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One-step preparation of polyimide-inlaid amine-rich porous organic block copolymer for efficient removal of chlorophenols from aqueous solution

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Journal of Environmental Sciences 2019年第4期31卷 215-229页

作者： Yanyang liu Haijian Ou Shangqing Li Qingliang You huixian liu Guiying Liao Dongsheng Wang Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Material Science and ChemistryChina University of Geosciences Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationSchool of Chemical and Environmental EngineeringJianghan University State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of Sciences

A novel polyimide-inlaid amine-rich porous organic block copolymer(PI-b-ARPOP) was prepared via one-step polymerization by using different molar ratios of melamine(MA)/terephthalaldehyde(TA)/pyromellitic dianhydride(PMDA), at molar ratios of 4/3/1, 4/2/2 and 4/1/3. The copolymer contained both aminal groups belonging to ARPOP and imide groups belonging to PI, and the bonding styles of the monomers and growth orientations of the polymeric chains were diversiform, forming an excellent porous structure. Notably, MA/TA/PMDA(4/2/2) had a surface area and pore volume of 487.27 m^2/g and 1.169 cm^3/g,respectively. The adsorption performance of the materials towards 2,4-dichlorophenol(2,4-DCP) in ultra-pure water was systematically studied. The pH value of 7 was optimal in aqueous solution. Na^+ and Cl^-ions did not negatively affect the adsorption process, while humic acid(HA) slightly decreased the capacity. The equilibrium time was 40 sec, and the maximum adsorption capacity reached 282.49 mg/g at 298 K. The removal process was endothermic and spontaneous, and the copolymer could maintain its porous structure and consistent performance after regeneration by treatment with alkali. Moreover, to further assess the practical applicability of the material, the adsorption performance towards 2,4-DCP in river water was also investigated. This paper demonstrated that the PI-b-ARPOP can be an efficient and practical adsorbent to remove chlorophenols from aqueous solution.

关键词： Porous block copolymer Schiff base Polyimide Adsorption 2,4-Dichlorophenol

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Induced Pluripotent Stem Cells Are Sensitive to DNA Damage

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Genomics, Proteomics & Bioinformatics 2013年第5期11卷 320-326页

作者： Minjie Zhang Caiyun Yang huixian liu Yingli Sun Beijing Institute of Genomics Chinese Academy of Sciences

Induced pluripotent stem cells （iPSCs） resemble embryonic stem cells （ESCs） in morphol- ogy, gene expression and in vitro differentiation, raising new hope for personalized clinical therapy. While many efforts have been made to improve reprogramming efficiency, significant problems such as genomic instability of iPSCs need to be addressed before clinical therapy. In this study, we try to figure out the real genomic state of iPSCs and their DNA damage response to ionizing radiation （IR）. We found that iPSC line 3FB4-1 had lower DNA damage repair ability than mouse embryonic fibroblast （MEF） cells, from which 3FB4-11ine was derived. After the introduction of DNA damage by IR, the number of 7-H2AX loci in 3FB4-1 increased modestly compared to a large increase seen in MEF, albeit both significantly （P 〈 0.01）. In addition, whole-genome sequencing analysis showed that after IR, 3FB4-1 possessed more point mutations than MEF and the point mutations spread all over chromosomes. These observations provide evidence that iPSCs are more sensitive to ionizing radiation and their relatively low DNA damage repair capacity may account for their high radiosensitivity. The compromised DNA damage repair capacity of iPSCs should be considered when used in clinical therapy.

关键词： iPSCs MEF cells γ-H2AX DNA damage Whole-genome sequencing

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Exploration of Hanshi Zufei prescription for treatment of COVID-19 based on network pharmacology

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Chinese Herbal Medicines 2022年第2期14卷 294-302页

作者： Xinrui Li Zishuai Wen Mingdong Si Yuxin Jia huixian liu Yuguang Zheng Donglai Ma School of Pharmacy Hebei University of Chinese MedicineShijiazhuang 050200China Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province Shijiazhuang 050091China Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation Shijiazhuang 050091China

Objective:Network pharmacology combines drug and disease targets with biological information networks based on the integrity and systematicness of the interactions between drugs and disease *** study aims to explore the molecular basis of Hanshi Zufei formula for treatment of COVID-19 based on network pharmacology and molecular docking ***:Using TCMSP,the chemical constituents and molecular targets of Atractylodis Rhizoma,Citri Reticulatae Pericarpium,Magnoliae Officinalis Cortex,Pogostemonis Herba,Tsaoko Fructus,Ephedrae Herba,Notopterygii Rhizoma et Radix,Zingiberis Rhizoma Recens,and Arecae Semen were *** predicted targets of novel coronavirus were screened using the NCBI and Gene Cards *** further screen the drug-disease core targets network,the corresponding target proteins were queried using multiple databases(Biogrid,DIP,and HPRD),a protein interaction network graph was constructed,and the network topology was *** molecular docking studies were also performed between the network’s top 15 compounds and the coronavirus(SARS-Co V-2)3 CL hydrolytic enzyme and angiotensin conversion enzymeⅡ(ACE2).Results:The herb-active ingredient-target network contained nine drugs,86 compounds,and 49 drugdisease *** ontology(GO)enrichment analysis resulted in 1566 GO items(P<0.05),among which 1438 were biological process items,35 were cell composition items,and 93 were molecular function *** signal pathways were obtained by enrichment screening of the KEGG pathway database(P<0.05).The molecular docking results showed that the affinity of the core active compounds with the SARS-CoV-23 CL hydrolase was better than for the other ***:Several core compounds can regulate multiple signaling pathways by binding with 3 CL hydrolase and ACE2,which might contribute to the treatment of COVID-19.

关键词： COVID-19 Hanshi Zufei prescription molecular docking network pharmacology SARS-CoV-2

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Lower genomic stability of induced pluripotent stem cells reflects increased non-homologous end joining

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Cancer Communications 2018年第1期38卷 520-541页

作者： Minjie Zhang liu Wang Ke An Jun Cai Guochao Li Caiyun Yang huixian liu Fengxia Du Xiao Han Zilong Zhang Zitong Zhao Duanqing Pei Yuan Long Xin Xie Qi Zhou Yingli Sun Key Laboratory of Genomic and Precision Medicine China Gastrointestinal Cancer Research CenterBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101P.R.China The Key Laboratory of Regenerative Biology Guangdong Provincial Key Laboratory of Stem Cell and Regenerative MedicineSouth China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530P.R.China CAS Key Laboratory of Receptor Research the National Center for Drug ScreeningShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203P.R.China

Background:Induced pluripotent stem cells(iPSCs)and embryonic stem cells(ESCs)share many common features,including similar morphology,gene expression and in vitro differentiation ***,genomic stability is much lower in iPSCs than in *** the current study,we examined whether changes in DNA damage repair in iPSCs are responsible for their greater tendency towards ***:Mouse iPSCs,ESCs and embryonic fibroblasts were exposed to ionizing radiation(4 Gy)to introduce dou-ble-strand DNA *** 4 h later,fidelity of DNA damage repair was assessed using whole-genome *** also analyzed genomic stability in mice derived from iPSCs versus ***:In comparison to ESCs and embryonic fibroblasts,iPSCs had lower DNA damage repair capacity,more somatic mutations and short indels after *** showed greater non-homologous end joining DNA repair and less homologous recombination DNA *** derived from iPSCs had lower DNA damage repair capacity than ESC-derived mice as well as C57 control ***:The relatively low genomic stability of iPSCs and their high rate of tumorigenesis in vivo appear to be due,at least in part,to low fidelity of DNA damage repair.

关键词： Genomic stability DNA damage repair iPSCs ESCs

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A NOVEL TRAFFIC CLASSIFICATION ALGORITHM USING MACHINE LEARNING

A NOVEL TRAFFIC CLASSIFICATION ALGORITHM USING MACHINE LEARN...

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2009 2nd IEEE International Conference on Broadband Network & Multimedia Technology（IC-BNMT2009）

作者： liu huixian Li Xiaojuan Capital Normal University Beijing

Internet traffic classification is of prime importance to the areas of network management and security monitoring,network planning,and QoS *** the Traditional Classifications depend on certain header fields （take port numbers for instance）.These port-based and payload-based approaches will be out of action when a lot of applications like P2P use dynamic port *** techniques and payload encryption requires a high amount of resource of computing and is easily infeasible in the protocol that unknown or *** paper describes a different level in network traffic-analysis using an unsupervised machine learning *** this approach flows are automatically classified by exploiting the different statistics characteristics of *** implement and estimate the efficiency and feasibility of our approach using data at different location of Internet.A new attribute selection method is put forward to determine optimal attribute set and evaluate the influence.

关键词： Machine-Learning (ML) Traffic Classification Attribute Selection

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免疫功能正常个体眶尖、海绵窦和鼻窦曲霉菌感染1例

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中国医学影像技术 2019年第9期35卷 1435-1436页

作者：刘惠娴李恒国暨南大学附属第一医院广州华侨医院医学影像中心

患者男,57岁,11个月前无明显诱因出现右眼视力下降,症状持续性加重,伴头痛、恶心、呕吐,1个月前右眼眼球及眼睑活动消失;既往免疫功能正常。查体:右侧眼睑、眼球无活动,右眼无视力,右侧瞳孔直接及间接对光反射消失。实验室检查:白细胞7... 详细信息

患者男,57岁,11个月前无明显诱因出现右眼视力下降,症状持续性加重,伴头痛、恶心、呕吐,1个月前右眼眼球及眼睑活动消失;既往免疫功能正常。查体:右侧眼睑、眼球无活动,右眼无视力,右侧瞳孔直接及间接对光反射消失。实验室检查:白细胞7.68×10^9/L,嗜中性粒细胞百分比77.8%,淋巴细胞百分比16.6%,嗜酸性粒细胞百分比0.05%。CT平扫:右侧海绵窦区、蝶窦、后组筛窦见约3.0cm×1.7cm不规则软组织密度影,边界欠清,邻近骨质可见轻度破坏(图1A)。

关键词：曲霉菌感染侵袭性鼻窦炎诊断显像

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师幼对话式阅读影响3~6岁幼儿情绪能力发展的实验研究

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教育科学 2023年第6期39卷 86-93页

作者：但菲刘慧贤沈阳师范大学学前与初等教育学院辽宁沈阳110034 成都艺术职业大学音乐学院四川成都611433

情绪能力是促进个体完成早期阶段情感交流、同伴交往等发展任务的重要因素。为验证对话式阅读对3~6岁幼儿情绪能力提升的促进作用,本研究以120名幼儿为实验对象,基于36本情绪绘本设计师幼对话式阅读方案,采用2(组别:实验组、控制组)×3... 详细信息

情绪能力是促进个体完成早期阶段情感交流、同伴交往等发展任务的重要因素。为验证对话式阅读对3~6岁幼儿情绪能力提升的促进作用,本研究以120名幼儿为实验对象,基于36本情绪绘本设计师幼对话式阅读方案,采用2(组别:实验组、控制组)×3(年级:小班、中班、大班)×2(时间:前测、后测)的三因素实验设计进行为期3个月的情绪能力培养实验。结果表明,在师幼对话式阅读的干预下,小班幼儿情绪觉察与辨识能力水平、情绪理解能力水平均提升较快;中班幼儿处于情绪能力发展的关键期,干预效果优于其他年龄班;大班幼儿实验前的情绪能力总体水平较高,但在干预的过程中情绪调节能力水平的提升较慢。教育者应关注幼儿情绪行为,丰富幼儿情绪认知,发挥对话式阅读的独特性,针对年龄差异开展情绪教育。

关键词：幼儿对话式阅读情绪能力情绪绘本

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Preliminary Scientific Results of Chang'E-1 Lunar Orbiter:Based on Payloads Detection Data in the First Phase

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空间科学学报 2008年第5期28卷 361-369页

作者： OUYANG Ziyuan JIANG Jingshan LI Chunlai SUN huixian ZOU Yongliao liu Jianzhong liu Jianjun ZHAO Baochang REN Xin YANG Jianfeng ZHANG Wenxi WANG Jianyu MOU Lingli CHANG Jin ZHANG Liyan WANG Huanyu LI Yongquan ZHANG Xiaohui ZHENG Yongchun WANG Shijin BIAN Wei Chinese Academy of Sciences Beijing 100864

Chang'E-1 lunar Orbiter was launched by Long March 3A rocket from Xichang Satel-lite Launch Center at 18:05BT(Beijing Time) Oct.24,*** is the first step of its ambitious three-stage moon program,a new milestone in the Chinese space exploration *** primary science objectives of Chang'E-1 lunar orbiter are to obtain three-Dimension(3D) stereo images of the lunar surface,to analyze the distribution and abundance of elements on the surface,to investigate the thickness of lunar soil,evaluate helium-3 resources and other characteristics,and to detect the space environment around the *** achieve the above four mission objectives,eight sets of scientific instruments are chosen as the payloads of the lunar orbiter,including a CCD stereo camera(CCD),a Sagnac-based interferometer spectrometer(ⅡM),a Laser Altimeter(LAM),a Microwave Radiometer(MRM),a Gamma-Ray Spectrometer(GRS),an X-ray spectrometer(XRS),a High-Energy Particle Detector(HPD),and two Solar Wind Ion Detectors(SWID).The detected data of the payloads show that all payloads work *** paper introduces the status of payloads in the first phase and preliminary scientific results.

关键词：嫦娥一号空间研究中国宇航员

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Irradiation Effect of C_(60) Films Induced by 2.0 GeV Xe Ions

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IMP & HIRFL Annual Report 2001年第1期 51-52页

作者： Jin Yunfan, Tian huixian, Xie Erqing, liu Jie, Wang Zhiguang, Sun Youmei and Zhu Zhiyong Physics Department, Lanzhou University.

In this paper we present experimentaI results on irradiation effects of C_(60) fims induced by 2.0 GeV^(136)*** C_(60) fims were prepared by vacuum evaporation at a temperature close to 450℃ onto Al *** C_(60) layers on Al foils were arranged as a foil stack with the intention of using them to search for preliminary information concerning the overall depth distribution of damage following 2.0 GeV Xe ions ***

关键词： irradiation evaporation stack intention concerning preliminary weakening annealing excited symmetry

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某型航空发动机台架滑油系统颗粒监控标准研究

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润滑与密封 2018年第1期43卷 135-140页

作者：马立恒颜维刘恢先中国航发南方工业有限公司湖南株洲412000

在航空发动机台架试车过程中,运用先进的滑油颗粒监测设备,开展发动机台架滑油系统颗粒监测实验,探索滑油系统颗粒变化规律;通过对某型航空发动机台架滑油系统进行分析,确定滑油取样位置和时机;运用三线值法制定发动机台架滑油系统颗粒... 详细信息

在航空发动机台架试车过程中,运用先进的滑油颗粒监测设备,开展发动机台架滑油系统颗粒监测实验,探索滑油系统颗粒变化规律;通过对某型航空发动机台架滑油系统进行分析,确定滑油取样位置和时机;运用三线值法制定发动机台架滑油系统颗粒监控标准并进行实例验证分析。结果表明,该监控标准合理可行,为监控发动机零部件磨损情况和台架滑油系统污染程度提供参考。

关键词：航空发动机滑油系统颗粒监控标准

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