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Food Bioscience 2022年第2期46卷 997-1005页

作者： huizi tan Shaoping Nie State Key Laboratory of Food Science and Technology China-Canada Joint Laboratory of Food Science and Technology(Nanchang)Key Laboratory of Bioactive Polysaccharides of Jiangxi ProvinceNanchang UniversityNanchang330047JiangxiPeople’s Republic of China

Epidemiologic observations provoke global concerns on the morbidity and mortality of chronic *** clinical researches cast light on the intake of complex polysaccharides/dietary fiber on the improvement of health ***,the precise molecular mechanism implicating the cross-talks among gut microbiome,host biomarkers and polysaccharides with clarified structural characteristics,can be explored by multi-omics techniques and effectuate the personalized dietary *** manufacturing technologies such as synthetic biology are emerging towards the successful implement of polysaccharides-based future food.

关键词： Polysaccharides Gut microbiome Biomarkers Multi-omics Precision intervention Future food

Impact of Bifidobacterium longum NSP001 on DSS-induced colitis in conventional and humanised mice

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Food Science and Human Wellness 2023年第4期12卷 1109-1118页

作者： Menglin Chen Hong Yao huizi tan Wenqi Huang Quanyong Wu Shaoping Nie State Key Laboratory of Food Science and Technology China-Canada Joint Laboratory of Food Science and Technology(Nanchang)Nanchang UniversityNanchang 330047China

Most scientific investigations regarding inflammatory bowel disease(IBD)pathogenesis or therapeutic strategies use dextran sulfate sodium(DSS)-induced models performed on ***,differences between human and animal microbiota may confound the data reproducibility from rodent experiments to clinical *** this study,the intervention effects of Bifidobacterium longum NSP001 on DSS-induced colitis were investigated using mice colonized with either native or humanised *** in disease activity index(DAI),morphology and histology of colon tissue,intestinal permeability,and secretion of MPO,TNF-αand IL-6 were ameliorated by daily intake of live *** NSP001 cells in both conventional and humanised colitis *** the abnormal thymus index,and colonic production of ZO-1 and iNOS were improved only in colitis mice treated with *** NSP001 and humanised *** accumulation of acetic acid and propionic acid in colon microbiome,and the optimization of primary bile acid biosynthesis and glycerophospholipid metabolism pathways in cecum commensals were likely to explain the beneficial effects of *** *** data revealed that intestinal microbiome baseline would possibly affect the manifestation features of interventions by probiotics or dietary components and highlighted the necessity to include humanised microbiome while investigating potential therapeutic strategies based on rodent models.

关键词： Bifidobacterium longum Ulcerative colitis Humanised mice Inflammation Metabolism pathways

食品胶体的健康干预新策略:靶向菌群的研究及应用

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中国食品学报 2022年第11期22卷 1-13页

作者：聂少平谭惠子南昌大学食品科学与技术国家重点实验室中国-加拿大食品科学与技术联合实验室江西省生物活性多糖重点实验室南昌330047

食品胶体资源丰富,其中复杂多糖类胶体更是天然来源的水溶性膳食纤维,是具有高营养附加值的食品添加剂。大量研究表明,不同类型的食品胶体会富集不同种属的关键菌,通过肠-肝轴、肠脑轴等发挥关联调节作用。建立“食品胶体-肠道菌群-人... 详细信息

食品胶体资源丰富,其中复杂多糖类胶体更是天然来源的水溶性膳食纤维,是具有高营养附加值的食品添加剂。大量研究表明,不同类型的食品胶体会富集不同种属的关键菌,通过肠-肝轴、肠脑轴等发挥关联调节作用。建立“食品胶体-肠道菌群-人体健康”的互作网络,对个性化膳食开发具有重要的创新意义。本文系统归纳了复杂多糖类胶体的理化性质及功能活性,重点阐述以肠道微生物为导向的食品胶体研究及开发策略,为未来健康干预提供理论依据。

关键词：食品胶体复杂多糖食品添加剂菌群靶向个性化应用

高校现代产业学院建设中“三链”有效衔接研究

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当代教育论坛 2023年第2期 10-17页

作者：于意谭慧子盛欣湖南人文科技学院娄底417000 湖南人文科技学院科研与社会服务处娄底417000 湘潭大学碧泉书院·哲学与历史文化学院湘潭411100 湖南第一师范学院长沙410000

产业链、教育链、创新链是围绕产业、教育和创新三大主题形成的活动链条,产业链、教育链、创新链的衔接,是产学研深度融合的体现。高校现代产业学院是产学研深度融合的创新组织形式,担负着产业链、教育链、创新链衔接的组织功能,在高校... 详细信息

产业链、教育链、创新链是围绕产业、教育和创新三大主题形成的活动链条,产业链、教育链、创新链的衔接,是产学研深度融合的体现。高校现代产业学院是产学研深度融合的创新组织形式,担负着产业链、教育链、创新链衔接的组织功能,在高校现代产业学院建设中,通过明确其在产业链、教育链、创新链中的角色作用,剖析产业链、教育链、创新链的衔接机理,并就产业链、教育链、创新链的衔接问题提出对策,对于全面发挥高校现代产业学院人才培养、技术创新和专业建设等功能,具有重要价值。

关键词：高校现代产业学院 “三链” 角色机理对策

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益生菌对消化道胃酸和胆盐胁迫的应激机理

中国食品学报 2010年第6期10卷 1-6页

作者：陈卫谭惠子胡斌刘小鸣江南大学食品学院食品科学与技术国家重点实验室无锡214122

益生菌进入人体消化道后,会遇到高酸及胆盐等不利益生菌存活的胁迫环境。酸和胆盐胁迫可使益生菌的活性下降,影响益生功能的发挥。亚致死剂量的酸或胆盐胁迫可以提高益生菌的耐受力,有助于益生菌在消化道中的存活。因此,研究益生菌酸胁... 详细信息

益生菌进入人体消化道后,会遇到高酸及胆盐等不利益生菌存活的胁迫环境。酸和胆盐胁迫可使益生菌的活性下降,影响益生功能的发挥。亚致死剂量的酸或胆盐胁迫可以提高益生菌的耐受力,有助于益生菌在消化道中的存活。因此,研究益生菌酸胁迫及胆盐胁迫应激机理具有非常重要的意义。本文主要综述益生菌酸胁迫和胆盐胁迫可能的机理,并对未来的研究方向进行探讨。

关键词：益生菌酸胁迫胆盐胁迫交叉应激

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夏枯草研究概述

江西食品工业 2008年第2期 38-41页

作者：谭惠子聂少平南昌大学生命科学学院江西南昌330031

夏枯草(Prunella vulgaris Linn)为临床常用中药,具有许多生物活性及药理作用。本文系统的介绍了夏枯草的化学成分、药理作用及其栽培研究等方面的研究进展。

关键词：夏枯草化学成份药理研究栽培研究

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膳食纤维的生理功能与改性

江西食品工业 2007年第4期 41-44页

作者：谭惠子万婕南昌大学生命科学学院江西南昌330031 南昌大学食品科学与技术国家重点实验室江西南昌330047

作为"第七营养素"的膳食纤维,对维持人体健康起着至关重要的作用。本文对膳食纤维的分类、物化性质、生理功能以及其改性研究的现状等进行了综述。

关键词：膳食纤维生理功能改性

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蜂王浆中活性因子对衰老小鼠的保护作用

食品与生物技术学报 2022年第7期41卷 130-139页

作者：余贤娴汪玲兰天余春涛黄文琦吴泉勇肖乾煌聂欣可谭惠子聂少平南昌大学食品科学与技术国家重点实验室/中国-加拿大食品学与技术联合实验室(南昌)/江西省生物活性多糖重点实验室江西南昌330047 江西汪氏蜜蜂园有限公司江西南昌330008

为了探索蜂王浆及其主要的蛋白质类、脂类功能活性因子对D-半乳糖(D-gal)致衰老小鼠的保护作用。实验通过透析、超滤、有机相萃取的方法分别提取分离了蜂王浆中粗蛋白、蛋白质类功能因子及脂类功能因子。通过连续7周每日腹腔注射100 mg/... 详细信息

为了探索蜂王浆及其主要的蛋白质类、脂类功能活性因子对D-半乳糖(D-gal)致衰老小鼠的保护作用。实验通过透析、超滤、有机相萃取的方法分别提取分离了蜂王浆中粗蛋白、蛋白质类功能因子及脂类功能因子。通过连续7周每日腹腔注射100 mg/kg(以干质量计)的D-gal建立衰老小鼠模型,并分别给予蜂王浆及不同剂量的粗蛋白组分、蛋白质类或脂类功能因子干预后,发现蜂王浆可以显著提高小鼠在T-迷宫中的准确率,并且降低肝脏器官指数,证实蜂王浆可能提高衰老小鼠的认知记忆水平,改善小鼠的衰老症状;脂类功能因子及高剂量的蛋白质类功能因子能够显著提高T-迷宫准确率、缓解肝脏肿大。因此推测,蜂王浆中的蛋白质类功能因子和脂类功能因子都具有良好的抗衰老作用,其机制可能与提高大脑的记忆能力有关。

关键词：蜂王浆蜂王浆蛋白质 10-羟基-2-癸烯酸(10-HDA) D-半乳糖抗衰老

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Specific Recognition of Breast Cancer Cells In Vitro Using Near Infrared-Emitting Long-Persistence Luminescent Zn_3Ga_2Ge_2O_(10):Cr^(3+)Nanoprobes

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Nano-Micro Letters 2015年第2期7卷 138-145页

作者： Jinlei Li Junpeng Shi Jiangshan Shen huizi Man Mingxi Wang Hongwu Zhang School of Biomedical Sciences Huaqiao University and Engineering Research Center of Molecular Medicine Ministry of Education Institute of Urban Environment Chinese Academy of Science

In this paper, near-infrared emitting long-persistence luminescent Zn3Ga2Ge2O10:Cr3?(ZGG) nanoparticles with diameters of 30–100 nm and bright luminescence were prepared by a sol–gel synthesis method. After the surface amination, the nanoparticles were further bioconjugated with breast cancer-specific monoclonal antibody(anti-Ep CAM) to form ZGG-Ep CAM nanoprobes which can specifically target breast cancer cell lines(MCF7) in vitro. The results of in vitro images show that the luminescence signals from the cells treated with ZGG-Ep CAM nanoprobes are stronger than those from cells treated with ZGG-unconjugated antibody, indicating that the prepared ZGG-Ep CAM nanoprobes possessed excellent specific recognition capability. Furthermore, due to their long afterglow properties, the imaging could persist more than 1 h. Therefore, these nanoprobes could not only provide a high specificity detection method for cancer cells but also realize the long-time monitoring. Developed near-infrared emitting long-persistence luminescent nanoprobes will be expected to find new perspectives for cell therapy research and diagnosis applications.

关键词： Nanoprobes Long afterglow Near-infrared luminescence Target imaging

Impacts of climate warming and crop management on maize phenology in northern China

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Journal of Arid Land 2019年第6期11卷 892-903页

作者： XIAO Dengpan ZHAO Yanxi BAI huizi HU Yukun CAO Jiansheng Engineering Technology Research Center Geographic Information Development and Application of HebeiInstitute of Geographical SciencesHebei Academy of SciencesShijiazhuang 050011China Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China

Climate warming has and will continue to exert a significantly impact on crop phenology in the past and coming *** observed data of phenology and a crop growth model provides a good approach for quantitating the effects of climate warming and crop management on crop *** purpose of this study is to determine the impacts of temperature change, sowing date(SD) adjustment and cultivar shift on maize phenology in northern China during 1981–*** indicated that climate warming caused anthesis date(AD) and maturity date(MD) of maize to advance by 0.2-5.5 and 0.6-11.1 d/10 a, *** to climate-driven changes in maize phenology, three growth periods of maize, i.e., vegetative growth period(VGP;from sowing to anthesis), reproductive growth period(RGP;from anthesis to maturity) and whole growth period(WGP;from sowing to maturity) shortened by 0.2-5.5, 0.4-5.6 and 0.6-11.1 d/10 a, *** SD adjustment(i.e., SD advancement), AD and MD occurred early by 0.5-2.6 and 0.1-3.4 d/10 a, *** adjustment caused duration of VGP of maize to ***, duration of RGP slightly shortened by 0.1-1.3 d/10 ***, due to cultivar shift, MD of maize significantly delayed by 4.9-12.2 d/10 *** of VGP, RGP and WGP of maize prolonged by 0.2-4.1, 1.6-8.4 and 4.3-11.8 d/10 a, *** conclusion, our results indicated that cultivar shift, to some extent, could mitigate the negative impact of climate warming on maize phenology.

关键词： anthesis date maturity date sowing date growth period cultivar shift