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Correlations between the Maximum Standard Uptake Value of Positron Emission Tomography/Computed Tomography and Laboratory Parameters before and after Treatment in Patients with Lymphoma

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Chinese Medical Journal 2018年第15期131卷 1776-1779页

作者： Edip Ucar hulya yalcin Gamze Hande Kavvasoglu Gul Ilhan Department of Internal Medicine Tayfur Ata Sokmen Medical School Mustafa Kemal University Antioch Hatay 31100 Turkey Department of Nuclear Medicinel Ta~ur Ata Sokmen Medical School Mustafa Kemal University Antioch HataY 31100 Turkey

Background： After the first examination of patients with lymphoma diagnosis, important laboratory tests such as complete blood count; albumin, kidney and liver function tests; uric acid; 132-microglobulin; C-reactive protein （CRP）; erythrocyte sedimentation rate （ESR）; and lactate dehydrogenase （LDH） examinations are recommended. In this study, our aim was to find the relationship between laboratory parameters and the maximum standard uptake value （SUVmax） of positron emission tomography/computed tomography （PET/CT） in patients with lymphoma at the diagnosis and after treatment. Methods： Thirty-tbur lymphoma patients treated at Mustafa Kemal University Internal Medicine Clinic between 2014 and 2017 were included in this retrospective study. Results ofCRP, ESR, LDH, albumin, and white blood cell （WBC） count were recorded betbre each PET scan test, and each parameter was analyzed for correlation with SUV measurements. Results： Spearman＇s correlation test showed that the after-treatment SUV values were significantly correlated with the alter-treatment LDH, ESR, and CRP values （for LDH, ESR, and CRP, R2： 0.453, 0.426, and 0.351; P = 0.007, 0.012, and 0.042, respectively）. On the other hand, albumin and WBC count did not show a significant correlation with the after-treatment SUVmax values （all P 〉 0.05）. Conclusions： CRP, ESR, and LDH values may also be good predictors in patients for whom PET/CT imaging cannot be performed.

关键词： Albumin C-reactive Protein: Erythrocyte Sedimentation Rate: Lactate Dehydrogenase Lymphoma Maximum StandardUptake Value: Positron Emission Tomography/Computed Tomography White Blood Cell Count

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Nano-design of ultra-efficient reversible block based on quantum-dot cellular automata

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Frontiers of Information Technology & Electronic Engineering 2023年第3期24卷 447-456页

作者： Seyed Sajad AHMADPOUR Nima Jafari NAVIMIPOUR Mohammad MOSLEH Senay yalcin Department of Computer Engineering Faculty of Engineering and Natural SciencesKadir Has UniversityIstanbul 34083Türkiye Materials and Energy Research Center Dezful BranchIslamic Azad UniversityDezful ***Iran Department of Computer Engineering Nisantasi UniversityIstanbul 34485Türkiye

Reversible logic has recently gained significant interest due to its inherent ability to reduce energy dissipation,which is the primary need for low-power digital *** of the newest areas of relevant study is reversible logic,which has applications in many areas,including nanotechnology,DNA computing,quantum computing,fault tolerance,and low-power complementary metal-oxide-semiconductor(CMOS).An electrical circuit is classified as reversible if it has an equal number of inputs and outputs,and a one-to-one relationship.A reversible circuit is conservative if the EXOR of the inputs and the EXOR of the outputs are *** addition,quantum-dot cellular automata(QCA)is one of the state-of-the-art approaches that can be used as an alternative to traditional ***,we propose an efficient conservative gate with low power demand and high speed in this ***,we present a reversible gate called ANG(Ahmadpour Navimipour Gate).Then,two non-resistant QCA ANG and reversible fault-tolerant ANG structures are implemented in QCA *** suggested reversible gate is realized through the Miller ***,reversible fault-tolerant ANG is implemented by the 2DW clocking ***,the power consumption of the suggested ANG is assessed under different energy ranges(0.5Ek,1.0Ek,and 1.5Ek).Simulations of the structures and analysis of their power consumption are performed using QCADesigner 2.0.03 and QCAPro *** proposed gate shows great improvements compared to recent designs.

关键词： Nanotechnology Reversible logic Energy dissipation Quantum-dot cellular automata(QCA) Reversible gate Miller algorithm

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The cross section calculation of 112Sn(α,γ)116Te reaction with different nuclear models at the astrophysical energy range

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Nuclear Science and Techniques 2017年第8期28卷 103-109页

作者： C. yalcin Department of Physics Kocaeli University 41380 UmuttepeKocaeli Turkey

The theoretical cross section calculations for the astrophysical p process are needed because most of the related reactions are technically very difficult to be measured in the laboratory. Even if the reaction was measured,most of the measured reactions have been carried out at the higher energy range from the astrophysical ***, almost all cross sections needed for p process simulation have to be theoretically calculated or extrapolated to the astrophysical energies.^(112)Sn(α,γ)^(116)Te is an important reaction for the p process nucleosynthesis. The theoretical cross section of ^(112)Sn(α,γ)^(116)Te reaction was investigated for different global optical model potentials,level density, and strength function models at the astrophysically interested energies. Astrophysical S factors were calculated and compared with experimental data available in the EXFOR database. The calculation with the optical model potential of the dispersive model by Demetriou et al., and the back-shifted Fermi gas level density model and Brink-Axel Lorentzian strength function model best served to reproduce experimental results at an astrophysically relevant energy region. The reaction rates were calculated with these model parameters at the p process temperature and compared with the current version of the reaction rate library Reaclib and Starlib.

关键词：核反应模型天体物理学截面计算能量范围光学模型势模型参数计算函数模型能级密度

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BRAF mutation in colorectal carcinomas with signet ring cell component

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Cancer Biology & Medicine 2017年第3期14卷 287-292页

作者： Serap yalcin Onder Onguru Department of Molecular Biology and Genetic Ahi Evran UniversityKirsehir 40100Turkey Department of Pathology Gulhane School of MedicineHealth Sciences UniversityAnkara 06010Turkey

Objective:Signet ring cell carcinoma is a rare subtype of colorectal carcinoma(CRC)with an associated BRAFV600E *** investigated frequencies of BRAF mutation in 28 CRCs containing variable signet ring cell component and their relation with clinicopathologic ***:According to the presence of signet ring cell component,tumors were categorized into groups as follows:0%–9%,10%–24%,25%–49%,and>50%.Genomic DNA was isolated and analyzed for BRAF V600E gene mutation by polymerase chain reaction-restriction fragment length *** of 28 cases(39.3%)showed BRAFV600E mutation,which was also confirmed by Sanger *** elucidate the importance of existence of signet ring cell component at the molecular level,we separated cases into two groups with cut-off levels of 10%and 50%,which pertain to percentages of signet ring ***:Seven of 19 cases(36.8%)under the threshold of 50%and four of nine cases(44.4%)over this threshold value demonstrated BRAF *** of 7 cases(42.8%)featuring10%were BRAF ***:BRAF mutation must be closely associated with the presence of malignant signet ring cells regardless of their percentages.

关键词： BRAF mutations colon cancer signet ring cell

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Reflection and Transmission of Regular Waves from/Through Single and Double Perforated Thin Walls

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China Ocean Engineering 2017年第4期31卷 466-475页

作者： Nadji CHIOUKH Esin CEVIK yalcin YUKSEL Department of Civil Engineering University of Djillali Liabes Sidi Bel-Abbes 22000 Algeria Laboratory of Naval Aero-Hydrodynamics Department of Maritime Engineering USTO MB Oran 31000 Algeria Department of Civil Engineering Yildiz Technical University Istanbul Turkey

In this paper, reflection and transmission coefficients of regular waves from/through perforated thin walls are investigated. Small scale laboratory tests have been performed in a wave flume firstly with single perforated thin Plexiglas plates of various porosities. The plate is placed perpendicular to the flume with the height from the flume bottom to the position above water surface. With this thin wall in the flume wave overtopping is prohibited and incident waves are able to transmit. The porosities of the walls are achieved by perforating the plates with circular holes. Model settings with double perforated walls parallel to each other forming so called chamber system, have been also examined. Several parameters have been used for correlating the laboratory tests’ results. Experimental data are also compared with results from the numerical model by applying the multi-domain boundary element method （MDBEM） with linear wave theory. Wave energy dissipation due to the perforations of the thin wall has been represented by a simple yet effective porosity parameter in the model. The numerical model with the MDBEM has been further validated against the previously published data.

关键词： wave-structure interaction perforated thin walls boundary element experimental tests wave reflection wave transmission

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Use of petrological and organic geochemical data in determining hydrocarbon generation potential of coals:miocene coals of Malatya Basin(Eastern Anatolia-Turkey)

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International Journal of Coal Science & Technology 2021年第4期8卷 510-533页

作者： Nazan yalcin Erik Faruk Ay Department of Geological Engineering Cumhuriyet University58140 SivasTurkey Department of Anthropology Cumhuriyet University58140 SivasTurkey

With this study,the hydrocarbon generation potential of Miocene aged coals around Arguvan-Parçikan in the northern district of Malatya province was evaluated with the aid of petrological and organic geochemical *** to organic petrography,coal quality data,and low thermal maturity,the Arguvan-Parçikan coals are of high-ash,high-sulfur subbituminous B/C *** organic fraction of the coals is mostly comprised of humic group macerals,with small percentages derived from the inertinite and liptinite *** mineral matter of the coals is comprised mainly of calcite and clay *** total organic carbon(TOC,wt%)values of the shale and coal samples are between 2.61 wt%and 43.02 wt%,and the hydrogen index values are between 73 and 229 mg HC/g ***(T_(max),PI),huminite/vitrinite reflectance(R_(o),%),and biomarker ratios CPI,Pr/Ph ratio,Ts/(Ts+Tm)ratio,C_(32) homohopane ratio(22S/22S+22R)and C_(29)ββ/(ββ+ααsterane ratio)indicate that the organic matter of the studied coals is thermally *** all these data are taken together,Miocene aged coals around Arguvan are suitable for hydrocarbon generation,especially gas,in terms of organic matter type(Type III and Type II/III mixed),organic matter amount(>10 wt%TOC),however,low liptinitic macerals(<15%–20%),low hydrogen index(<200 mg HC/g TOC)and low thermal maturity values inhibit the hyrocarbon generation.

关键词： Arguvan Malatya basin Eastern Anatolia Organic geochemistry Organic petrography Miocene coal

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Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth

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Genes & Diseases 2022年第3期9卷 717-730页

作者： Daqian Zhan Fatih yalcin Ding Ma Yi Fu Shuang Wei Bachchu Lal Yunqing Li Omar Dzaye John Laterra Mingyao Ying Hernando Lopez-Bertoni Shuli Xia Neurology Hugo IV.Moser Research Institute at Kennedy KriegerJohns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China Department of Radiology and Neuroradiology ChariteBerlin 10117Germany Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of MedicineBaltimoreMD 21205USA Department of Respiratory and Critical Care Medicine Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430074PR China University Hospital Center Schleswig Holstein Department of NeurosurgeryKielSchleswig-Holstein 24105Germany Departments of Neurology Oncology and NeuroscienceJohns Hopkins University School of MedicineBaltimoreMD 21205USA Blood and Cell Therapy Institute University of Science and Technology of ChinaAnhui Provincial HospitalHefeiAnhui 230026PR China

Glioblastoma(GBM,WHO grade IV glioma)is the most common and lethal malignant brain tumor in aduts with a dismal *** extracellular matrix(ECM)supports GBM progression by promoting tumor cell proliferation,migration,and immune *** diphosphate(UDP)-glucose 6-dehydrogenase(UGDH)is the rate-limiting enzyme that catalyzes the biosynthesis of glycosaminoglycans that are the principal component of the CNS *** investigated how targeting UGDH in GBM infuence$the GBM immune microenvironment,including tumor-associated microglia/macrophages(TAMs)and T *** are the main im-mune effector cells in GBM and can directly target tumor cells if properly *** co-cultures of GBM cells and human primary macrophages,UGDH knockdown in GBM cells pro-moted macrophage phagocytosis and M-like *** orthotropic human GBM xeno-grafts and syngeneic mouse glioma models,targeting UGDH decreased ECM deposition,increased TAM phagocytosis marker expression,reduced M2-like TAMS and inhibited tumor *** knockdown in GBM cells also promoted cytotoxic T cell ifltration and activa-tion in orthotopic syngeneic mouse glioma *** potent and in-human-use small mole-cule GAG synthesis inhibitor 4-methylumbelliferone(4-MU)was found to inhibit GBM cell proliferation and migration in vitro,mimic the macrophage and T-cell responses to UGDH knockdown in vitro and in vivo and inhibit growth of orthotopic murine *** study shows that UGDH supports GBM growth through multiple mechanisms and supports the development of ECM-based therapeutic strategies to simultaneously target tumor cells and their microenvi-ronment.

关键词： 4-MU Extracellular matrix(ECM) Glioblastoma(GBM) Hyaluronic acid(HA) Phagocytosis T cells Tumor-associated microglia/macrophages(TAMs) UGDH

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Chronic otitis media and middle ear variants:Is there relation?

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World Journal of Clinical Cases 2023年第15期11卷 3481-3490页

作者： Fatma Dilek Gokharman Düzgün Can Senbil Sonay Aydin Erdal Karavas Ozge Ozdemir Arzu Gülsah yalcin Pınar Nercis Kosar Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Radiology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Radiology Bandırma 17 Eylül UniversityBalıkesir 10200Turkey

BACKGROUND Chronic otitis media(COM)is an inflammatory disease that lasts for a long *** is common in developing *** loss can result from *** relationship between variations in middle ear anatomy and COM was investigated in our *** To compare the prevalence of middle ear anatomic variations between the cases with COM and healthy *** This retrospective study included 500 patients with COM and 500 healthy *** presence of those variants was determined:Koerner’s septum,facial canal dehiscence,high jugular bulb,jugular bulb dehiscence,jugular bulb diverticulum,sigmoid sinus anterior location and deep tympanic *** A total of 1000 temporal bones were *** incidences of these variants were respectively(15.4%-18.6%),(38.6%-41.2%),(18.2%-4.6%),(2.6%-1.2%),(1.2%-0%),(8.6%-0%),(0%-0%).It was observed that only high jugular bulb(P<0.001)and anteriorly located sigmoid sinus frequencies(P=0.002)in the case group were statistically significantly higher than the control *** COM is a multifactorial disease and variants of middle ear have always been important in terms of potential risk for complication during surgery but rarely associated with COM as an etiology or as a consequence of the *** didn't find a positive correlation between COM and Koerner’s septum and facial canal *** ended up with a significant conclusion with the variants of dural venous sinuses-high jugular bulb,dehiscence of jugular bulb,diverticulum of jugular bulb and anteriorly located sigmoid sinus-that have been studied less and frequently associated with inner ear illnesses.

关键词： Chronic otitis media Radiology Inflammation Hearing loss Mastoid cells Head and neck

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Effects of resveratrol on hydrogen peroxide-induced oxidative stress in embryonic neural stem cells

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Neural Regeneration Research 2013年第6期8卷 485-495页

作者： Sibel Konyalioglu Guliz Armagan Ayfer yalcin Cigdem Atalayin Taner Dagci Department of Biochemistry Faculty of PharmacyEge University Department of Restorative Dentistry and Endodontics Faculty of DentistryEge University Department of Physiology School of MedicineEge University Center for Brain Research Ege University

Resveratrol, a natural phenolic compound, has been shown to prevent cardiovascular diseases and cancer and exhibit neuroprotective effects. In this study, we examined the neuroprotective and antJoxJdant effects of resveratrol against hydrogen peroxide in embryonic neural stem cells. Hydrogen peroxide treatment alone increased catalase and glutathione peroxidase activities but did not change superoxide dismutase levels compared with hydrogen peroxide ＋ resveratrol treatment. Nitric oxide synthase activity and concomitant nitric oxide levels increased in response to hydrogen peroxide treatment. Conversely, resveratrol treatment decreased nitric oxide synthase activity and nitric oxide levels. Resveratrol also attenuated hydrogen peroxide-induced nuclear or mitochondrial DNA damage. We propose that resveratrol may be a promising agent for protecting embryonic neural stem cells because of its potential to decrease oxidative stress by inducing higher activity of antioxidant enzymes, decreasing nitric oxide production and nitric oxide synthase activity, and alleviating both nuclear and mitochondrial DNA damage.

关键词： neural regeneration traditional Chinese medicine stem cells resveratrol embryonic neural stemcells hydrogen peroxide catalase glutathione peroxidase nitric oxide synthase nitric oxide DNAdamage neuroprotection grants-supported paper neuroregeneration

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A micromirror array with annular partitioning for high-speed random-access axial focusing

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Light(Science & Applications) 2020年第1期9卷 241-255页

作者： Nathan Tessema Ersumo Cem yalcin Nick Antipa Nicolas Pegard Laura Waller Daniel Lopez Rikky Muller The University of California Berkeley and University of CaliforniaSan Francisco Graduate Program in BioengineeringBerkeleyCA 94720USA Department of Electrical Engineering&Computer Sciences University of CaliforniaBerkeleyCA 94720USA Department of Applied Physical Sciences University of North Carolina at Chapel HillChapel HillNC 27514USA Chan Zuckerberg Biohub San FranciscoCA 94158USA Physical Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA

Dynamic axial focusing functionality has recently experienced widespread incorporation in microscopy,augmented/virtual reality(AR/VR),adaptive optics and material ***,the limitations of existing varifocal tools continue to beset the performance capabilities and operating overhead of the optical systems that mobilize such *** varifocal tools that are the least burdensome to operate(*** crystal,elastomeric or optofluidic lenses)suffer from low(≈100 Hz)refresh ***,the fastest devices sacrifice either critical capabilities such as their dwelling capacity(*** gradient lenses or monolithic micromechanical mirrors)or low operating overhead(*** mirrors).Here,we present a general-purpose random-access axial focusing device that bridges these previously conflicting features of high speed,dwelling capacity and lightweight drive by employing lowrigidity micromirrors that exploit the robustness of defocusing phase ***,the device consists of an 8.2mm diameter array of piston-motion and 48-μm-pitch micromirror pixels that provide 2πphase shifting for wavelengths shorter than 1100 nm with 10-90% settling in 64.8μs(i.e.,15.44 kHz refresh rate).The pixels are electrically partitioned into 32 rings for a driving scheme that enables phase-wrapped operation with circular symmetry and requires<30 V per *** experiments demonstrated the array’s wide focusing range with a measured ability to target 29 distinct resolvable depth ***,the features of the proposed array offer the potential for compact,straightforward methods of tackling bottlenecked applications,including high-throughput single-cell targeting in neurobiology and the delivery of dense 3D visual information in AR/VR.

关键词： mirror axial random

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