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Multifactor dimensionality reduction analysis of syndrome characteristics of chronic persistent asthma

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Journal of Traditional Chinese Medical Sciences 2015年第3期2卷 159-165页

作者： Yanyan meng Aiping Chen Qi Shi Yue Yan Chaolumen Han huiyuan Sun Youlin Li Beijing University of Chinese Medicine Beijing 100029China The Key Institute of State Administration of Traditional Chinese Medicine China-Japan Friendship HospitalBeijing 100029China

Objective:To analyze the syndrome characteristics in patients with chronic persistent ***:365 patients(121 males,244 females,60.829.1 years old)with chronic persistent asthma were enrolled in this cross-sectional *** information of syndrome,symptoms,signs,tongue coating and pulse were collected from all *** syndrome characteristics of chronic persistent asthma were examined through the multifactor dimensionality reduction(MDR)analysis and the results were verified by the Chi-square ***:The results of the MDR analysis and the Chi-square test showed the following positive correlation of the interaction among:the deficiency syndrome of the lung and spleen and deep pulse,disinclination to talk due to lack of qi,fatigue,lassitude and thick tongue coating;the deficiency syndrome of the lung and kidney and dizziness and disinclination to talk due to lack of qi,fatigue,lassitude and pallid complexion;the syndrome of phlegm-heat obstructing the lung and rapid pulse,abdominal distension,disinclination to talk due to lack of qi,frequent urination and lassitude;the syndrome of phlegm-dampness obstructing the lung and disinclination to talk due to lack of qi,greasy coating,fatigue and lassitude.(P<.05 for all).Conclusion:The syndrome of chronic persistent asthma is characterized by fatigue and lassitude due to dysfunction of the lung,spleen and kidney.

关键词： Bronchial asthma Chronic persistent period Traditional Chinese medicine Syndrome characteristics Multifactor dimensionality reduction

Occurrence of global natural hydrogen and profitable preservation

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Journal of Earth Science 2024年

作者： Quanyou Liu Xiaoqi Wu Xiaowei Huang Di Zhu Qingqiang meng Dongya Zhu huiyuan Xu Jiayi Liu Pengpeng Li Zheng Zhou Kaiqiang Zhang Zhijun Jin Institute of Energy， Peking University Northwest Institute of Eco-Environment and Resource， Chinese Academy of Sciences Petroleum Exploration & Production Research Institute，SINOPEC Key Laboratory for Biomass Gasification Technology of Shandong Province， Energy Research Institute， Qilu University of Technology (Shandong Academy of Sciences) Lancaster Environment Centre， Lancaster University

Occurrence and abundance of molecular hydrogen in natural geologic reservoirs are enigmatic， due to its various sources， diverse migration pathways and complicated biological and chemical reactions. Natural gas samples containing hydrogen from producing wells in several sedimentary basins in China were collected in this study， and gas abundances and isotopic compositions of these gases were compared with those in global petroliferous basins and deep intrusive rocks. Several geochemical indicators were suggested for identifying sources， migration and accumulation mechanisms of hydrogen in the subsurface environment. Hydrogen contents in natural gas deposits have contributions from various sources with the following high-to-low order: microbial degradation > serpentinization > deep mantle volatile release > radiation-induced water decomposition > thermal cracking of organic matter. A hydrogen-rich reservoir in Kansas， USA， is specifically analyzed to determine its formation mechanism. This study suggests that future exploration of geological hydrogen resources may focus on the igneous rock bodies with overlying dense sedimentary rocks in the continental rift systems.

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Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

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Genomics, Proteomics & Bioinformatics 2024年第4期22卷 99-117页

作者： Rou Zhang meng Hu Yu Liu Wanmeng Li Zhiqiang Xu Siyu He Ying Lu Yanqiu Gong Xiuxuan Wang Shan Hai Shuangqing Li Shiqian Qi Yuan Li Yang Shu Dan Du huiyuan Zhang Heng Xu Zongguang Zhou Peng Lei Hai-Ning Chen Lunzhi Dai National Clinical Research Center for Geriatrics and General Practice Ward/International Medical Center Ward General Practice Medical CenterState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Institute of Digestive Surgery West China HospitalSichuan UniversityChengdu 610041China Colorectal Cancer Center Department of General SurgeryWest China HospitalSichuan UniversityChengdu 610041China Advanced Mass Spectrometry Center Research Core FacilityFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China

Magnesium(Mg)deficiency is associated with increased risk and malignancy in colorectal cancer(CRC),yet the underlying mechanisms remain ***,we used genomic,proteomic,and phosphoproteomic data to elucidate the impact of Mg deficiency on *** analysis identified 160 genes with higher mutation frequencies in Low-Mg tumors,including key driver genes such as KMT2C and ***,initiation driver genes of CRC,such as TP53 and APC,displayed higher mutation frequencies in High-Mg ***,proteomic and phosphoproteomic data indicated that low Mg content in tumors may activate epithelial–mesenchymal transition(EMT)by modulating inflammation or remodeling the phosphoproteome of cancer ***,we observed a negative correlation between the phosphorylation of DBN1 at S142(DBN1S142p)and Mg content.A mutation in S142 to D(DBN1S142D)mimicking DBN1S142p up-regulated MMP2 and enhanced cell migration,while treatment with MgCl2 reduced DBN1S142p,thereby reversing this ***,Mg2þattenuated the DBN1–ACTN4 interaction by decreasing DBN1S142p,which in turn enhanced the binding of ACTN4 to F-actin and promoted F-actin polymerization,ultimately reducing MMP2 *** findings shed new light on the crucial role of Mg deficiency in CRC progression and suggest that Mg supplementation may be a promising preventive and therapeutic strategy for CRC.

关键词： Magnesium deficiency Colorectal cancer Genome instability Tumor metastasis Phosphorylation.

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机械制造专业中高职衔接人才培养方案的设计

职业技术教育 2016年第29期37卷 13-16页

作者：孟鑫沛曹会元东莞职业技术学院机电系机械制造与自动化专业教研室东莞职业技术学院机电系

中高职衔接作为中职、高职教育发展的"立交桥",是探索构建技能型人才选拔和培养长效机制的重要途径。针对当前中高职衔接存在的职业目标衔接不连贯、课程体系衔接不当、课程内容重复等问题,通过对机械制造专业的供需调研、职业能力分析... 详细信息

中高职衔接作为中职、高职教育发展的"立交桥",是探索构建技能型人才选拔和培养长效机制的重要途径。针对当前中高职衔接存在的职业目标衔接不连贯、课程体系衔接不当、课程内容重复等问题,通过对机械制造专业的供需调研、职业能力分析、课程体系构建,制定中高职衔接专业教学标准,在专业教学标准的基础上,完成机械制造专业中高职衔接人才培养方案的设计。

关键词：机械制造中高职衔接教学标准人才培养方案

中国省域医药制造业技术承接能力及空间差异研究

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中国医药工业杂志 2023年第3期54卷 455-461页

作者：王佳洛黄慧媛韩朦褚淑贞中国药科大学江苏南京211198

文章构建了医药制造业技术承接能力评价指标体系,采用熵权法和优劣解距离(TOPSIS)法测度我国省域医药制造业2014、2016、2018和2020年的技术承接能力发展水平,并根据测度结果,采用全局和局部莫兰指数分析各年份医药制造业技术承接能力... 详细信息

文章构建了医药制造业技术承接能力评价指标体系,采用熵权法和优劣解距离(TOPSIS)法测度我国省域医药制造业2014、2016、2018和2020年的技术承接能力发展水平,并根据测度结果,采用全局和局部莫兰指数分析各年份医药制造业技术承接能力的空间分布特征。从结果可见,技术获取能力和技术吸收能力是影响省域医药制造业技术承接能力的主要因素;我国省域医药制造业技术承接能力总体发展趋于稳定,但区域间差异较大,东部地区省份显著高于中西部地区;省域医药制造业技术承接能力呈现显著的空间正相关性关系,部分地区由于自身特殊性呈现出高低集聚或低高集聚的现象。

关键词：医药制造业技术承接能力熵权法优劣解距离法空间关联

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加味芪黄饮对糖尿病肾病的作用及其机制研究

中药新药与临床药理 2020年第8期31卷 930-933页

作者：赵威蒙向欣李辉远广州市中医医院广东广州510130

目的研究加味芪黄饮治疗糖尿病肾病(DN)的作用及其机制。方法雄性SD大鼠60只,随机分成正常对照组、模型对照组及加味芪黄饮低、高剂量组(400、800 mg·kg-1·d-1)。以高糖高脂饮食及链脲佐菌素复制DN大鼠模型。给药12周后,测定各组大鼠2... 详细信息

目的研究加味芪黄饮治疗糖尿病肾病(DN)的作用及其机制。方法雄性SD大鼠60只,随机分成正常对照组、模型对照组及加味芪黄饮低、高剂量组(400、800 mg·kg-1·d-1)。以高糖高脂饮食及链脲佐菌素复制DN大鼠模型。给药12周后,测定各组大鼠24 h尿白蛋白(24 h UAlb)、血肌酐(Scr)、尿素氮(BUN)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素敏感指数(ISI)等指标,HE染色观察大鼠肾组织病理改变,Western Blot法检测大鼠肾组织中胰岛素受体底物-1(IRS-1)的表达。结果与模型对照组比较,加味芪黄饮低、高剂量组大鼠24 h UAlb、Scr、BUN、FBG、FINS水平均较明显降低(P<0.05),ISI则明显升高(P<0.05),且有一定的量效关系;能减轻DN大鼠肾小球肥大,系膜细胞、系膜基质弥漫增生等病理改变;使大鼠肾组织IRS-1表达明显升高(P<0.05)。结论加味芪黄饮能保护DN大鼠的肾功能,减轻DN大鼠肾组织损伤,其可能通过上调IRS-1表达,以改善胰岛素抵抗状态而发挥作用。

关键词：加味芪黄饮糖尿病肾病胰岛素抵抗胰岛素受体底物-1 大鼠

Identification and characterization of the pathogen of Corynespora leaf spot of strawberry from China

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Identification and characterization of the pathogen of Coryn...

中国植物病理学会2021年学术年会

作者： XUE Caiying MA Qingzhou XU huiyuan WU Haiyan GENG Yuehua ZANG Rui XU Chao ZHANG meng Department of Plant Pathology College of Plant ProtectionHenan Agricultural University

Corynespora leaf spot,caused by the fungus Corynespora cassiicola,has become a great threat that affect the yield of various crops in *** 2016-2019,we isolated five typical Corynespora strains from the disease spots of strawberry leaves in different cities of Henan *** on analysis of their morphological characters and DNA sequences of ITS,TUB and EF-1 a gene regions,all of these isolates were undoubtedly identified as the species Corynespora cassiicola,which was then proved to be the only true pathogen by Koch’s *** on the biological properties of *** showed that PDA medium,25-30℃,pH 6-9,and alternating light and dark（12 h/12 h） are the optimal conditions for its mycelial *** best carbon and nitrogen sources were glucose and potassium nitrate,*** line with its wide host range,this pathogen could at least infect ten different crops while causing varying degrees of ***,preliminary exploration of the infection process of *** revealed that appressorium-like structures could form at the top of germ tubes on strawberry leaves（but not observed on the inner epidermis of onion）,which only distributed away from *** the above research results would provide a theoretical basis for the comprehensive control of Corynespora leaf spot disease of strawberry.

关键词： Corynespora leaf spot biological characteristics conidia germination appressoriumlike structures

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秦岭水源涵养功能解析

水土保持学报 2020年第6期34卷 211-218页

作者：王辉源宋进喜孟清西北大学城市与环境学院陕西省地表系统与环境承载力重点实验室西安710127 西北大学秦岭研究院西安710127 中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室陕西杨凌712100

稳定且良好的水源涵养功能是区域发展的基础,生态系统的水源涵养功能是当下区域生态水文研究的关键领域。秦岭因其重要的生态功能与地理环境特征,掌握其水源涵养功能的变化、水源涵养功能空间格局、影响因素敏感性等信息具有科学和实践... 详细信息

稳定且良好的水源涵养功能是区域发展的基础,生态系统的水源涵养功能是当下区域生态水文研究的关键领域。秦岭因其重要的生态功能与地理环境特征,掌握其水源涵养功能的变化、水源涵养功能空间格局、影响因素敏感性等信息具有科学和实践指导双重意义。选取陕西秦岭为研究区,基于InVEST产水模块和水源涵养模型,计算秦岭2000-2014年15年间水源涵养量的变化,从坡度、高程、坡向方面分析了水源涵养空间格局,选取降水、蒸散发、季节常数、根系深度、叶面积指数等因素敏感性。结果表明:(1)年均水源涵养量与年均降雨量基本同步波动,2000-2014年15年间秦岭水源涵养总量呈增加趋势,年均增加值为2×10^9 m^3,并且增加的趋势越来越明显。秦岭主要流域年平均水源涵养量为汉江流域>丹江流域>渭河流域>洛河流域>嘉陵江流域。(2)秦岭水源涵养功能与高程、坡度、植被覆盖度呈正相关,阴坡水源涵养量大于阳坡,子流域水源涵养功能以中等重要和重要为主,一般重要和极重要较少。(3)影响水源涵养功能关键因子参数敏感性为降雨>潜在蒸散发>叶面积指数>季节常数>植被根系深度。

关键词：秦岭 InVEST模型水源涵养功能空间格局

基于半桥MMC特征信号注入的柔性直流线路频变参数辨识

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电力系统保护与控制 2023年第24期51卷 33-43页

作者：聂铭和敬涵李猛张慧媛陈可傲李艳北京交通大学电气工程学院北京100044 国网山西省电力公司经济技术研究院山西太原030024

柔性直流电网故障电流上升速度快与电力电子器件过流能力弱形成突出矛盾,线路保护需要在数毫秒级完成故障判别,输电线路精确参数的获取对于提升继电保护的性能至关重要。然而直流系统中缺乏稳定基频,导致输电线路相关参数难以获取、保... 详细信息

柔性直流电网故障电流上升速度快与电力电子器件过流能力弱形成突出矛盾,线路保护需要在数毫秒级完成故障判别,输电线路精确参数的获取对于提升继电保护的性能至关重要。然而直流系统中缺乏稳定基频,导致输电线路相关参数难以获取、保护实现较为困难。针对柔性直流线路频变参数难以获取的问题,提出基于半桥模块化多电平换流器(half bridge modular multilevel converter, HB-MMC)特征信号注入的柔性直流线路频变参数辨识方法。首先通过换流器控制在线路中注入特定频率信号,然后利用快速傅里叶分解提取不同频率的信号并计算指定频率下的线路参数,最后依据不同线路参数的频变特性拟合出对应的幅频特性曲线。仿真表明,所提参数辨识方法可以准确拟合保护所需直流线路频变参数,参数辨识频段内相对误差小于1.5%。

关键词：半桥模块化多电平换流器特征信号注入线路参数计算频变参数