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Purification of β-Glucan of Oyster Mushroom (Pleurotus pulmonarius) and Its Application in Model Food

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Agricultural Sciences 2023年第12期14卷 1732-1750页

作者： hulya Demir Health Science Faculty Yeditepe University Istanbul Türkiye

Mushrooms are recognized as sources of β-glucan. The aim of this study was to purify β-glucan from oyster mushrooms (Pleurotus pulmonarius) by alkaline extraction. The extracted β-glucan was added to a cracker recipe and the sensory, physical and estimated glycemic index of the final product were evaluated. Optimum extraction parameters were determined to be 80˚C, 90 minutes and 30% KOH. The β-glucan crackers had a glycemic index ranging from 88.07 to 67.32, while glucose had a glycemic index of 100. Based on the sensory study, it can be concluded that crackers enriched with β-glucan and possessing functional qualities may meet consumer expectations.

关键词： Oyster Mushroom Alkaline Extraction Glycemic Index

Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats

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World Journal of Gastroenterology 2008年第8期14卷 1222-1230页

作者： Alper Akcan Sebahattin Muhtaroglu hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci Namik Yilmaz Department of General Surgery ErciyesUniversity School of Medicine Kayseri 38039 Turkey Department of Biochemistry ErciyeUniversity School of Medicine Kayseri 38039 Turkey Department of Pathology Erciyes University School of Medicine Kayseri 38039 Turkey Department of Gastroenterology Erciyes University School of Medicine Kayseri 38039 Turkey

AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95

关键词： Bombesin Neurotensin Colitis Apoptosis

Complementary and alternative medicine in pediatrics in Turkey

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World Journal of Pediatrics 2014年第4期10卷 299-305页

作者： Candan Ozturk hulya Karatas Alfred Längler Tim Schütze Rebekka Bailey Tycho Jan Zuzak Istanbul Sabahattin Zaim University Faculty of Health SciencesHead of Nursing DepartmentIstanbulTurkey Harran University School of HealthPediatric Nursing DepartmentSanliurfa Turkiye Gemeinschaftskrankenhaus Department for Integrative Pediatric and Adolescent MedicineHerdeckeGermany University of Witten/Herdecke Faculty of HealthCentre for Integrative MedicineWittenGermany University Children's Hospital Department of Pediatric Oncology and HematologyEssenGermany

Background:Complementary and alternative medicine(CAM)is applied both to children and adults widely throughout the world.A previous pan-European survey showed a surprisingly high CAM-use in Turkish *** review aimed to survey information on the use of CAM in pediatrics in *** sources:A narrative,non-systematic review was conducted by melding expert opinions with a thorough and balanced review of available *** unrestricted literature search using the key words,"alternative","complementary","integrative","prevalence"and"pediatric"or"children"and"Turkey"was performed by internet search in March,2012 using PubMed and Google ***:CAM use was examined in general pediatrics,pediatric oncology,patients with asthma,and patients with diabetes.A frequency of CAM use was 87%in Turkish pediatric patients,with a mean of 60%.The primary sources of information about CAM are family and *** with patients/parents and health care professionals showed that most parents do not speak about CAM use with their physicians or ***:CAM is extensively used in Turkish pediatric *** might be due to Turkey's status as a developing country in which a traditional medical system still dominates in comparison to developed ***,larger studies are required to prove an extensive use of CAM in Turkey,as this review article does not have the capacity for in-depth *** about CAM and its related topics is essential for physicians and nurses in order to meet the patients'wish for a competent consultation concerning all aspects of a possible therapy.

关键词： acupuncture alternative medicine herbal medicine homeopathy mind-body

Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B_1 exposure

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World Journal of Hepatology 2012年第5期4卷 169-175页

作者： hulya Yazici Ming-Whei Yu Po-Huang Lee Regina M Santella Department of Oncology Oncology InstituteIstanbul UniversityIstanbul 34093Turkey Graduate Institute of Epidemiology College of Public HealthNational Taiwan University Department of Surgery College of MedicineNational Taiwan University Department of Environmental Health Sciences Mailman School of Public Health of Columbia University630 W 168 Th St.New YorkNY 10032United States

AIM:To determine global DNA methylation in paired hepatocellular carcinoma(HCC) samples using several different assays and explore the correlations between hypomethylation and clinical parameters and biomarkers,including that of aflatoxin B 1 ***:Using the radio labeled methyl acceptance assay as a measure of global hypomethylation,as well as two repetitive elements,including satellite 2(Sat2) by MethyLight and long interspersed nucleotide elements(LINE1),by ***:By all three assays,mean methylation levels in tumor tissues were significantly lower than that in adjacent *** acceptance assay log(mean ± SD) disintegrations/min/ng DNA are 70.0 ± 54.8 and 32.4 ± 15.6,respectively,P = 0.040;percent methylation of Sat2 42.2 ± 55.1 and 117.9 ± 88.8,respectively,P < 0.0001 and percent methylation LINE1 48.6 ± 14.8 and 71.7 ± 1.4,respectively,P < *** B 1 albumin(AFB 1-Alb) adducts,a measure of exposure to this dietary carcinogen,were inversely correlated with LINE1 methylation(r =-0.36,P = 0.034).CONCLUSION:Consistent hypomethylation in tumor compared to adjacent tissue was found by the three different *** 1 exposure is associated with DNA global hypomethylation,suggesting that chemical carcinogens may influence epigenetic changes in humans.

关键词： Hepatocellular carcinoma Epigenetics Hypomethylation [3 H]-methyl acceptance assay Satellite 2 Long interspersed nucleotide element-1 Aflatoxin B_1

Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

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World Journal of Gastroenterology 2014年第29期20卷 10158-10165页

作者： Sami Akbulut hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli Yusuf Turkoz Liver Transplant Institute Inonu University Faculty of Medicine Department of Histology and Embriology Inonu University Faculty of Medicine Department of Anatomy Adiyaman University Faculty of Medicine Department of Biochemistry Dicle University Faculty of Medicine Department of Biochemistry Inonu University Faculty of Medicine

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX)-induced hepatotoxicity.

关键词： Methotrexate Amifostine N-acetyl cysteine Ascorbic acid Hepatotoxicity Oxidative stress

Family Lifestyle and Housing Preferences during the Process of Globalization： The Case of Turkey

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Journalism and Mass Communication 2014年第12期4卷 787-793页

作者： Betel Gurel hulya Oztop Hacettepe University Ankara Turkey

Although the fundamental physical role of housing is safety and sheltering for individuals, it is in fact the collection of places that hold the family together. Due to globalization and changes in the world, housing is no longer only a structure that provides sheltering but is also a factor that provides mutual interaction in formation of life style and quality. The elements such as the increase in the effect of consumption preferences and life style on selections, the changes in family structure, and urban structures also influence the residences used and housing preferences. The purpose of this study is to determine the general situation of housing preferences while taking into account the family life style in Turkey and at the same time to make an evaluation based on international publications.

关键词： family life styles housing preference globalization

Mobility in the Retirement Period An Assessment of the Current Situation

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Journalism and Mass Communication 2014年第3期4卷 209-214页

作者： hulya Oztop Pelin Pekmezci Hacettepe University Ankara Turkey

Today, individuals＇ attitudes towards retirement and old age have changed with the increase of life expectancy and healthy and active years after retirement, rise in purchasing power, and mobility opportunities. As a result of this change, the rate of post-retirement migration, settling into a new life in a new region after retirement, has considerably increased. However, despite of this increase, post-retirement migration is one of the least analyzed migration movements among existing studies. Hence, in this article, studies analyzing properties of post-retirement migration and factors causing this migration are assessed. As every migration movement, post-migration movements also create changes laying different responsibilities on both emigrant and immigrant regions and migrating person and require settling into a new life in the place of arrival. In the relevant studies, the basic reason for post-retirement migration is considered as pursuit of peace and joy and it is defined as a migration type under the high influence of counter-urbanization movement. According to the results of the study, it is stated that post-retirement migrants, unlike many international migrants, can buy their own houses in the countries of arrival and can maintain a relatively high standard of living compared to that local community, and that this situation is a very attractive factor encouraging them to migrate. Moreover in the studies, characteristics causing migration and belonging to the region of departure are analyzed as aversive while characteristics belonging to the region of arrival are analyzed as attractive factors.

关键词： aging post-retirement migration international retirement migration mobility

Chemical Composition and Antimicrobial Activity of Essential Oils of Ocimum basilicum var. album （L.） Benth, Lavandula angustifolia subsp. Angustifolia,Melissa officinalis Belonging to Lamiaceae Family

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Journal of Food Science and Engineering 2017年第10期7卷 461-471页

作者： hulya Demir Sadlk Kalaycl Department of Nutrition and Dietetics Yeditepe University of Health Sciences lstanbul 34755 TR Department of Genetic and Bioengineering Yeditepe University of Engineering Istanbul 34755 TR

The present study was conducted to evaluate the chemical composition and antimicrobial activities of essential oils ofOcimum basilicum var. album （L.） Benth, Lavandula angustifolia subsp, angustifolia, Melissa officinalis. The chemical compositionof a hydrodistilled essential oils of Ocimum basilicum var. album （L.） Benth., Lavandula angustifolia subsp, angustifolia, Melissaofficinalis was analyzed by a GC/MS system. Ocimum basilicum var. album （L.） Benth essential oil contains1,6-octadien-3-ol,3,7-dimethyl （53.79%）, Lavandula angustifolia subsp, angustifolia essential oil 1,6-octadien-3-ol,3,7-dimethyl（42.07%）, Melissa officinalis essential oil d-limonene （26%）. Antimicrobial screening of the essential oils was made by disc *** antimicrobial test results showed that the Ocimum basilicum var. album （L.） Benth, Melissa officinalis, Lavandula angustifoliasubsp, angustifolia essential oils have great potential of antimicrobial activity against all three （Staphylococcus aureus （ATCC 6338）Gram positive, Escherichia coli （ATCC 10536）, Pseudomonas aeruginosa （ATCC 15442） Gram negative bacteria）, one fungi（Aspergillus niger）, one yeast （Candida albicans） species tested.

关键词： Essential oil, GC/MS composition, antimicrobial activity.

Existing anti-angiogenic therapeutic strategies for patients with metastatic colorectal cancer progressing following first-line bevacizumab-based therapy

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World Journal of Clinical Oncology 2019年第2期10卷 52-61页

作者： Ozkan Kanat hulya Ertas Department of Medical Oncology Faculty of Medicine Uludag University

Continuous inhibition of angiogenesis beyond progression is an emerging treatment concept in the management of metastatic colorectal cancer patients with prior bevacizumab exposure. Treatment options include the continuation or reintroduction of bevacizumab during the second-line chemotherapy or switching to a different antiangiogenic monoclonal antibody such as aflibercept or ramucirumab. In the selection of treatment, patient-based factors such as performance status, age, tumor burden, and tolerance and sensitivity to the firstline bevacizumab-based therapy, as well as treatment-related factors such as toxicity, efficacy, and cost, should be taken into consideration.

关键词： Angiogenesis inhibition Second-line chemotherapy Colorectal cancer Bevacizumab Aflibercept Ramucirumab