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Neurological diseases caused by coronavirus infection of the respiratory airways

Brain Science Advances 2020年第4期6卷 324-343页

作者： Waqas Ahmed Adeel Khan Wish Hal Sundar humaira naseem Wanghao Chen Jia Feng Samran Durrani Lukui Chen Department of Neurosurgery Neuroscience CenterCancer CenterIntegrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510310GuangdongChina School of Medicine Southeast UniversityNanjing 210009JiangsuChina School of Biological Science and Medical Engineering Southeast UniversityNanjing 210009JiangsuChina Department of Medicine Dow University of Health SciencesKarachiSindhPakistan Department of General Surgery Allied Hospital FaisalabadPunjabPakistan

Infections of the central nervous system(CNS)infections are critical problems for public *** are caused by several different organisms,including the respiratory coronaviruses(Co Vs).Co Vs usually infect the upper respiratory tract causing the common ***,in infants,and in elderly and immunocompromised persons,they can also affect the lower respiratory tract causing pneumonia and various syndromes of respiratory *** Vs also have neuroinvasive capabilities because they can spread from the respiratory tract to the *** infection begins in the CNS cells,it can cause various CNS problems such as status epilepticus,encephalitis,and long-term neurological *** neuroinvasive properties of Co Vs may damage the CNS as a result of misdirected host immune response,which could be associated with autoimmunity in susceptible individuals(virus-induced neuro-immunopathology)or associated with viral replication directly causing damage to the CNS cells(virus-induced neuropathology).In December 2019,a new disease named COVID-19 emerged which is caused by Co *** significant clinical symptoms of COVID-19 are related to the respiratory system,but they can also affect the CNS,causing acute cerebrovascular and intracranial *** describe the possible invasion routes of coronavirus in this review article,and look for the most recent findings associated with the neurological complications in the recently published literature.

关键词： human coronavirus respiratory viral infection neuroinvasion CNS infection neurological diseases COVID-19

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