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First-line penpulimab(an anti-PD1 antibody)and anlotinib(an angiogenesis inhibitor)with nab-paclitaxel/gemcitabine(PAAG)in metastatic pancreatic cancer:a prospective,multicentre,biomolecular exploratory,phase II trial

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2960-2969页

作者： huizi sha.fan tong Jiayao Ni Yi Sun Yahui Zhu Liang Qi Xiaoqin Li Wei Li Yan Yang Qing Gu Xing Zhang Xiaoxuan Wang Chan Zhu Dongsheng Chen Baorui Liu Juan Du The Comprehensive Cancer Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingChina The Comprehensive Cancer Center Nanjing Drum Tower HospitalClinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingChina Department of Oncology The Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhouChina Department of Oncology The Affiliated Jiangning Hospital of Nanjing Medical UniversityNanjingChina National Institute of Healthcare Data Science at Nanjing University NanjingChina State Key Laboratory of Neurology and Oncology Drug Development Jiangsu Simcere Diagnostics Co.Ltd.Nanjing Simcere Medical Laboratory Science Co.Ltd.NanjingChina

Metastatic pancreatic cancer(mPC)has a dismal ***,we conducted a prospective,multicentre,single-arm,phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcitabine(PAAG)in patients with first-line mPC(NCT05493995).The primary endpoints included the objective response rate(ORR)and disease control rate(DCR),while secondary endpoints encompassed progression-free survival(PFS),overall survival(OS),and *** 66 patients analysed for efficacy,the best response,indicated by the ORR,was recorded at 50.0%(33/66)(95%CI,37.4–62.6%),with 33 patients achieving partial response(PR).Notably,the DCR was 95.5%(63/66,95%CI,87.3–99.1%).The median PFS(mPFS)and OS(mOS)were 8.8(95%CI,8.1–11.6),and 13.7(95%CI,12.4 to not reached)months,*** 3/4 treatment-related adverse events(TRAEs)were reported in 39.4%of patients(26/66).In prespecified exploratory analysis,patients with altered SWI/SNF complex had a poorer ***,low serum CA724 level,high T-cell recruitment,low Th17 cell recruitment,and high NK CD56dim cell scores at baseline were potential predicative biomarkers for more favourable *** conclusion,PAAG as a first-line therapy demonstrated tolerability with promising clinical efficacy for *** biomolecular findings identified in this study possess the potential to guide the precise clinical application of the triple-combo regimen.

关键词： CA724 prospective centre

Finite-Time Fuzzy Adaptive Output Feedback Resilient Control of Nonlinear Cyber-Physical Systems with Sensor Attacks and Actuator Faults

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Journal of Systems Science & Complexity 2024年第4期37卷 1545-1560页

作者： fan Xianrui LI Yongming tong shaocheng College of Science Liaoning University of TechnologyJinzhou 121001China

This paper studies the finite-time fuzzy adaptive output feedback resilient control problem for nonlinear cyber-physical systems(CPSs) with sensor attacks and actuator *** logic systems(FLSs) are used to approximate the unknown nonlinear functions,and a fuzzy state observer is constructed to estimate the unmeasured *** combining the Nussbaum function with the backstepping control design technique,a fuzzy adaptive resilient control scheme is designed to successfully address the effects of sensor attacks and actuator *** is proved that the controlled system is semi-global practical finite-time stability(SGPFS),and the tracking error converges to a small neighborhood of the origin in a finite time ***,the simulation and comparison results further demonstrate the effectiveness of the designed control method.

关键词： Cyber-physical systems fuzzy adaptive resilient control Nussbaum functions sensor attacks

Review of the research on the development and utilization of clay-type lithium resources

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Particuology 2024年第4期87卷 46-53页

作者： Ruiqi Xie Zhihui Zhao Xiong tong Xian Xie Qiang Song Peiqiang fan Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Engineering Research Center for Metal Tailings Resource Utilization Kunming650093China

Since the demands for lithium have been in explosive growth recently and several great clay lithium resources were founded in China,the development and utilization of clay-type lithium resources become a hot *** order to provide a guidance for the concentration and extracting lithium of clay-type lithium resources,this review systematically summarized the main types and characteristics of clay-type lithium resources and the research status of lithium extraction from clay lithium ***,the flotation research status of the main mineral of clay lithium ore was also ***,we discussed the difficulties in the development and utilization of clay-type lithium ore and put forward the subsequent research *** paper can provide a guidance for the con-centration and extracting lithium of clay-type lithium resources in the future.

关键词： Clay lithium Clay mineral flotation Lithium extraction Leaching

MnO-pillared graphene blocks enabling the ultrastable and ultrafast aqueous zinc ion batteries

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Science China Chemistry 2024年第9期67卷 2930-2940页

作者： Zheng Liu Zhipeng Qiu Zhiyuan Li tong Wei Zhuangjun fan Huan Pang School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China School of Materials Science and Engineering China University of PetroleumQingdao 266580China

Due to the low cost,high theoretical capacity,and environmental friendliness,manganese-based cathodes are regarded as promising alternatives for aqueous zinc ion batteries(AZIBs).However,the practicality of the zinc-manganese system is faced with great challenges,such as the inevitable structural collapse of the cathode and controversial energy storage ***,we propose a novel concept of spatial deposition mechanism through the addition of MnSO_(4) additives in the Mn O-pillared graphene blocks(G-MnO).The covalent interface between MnO nanoparticles and multilayered graphene nanosheets can construct an in-built micro-electric field,which is beneficial for consecutive electron transfer(in both horizontal and vertical directions).On this basis,the surficial activity of MnO confined in the interlayered nano-space is greatly enhanced and provides enough spatial deposition and subsequent reaction site for MnSO_(4) additives,thus firstly extending the surficial controlled process to stereoscopic space,effectively improving the electrochemical performance of ***,the assembled Zn//G-Mn O battery exhibits an excellent rate capability of 281.5 mAhg^(-1)at 0.1 A g^(-1)and 106 mAhg^(-1)at 20 Ag^(-1),and impressive cycling stability(93 mAhg^(-1)remaining after 5,000 cycles).This finding may provide a new opportunity for the rational design of surficial controlled energy storage and conversion devices.

关键词： zinc-ion battery manganese monoxide laminated constructure ultrahigh rate performance graphene

A novel Ag/ZnO core-shell structure for efficient sterilization synergizing antibiotics and subsequently removing residuals

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Green Energy & Environment 2024年第2期9卷 366-377页

作者： Wenmei Han Wenli Wang Jie fan Runping Jia Xuchun Yang tong Wu Qingsheng Wu School of Chemical Science and Engineering Shanghai Key Laboratory of Chemical Assessment and SustainabilityInstitute of Advanced StudyTongji UniversityShanghai200092China College of Textile and Clothing Engineering China National Textile and Apparel Council Key Laboratory of Natural DyesSoochow UniversitySuzhou215123China Department of Urology Shanghai First People’s HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai201418China

The massive use of antibiotics has led to the aggravation of bacterial resistance and also brought environmental pollution *** poses a great threat to human *** the dosage of antibiotics is reduced by increasing its bactericidal performance,the emergence of drug resistance is certainly delayed,so that there's not enough time for developing drug resistance during ***,we selected typical representative materials of metal Ag and semiconductor ZnO nano-bactericides to design and synthesize Ag/ZnO hollow core-shell structures(AZ for short).Antibiotics are grafted on the surface of AZ through rational modification to form a composite sterilization *** research results show that the antibacterial efficiency of the composite system is significantly increased,from the sum(34.7%+22.8%-57.5%)of the antibacterial efficiency of AZ and gentamicin to 80.2%,net synergizes 22.7%,which fully reflects the effect of 1+1>***,the dosage of antibiotics can be drastically reduced in this way,which makes both the possibility of bacterial resistance and medical expenses remarkably ***,residual antibiotics can be degraded under simple illumination using AZ-self as a photocatalyst,which cuts off the path of environmental *** short,such an innovative route has guiding significance for drug resistance.

关键词： Ag/ZnO hollow Core-shell structures Antibiotics Gentamycin Synergistic sterilization Photodegradation

Two Stages Segmentation Algorithm of Breast Tumor in DCE-MRI Based on Multi-Scale Feature and Boundary Attention Mechanism

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Computers, Materials & Continua 2024年第7期80卷 1543-1561页

作者： Bing Li Liangyu Wang Xia Liu Hongbin fan Bo Wang Shoudi tong School of Automation Harbin University of Science and TechnologyHarbin150080China Heilongjiang Provincial Key Laboratory of Complex Intelligent System and Integration Harbin150080China School of Computer Engineering Technology Guangdong Institute of Science and TechnologyZhuhai519090China

Nuclearmagnetic resonance imaging of breasts often presents complex *** tumors exhibit varying sizes,uneven intensity,and indistinct *** characteristics can lead to challenges such as low accuracy and incorrect segmentation during tumor ***,we propose a two-stage breast tumor segmentation method leveraging multi-scale features and boundary attention ***,the breast region of interest is extracted to isolate the breast area from surrounding tissues and ***,we devise a fusion network incorporatingmulti-scale features and boundary attentionmechanisms for breast tumor *** incorporate multi-scale parallel dilated convolution modules into the network,enhancing its capability to segment tumors of various sizes through multi-scale convolution and novel fusion ***,attention and boundary detection modules are included to augment the network’s capacity to locate tumors by capturing nonlocal dependencies in both spatial and channel ***,a hybrid loss function with boundary weight is employed to address sample class imbalance issues and enhance the network’s boundary maintenance capability through additional *** was evaluated using breast data from 207 patients at RuijinHospital,resulting in a 6.64%increase in Dice similarity coefficient compared to the *** results demonstrate the superiority of the method over other segmentation techniques,with fewer model parameters.

关键词： Dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI) breast tumor segmentation multi-scale dilated convolution boundary attention the hybrid loss function with boundary weight

Coulomb-assisted nonlocal electron transport between two pairs of Majorana bound states in a superconducting island

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Chinese Physics B 2024年第5期33卷 275-279页

作者：王浩迪任俊潼吕海峰柯莎莎 School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China

We investigate the nonlocal transport modulated by Coulomb interactions in devices comprising two interacting Majorana wires,where both nanowires are in proximity to a mesoscopic superconducting(SC)*** Majorana bound state(MBS)is coupled to one lead via a quantum dot with resonant *** this device,the nonlocal correlations can be induced in the absence of Majorana energy *** find that the negative differential conductance and giant current noise cross correlation could be induced,due to the interplay between nonlocality of MBSs and dynamical Coulomb blockade *** feature may provide a signature for the existence of the MBSs.

关键词： Majorana bound states superconducting island current cross correlation

A high-performance multi-wavelength optical switch based on multiple fano resonances in an all-dielectric metastructure

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Optoelectronics Letters 2024年第4期20卷 193-199页

作者： CAO Shuangshuang fan Xinye fanG Wenjing CHEN Huawei BAI Chenglin tong Cunzhu School of Physics Science and Information Engineering Liaocheng UniversityLiaocheng 252000China shandong Provincial Key Laboratory of Optical Communication Science and Technology Liaocheng 252000China Liaocheng Key Laboratory of Industrial-Internet Research and Application Liaocheng 252000China Institute of Semiconductors Chinese Academy of SciencesBeijing 100083China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

The multi-wavelength optical switch based on an all-dielectric metastructure consisting of four asymmetric semi-circular rings was designed and analyzed in this *** fano resonance modes,which can be explained by bound states in the continuum(BIC)theory,are excited in our structure with a maximum Q-factor of about 2450 and a modulation depth close to 100%.By changing the polarization direction of the incident light,the transmission amplitude of fano resonances can get effectively *** on this tuning property,the metastructure can achieve a multi-wavelength optical switch in the near-infrared region(900—980 nm)and the maximum extinction ratio can reach 38.3 d *** addition,the results indicate that the fano resonances are sensitive to the changes in the refractive *** sensitivity(S)and the figure of merit(FOM)are 197 nm/RIU and 492 *** proposed metastructure has promising potential in applications such as optical switches,sensors,modulators and lasers.

关键词： dielectric structure resonance

Reservoir characteristics and controlling factor of tight sandstone in Shuixigou Group in Taibei depression,Turpan-Hami basin

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Energy Geoscience 2024年第2期5卷 70-80页

作者： tong Lin Xuan Chen fan Yang Hongguang Gou Mingyu Liu Runze Yang PetroChina Research Institute of Petroleum Exploration&Development Beijing100083China Research Institute of Exploration&Development PetroChina Tuha Oilfield Company HamiXinjiang839009China China University of Geosciences(Beijing) Beijing100083China

The positive structure belts surrounding the Taibei Sag,Turpan-Hami Basin,have been the main targets for oil and gas exploration for years and are now left with remaining resources scattering in reservoirs adjacent to source rocks in the sag,where the Shuixigou Group with substantial oil and gas potential constitutes the primary focus for near-source ***,characterization of development and key controlling factors of reservoir space becomes a must for future exploration in the *** study investigates the development traits,genesis,and controlling factors of the Xishanyao and Sangonghe formations in the Shengbei and Qiudong Sub-sags of the Taibei Sag with techniques such as cast thin-section observation,porosity and permeability tests,high-pressure mercury injection,and saturation fluid NMR analysis of reservoir *** findings reveal that the Shuixigou Group in the Taibei Sag consists of lithic *** in the group are mostly poor in terms of physical properties,with undeveloped primary pores dominated by intergranular dissolved pores as a result of a strong *** analysis of key controlling factors of the Sangonghe Formation reveals significant distinctions in sandstone particle size,sand body thickness,genesis and distribution,provenance location,and source rock type between the Qiudong area and Shengbei ***,the coal seams of the Xishanyao Formation exhibit heightened development with shallower burial depth and lower maturity compared to those of the Sangonghe ***,this environment fosters the formation of organic acids,which have a stronger dissolution effect on minerals to develop secondary dissolution pores,and ultimately resulting in better reservoir physical ***,the reservoirs within the Qiudong area of the Taibei Sag demonstrate superior characteristics compared to those in the Shengbei ***,the reservoir physical properties of the Xishanyao For

关键词： Intergranular dissolved pore Organic acid dissolution Secondary dissolution pore Tight sandstone Shuixigou group Turpan-Hami basin