 133-145页

作者：黄沁愉吕丽娜李洁琚慧敏苏宏飞广西大学海洋学院广西南宁530004 中国科学院热带海洋生物资源与生态重点实验室中国科学院南海海洋研究所广东广州510301

对甲氧基肉桂酸辛酯(2-ethylhexyl-4-methoxycinnamic acid, EHMC)是国内防晒产品中最常见的有机紫外吸收剂成分,随人类活动汇入海洋并在珊瑚组织内积累,加速珊瑚白化。微生物降解法是去除珊瑚EHMC污染的有效手段之一,然而目前珊瑚的EHM... 详细信息

对甲氧基肉桂酸辛酯(2-ethylhexyl-4-methoxycinnamic acid, EHMC)是国内防晒产品中最常见的有机紫外吸收剂成分,随人类活动汇入海洋并在珊瑚组织内积累,加速珊瑚白化。微生物降解法是去除珊瑚EHMC污染的有效手段之一,然而目前珊瑚的EHMC降解细菌资源及EHMC对珊瑚微生物群落的影响仍知之甚少。本文选择三亚鹿回头近岸海域珊瑚为研究对象,开展EHMC降解菌多样性研究。首先,以EHMC为唯一碳源对珊瑚组织样品进行多次富集,获得EHMC的耐受菌群,利用高通量测序技术,分析富集菌群组成和多样性;同时通过细菌的分离鉴定和功能验证,筛选出潜在的EHMC降解菌株。16S rRNA基因高通量测序结果显示,在EHMC胁迫下,滨珊瑚(Poriteslutea)、角蜂巢珊瑚(Favositessp.)和鹿角珊瑚(Acropora sp.)三个样品的细菌群落多样性下降。从属水平上看,壤霉菌属(Agromyces)、副球菌属(Paracoccus)、Pelagibaca属和赤杆菌属(Erythrobacter)等细菌在原始珊瑚中占比极低,经EHMC多次富集后成为优势菌属。通过纯化培养,EHMC富集样品共分离出60株可培养细菌。16S r RNA基因鉴定结果显示,60株细菌分别归属于3个门、3个纲、6个目、8个科、13个属和17个种。可培细菌的优势菌属主要为芽孢杆菌属(Bacillus),其次是红球菌属(Rhodococcus),副球菌属,微小杆菌属(Exiguobacterium)和尖球菌属(Acuticoccus)。经对单个纯培养菌株的活性筛选,最终筛选出8株潜在EHMC降解菌株,分别归属于芽孢杆菌属、短波单胞菌属(Brevundimonas)、副球菌属、尖球菌属、Phycicoccus属、红球菌属和分枝杆菌属(Mycolicibacterium)。前人研究表明,红球菌属、芽孢杆菌属和副球菌属等细菌与芳香族化合物的生物降解相关。本研究分析了EHMC污染对珊瑚细菌群落的影响,并分离出潜在的EHMC降解细菌,为珊瑚抵御有机紫外吸收剂污染提供有用信息,也为后续构建珊瑚益生微生物组减轻珊瑚礁有机污染积累了宝贵的菌种资源。

关键词：珊瑚对甲氧基肉桂酸辛酯菌群多样性微生物降解

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Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance

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JOURNAL OF ADVANCED CERAMICS 2025年第1期14卷 163-176页

作者： Shin, Yu-Bin Ham, su Been Kim, Ha-Neul Kim, Mi-ju Ko, Jae-Woong Lee, Jae-Wook Park, Young-Jo Kim, jung-Hyung Lee, Hyo-Chang jung, Young Hwa Lee, jung Woo Ma, Ho Jin Korea Inst Mat Sci Nano Mat Res Div Chang Won 51508 Gyeongsangnam South Korea Pusan Natl Univ Dept Mat Sci & Engn Pusan 46241 South Korea Korea Res Inst Stand & Sci Semicond Integrated Metrol Team Daejeon 34113 South Korea Korea Aerosp Univ Dept Semicond Sci Engn & Technol Goyang 10540 South Korea Korea Aerosp Univ Sch Elect & Informat Engn Goyang 10540 South Korea Pohang Accelerator Lab PLS II Beamline Div Pohang 37673 South Korea

High-entropy ceramics exhibit novel intrinsic properties. Hence, they have been explored for a wide range of applications ranging from thermal insulation and energy storage to advanced optical components. Recently, the semiconductor industry has faced a demand for higher-performance chips, necessitating higher aspect ratios in wafer fabrication and further miniaturization of linewidths. Therefore, novel materials with high plasma etching resistance and minimal contaminant generation are needed. The plasma-etching resistance displayed by high-entropy ceramics can be an innovative solution to this emerging challenge. In this study, we successfully fabricated single-phase high-entropy sesquioxide ceramics with high optical transparency, dense microstructure, and minimal residual pores. A structural analysis of the fabricated samples revealed a single-phase structure with excellent phase homogeneity. An evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant materials. These comprehensive characterizations of high-entropy ceramics indicate that they are promising candidates for significantly improving the production yield of semiconductors and for a wide range of potential applications, such as next-generation active optical ceramics.

关键词： high-entropy ceramics plasma etching resistance transparent ceramics sintering semiconductor manufacturing

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多种摩擦形式的齿轮油抗微点蚀性能评价

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摩擦学学报 2025年第1期45卷 81-90页

作者：苏桐鞠超赵勤郑东东郭峰王晓波青岛理工大学机械与汽车工程学院中国科学院兰州化学物理研究所固体润滑国家重点实验室徐州工程学院材料与化学工程学院

为高效研究齿轮油及添加剂对齿面微点蚀影响规律，降低研究初期抗微点蚀齿轮油开发的成本，采用四球试验机、往复摩擦试验机(SRV)及滑滚摩擦试验机(MPR)考察了PAO基础油、由市售高性能复合剂调和的齿轮油以及由通用齿轮油复合剂调和的... 详细信息

为高效研究齿轮油及添加剂对齿面微点蚀影响规律，降低研究初期抗微点蚀齿轮油开发的成本，采用四球试验机、往复摩擦试验机(SRV)及滑滚摩擦试验机(MPR)考察了PAO基础油、由市售高性能复合剂调和的齿轮油以及由通用齿轮油复合剂调和的齿轮油的摩擦学行为与抗微点蚀性能的对应性，并分析MPR试验后辊子表面3种齿轮油对微点蚀造成的影响.试验结果表明：四球机法未能凸显不同添加剂之间的微点蚀差异，SRV试验机在低频重载条件下的摩擦测试结果与3种齿轮油的实际应用中抗微点蚀性能保持一致.此外，MPR滑滚摩擦试验结合辊子表面形貌及元素分析能够有效地区分不同齿轮油的抗微点蚀性能，其中基础油由于较差的润滑，对摩擦副表面起到机械抛光作用使微点蚀面积仅为1.36%，高性能复合剂的添加导致了1.45%的微点蚀面积，优于通用复合剂作用下4.67%的结果，这是由于表面形成了含硼化合物保护膜.对此本文中提出了采用SRV初步评价与MPR相结合的经济高效抗微点蚀性能评价手段.

关键词：齿轮油微点蚀摩擦学性能

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On Two-stage Estimate Based on Independent Estimate of Covariance Matrix

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Acta Mathematica Sinica,English Series 2006年第1期22卷 283-288页

作者： su ju YIN Song Gui WANG College of Applied Sciences Beijing University of Technology Beijing 100022 P. R. China

When an independent estimate of covariance matrix is available, we often prefer two-stage estimate （TSE）. Expressions of exact covarianee matrix of the TSE obtained by using all and some covariables in eovariance adjustment approach are given, and a necessary and sufficient condition for the TSE to be superior to the least square estimate and related large sample test is also established. Furthermore the TSE, by using some covariables, is expressed as weighted least square estimate. Basing on this fact, a necessary and sufficient condition for the TSE by using some covariables to be superior to the TSE by using all eovariables is obtained. These results give us some insight into the selection of covariables in the TSE and its application.

关键词： two-stage estimate covariance adjusted estimate canonical correlation coefficients

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新质生产力引领现代海洋城市高质量发展研究

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北方论丛 2025年第1期 119-128页

作者：王举颖苏慧怡中国海洋大学管理学院青岛266100

新质生产力是推动现代海洋城市高质量发展的关键动力。本研究聚焦于新质生产力对现代海洋城市高质量发展的推动作用,通过扎根理论方法明确了创新驱动发展、产业转型升级、深化改革创新、区域协同发展和绿色生态发展五大核心要素及其相... 详细信息

新质生产力是推动现代海洋城市高质量发展的关键动力。本研究聚焦于新质生产力对现代海洋城市高质量发展的推动作用,通过扎根理论方法明确了创新驱动发展、产业转型升级、深化改革创新、区域协同发展和绿色生态发展五大核心要素及其相互作用,深入分析了新质生产力通过高科技赋能、高水平支撑和高效能变革三大特征,有效促进了海洋城市的动能转换和形态升级,构建了新质生产力引领海洋城市高质量发展的理论模型,提出了数智化赋能海洋科技创新驱动发展、海洋产业转型升级与协同体系构建等五大策略建议,为相关政策制定与实践提供了科学依据。

关键词：新质生产力现代海洋城市高质量发展扎根理论

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Bayesian Estimation and Model Selection for the Spatiotemporal Autoregressive Model with Autoregressive Conditional Heteroscedasticity Errors

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Acta Mathematicae Applicatae Sinica 2023年第4期39卷 972-989页

作者： Bing su Fu-kang ZHU ju HUANG Department of Statistics&Actuarial Science University of Hong KongHong Kong 999077China School of Mathematics Jilin UniversityChangchun 130012China National Energy Administration Information Center Beijing 100045China

The spatial and spatiotemporal autoregressive conditional heteroscedasticity(STARCH) models receive increasing attention. In this paper, we introduce a spatiotemporal autoregressive(STAR) model with STARCH errors, which can capture the spatiotemporal dependence in mean and variance simultaneously. The Bayesian estimation and model selection are considered for our model. By Monte Carlo simulations, it is shown that the Bayesian estimator performs better than the corresponding maximum-likelihood estimator, and the Bayesian model selection can select out the true model in most times. Finally, two empirical examples are given to illustrate the superiority of our models in fitting those data.

关键词： autoregressive conditional heteroscedasticity model Bayesian estimation model selection spatial ARCH model spatial panel model spatiotemporal model

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Altered 3D genome reorganization mediates precocious myeloid differentiation of aged hematopoietic stem cells in inflammation

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Science China Life Sciences 2025年

作者： Xinyu Cui Yu Dong Qiang Zhan Yixin Huang Qianshu Zhu Zihao Zhang Guang Yang Liping Wang Shijun Shen Jia Zhao Zhiyi Lin Jiatong sun Zhongqu su Yihan Xiao Chuyu Zhang Yuwei Liang Lu Shen Lichen Ji Xuguang Zhang Jiqing Yin Hong Wang Zhiyang Chen Zhenyu ju Cizhong Jiang Rongrong Le Shaorong Gao Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital Frontier Science Center for Stem Cells School of Life Sciences and Technology Tongji University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education Orthopaedic Department of Tongji Hospital School of Life Sciences and Technology Tongji University Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Aging and Regenerative Medicine Department of Developmental & Regenerative Medicine College of Life Science and Technology Jinan University Shandong Key Laboratory of Animal Bioengineering and Disease Prevention College of Animal Science and Technology Shandong Agricultural University Department of Joint surgery Shanghai East Hospital Tongji University School of Medicine Shanghai Institute of Nutrition and Health Chinese Academy of Sciences

Inflammation is a driving force of hematopoietic stem cells(HSCs) aging, causing irreversible exhaustion of functional HSCs. However, the underlying mechanism of HSCs erosion by inflammatory insult remains poorly understood. Here, we find that transient LPS exposure primes aged HSCs to undergo accelerated differentiation at the expense of self-renewal, leading to depletion of HSCs. Meanwhile, the central regulator nuclear factor kappa B(NF-κB) mediating functional impairment by inflammation insult induces differential transcriptional response in aged HSCs compared with young HSCs, with precocious activation of myeloid lineage genes. Altered compartmentalization and chromatin loop formation are associated with aging-related differential transcriptional response in HSCs upon lipopolysaccharide(LPS)stimulation. Mechanistically, enhancer and promoter regions of myeloid lineage genes in aged HSCs are more accessible and display more rapid and prominent CTCF occupancy upon LPS stimulation. Our study provides comprehensive resources for the three-dimensional(3D)genome structure of HSCs and sheds light into the ordered genome organization and the associated transcriptome signature underlying HSCs aging.

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