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Cellular & Molecular Immunology 2019年第12期16卷 943-945页

作者： Peng Zhang hung-yen chou Lei Young Pan Zheng Yang Liu Division of Immunotherapy Institute of Human VirologyUniversity of Maryland School of MedicineBaltimoreMD 21201USA The Institute for Biomedical Sciences The George Washington UniversityWashingtonDC 20037USA Center for Cancer and Immunology Research Children’s Research InstituteChildren’s National Health SystemWashingtonDC 20010USA OncoImmune IncRockvilleMD 20852USA

TO THE EDITOR:Characterization of the tumor-infiltrating B cell immunoglobulin(Ig)repertoire is critical to understanding B cell immunity in tumors and developing monoclonal antibody ***,the generation of specific antibodies for cancer therapy1,2 is a major endeavor,involving a lengthy process of antigen identification,immunization,hybridoma production and,in most cases,antibody *** a radical departure from the conventional approach,we hereby describe a rapid and potentially en masse identification of cancer-specific antibodies directly from human cancer tissues by de novo assembly from transcriptome and genome *** integrated computational framework was developed and successfully tested for antibody discovery by mining 1945 solid tumor RNA-sequencing-based samples for abundant Ig CDR3 sequences among the TCGA database of glioblastoma multiforme(GBM),lower grade glioma(LGG),lung adenocarcinoma(LUAD),lung squamous carcinoma(LUSC),pancreatic adenocarcinoma(PAAD),and skin cutaneous melanoma(SKCM).

关键词： monoclonal antibodies cancer

Study on the Carbon Nanotube Separative Structure for the Extended Gate H^+-Ion Sensitive Field Effect Transistor

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稀有金属材料与工程 2006年第A3期35卷 225-227页

作者： Yi-hung Liao Jung-Chuan chou Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyDouliouYunlinTaiwan 640China

We use the carbon nanotube (CNT) as the material of the pH sensing layer of the separative structure for the extended gate H^+-ion sensitive field effect transistor (EGFET) *** CNT paste was prepared with CNT powder,Ag powder,silicagel,the di-n-butyl phthalate and the toluene solvents by appropriate ratio,then immobilized on the silicon substrate to form the carbon nanotube sensing *** measured theⅠ_(DS)-Ⅴ_G curves of the carbon nanotube separative structure EGFET device in the different pH buffer solutions by the Keithley 236Ⅰ-Ⅴmeasurement *** to the experimental results,we can obtain the pH sensitivities of the carbon nanotube separative structure EGFET device,which is 62.54mV/pH from pH1 to pH13.

关键词： carbon nanotube extended gate field effect transistor pH sensitivity buffer solution

Study the Characteristics of Titanium Oxide Hydrogen Ion Sensor Using XRD and AES

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稀有金属材料与工程 2006年第A3期35卷 250-251页

作者： Jung-Chuan chou hung-Hsi Yang Graduate School of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China

We study the extended gate ion sensitive structure,and deposit the titanium oxide (TiO_2) thin film on p-type (100) silicon *** device of the hydrogen ion sensing structure is TiO_2/Si-substrate,and a commercial device of the metal oxide semiconductor field effect transistor (MOSFET) is connected to the separative sensing *** sensitivity and linearity are measured under different work *** the mixed ratio of Ar/O_2 is 80 ml·min^(-1)/20 ml·min^(-1),the work pressure is 4 Pa,the sputtering power is 150 W,and the sputtering time is two hours,the better sensing properties of the sensitivity and linearity are 36.49 mV/pH and 0.99654,***,some instruments are analyzed the surface of TiO_2 membrane,such as X-ray diffraction (XRD) and Auger Electron Spectrometer (AES).The characteristics of TiO_2 thin film can be demonstrated.

关键词： titanium oxide separative sensing device sensitivity linearity X-ray diffraction auger electron spectrometer

Study of Drift Behavior for RuO_x Sensing Membrane with Penicillinase Immobilized by GPTS

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稀有金属材料与工程 2006年第A3期35卷 228-229页

作者： Jung-Chuan chou Sheng-hung Chen Graduate School of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China

The ruthenium oxide(RuO_x) thin film was prepared by using the *** *** RuO_x pH-sensitive electrode possesses a nearly-Nernstian pH sensitivity(about 57 mV/pH).For the enzyme penicillinase was immobilized directly onto a RuO_x pH-sensitive surface by 3-glycidoxypropyltrimethoxysilane(GPTS).Some characteristics of the biosensor, such as sensitivity,linear range,and drift,are investigated and the difference between penicillinase immobilized and without are *** to the time-constant model,we can extract the time constant and amplitude at the response curve of the ***,the extracted parameters were used to simulate the mechanism of the drift behavior.

关键词： ruthenium oxide pH-sensitive electrode penicillinase drift behavior

Study on Extended Gate Field Effect Transistor with Nano-TiO-2 Sensing Membrane by Sol-Gel Method

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稀有金属材料与工程 2006年第A3期35卷 252-253页

作者： Yi-hung Liao Jung-Chuan chou Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyDouliouTaiwan 640China

The nano-titanium dioxide (nano-TiO_2) sensing membrane,fabricated by sol-gel technology,was used as the pH-sensing layer of the extended gate field effect transistor (EGFET) *** objective of this research is the preparation of titanium dioxide materials by sol-gel method using Ti(OBu)_4 as the *** this study,we fabricated a nano-titanium dioxide sensing layer on the ITO glass by dip *** order to examine the sensitivity of the nano-TiO_2 films applied to the EGFET devices,we adopted the ITO glass as substrate,and measured theⅠ_(DS)-Ⅴ_G curves of the nano-titanium dioxide separative structure EGFET device in the pH buffer solutions that have different pH values by the Keithley 236 *** the experimental results,we can obtain the pH sensitivities of the EGFET with nano-TiO_2 sensing membrane prepared by sol-gel method,which is 59.86mV/pH from pH 1 to pH 9.

关键词： extended gate field effect transistor(EGFET) sol-gel nano-TiO2 sensing membrane buffer solution

Patients with cirrhosis during the COVID-19 pandemic:Current evidence and future perspectives

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World Journal of Clinical Cases 2021年第13期9卷 2951-2968页

作者： hung-Yuan Su Yin-chou Hsu Department of Emergency Medicine E-DA HospitalI-Shou UniversityKaohsiung 82445Taiwan China School of Chinese Medicine for Post Baccalaureate I-Shou UniversityKaohsiung 82445Taiwan China

The outbreak of coronavirus disease-2019(COVID-19)has resulted in a global public health *** with cirrhosis were deemed more susceptible to viral infection because of their dysregulated immune *** to the general population,cirrhotic patients exhibit various degrees of COVID-19-related liver injury,which could be attributed to direct virus cytotoxicity,systemic immune system activation,drug-related liver injury,reactivation of pre-existing liver disease,and hypoxic *** clinical symptoms in patients with cirrhosis and COVID-19 were similar to those in the general population with COVID-19,with a lower proportion of patients with gastrointestinal *** respiratory failure is the predominant cause of mortality in cirrhotic patients with COVID-19,a significant proportion of them lack initial respiratory *** evidence has shown that cirrhotic patients have relatively higher rates of morbidity and mortality associated with *** cirrhosis was also proposed as an independent factor affecting a poor prognosis and the need to consider COVID-19 palliative *** measures implemented to prevent the transmission of the virus are also essential for cirrhotic patients,and they should also receive standard cirrhosis care with minimal *** efficacy of the available COVID-19 vaccines in cirrhotic patients still needs investigation.

关键词： COVID-19 SARS-CoV-2 Cirrhosis Acute liver injury Prognosis Therapy

Data-Driven Modeling of Partially Observed Biological Systems

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Communications on Applied Mathematics and Computation 2024年第1期6卷 739-754页

作者： Wei-hung Su Ching-Shan chou Dongbin Xiu Department of Mathematics The Ohio State UniversityColumbusOH43221USA

We present a numerical approach for modeling unknown dynamical systems using partially observed data,with a focus on biological systems with(relatively)complex dynamical *** an extension of the recently developed deep neural network(DNN)learning methods,our approach is particularly suitable for practical situations when(i)measurement data are available for only a subset of the state variables,and(ii)the system parameters cannot be observed or measured at *** demonstrate that,with a properly designed DNN structure with memory terms,effective DNN models can be learned from such partially observed data containing hidden *** learned DNN model serves as an accurate predictive tool for system *** a few representative biological problems,we demonstrate that such DNN models can capture qualitative dynamical behavior changes in the system,such as bifurcations,even when the parameters controlling such behavior changes are completely unknown throughout not only the model learning process but also the system prediction *** learned DNN model effectively creates a“closed”model involving only the observables when such a closed-form model does not exist mathematically.

关键词： Deep neural network(DNN) Governing equation discovery Biological system Partial observation

Intraperitoneal metastasis of hepatocellular carcinoma after spontaneous rupture:A case report

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World Journal of Gastroenterology 2008年第24期14卷 3927-3931页

作者： Yueh-Tsung Lee Chih-hung Hsu Dev-Aur chou Department of Surgery Chang Bing Show-Chwan Memorial Hospital

Rupture of hepatocellular carcinoma (HCC) is a life-threatening complication. Peritoneal metastasis of HCC after spontaneous rupture was seldom noted. We report a case of intraperitoneal metastasis of HCC after spon-taneous rupture. A previously asymptomatic 72-year-old man was admitted due to dull abdominal pain with abdominal fullness. He had a history of HCC rupture 10 mo ago and transarterial embolization was performed at that time. Abdominal computer tomograghy (CT) scan showed a huge peritoneal mass over the right up-per quadrant area. Surgical resection was arranged and subsequent microscopic examination conf irmed a diag-nosis of moderately-differentiated HCC.

关键词： Hepatocellular carcinoma Spontaneousrupture Peritoneal metastasis

Glucose Oxidase/Polypyrrole Biosensor Fabricated by Galvanostatic Electropolymerization Accompanied with a Potential Jumping

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稀有金属材料与工程 2006年第A3期35卷 277-281页

作者： Yuh-Ming Uangl hung-Te Chung Tse-Chuan chou Department of Chemical Engineering WuFeng Institute of TechnologyChiayiTaiwan62153China Dpartment of Chemical Engineering National Cheng Kung UniversityTainanTaiwan70101China

A galvanostatic glucose oxidase (GOD_x)/polypyrrole (Ppy) biosensor fabricated through a potential jumping process was *** spite of the instantaneous voltage jumping from 0.95 V to 1.7 V versus Ag/AgCl in the galvanostatic polymerization of pyrrole with commercial GOD_x,this GOD_x enzyme still could be successfully bundled with polypyrrole (Ppy).And,the results also confirmed that this glucose sensor not only possessed of better sensitivity to glucose than that fabricated from potentiometry or mild voltage elevating galvanometry for the similar preparing conditions but also exhibited two-week long-term ***,the kinetic data of Michalis constant (K_m) and Maximum current (I_m) for the optimized sensor were *** discovery this electro-modification process may disclose a novel method for fabricating the other enzyme biosensors.

关键词： conformation conducting galvanostatic dentritic jumping

Thalidomide-based multidisciplinary treatment for patients with advanced hepatocellular carcinoma:A retrospective analysis

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World Journal of Gastroenterology 2012年第5期18卷 466-471页

作者： Yang-Yuan Chen Hsu-Heng yen Kun-Ching chou Shun-Sheng Wu Department of Gastroenterology ChinaMedical University Hospital China Medical University Taic-hung 40000 Taiwan China Depart-ment of Gastroenterology Changhua Christian Medical CenterChanghua 50000 Taiwan China

AIM： To evaluate the efficacy of thalidomide in com- bination with other therapies to treat patients with ad- vanced hepatocellular carcinoma （HCC）. METHODS： We performed a retrospective analysis of all patients with HCC who were treated with thalido- mide for at least two months. The medical records of patients with HCC who were treated at our institution between April 2003 and March 2008 were reviewed. Image studies performed before and after treatment, tumor response, overall survival, and the decrease in o-fetoprotein （AFP） levels were evaluated. RESULTS： A total of 53 patients with HCC received either 100 or 200 mg/d of thalidomide. The patient population consisted of 9 women and 44 men with a median age of 61 years. Thirty patients （56.6%） were classified as Child-Pugh A, and 12 patients （22.6%） were classified as Child-Pugh B. Twenty-six patients had portal vein thrombosis （49.1%）, and 25 patients had extrahepatic metastasis （47.1%）. The median duration of thalidomide treatment was 6.0 mo. Six of the 53 patients achieved a confirmed response （11.3%）, one achieved a complete response （1.9%） and 5 achieved a partial response （9.4%）. The disease control rate （CR ＋ PR ＋ SD） was 28.3% （95% CI： 17.8-42.4）, and the median overall survival rate was 10.5 too. The 1- and 2-year survival rates were 45% and 20%, respectively. Only one complete response patient showed an im- proved overall survival rate of 66.8 mo. Sixteen patients （30.2%） showed more than a 50% decrease in their serum AFP levels from baseline, indicating a better re- sponse rate （31.3%）, disease control rate （43.8%）, and overall survival time （20.7 mo）. The therapy was well tolerated, and no significant toxicities were observed. CONCLUSION： Thalidomide was found to be safe for advanced HCC patients, demonstrating anti-tumor ac- tivity including response, survival, and AFP decreases of greater than 50% from baseline.

关键词： Thalidomide Hepatocellular carcinoma