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Efficacy of Saam acupuncture treatment on improvement of immune cell numbers in cancer patients:a pilot study

Journal of Traditional Chinese Medicine 2014年第5期34卷 550-554页

作者： Dae-Joon Kim Seong-Hoon Park Jung-Chul Seo Kyung Soon Kim Ki Cheul Sohn Im Hee Shin hun mo ryoo Department of Internal Medicine Oriental Medical HospitalDaegu Haany UniversityDaegu 730-090Korea Department of Research Comprehensive and Integrative Medicine InstituteDaegu 705-030Korea Department of Preventive Medicine Hospital of Catholic University of DaeguDaegu 705-718Korea Department of Medical Statistics School of MedicineCatholic University of DaeguDaegu 705-718Korea Department of Internal Medicine School of MedicineCatholic University of DaeguDaegu 705-718Korea

OBJECTIVE: To collect preliminary data on the effects of Saam acupuncture with regard to the immunity in cancer ***: Ten cancer patients were analyzed for improvements in immunity. Acupuncture was applied at the 5 acupuncture points, Jingqu(LU 8), Zutonggu(BL 66), Yanggu(SI 5), Yangchi(TE 4), and Zhongwan(CV 12) for 2 weeks with 4 sessions. We assessed the effect of Korean Saam acupuncture on the immune system in cancer patients by measuring particular blood cell subsets, including CD3 +,CD4+, CD8+, CD19+, and CD56+ cells, as well as total white blood cell count, absolute neutrophil count, and fatigue score. The measurement was performed before and after acupuncture and at a 2-week ***: There was a statistically significant increase in the number of CD3+(P=0.023) and CD8+ cells(P<0.001) and T-cell subsets, as well as a decrease in the fatigue severity scale(FSS) score(P=0.001) after Saam acupuncture using the 5 ***: Acupuncture may improve the immune system by increasing the counts of a few immune cells and relieve fatigue in cancer patients by decreasing FSS scores. Although this was a non-controlled study, it constitutes preliminary research investigating the potential effects of Saam acupuncture in increasing the counts of several immune cells in cancer patients.

关键词： Acupuncture Leukocyte count Neutro-phils Fatigue severity scale Pilot projects

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Real-world outcomes of ibrutinib therapy in Korean patients with relapsed or refractory mantle cell lymphoma:amulticenter,retrospective analysis

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Cancer Communications 2021年第3期41卷 275-278页

作者： Jun Ho Yi Seok Jin Kim Dok Hyun Yoon Cheolwon Suh Myung Hee Chang Deok Hwan Yang Jae-Cheol Jo Shin Young Hyun Hyeon-Seok Eom Jeong-Ok Lee Ji Hyun Kwon Sang Hoon Han Seung-Shin Lee Jae-Yong Kwak Se Hyung Kim Dae Sik Kim Ji Hyun Lee Sung Yong Oh hun mo ryoo Hyo Jung Kim Won Seog Kim Division of Hematology-Oncology Department of MedicineChung-Ang UniversityDongjak-guSeoul 06973Korea Division of Hematology and Oncology Department of MedicineSamsung Medical Center Sungkyunkwan University School of MedicineGangnam-guSeoul 06351Korea Department of Oncology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea National Health Insurance Corporation Ilsan Hospital Ilsandong-guGoyang 10444Korea Department of Hemato-Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolHwasunGwangju 58128Korea Department of Hematology and Oncology Ulsan University HospitalUniversity of Ulsan College of MedicineDong-guUlsan 44033Korea Department of Internal Medicine Yonsei University Wonju College of MedicineGangwon-DoWonju 26426Korea Department of Internal Medicine National Cancer CenterGoyang-si Gyeonggi-doGoyang 10408Korea Department of Internal Medicine Seoul National University Bundang HospitalBundang-guSeongnam 13620Korea Department of Internal Medicine ChungBuk National University HospitalChungbukCheongju 28644Korea Department of Internal Medicine Jeju National University HospitalJeju National University School of MedicineJeju 63241Korea Department of Hematology-Oncology Wonkwang University HospitalIksan-daeroIksan 54538Korea Department of Internal Medicine Jeonbuk National University Medical SchoolJeollabuk-doJeonju 54907Korea Division of Hematology-Oncology Department of Internal MedicineSoonchunhyang University College of MedicineBucheon HospitalWonmi-guBucheon 14584Korea Division of Hematology-Oncology Department of Internal MedicineKorea University Guro HospitalGuro-guSeoul 08308Korea Division of Hematology-Oncology Department of Internal MedicineDong-A University College of MedicineSeo-guBusan 49201Korea Department of Internal Medicine Division of Hematology-Oncology Catholic University of DaeguDaegu 42472Korea Division of Hematology-Oncology Department of Internal MedicineHallym U

Dear Editor,Despite the introduction of novel front-line therapies including rituximab plus high-dose cytarabine followed by consolidative autologous stem cell transplantation(ASCT)and salvage therapy with bendamustine,lenalidomide or bortezomib,mantle cell lymphoma(MCL)is still considered incurable and most patients experience relapse or refractory(RR)disease.

关键词： patients relapse lymphoma

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Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots

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Nano Research 2020年第12期13卷 3338-3346页

作者： Xuan-hung Pham Eunil Hahm Tae Han Kim Hyung-mo Kim Sang hun Lee Sang Chul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi Bong-Hyun Jun Department of Bioscience and Biotechnology Konkuk UniversitySeoul143-701Republic of Korea Department of Nuclear Medicine Seoul National University Bundang HospitalSeongnam13620Republic of Korea Gordon Center for Medical Imaging Department of RadiologyMassachusetts General Hospital and Harvard Medical SchoolBostonMA02114USA Department of Chemistry Education Seoul National UniversitySeoul151-742Republic of Korea

Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high ***,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active *** this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS *** the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen *** plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for *** results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays.

关键词： surface-enhanced Raman scattering(SERS)-based immunoassay Au-Ag alloy surface-enhanced Raman scattering silica template immunoglobulin G(IgG)detection

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Development of Safety Factors for the UT Data Analysis Method in Plant Piping

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World Journal of Nuclear Science and Technology 2013年第4期3卷 143-149页

作者： hun Yun Kyeong-mo Hwang Chan-Kyoo Lee Power Engineering Research Institute KEPCO E&C Yongin South Korea

There are several thousand piping components in a nuclear power plant. These components are affected by degradation mechanisms such as FAC (Flow-Accelerated Corrosion), cavitation, flashing, and LDI (Liquid Droplet Impingement). Therefore, nuclear power plants implement inspection programs to detect and control damages caused by such mechanisms. UT (Ultrasonic Test), one of the non-destructive tests, is the most commonly used method for inspecting the integrity of piping components. According to the management plan, several hundred components, being composed of as many as 100 to 300 inspection data points, are inspected during every RFO (Re-Fueling Outage). To acquire UT data of components, a large amount of expense is incurred. It is, however, difficult to find a proper method capable of verifying the reliability of UT data prior to the wear rate evaluation. This study describes the review of UT evaluation process and the influence of UT measurement error. It is explored that SAM (Square Average Method), which was suggested as a method for reliability analysis in the previous study, is found to be suitable for the determination whether the measured thickness is acceptable or not. And, safety factors are proposed herein through the statistical analysis taking into account the components’ type.

关键词： Wall Thinning UT (Ultrasonic Test) Reliability Analysis FAC (Flow-Accelerated Corrosion) Safety Factor Measurement Data

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Development of New Methodology for Distinguishing Local Pipe Wall Thinning in Nuclear Power Plants

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World Journal of Nuclear Science and Technology 2012年第4期2卷 192-199页

作者： Kyeong mo Hwang hun Yun Chan Kyoo Lee Power Engineering Research Institute Yongin Korea

To manage the wall thinning of carbon steel piping in nuclear power plants, the utility of Korea has performed thickness inspection for some quantity of pipe components during every refueling outage and determined whether repair or replacement after evaluating UT data. Generally used UT thickness data evaluation methods are Band, Blanket, and PTP (Point to Point) methods. Those may not desirable to identify wall thinning on local area caused by erosion. This is because the space between inspecting points of those methods are wide for covering full surface being inspected components. When the evaluation methods are applied to a certain pipe component, unnecessary re-inspection may also be generated even though wall thinning of components does not progress. In those cases, economical loss caused by repeated inspection and problems of maintaining the pipe integrity followed by decreasing the number of newly inspected components may be generated. EPRI (Electric Power Research Institute in USA) has suggested several statistical methods such as FRIEDMAN test method, ANOVA (Analysis of Variance) method, monte Carlo method, and TPM (Total Point Method) to distinguish whether multiple inspecting components have been thinned or not. This paper presents the NAM (Near Area of Minimum) method developed by KEPCO-E & C for distinguishing whether multiple inspecting components have been thinned or not. In addition, this paper presents the analysis results for multiple inspecting ones over three times based on the NAM method compared with the other methods suggested by EPRI.

关键词： Pipe Wall Thinning Component Multiple Inspection ANOVA-1 Method TPM (Total Point Method) NAM (Near Area of Minimum) Method

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A compact polymer–inorganic hybrid gas barrier nanolayer for flexible organic light-emitting diode displays

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npj Flexible Electronics 2022年第1期6卷 204-209页

作者： Seung hun Kim Seung Yong Song Soo Youn Kim moon Won Chang Hyo Jeong Kwon Kwan Hyuck Yoon Woo Yong Sung Myung mo Sung Hye Yong Chu Display Research Center Samsung DisplayYongin-siGyeonggi-do 17113Republic of Korea Department of Chemistry Hanyang UniversitySeoul 04763Republic of Korea

Atomic layer infiltration technology allows the formation of a nanometer-thick polymer-inorganic hybrid barrier layer in polymer material for flexible organic light-emitting diode(OLED)*** this study,according to transmission electron microscopy and secondary-ion mass spectrometry analysis results under various process conditions,a compact polymer-inorganic hybrid nanolayer was successfully formed in a polymer and good barrier performance was revealed with a low water vapor transmission rate under optimal process ***,through gas chromatography-mass spectrometry measurements after ultra-violet radiation testing,polymer out-gassing decreased compared to bare *** on barrier properties,the polymer with a polymer-inorganic hybrid barrier nanolayer was applied to a flexible OLED display as a *** storage tests and folding tests,the flexible OLED display exhibits good reliability and better flexibility compared to those with an inorganic barrier *** results confirm that the polymer-inorganic hybrid nanolayer is suitable for barrier layer formation in flexible OLED displays.

关键词： diode barrier layer

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Analysis of Material Loss Behavior According to Long-Term Experiments on LDIE-FAC Multiple Degradation of Carbon Steel Materials

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World Journal of Nuclear Science and Technology 2022年第1期12卷 1-10页

作者： Kyeong mo Hwang Dong Jin Lee hun Yun Seung Chang Yoo Ji Hyeon Kim SI Business Department KEPCO E&C Gimcheon-si Korea Nuclear Engineering Department UNIST Ulsan-si Korea

Recently, damage caused by liquid droplet impingement erosion (LDIE) in addition to flow-accelerated corrosion (FAC) has frequently occurred in the secondary side steam piping of nuclear power plants, and the damage-occurring frequency is expected to increase as their operating years’ increase. In order to scrutinize its causes, therefore, an experimental study was conducted to understand how the behavior of LDIE-FAC multiple degradation changes when the piping of nuclear power plants is operated for a long time. Experimental results show that more magnetite was formed on the surface of the carbon steel specimen than on the low-alloy steel specimen, and that the rate of magnetite formation and extinction reached equilibrium due to the complex action of liquid droplet impingement erosion and flow-accelerated corrosion after a certain period of time. Furthermore, it was confirmed at the beginning of the experiment that A106 Gr.B specimen has more mass loss than A335 P22 specimen. After a certain period of time, however, the mass loss tends to be the opposite. This is presumed to have resulted from the magnetite formed on the surface playing a role in suppressing liquid droplet impingement erosion. In addition, it was confirmed that the amount of erosion linearly increases under the conditions in which the formation and extinction of magnetite reach equilibrium.

关键词： Liquid Droplet Impingement Erosion (LDIE) Flow-Accelerated Corrosion (FAC) Multiple Degradations ToSPACE Wall Thinning Magnetite

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Classification of hepatobiliary scintigraphy patterns in segmented gallbladder according to anatomical discordance

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World Journal of Clinical Cases 2023年第11期11卷 2423-2434页

作者： Yun-Chae Lee Won-Sik Jung Chang-hun Lee Seong-hun Kim Seung-Ok Lee Division of Gastroenterology Department of Internal MedicineJeonbuk National University Medical SchoolJeonju 54907JeonbukSouth Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907JeonbukSouth Korea

BACKGROUND Hepatobiliary scintigraphy(HBS)is a useful diagnostic imaging technique that uses radiotracers to evaluate the function of the gallbladder(GB)and biliary *** segmented GB,some HBS images reveal a discordant GB boundary as compared to anatomical *** To evaluate the characteristics of HBS in segmented GB and determine the clinical relevance according to HBS *** A total of 268 patients with chronic cholecystitis,gallstones,or biliary colic symptoms who underwent HBS between 2011 and 2020 were *** GB was defined as segmental luminal narrowing of the GB body on computed tomography(CT)or magnetic resonance(MR)images,and HBS was examined 1 mo before or after CT or *** GB was classified into 3 types based on the filling and emptying patterns of the proximal and distal segments according to the characteristics of HBS images,and GB ejection fraction(GBEF)was identified:Type 1 was defined as a normal filling and emptying pattern;Type 2 was defined as an emptying defect on the distal segment;and Type 3 was defined as a filling defect in the distal *** Segmented GB accounted for 63 cases(23.5%),including 36 patients(57.1%)with Type 1,18 patients(28.6%)with Type 2,and 9 patients(14.3%)with Type 3 emptying ***,approximately 43%of HBS images showed a discordant pattern as compared to anatomical imaging of segmented *** there were no significant differences in clinical symptoms,rate of cholecystectomy,or pathological findings based on the type,most gallstones occurred in the distal *** GBEF was 62.50%±24.79%for Type 1,75.89%±17.21%for Type 2,and 88.56%±7.20%for Type *** 1 showed no difference in reported GBEF compared to the non-segmented GB group(62.50%±24.79%vs 67.40%±21.78%).In contrast,the reported GBEF was higher in Types 2 and 3 with defective emptying and filling when compared to Type 1(80.11%±15.70%vs 62.57%±24.79%;P=0.001).CONCLUSION In segmented GB,discordance i

关键词： Gallbladder Segmented Gallbladder emptying Radionuclide imaging Misdiagnosis Cholecystitis

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TBE EFFIGIENGIES OF THREE INITIATORS OF Fe^(2+)—H_2O_2, K_2S_2O_8, KMnO_4 AND TBE KINETIC EQUATION IN THE GRAFTING OF AGRYLAMIDE ONTO STARCH

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Chinese Chemical Letters 1991年第12期2卷 913-916页

作者： Guang Zhong YAHG Wen Hua GUO Quan Sheng LI Shao Jie LU Xi Hai CUI Shu Cheng mo Yin hun SHI Department of Chemistry Tianjin UniversityTianjin 300072 Department of Chemical Engineering Beijing University of Light Industry Beijing 100037

A comparative study is made on the efficiencies of three initiators of Fe^(2+)-H_2O_2, K_2S_2O_8 and KMnO_4 in the grafting of acrylamide onto starch. Of the three initiators the best one is KMnO_4. moreover, the kine... 详细信息

关键词： St TBE EFFIGIENGIES OF THREE INITIATORS OF Fe AM IV KMnO4 AND TBE KINETIC EQUATION IN THE GRAFTING OF AGRYLAMIDE ONTO STARCH K2S2O8 H2O2 Fe

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红侧耳裂解多糖单加氧酶基因PdLPmo9B的克隆及生物信息学分析

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吉林农业大学学报 2024年第3期46卷 425-430页

作者：李桐冰赖雨微莫国庆刘泽李艳丽王刚吉林农业大学生命科学学院长春130118 秸秆综合利用与黑土地保护教育部重点实验室长春130118

LPmo是一种含铜的裂解多糖单加氧酶,通过PCR技术扩增红侧耳CM13菌株PdLPmo9B基因cDNA序列,对其进行生物信息学分析,构建系统进化树。结果表明:成功克隆PdLPmo9B基因,其开放阅读框ORF长为744 bp,共编码247个氨基酸。编码蛋白的分子量为26... 详细信息

LPmo是一种含铜的裂解多糖单加氧酶,通过PCR技术扩增红侧耳CM13菌株PdLPmo9B基因cDNA序列,对其进行生物信息学分析,构建系统进化树。结果表明:成功克隆PdLPmo9B基因,其开放阅读框ORF长为744 bp,共编码247个氨基酸。编码蛋白的分子量为26.17 kDa,等电点为5.91,N端含有信号肽,疏水性较强。二级结构富含β-折叠和无规则卷曲,含有GH61家族结构域和纤维素结合模体CBM。三维建模显示,该基因与AA9家族成员最接近。系统进化树显示,红侧耳PdLPmo9B蛋白与糙皮侧耳(Pleurotus ostreatus)编码的GH61蛋白亲缘关系最近,聚为一类。

关键词：裂解多糖单加氧酶生物信息学分析红侧耳基因克隆

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