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Research 2024年第1期2023卷 663-674页

作者： Yang yu Zhe Wang Lingling Wang Qinghua Wang Rongfan Tang Sutong Xiang Qirui Deng Tingjun Hou huiyong Sun Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 210009JiangsuP.R.China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058ZhejiangP.R.China

Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous malignancies.Although there have been already at least 3 generations of ALK inhibitors approved by FDA or in clinical trials,the occurrence of various mutations seriously attenuates the effectiveness of the drugs.Unfortunately,most of the drug resistance mechanisms still remain obscure.Therefore,it is necessary to reveal the bottom reasons of the drug resistance mechanisms caused by the mutations.In this work,on the basis of verifying the accuracy of 2 main kinds of binding free energy calculation methodologies[end-point method of Molecular Mechanics with Poisson-Boltzmann/Generalized Born and Surface Area(MM/PB(GB)SA)and alchemical method of Thermodynamic Integration(TI)],we performed a systematic analysis on the ALK systems to explore the underlying shared and specific drug resistance mechanisms,covering the one-drug-multiple-mutation and multiple-drug-onemutation cases.

关键词： drugs Anaplastic clinical

Modification of polyetheretherketone(PEEK)physical features to improve osteointegration

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第3期23卷 189-203页

作者： Dan yu Xiaoyue LEI huiyong ZHU Department of Oral and Maxillofacial Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Department of Stomatology Zhejiang University School of MedicineHangzhou310058China

Polyetheretherketone(PEEK)has been widely applied in orthopedics because of its excellent mechanical properties,radiolucency,and biocompatibility.However,the bioinertness and poor osteointegration of PEEK have greatly limited its further application.Growing evidence proves that physical factors of implants,including their architecture,surface morphology,stiffness,and mechanical stimulation,matter as much as the composition of their surface chemistry.This review focuses on the multiple strategies for the physical modification of PEEK implants through adjusting their architecture,surface morphology,and stiffness.Many research findings show that transforming the architecture and incorporating reinforcing fillers into PEEK can affect both its mechanical strength and cellular responses.Modified PEEK surfaces at the macro scale and micro/nano scale have positive effects on cell-substrate interactions.More investigations are necessary to reach consensus on the optimal design of PEEK implants and to explore the efficiency of various functional implant surfaces.Soft-tissue integration has been ignored,though evidence shows that physical modifications also improve the adhesion of soft tissue.In the future,ideal PEEK implants should have a desirable topological structure with better surface hydrophilicity and optimum surface chemistry.

关键词： Polyetheretherketone(PEEK) Surface topography Architecture Stiffness Bone integration

CO2 corrosion behaviors of 13Cr steel in the high-temperature steam environment

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Petroleum 2020年第1期6卷 106-113页

作者： Guoqing Xiao SiZhou Tan Zhiming yu Baojun Dong Yonggang Yi Gang Tian huiyong yu Shanzhi Shi College of Chemical Engineering Southwest Petroleum UniversityChengdu610500China State Key Laboratory of Oil&Gas Reservoir Geology and Exploitation(Southwest Petroleum University) Chengdu610500China Research Institute of Engineering Technology Xinjiang Oilfield CompanyPetroChinaKaramay834000China

The study aims to explore the corrosion behaviors of 13Cr steel in the high-temperature steam environment.The corrosion behaviors of 13Cr steel were tested in CO2 auxiliary steam drive environment simulated with the HTHP autoclave.The corrosion morphology and product composition were explored by SEM,EDS,XRD and XPS.The exploration results showed the corrosion rate of 13Cr steel in the high-temperature steam environment was less than 0.04 mm/a.The corrosion behaviors of 13Cr steel were mainly affected by temperature and chloride ion concentration.Temperature inhibited steam condensation and the compactness of Cr-rich layer.With the increase in temperature,more droplets were adsorbed on the surface of 13Cr steel and the compactness of the Crrich layer is worse.Chloride ions affects the activity of Fe atoms in the metal matrix.When chloride concentration increased,Fe^2+concentration in the solution and FeCO3 content in the rich-Cr layer were increased and the rich-Cr layer became looser.

关键词： CO2 auxiliary steam drive Temperature Cl−concentration Corrosion 13Cr steel

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中药及其有效成分治疗阿尔茨海默病研究进展

中国实验方剂学杂志 2024年第10期30卷 258-268页

作者：曹珊陈智慧秦静琪张会永于莉吴威辽宁中医药大学沈阳110847 辽宁中医药大学附属医院沈阳110032 珠海科技学院广东珠海519041

阿尔茨海默病是一种常见的中枢神经退行性疾病,以认知功能减退和非认知性神经精神症状为主要表现,严重影响患者日常生活及行为能力。该病发病机制尚不明确,目前用于治疗阿尔茨海默病的西药均仅为对症治疗,途径单一,疗效有限且不良反应... 详细信息

阿尔茨海默病是一种常见的中枢神经退行性疾病,以认知功能减退和非认知性神经精神症状为主要表现,严重影响患者日常生活及行为能力。该病发病机制尚不明确,目前用于治疗阿尔茨海默病的西药均仅为对症治疗,途径单一,疗效有限且不良反应大。近年来,随着对阿尔茨海默病研究的不断深入,利用中药治疗阿尔茨海默病的探索与应用逐渐增多。多项研究表明中药及其有效成分能够通过调控病理蛋白产生和聚集、氧化应激、神经炎症、铁死亡、线粒体功能障碍、神经发生及传递、脑-肠轴等分子机制来发挥抗阿尔茨海默病的作用。该文归纳总结了近年中药治疗阿尔茨海默病的研究进展,以期为深入研究中药防治阿尔茨海默病的具体机制及发现有效中药活性成分提供参考。

关键词：阿尔茨海默病中药作用机制铁死亡脑-肠轴

山西省男男性行为者新精神活性物质使用现况与艾滋病性病感染相关因素分析

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中国艾滋病性病 2024年第3期30卷 275-281页

作者：赵田王静黄钰李慧咏秦玉明傅更锋南京医科大学公共卫生学院南京211166 晋城市疾病预防控制中心山西晋城048000 江苏省疾病预防控制中心南京210009

目的了解山西省MSM新精神活性物质使用状况与艾滋病性病感染的相关影响因素,为MSM艾滋病精准防控提供依据。方法2022年9月至2023年10月,在山西省晋城、临汾和长治市通过面对面访谈、网络调查的形式收集MSM相关信息。采用SPSS 23.0统计... 详细信息

目的了解山西省MSM新精神活性物质使用状况与艾滋病性病感染的相关影响因素,为MSM艾滋病精准防控提供依据。方法2022年9月至2023年10月,在山西省晋城、临汾和长治市通过面对面访谈、网络调查的形式收集MSM相关信息。采用SPSS 23.0统计软件分析数据,分别使用Pearsonχ^(2)检验和Logistic回归分析进行单因素和多因素分析。结果共收取724份有效问卷,MSM新精神活性物质使用率为27.49%(199人),HIV感染率为7.73%(56人);性病检测阳性126人(17.40%),不同性病阳性率分别为:梅毒6.49%(47人),生殖道沙眼衣原体8.43%(61人),淋球菌4.56%(33人)。校正年龄、婚姻状况、文化程度后,多因素Logistic回归分析结果显示,MSM最近6个月内发生同性商业性性行为、最近6个月内发生同性无保护性肛交、最近6个月内使用新精神活性物质、既往进行HIV检测者HIV感染风险高,文化程度为大专/本科及以上人群的HIV感染风险低;最近6个月内发生同性无保护性肛交、最近6个月内发生同性商业性性行为、使用新精神活性物质的MSM感染性病的风险高。结论山西省研究地区MSM新精神活性物质的使用率较高,是感染艾滋病性病的高风险人群,应加强该人群的艾滋病宣传教育、干预以及HIV/STD检测工作,通过MSM同伴教育来引导该人群坚持正确使用安全套从而减少高危性行为的发生。

关键词：男男性行为者新精神活性物质艾滋病病毒感染性病感染相关危险因素

砾岩致密油地质工程一体化井距优化——以玛131小井距立体开发示范区为例

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石油科学通报 2024年第1期9卷 103-116页

作者：曹炜鲜成钢吴宝成文恒于会永申颍浩余智超余凯中国石油大学(北京)非常规油气科学技术研究院北京102249 中国石油新疆油田公司工程技术研究院克拉玛依834000 中国石油长庆油田公司油气工艺研究院西安710018 中海油研究总院有限责任公司北京100028 中国石油大学(北京)地球科学学院北京102249 中国石油西南油气田公司勘探开发研究院成都610041

玛湖砾岩致密油藏的开发存在着地层非均质性强,两向应力差大,天然裂缝不发育和物性差的问题,为了更经济有效的开发,在玛131井区首次开展了小井距立体开发现场试验,试验区整体采收率较高但经济效益并未达到预期,急需开展井距优化工作。... 详细信息

玛湖砾岩致密油藏的开发存在着地层非均质性强,两向应力差大,天然裂缝不发育和物性差的问题,为了更经济有效的开发,在玛131井区首次开展了小井距立体开发现场试验,试验区整体采收率较高但经济效益并未达到预期,急需开展井距优化工作。本文采用地质工程一体化的思路和方法,建立了完整的立体井网井距优化流程,同时结合压裂参数和响应特征提出了一种多井多段条件下快速拟合压裂缝网模型的方法,主要包括:开展系统性油藏工程分析,基于精细地质和地质力学模型采用非常规裂缝模型进行复杂缝网模拟与拟合,耦合油藏数值模拟开展生产历史拟合,通过压裂数模一体化模拟完成了示范区井距优化并结合大范围井距矿场试验进行了验证。研究结果表明,解析缝长和模拟缝长结果可相互验证,百3段水平井裂缝相对较长,平均支撑半缝长70.1 m,平均水力裂缝高度24.6 m;百2段水平井裂缝相对较短且存在穿层效应,平均支撑半缝长61.1 m,平均水力裂缝高度28.3 m。在具备一定渗透性的地层条件下,两套开发层系的井距均可适当扩大至200~300 m,在确保较高采收率条件下提高单井产能和经济效益。本文优化验证后的井距范围可在同区块同层位进一步推广,所使用的立体井网井距优化流程可以被其他非常规油气藏类型所借鉴。

关键词：致密砾岩立体井网地质工程一体化多级水力压裂井距优化

通过密度泛函理论对溶剂效应对碳氢键断裂步骤的影响研究

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辽宁化工 2024年第5期53卷 667-670页

作者：田腾安会勇王涛于芳辽宁石油化工大学石油化工学院辽宁抚顺113001 大连理工大学宁波研究院浙江宁波315016 无锡市药品安全检验检测中心江苏无锡214000

碳氢键活化反应在合成方面的作用已经被研究证明了。其中8-氨基喹啉导向基介导的碳氢键活化反应是实现此策略最常用的方法。大量的计算化学研究都已证明8-氨基喹啉导向基自身强大的供电子效应以及刚性结构是其反应高效的关键。然而,与... 详细信息

碳氢键活化反应在合成方面的作用已经被研究证明了。其中8-氨基喹啉导向基介导的碳氢键活化反应是实现此策略最常用的方法。大量的计算化学研究都已证明8-氨基喹啉导向基自身强大的供电子效应以及刚性结构是其反应高效的关键。然而,与此相关的溶剂效应并没有得到充分研究。依次选取极性从低到高的溶剂甲苯、1,2-二氯乙烷、丙酮、乙腈、二甲基亚砜的隐式溶剂模型来对8-氨基喹啉导向基介导的sp~3碳氢键活化反应的决速步(碳氢键断裂步骤)进行密度泛函理论(DFT)计算,最终得知随着溶剂极性的提高,碳氢键断裂步骤的过渡态的熵减程度会明显下降,从而使得对应的吉布斯自由能垒降低,进而加快碳氢键断裂步骤的进行。

关键词：碳氢键活化密度泛函理论吉布斯自由能

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Multi-Wavelength Ultra-Weak Fiber Bragg Grating Arrays for Long-Distance Quasi-Distributed Sensing

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Photonic Sensors 2022年第2期12卷 185-195页

作者： Wenjing GAO Jianxia LIU huiyong GUO Xin JIANG Shaofa SUN Haihu yu Hubei Key Laboratory of Radiation Chemistry and Functional Materials Hubei University of Science and TechnologyXianning437100China National Engineering Laboratory for Fiber Optic Sensing Technology Wuhan University of TechnologyWuhan 430070China

Fiber Bragg grating(FBG)array,consisting of a number of sensing units in a single optical fiber,can be practically applied in quasi-distributed sensing networks.Serious signal crosstalk occurring between large-serial of identical FBGs,however,has limited the further increase in the number of sensing units,thus restricting applications only for short-distance sensing networks.To reduce the signal crosstalk,we design two novel types of 10-kilometer-long FBG arrays with 10000 equally spaced gratings,written on-line using a customized grating inscription system,which is affiliated to a drawing tower.Main factors causing signal crosstalk,such as spectral shadowing and multiple reflections,are firstly investigated in theory.Consistent with the theoretical findings,experimental results are proving that ultra-weak(the reflectivity of—40 dB)and multi-wavelength gratings of a number more than 10000 can be readily identified,with satisfied low crosstalk.The maximum attenuation of grating signal and minimum signal-to-noise ratio(SNR)in a single-wavelength array are 10.69 dB and 5.62 dB,respectively.As a comparison,by increasing the number of central wavelengths to three,the attenuation can be effectively reduced to 5.54dB and the minimum SNR has been improved to 8.14 dB.The current study significantly enhances the multiplexing capacity of FBG arrays and demonstrates promising potentials for establishing large-capacity quasi-distributed sensing networks.

关键词： Multi-wavelength gratings array large scale sensing network crosstalk ultra-weak grating

Influence of strain rate on grain refinement and texture evolution under complex shear stress conditions

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镁合金学报(英文) 2023年第7期11卷 2558-2584页

作者： Zhaocan Li Guoqin Wu Jianmin yu Jiebing Wang Jingjing Han huiyong Cui Zhimin Zhang College of Materials Science and Engineering North University of China3 Xueyuan RoadTaiyuan 030051China Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle TechnologyBeijing 100076China

The effects of different complex shear stress conditions on grain refinement and texture evolution of Mg-13Gd-4Y-2Zn-0.5Zr alloy were investigated.With increasing strain rate,the average grain size of compression-shear(CS)and compression-torsion(CT)samples are decreased,and the grain size of dynamic recrystallization(DRX)grains is also decreased.This is because that the precipitation number ofβphases is increased,and the hindering effect on grain growth can be significantly enhanced.The DRX fractions of CS and CT samples are decreased with increased strain rate.The low DRX fraction at high strain rate is related to the insufficient time for grains to nucleate.The DRX process can be promoted by the PSN mechanism of second phases,and the grain growth can be restricted by the pinning effect.At the same time,the texture strength is enhanced as the strain rate increased.Besides,the kinking degree of lamellar long-period stacking ordered(LPSO)phases is increased.Under complex shear stress conditions,non-basal slip,especially pyramidal slip,is easily activated and the texture is deflected greatly.Compared with the CS samples,CT samples have smaller average grain size,higher DRX fraction,and lower texture strength for a certain strain rate.This is because that the equivalent stress of the CT sample is larger,the stress triaxiality is smaller,so more serious dislocations are piled up near grain boundaries and second phases.At the same time,since CT sample was sheared with torsion,the dislocation movement path can be called“rotational dislocation accumulation”,and the longer distribution path of the CT sample is generated,so more sub-grains and low-angle grain boundaries(LAGBs)are formed.Compared with the CS sample,more huge-angle grain boundaries(HAGBs)and DRX grains are formed from grain boundary to grain interior,so better grain refinement effect is achieved.

关键词： Simple shear Compression-shear Compression-torsion Grain refinement Texture evolution ASB

加热与常温输送在役原油管道对调运行投产技术

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油气储运 2024年第2期43卷 232-239页

作者：孙勇吕全马宁刁宇温晓峰刘慧勇姚志强邓梁国家管网集团北方管道有限责任公司河北省廊坊市065000 国家管网集团建设项目管理分公司国家管网集团科学技术研究总院分公司

【目的】原油管道Q_(1)线与Q_(2)线对调运行是中国首例加热与常温输送在役原油管道对调运行工程,其采用“一边改造,一边运行”不停输方式进行对调运行,涉及工艺流程复杂、工程实施难度大、分输与注入用户多等众多因素制约。【方法】开... 详细信息

【目的】原油管道Q_(1)线与Q_(2)线对调运行是中国首例加热与常温输送在役原油管道对调运行工程,其采用“一边改造,一边运行”不停输方式进行对调运行,涉及工艺流程复杂、工程实施难度大、分输与注入用户多等众多因素制约。【方法】开展加热与常温输送管道水力、热力系统改造研究,分析对调运行投产期间影响常温管道预热、热油管道温降的各项因素及不同对调运行置换方式的优缺点,确定合理的改造及对调方式,以减少其对正常生产运行带来的影响;校核Q_(2)线常温输送管道改造为加热输送后预热模拟计算的准确性,并通过实际工程数据验证模拟结果是否满足工程实际需求,同时积累Q_(1)线热油管道改造为常温输送后油品置换的现场实践经验,并针对对调运行期间的关键节点提出合理建议。【结果】在役常温输油管道改造为加热输送,其预热方式要结合现场实际情况来选择,以Q_(2)线为例,其采用“提前加热管输俄油+高温俄油预热”的方式,可使管道满足庆油输送要求。由加热输送方式改为常温输送方式应考虑采取相应措施使站间油品温度逐渐降低,如采用按批次定量输送温度逐渐降低的油品的方式;沿线各加热站对不同批次油品加热,以确保各站间油品温度逐步降低。【结论】研究结果可为在役原油管道运行方式变更的投产提供参考依据。

关键词：原油管道常温输送加热输送投产对调运行