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Intraperitoneal metastasis of hepatocellular carcinoma after spontaneous rupture:A case report

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World Journal of Gastroenterology 2008年第24期14卷 3927-3931页

作者： Yueh-Tsung Lee Chih-hung Hsu Dev-Aur chou Department of Surgery Chang Bing Show-Chwan Memorial Hospital

Rupture of hepatocellular carcinoma (HCC) is a life-threatening complication. Peritoneal metastasis of HCC after spontaneous rupture was seldom noted. We report a case of intraperitoneal metastasis of HCC after spon-taneous rupture. A previously asymptomatic 72-year-old man was admitted due to dull abdominal pain with abdominal fullness. He had a history of HCC rupture 10 mo ago and transarterial embolization was performed at that time. Abdominal computer tomograghy (CT) scan showed a huge peritoneal mass over the right up-per quadrant area. Surgical resection was arranged and subsequent microscopic examination conf irmed a diag-nosis of moderately-differentiated HCC.

关键词： Hepatocellular carcinoma Spontaneousrupture Peritoneal metastasis

Glucose Oxidase/Polypyrrole Biosensor Fabricated by Galvanostatic Electropolymerization Accompanied with a Potential Jumping

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稀有金属材料与工程 2006年第A3期35卷 277-281页

作者： Yuh-Ming Uangl hung-Te Chung Tse-Chuan chou Department of Chemical Engineering WuFeng Institute of TechnologyChiayiTaiwan62153China Dpartment of Chemical Engineering National Cheng Kung UniversityTainanTaiwan70101China

A galvanostatic glucose oxidase (GOD_x)/polypyrrole (Ppy) biosensor fabricated through a potential jumping process was *** spite of the instantaneous voltage jumping from 0.95 V to 1.7 V versus Ag/AgCl in the galvanostatic polymerization of pyrrole with commercial GOD_x,this GOD_x enzyme still could be successfully bundled with polypyrrole (Ppy).And,the results also confirmed that this glucose sensor not only possessed of better sensitivity to glucose than that fabricated from potentiometry or mild voltage elevating galvanometry for the similar preparing conditions but also exhibited two-week long-term ***,the kinetic data of Michalis constant (K_m) and Maximum current (I_m) for the optimized sensor were *** discovery this electro-modification process may disclose a novel method for fabricating the other enzyme biosensors.

关键词： conformation conducting galvanostatic dentritic jumping

面向核事故应急处置的遥操作系统设计与实验研究

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系统工程与电子技术 2024年第5期46卷 1607-1618页

作者：李航侯彦朋丑武胜孟令达北京航空航天大学机械工程及自动化学院北京100191

针对核事故现场的物理屏蔽严重、应急处置作业条件复杂、作业对象不明确等特点,研究并设计了一款基于动态自组网的机器人遥操作系统。在自组织网络实时Mesh保持良好通讯的情况下,利用叠加在真实回传视频中的虚拟模型,提出一种基于空间... 详细信息

针对核事故现场的物理屏蔽严重、应急处置作业条件复杂、作业对象不明确等特点,研究并设计了一款基于动态自组网的机器人遥操作系统。在自组织网络实时Mesh保持良好通讯的情况下,利用叠加在真实回传视频中的虚拟模型,提出一种基于空间梯度的人工势场力觉引导算法。操作者可通过观察视觉交互系统中模型的变化和感受施加在自研主手的引导力,提高时延条件下的操作效率和临场感。实验表明,核辐射条件下遥操作系统130 m的通讯时延在30 ms以下,可满足视频传输的带宽要求。力觉引导下的物体避障抓取实验验证了算法的可行性和遥操作系统的工程实用性。因此,本文设计的基于动态自组网的机器人遥操作系统,可使操作者以更加直观自然的方式参与到遥操作系统中,有效提高操作员完成复杂遥操作任务的安全性和操作性能。

关键词：核事故遥操作系统自组织网络力觉引导临场感

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Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis

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World Journal of Gastroenterology 2012年第5期18卷 466-471页

作者： Yang-Yuan Chen Hsu-Heng yen Kun-Ching chou Shun-Sheng Wu Department of Gastroenterology ChinaMedical University Hospital China Medical University Taic-hung 40000 Taiwan China Depart-ment of Gastroenterology Changhua Christian Medical CenterChanghua 50000 Taiwan China

AIM： To evaluate the efficacy of thalidomide in com- bination with other therapies to treat patients with ad- vanced hepatocellular carcinoma （HCC）. METHODS： We performed a retrospective analysis of all patients with HCC who were treated with thalido- mide for at least two months. The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed. Image studies performed before and after treatment, tumor response, overall survival, and the decrease in o-fetoprotein （AFP） levels were evaluated. RESULTS： A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide. The patient population consisted of 9 women and 44 men with a median age of 61 years. Thirty patients （56.6%） were classified as Child-Pugh A, and 12 patients （22.6%） were classified as Child-Pugh B. Twenty-six patients had portal vein thrombosis （49.1%）, and 25 patients had extrahepatic metastasis （47.1%）. The median duration of thalidomide treatment was 6.0 mo. Six of the 53 patients achieved a confirmed response （11.3%）, one achieved a complete response （1.9%） and 5 achieved a partial response （9.4%）. The disease control rate （CR ＋ PR ＋ SD） was 28.3% （95% CI： 17.8-42.4）, and the median overall survival rate was 10.5 too. The 1- and 2-year survival rates were 45% and 20%, respectively. Only one complete response patient showed an im- proved overall survival rate of 66.8 mo. Sixteen patients （30.2%） showed more than a 50% decrease in their serum AFP levels from baseline, indicating a better re- sponse rate （31.3%）, disease control rate （43.8%）, and overall survival time （20.7 mo）. The therapy was well tolerated, and no significant toxicities were observed. CONCLUSION： Thalidomide was found to be safe for advanced HCC patients, demonstrating anti-tumor ac- tivity including response, survival, and AFP decreases of greater than 50% from baseline.

关键词： Thalidomide Hepatocellular carcinoma

Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

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Chinese Journal of Cancer Research 2017年第3期29卷 172-178页

作者： Pei-hung Chang Cheng-Hsu Wang Eric yen-Chao Chen Shih-Wei Yang Wen-Chi chou Jason Chia-Hsun Hsieh Feng-Che Kuan Kun-Yun Yeh Division of Hemato-oncology Department of Internal MedicineChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445 TaiwanChina Cancer Center Chang Gung Memorial HospitalKeelung 20445TaiwanChina Department of Radiation Oncology Chang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Otolaryngology Head and Neck SurgeryChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Division of Medical Oncology Department of Internal MedicineChang Gung Memorial Hospital at LinkouTaoyuan 33305TaiwanChina Department of Hematology and Oncology Department of MedicineChang-Gung Memorial HospitalChiayi 61363TaiwanChina

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

关键词： Glasgow prognostic score (GPS) head and neck cancer chemoradiation inflammation cachexia nutrition

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“印太战略”视域下美国太平洋岛国政策论析

亚太经济 2024年第1期 108-119页

作者：丑则静郭晓萱国际关系学院国际政治系北京100091 南开大学周恩来政府管理学院天津300350

美国“印太战略”出台与全面强化后,太平洋岛国的战略价值被不断抬升。美国从安全、经济与意识形态多领域系统加强了对太平洋岛国的争夺,其政策体系趋于完善。在大国竞争回归背景下,中国在太平洋岛国地区的存在与影响力上升引发了美国... 详细信息

美国“印太战略”出台与全面强化后,太平洋岛国的战略价值被不断抬升。美国从安全、经济与意识形态多领域系统加强了对太平洋岛国的争夺,其政策体系趋于完善。在大国竞争回归背景下,中国在太平洋岛国地区的存在与影响力上升引发了美国等西方发达国家的战略焦虑,美国正将太平洋岛国视作“印太战略”与对华战略竞争的重点推进地区。然而,在“竞赢”中国、霸权护持战略目标支配下的美国太平洋岛国政策,表现出对地区和平稳定、发展繁荣及应对气候变化等核心关切的漠视,在导致太平洋岛国地区阵营化、大国竞争化与意识形态化风险上升的同时,其政策限度不断显现。

关键词： “印太战略” 美国太平洋岛国政策政策限度

端部嵌贴CFRP板加固钢筋混凝土结构的斜嵌段粘结性能试验

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复合材料学报 2024年第2期41卷 871-883页

作者：娄逸群彭晖兰川云丑佳璇长沙理工大学桥梁工程安全控制教育部重点实验室长沙410114 长沙理工大学土木工程学院长沙410114

端部嵌贴预应力碳纤维增强复合材料(CFRP)板加固混凝土结构是一种高效经济的新型混凝土结构加固方法,端部嵌贴段的CFRP与混凝土的粘结性能是锚固预应力CFRP、确保加固效果充分发挥的关键因素。为确定端部嵌贴段中斜向嵌贴段CFRP-混凝土... 详细信息

端部嵌贴预应力碳纤维增强复合材料(CFRP)板加固混凝土结构是一种高效经济的新型混凝土结构加固方法,端部嵌贴段的CFRP与混凝土的粘结性能是锚固预应力CFRP、确保加固效果充分发挥的关键因素。为确定端部嵌贴段中斜向嵌贴段CFRP-混凝土的界面粘结性能,本文开展9个单剪拔出试验,研究了斜嵌段的粘结性能。通过设计混凝土棱柱试件,研究了斜槽角度、CFRP板埋深、CFRP板粘结长度对斜向嵌贴界面粘结性能的影响,并基于试验结果构建了CFRP板-混凝土局部界面的粘结-滑移关系模型。试验结果表明:随斜槽角度增大,试件的承载力及CFRP-混凝土局部界面断裂能也在逐渐增大。CFRP-混凝土界面粘结性能随CFRP埋深比增加而明显增加,并在埋深比为50%时达到最大,此后不再明显变化。基于试验结果所建立的粘结-滑移模型能较准确地模拟出CFRP板在混凝土斜槽中的受力过程。

关键词：端部嵌贴 CFRP 单剪拔出粘结性能粘结-滑移本构关系

Application of a wire-guided side-viewing duodenoscope in total esophagectomy with colonic interposition

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World Journal of Gastroenterology 2011年第13期17卷 1787-1790页

作者： Chin-Yuan Yii Jen-Wei chou yen-Chun Peng Wai-Keung Chow Division of Gastroenterology and Hepatology Department of Internal Medi- cine China Medical University Hospital Taichung 40447 Taiwan China Division of Gastroenterology and Hepatology Department of Internal Medicine Taichung Veterans General Hospital Taichung 40447 Taiwan China

Therapeutic endoscopic retrograde cholangiopancreatography (ERCP) is the mainstay treatment for bile duct disease. The procedure is difficult per se, especially when a side-viewing duodenoscope is used, and when the patient has altered anatomical features, such as colonic interposition. Currently, there is no consensus on the standard approach for therapeutic ERCP in patients with total esophagectomy and colonic interposition. We describe a novel treatment design that involves the use of a side-viewing duodenoscope to perform therapeutic ERCP in patients with total esophagectomy and colonic interposition. A gastroscope was initially introduced into the interposed colon and a radio-opaque standard guidewire was advanced to a distance beyond the papilla of Vater, before the gastroscope was withdrawn. A sideviewing duodenoscope was then introduced along the guidewire under fluoroscopic guidance. After cannulation into the papilla of Vater, endoscopic retrograde chol-angiography (ERC) revealed a filling defect (maximum diameter: 15 cm) at the distal portion of the common bile duct (CBD). This defect was determined to be a stone, which was successfully retrieved by a Dormia basket after complete sphincterotomy. With this treatment design, it is possible to perform therapeutic ERCP in patients with colonic interposition, thereby precluding the need for percutaneous drainage or surgery.

关键词： Wire-guided Duodenoscope Endoscopic retrograde cholangiopancreatography Esophagectomy Interposition of colon

Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor

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Cancer Communications 2018年第1期38卷 393-399页

作者： Ling-Wei Wang yen-Wan Hsueh Liu Fong-In chou Shiang-Huei Jiang Department of Oncology Taipei Veterans General HospitalNo.201Section 2Shih-Pai RoadTaipei 11217TaiwanChina School of Medicine National Yang Ming UniversityTaipei 11217TaiwanChina Institute of Nuclear Engineering and Science National Tsing Hua UniversityHsin-ChuTaiwanChina Nuclear Science and Technology Development Center National Tsing Hua UniversityHsin-ChuTaiwanChina

Head and neck(HN)cancer is an endemic disease in Taiwan,*** recurrent HN cancer after full-dose irradia-tion poses a therapeutic challenge,and boron neutron capture therapy(BNCT)may be a solution that could provide durable local control with tolerable *** Tsing-Hua Open Pool Reactor(THOR)at National Tsing-Hua University in Hsin-Chu,provides a high-quality epithermal neutron source for basic and clinical BNCT *** first clinical trial,entitled“A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR”,was carried out between 2010 and 2013.A total of 17 patients with 23 recurrent HN tumors who had received high-dose photon irradiation were enrolled in the *** fructose complex of l-boronophenylalanine was used as a boron carrier,and a two-fraction BNCT treatment regimen at 28-day intervals was used for each *** was acceptable,and although the response rate was high(12/17),re-recurrence within or near the radiation site was *** obtain better local control,another clinical trial entitled“A phase I/II trial of boron neutron capture therapy combined with image-guided intensity-modulated radiotherapy(IG-IMRT)for locally recurrent HN cancer”was initiated in *** first administration of BNCT was performed according to our previous protocol,and IG-IMRT was initiated 28 days after *** of May 2017,seven patients have been treated with this *** treatment-related toxicity was similar to that previously observed with two BNCT *** patients had a complete response,but locoregional recurrence was the major cause of failure despite initially good *** clinical trials combining BNCT with other local or systemic treatments will be carried out for recurrent HN cancer patients at THOR.

关键词： Head and neck cancer Boron neutron capture therapy Tsing-Hua Open Pool Reactor Boronophenylalanine