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作者： Xiao Ni Han Zhou Ping Liao Dejie Yu Guang Li tuck Wah Soong Key Laboratory of Medical Electrophysiology Ministry of EducationInstitute of Cardiovascular ResearchSouthwest Medical University Department of Physiology Yong Loo Lin School of MedicineNational University of Singapore

Alternative splicing generates from one pre-mRNA into an array of splice variants encoding proteins displaying structural and functional ***,we systematically examined the phenotypic changes associated with alternative splicing at the 5 acceptor site of exon 7 of Cav1.2 *** alternate utilization of its acceptor site generated a 12 nucleotide(12-nt) splice variation that encodes+/D DVPA in domain I S5-P linker of the *** found that DDVPA variant of Cav1.2 channels was only detected in human tissues,but not in rabbit,rat or mouse,indicating potentially a species-specific *** addition,transcript-scarming showed that the Cav1.2△VPA splice variant was predominantly expressed in human heart,especially in the left *** cell patch-clamp electrophysiological recordings of Cav1.2 channels expressed in HEK 293 cells indicated that the Cav1.2△DVPA splice variant did not alter channel conductance,inactivation property and antagonist ***,it showed depolarization shift of relatively depolarized voltage dependence of activation and reduced activation *** altered activation property did not change channel density or ***-vitro mutagenesis study identified aspartate(D),but not proline(P) or valine(V) residues,contributed to the depolarized shift in activation property of the Cav1.2 *** together,we have discovered one unexpected human specific splice variant of Cav1.2 channel,and this could be another mechanism to enlarge the channel repertoire to meet the functional demands of human heart.

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心肺复苏历史回顾,生理学和展望

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美国医学会杂志（中文版） 1995年第3期14卷 169-175页

作者： tuck.,KJ 黄晓强

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1980—1997年撒哈拉沙漠的面积变化

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AMBIO－人类环境杂志 1999年第7期28卷 587-594页

作者： tuck.,CJ 李香莲 Laboratory for Terrestrial Physics Department of Meteorology Florida State University Tailahaesee 中国科学院地理科学与资源研究所

我们应用卫星数据和地面降雨测量资料研究了1980－1997年撒哈拉沙漠面积的变化。结合卫星和地面数据，绘制出了撒哈拉－萨赫勒地区每年的200mm年降雨量界线图。尽管撒哈拉沙漠面积发生了非常大的年际变化，但是1980－1997年没有明显的... 详细信息

我们应用卫星数据和地面降雨测量资料研究了1980－1997年撒哈拉沙漠面积的变化。结合卫星和地面数据，绘制出了撒哈拉－萨赫勒地区每年的200mm年降雨量界线图。尽管撒哈拉沙漠面积发生了非常大的年际变化，但是1980－1997年没有明显的系统性面积增加或减少趋势。撒哈拉沙漠面积从1984年的998000km^2变化为1994年的8600000km^2，1980－1997年间的平均面积是9150000km^2。

关键词：撒哈拉沙漠面积变化年降雨景界线图

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