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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1763-1771页

作者： chen Yu Lin hung ju chen Yi Kit Chan Wei Ping Hsia Yu Len Huang Chia Jen Chang Department of Ophthalmology Taichung Veterans General HospitalTaichung 407TaiwanChina Department of Computer Science Tunghai UniversityTaichung 407TaiwanChina

AIM:To develop an automated model for subfoveal choroidal thickness(SFCT)detection in optical coherence tomography(OCT)images,addressing manual fovea location and choroidal contour ***:Two procedures were proposed:defining the fovea and segmenting the *** localization from B-scan OCT image sequence with three-dimensional reconstruction(LocBscan-3D)predicted fovea location using central foveal depression features,and fovea localization from two-dimensional en-face OCT(LocEN-2D)used a mask region-based convolutional neural network(Mask R-CNN)model for optic disc detection,and determined the fovea location based on optic disc relative *** segmentation also employed Mask ***:For 53 eyes in 28 healthy subjects,LocBscan-3D’s mean difference between manual and predicted fovea locations was 170.0μm,LocEN-2D yielded 675.9μ***-2D performed better in non-high myopia group(P=0.02).SFCT measurements from Mask R-CNN aligned with manual ***:Our models accurately predict SFCT in OCT ***-3D excels in precise fovea localization even with high ***-2D shows high detection rates but lower accuracy especially in the high myopia *** both models offers a robust SFCT assessment approach,promising efficiency and accuracy for large-scale studies and clinical use.

关键词： subfoveal choroidal thickness optical coherence tomography automatic foveal detection automatic choroid segmentation

Robust facial expression recognition via lightweight reinforcement learning for rehabilitation robotics

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Optoelectronics Letters 2025年第2期21卷 97-104页

作者： chen Yifan FAN Weiming GAO Hongwei YU Jiahui ju Zhaojie School of Computing University of Portsmouth School of Automation and Electrical Engineering Shenyang Ligong University Department of Biomedical Engineering Zhejiang University

This paper proposes a lightweight reinforcement network (LRN) and auxiliary label distribution learning (ALDL)based robust facial expression recognition (FER) *** designed representation reinforcement (RR) network mainly comprises two modules,i.e.,the RR module and the auxiliary label space construction (ALSC) *** RR module highlights key feature messaging nodes in feature maps,and ALSC allows multiple labels with different intensities to be linked to one ***,LRN has a more robust feature extraction capability when model parameters are greatly reduced,and ALDL is proposed to contribute to the training effect of LRN in the condition of ambiguous training *** tested our method on FER-Plus and RAF-DB datasets,and the experiment demonstrates the feasibility of our method in practice during rehabilitation robots.

关键词： Reinforcement learning

Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan Cao Zhiqun He Chunjun Liang Mingxing chen Jing ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Energy dispersive spectroscopy

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： Zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang Jia-Qian ju Jing-Cai Liu Shao-chen Sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie chen Hai-Di Fan Wan Wang Bin Wang ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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面向新型人机关系的社会临场感

心理科学进展 2025年第1期33卷 146-162页

作者：翁智刚陈潇潇张小妹张琚西南财经大学工商管理学院成都611130 四川省妇幼保健院成都610041

社会临场感(Social Presence,SP)又称社会存在,是一种与他人在一起的共在感。社会临场感作为面向新型人机关系态度形成机制的经典与主流中介变量,亟待对多学科相关文献进行系统性梳理与理论体系的整体性构建。本文以人机关系演进为背景... 详细信息

社会临场感(Social Presence,SP)又称社会存在,是一种与他人在一起的共在感。社会临场感作为面向新型人机关系态度形成机制的经典与主流中介变量,亟待对多学科相关文献进行系统性梳理与理论体系的整体性构建。本文以人机关系演进为背景,从人与计算机交互(Human-Computer Interaction,HCI)和人与机器人交互(Human-Robot Interaction,HRI)的历史视角对社会临场的概念内涵与适用边界进行界定。再以拟人化为前置变量,个体因素为调节变量,认知、情感、行为的态度为结果变量,构建了以社会临场感为中介变量的整合性理论框架,解构面向新型人机关系的心理机制。最后,对人机关系调整与机器社会心理、社会临场感的概念内涵外延的扩展、拟人化与社会临场感三方面进行了展望。

关键词：人工智能人机关系社会临场感拟人化态度

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Wall shear-stress extraction by an optical flow algorithm with a sub-grid formulation

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Acta Mechanica Sinica 2021年第1期37卷 65-79,I0003页

作者： The hung Tran Lin chen Faculty of Aerospace Engineering Le Quy Don Technical UniversityHanoi10000Vietnam Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China School of Aeronautics and Astronautics University of Chinese Academy of SciencesBeijing100049China

In this study,we developed a novel optical-flow algorithm for determining the wall shear-stress on the surface of *** algorithm solves the thin-oil-film equation using a numerical scheme that recovers local features neglected by smoothing filters.A variational formulation with a smoothness constraint was applied to extract the global shear-stress *** algorithm was then applied to scalar images generated using direct numerical simulation(DNS)method,which revealed that the errors were smaller than those of conventional *** application of the proposed algorithm to recover the wall shear-stress on a low-aspect-ratio wing and on an axisymmetric boattail model taken as examples in this study showed a strong potential for analysing shear-stress *** to the methods used in previous studies,proposed method reveals more local features of separation line and singular points on object surface.

关键词： Wall shear-stress Optical flow Thin-oil-film equation Sub-grid model

Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain

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World Journal of Gastroenterology 2006年第4期12卷 574-581页

作者： chen-Road hung Department of Pharmacology College of MedicineNational Cheng Kung UniversityTainanChina

AIM： To investigate the role of gastric oxidative stress and nitric oxide （NO） in the formation of gastric hemorrhagic erosion and their protection by drugs in rats with ischemic brain. METHODS： Male Wistar rats were deprived of food for 24 h. Under chloral hydrate （300 mg/kg） anesthesia, bilateral carotid artery ligation was performed. The pylorus and carotid esophagus of the rats were also ligated. The stomachs were then irrigated for 3 h with either normal saline or simulated gastric juice containing 100 mmol/L HCI plus 17.4 mmol/L pepsin and 54 mmol/L NaCI. Rats were killed and stomachs were dissected. Gastric mucosa and gastric contents were harvested. The rat brain was dissected for the examination of ischemia by triphenyltetrazolium chloride staining method. Changes in gastric ulcerogenic parameters, such as decreased mucosal glutathione level as well as enhanced gastric acid back-diffusion, mucosal lipid peroxide generation, histamine concentration, luminal hemoglobin content and mucosal erosion in gastric samples, were measured. RESULTS： Bilateral carotid artery ligation produced severe brain ischemia （BI） in rats. An exacerbation of various ulcerogenic parameters and mucosal hemorrhagic erosions were observed in these rats. The exacerbated ulcerogenic parameters were significantly （P〈 0.05） attenuated by antioxidants, such as exogenous glutathione and allopurinol. These gastric parameters were also improved by intraperitoneal aminoguanidine （100 mg/kg） but were aggravated by N^G-nitro-L-argininemethyl ester （L-NAME： 25 mg/kg）. Intraperitoneal L-arginine （0-500 mg/kg） dose-dependently attenuated BI-induced aggravation of ulcerogenic parameters and hemorrhagic erosions that were reversed by L-NAME. CONCLUSION： BI could produce hemorrhagic erosions through gastric oxidative stress and activation of arginine-nitric oxide pathway.

关键词： Lipid peroxide Acid back-diffusion Glutathione AIIopurinol L-arginine Nitric oxide synthase Aminoguanidine

Effect of lysozyme chloride on betel quid chewing aggravated gastric oxidative stress and hemorrhagic ulcer in diabetic rats

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World Journal of Gastroenterology 2005年第37期11卷 5853-5858页

作者： chen-Road hung Department of Pharmacology College of Medicine National Cheng Kung University Tainan Taiwan China

AIM： To evaluate the protective effect of lysozyme chloride on betel quid chewing （BQC） aggravated gastric oxidative stress and hemorrhagic ulcer in rats with diabetes mellitus （DM）. METHODS： Male Wistar rats were challenged intravenously with streptozotocin （65 mg/kg） to induce DM. Rats were fed with regular pellet food or BQC-containing diets. Afcer 90 d, rats were deprived of food for 24 h. Rat stomachs were irrigated for 3 h with normal saline or simulated gastric juice. Rats were killed and gastric specimens were harvested. RESULTS： An enhancement of various gastric ulcerogenic parameters, including acid back-diffusion, mucosal lipid peroxide generation, as well as decreased glutathione levels and mucus content, were observed in DM rats. Afcer feeding DM rats with BQC, an exacerbation of these ulcerogenic parameters was achieved. Gastric juice caused a further aggravation of these ulcerogenic parameters. Daily intragastric lysozyme chloride dose-dependently inhibited exacerbation of various ulcerogenic parameters in those BQC-fed DM rats. CONCLUSION：（1） Gastric juice could aggravate both DM and BQC-fed DM rat hemorrhagic ulcer; （2） BQC exacerbated gastric hemorrhagic ulcer in DM rats via enhancing oxidative stress and reducing defensive factors; （3） lysozyme chloride effectively protected BQC aggravated gastric damage in DM rats.

关键词： Glutathione Lipid peroxide Oxyradical Prostaglandins Gastric mucus Mucosal damage Acid back-diffusion

Skew Derivations with Power Central Values on Commutators

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Algebra Colloquium 2015年第3期22卷 479-494页

作者： hung-Yuan chen Department of Mathematics National Changhua University of Education Changhua City 500 Taiwan

Let R be a prime ring with center Z, 5 ： R → R a nonzero skew derivation, and n a fixed positive integer. In this paper, we show that R is a commutative ring if （i） [（δ（[x, y]）, [x, y]]n = 0 for all x, y ∈ R ... 详细信息

关键词： automorphism prime ring Martindale quotient ring skew derivation Minner