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化工学报 2017年第12期68卷 4709-4716页

作者：路会同江龙王丽伟王如竹上海交通大学制冷与低温工程研究所动力机械与工程教育部重点实验室上海200240

建立了一套低温热源驱动的小型无泵有机朗肯循环系统,研究无泵有机朗肯循环回收利用余热发电的性能。该系统中热水温度为75~95℃,冷却水温度为25℃,选择制冷剂R245fa作为系统工质,选择涡旋膨胀机将热能转换为机械能,并通过发电机进行发... 详细信息

建立了一套低温热源驱动的小型无泵有机朗肯循环系统,研究无泵有机朗肯循环回收利用余热发电的性能。该系统中热水温度为75~95℃,冷却水温度为25℃,选择制冷剂R245fa作为系统工质,选择涡旋膨胀机将热能转换为机械能,并通过发电机进行发电。实验结果表明当热水进口温度为95℃时,最大瞬时发电功率为232 W,并可以在250 s的时间内保持稳定在230 W左右,总的发电持续时间为380 s。随着热源水温度下降,功率输出减小,但发电持续时间增加。系统稳定发电平均效率最大为3.92%,此时热源水温度为95℃,最低为3.02%,此时热源水温度为85℃。

关键词：无泵有机朗肯循环焓值余热回收涡旋膨胀机发电效率

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两级吸附式制冷工质对性能实验研究

制冷学报 2017年第6期38卷 7-11页

作者：江龙路会同王如竹王丽伟上海交通大学制冷与低温工程研究所上海200240

本文针对不同两级吸附工质对CaCl_2-Na Br-NH3,CaCl_2-BaCl_2-NH3,SrCl_2-BaCl_2-NH3与SrCl_2-NH4Cl-NH3进行了实验研究,同时模拟了两级吸附制冷样机的工作性能。结果表明:SrCl_2-NH4Cl-NH3与CaCl_2-Na Br-NH3的循环吸附量可以分别达到理论值的95.4%与88.6%;对于不同两级吸附工质对,样机系统的COP、制冷量与SCP分别介于0.215~0.285、2~3.65 k W与161.4~260.74 W/kg;采用硫化石墨配置吸附剂能够大幅度提高两级制冷系统的SCP,以CaCl_2-BaCl_2-NH3为例,与采用普通石墨作为基质相比,采用硫化石墨的系统SCP最高可以提高40.2%。

关键词：吸附制冷循环工质对硫化石墨

电子膨胀阀的开度对变频除湿机低温工况下除湿性能的影响

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家电科技 2024年第2期2卷 92-97,102页

作者：路会同施兴陶钟玉金刘迎文广东美的制冷设备有限公司广东佛山528311 西安交通大学陕西西安710049

在低温工况下,霜层容易在冷冻除湿机的蒸发盘管表面出现,从而恶化其除湿性能。为了提升冷冻除湿机在低温工况下的除湿性能,搭建了变频除湿机性能测试系统,通过实验研究了在低温工况下,压机频率和风机转速不同组合下,电子膨胀阀的开度对... 详细信息

在低温工况下,霜层容易在冷冻除湿机的蒸发盘管表面出现,从而恶化其除湿性能。为了提升冷冻除湿机在低温工况下的除湿性能,搭建了变频除湿机性能测试系统,通过实验研究了在低温工况下,压机频率和风机转速不同组合下,电子膨胀阀的开度对除湿系统运行参数、除湿性能以及结霜现象的影响。得出以下结论:电子膨胀阀开度的增大可以提高蒸发温度,使蒸发器最低温度点推迟到流程后半段,使霜层在冷凝水分布稀疏的区域首先出现,从而缓解结霜现象,提高除湿性能。并且当蒸发温度达到-4℃附近时,结霜覆盖率接近100%,蒸发盘管表面严重结霜,此时吸气压力也异常降低,达到0.2 MPa。实验结果表明,-4℃的蒸发温度和0.2 MPa的吸气压力可以作为除霜开始的一般判据。研究成果可以为冷冻除湿机在低温工况下的除湿性能提升提供优化方向和参考依据。

关键词：变频除湿机低温工况电子膨胀阀的开度结霜除湿性能

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Envt cells in vivo

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Virologica Sinica 2023年第2期38卷 285-295页

作者： Hanyu Pan Xinyi Yang Jing Wang huitong Liang Zhengtao Jiang Lin Zhao Yanan Wang Zhiming Liang Xiaoting Shen Qinru Lin Yue Liang Jinglong Yang Panpan lu Yuqi Zhu Min Li Pengfei Wang Jianqing Xu Hongzhou lu Huanzhang Zhu State Key Laboratory of Genetic Engineering And Key Laboratory of Medical Molecular Virology of Ministry of Education/HealthSchool of Life SciencesFudan UniversityShanghai200438China Shanghai Institute of Infectious Disease and Biosecurity School of Life SciencesFudan UniversityShanghai200438China Department of Infectious Disease Key Laboratory of Medical Molecular Virology of Ministry of Education/HealthSchool of Basic Medical Sciences and Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

HIV-specific chimeric antigen receptor(CAR)T-cells have been developed to target HIV-1 infected CD4t T-cells that express HIV Env ***,T cell exhaustion and the patient-specific autologous paradigm of CAR-T cell hurdled clinical ***,we created HIV-specific CAR-T cells using human peripheral blood mononuclear cells and a 3BNC117-E27(3BE)CAR construct that enabled the expression of programmed cell death protein(PD-1)-blocking scFv E27 and the single-chain variable fragment of the HIV-1-specific broadly neutralizing antibody 3BNC117 to target native HIV *** with T cells expressing 3BNC117-CAR alone,3BE CAR-T cells showed greater cytotoxic activity against HIV Envt cells with stronger proliferation capability,higher killing efficiency,and enhanced cytokine secretion in the presence of HIV Env-expressing ***,we manufactured TCR-deficient 3BE CAR-T cells through gene editing and demonstrated that these CAR-T cells could effectively kill HIV Env^(+) cells in vivo without the occurrence of severe graft-versus-host disease(GvHD)in NSG *** data suggest that we have provided a feasible approach to the generation of“off-theshelf”anti-HIV CAR-T cells in combination with PD-1 checkpoint blockade immunotherapy,which can be a powerful therapeutic candidate for the functional cure of HIV.

关键词： Anti-HIV CAR-T PD-1 blocking TCR disruption Cellular immunotherapy

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1199-1208页

作者： Xinyi Yang Xu Zheng Yuqi Zhu Xiaying Zhao Jun Liu Jiangna Xun Songhua Yuan Jun Chen Hanyu Pan Jinlong Yang Jing Wang Zhimin Liang Xiaoting Shen Yue Liang Qinru Lin huitong Liang Min Li Fei Peng Daru lu Jianqing Xu Hongzhou lu Shibo Jiang Ping Zhao Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesYiwu Research InstituteFudan UniversityShanghaiChina Department of Microbiology Faculty of Naval MedicineNaval Medical UniversityShanghai 200433China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Changzheng Hospital Naval Medical UniversityShanghaiChina Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) Shanghai Institute of Infectious Disease and BiosecuritySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People’s Hospital of ShenzhenShenzhenGuangdongChina

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)causes multi-organ damage,which includes hepatic dysfunction,as observed in over 50%of COVID-19 *** I converting enzyme(peptidyl-dipeptidase A)2(ACE2)is the primary receptor for SARS-CoV-2 entry into host cells,and studies have shown the presence of intracellular virus particles in human hepatocytes that express ACE2,but at extremely low ***,we asked if hepatocytes might express receptors other than ACE2 capable of promoting the entry of SARS-CoV-2 into *** address this question,we performed a genome-wide CRISPR-Cas9 activation library screening and found that Asialoglycoprotein receptor 1(ASGR1)promoted SARS-CoV-2 pseudovirus infection of HeLa *** Huh-7 cells,simultaneous knockout of ACE2 and ASGR1 prevented SARS-CoV-2 pseudovirus *** the immortalized THLE-2 hepatocyte cell line and primary hepatic parenchymal cells,both of which barely expressed ACE2,SARSCoV-2 pseudovirus could successfully establish an ***,after treatment with ASGR1 antibody or siRNA targeting ASGR1,the infection rate significantly dropped,suggesting that SARS-CoV-2 pseudovirus infects hepatic parenchymal cells mainly through an ASGR1-dependent *** confirmed that ASGR1 could interact with Spike protein,which depends on receptor binding domain(RBD)and N-terminal domain(NTD).Finally,we also used Immunohistochemistry and electron microscopy to verify that SARS-CoV-2 could infect primary hepatic parenchymal *** inhibiting ASGR1 in primary hepatic parenchymal cells by siRNA,the infection efficiency of the live virus decreased ***,these findings indicate that ASGR1 is a candidate receptor for SARS-CoV-2 that promotes infection of hepatic parenchymal cells.

关键词： ACE2 infection glycoprotein

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

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Virologica Sinica 2022年第6期37卷 831-841页

作者： Yuqi Zhu Xinyi Yang Jingna Xun Jun Liu Qing Wen Yixiao Lin Xiaoting Shen Jun Chen Songhua Yuan Xiaying Zhao Jing Wang Hanyu Pan Jinlong Yang Zhiming Liang Yue Liang Qinru Lin huitong Liang Min Li Jianping Liu Yinzhong Shen Xiaoyan Zhang Pengfei Wang Daru lu Chunhua Yin Jianqing Xu Shibo Jiang Hongzhou lu Huanzhang Zhu State Key Laboratory of Genetic Engineering and Engineering Research Center of Gene Technology Ministry of EducationInstitute of GeneticsSchool of Life SciencesFudan UniversityShanghai200438China Scientific Research Center Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Fubio(Suzhou)Biomedical Technology Co. LtdSuzou215300China Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan UniversityShanghai201508China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesFudan UniversityShanghai200032China Department of Infectious Diseases and Nursing Research Institution National Clinical Research Center for Infectious DiseasesThe Third People's Hospital of ShenzhenShenzhen518112China

The prevalence of SARS-CoV-2 variants of concern(VOCs) is still escalating throughout the world. However, the level of neutralization of the inactivated viral vaccine recipients’ sera and convalescent sera against all VOCs,including B.1.1.7(Alpha), B.1.351(Beta), P.1(Gamma), B.1.617.2(Delta), and B.1.1.529(Omicron) remains to be lack of comparative analysis. Therefore, we constructed pseudoviruses of five VOCs using a lentiviral-based system and analyzed their viral infectivity and neutralization resistance to convalescent and BBIBP-CorV vaccinee serum at different times. Our results show that, compared with the wild-type strain(WT), five VOC pseudoviruses showed higher infection, of which B.1.617.2 and B.1.1.529 variant pseudoviruses exhibited higher infection rates than wild-type or other VOC strains, respectively. Sera from 10 vaccinated individuals at the 1, 3and 5-month post second dose or from 10 convalescent at 14 and 200 days after discharge retained neutralizing activity against all strains but exhibited decreased neutralization activity significantly against the five VOC variant pseudoviruses over time compared to WT. Notably, 100%(30/30) of the vaccinee serum samples showed more than a 2.5-fold reduction in neutralizing activity against B.1.1.529, and 90%(18/20) of the convalescent serum samples showed more than 2.5-fold reduction in neutralization against B.1.1.529. These findings demonstrate the reduced protection against the VOCs in vaccinated and convalescent individuals over time, indicating that it is necessary to have a booster shot and develop new vaccines capable of eliciting broad neutralization antibodies.

关键词： SARS-CoV-2 Variants of concern(VOCs) Convalescent BBIBP-CorV vaccine Neutralization

中空结构双模板分子印迹微球的制备及在燃油脱硫中的应用

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高分子材料科学与工程 2016年第10期32卷 154-159页

作者：司汇通王兵孙智纯张英英鲁佩佩天津工业大学省部共建分离膜与膜过程国家重点实验室天津工业大学环境与化学工程学院天津300387

以Si O2为载体,甲基丙烯酸(MAA)为功能单体,运用蒸馏沉淀法制备出苯并噻吩(BT)、二苯并噻吩(DBT)复合模板分子印迹聚合物,去除载体后得到中空分子印迹聚合物(H-MIP)。利用傅里叶变换红外光谱仪、透射电镜对其进行表征,在模拟汽油环境中... 详细信息

以Si O2为载体,甲基丙烯酸(MAA)为功能单体,运用蒸馏沉淀法制备出苯并噻吩(BT)、二苯并噻吩(DBT)复合模板分子印迹聚合物,去除载体后得到中空分子印迹聚合物(H-MIP)。利用傅里叶变换红外光谱仪、透射电镜对其进行表征,在模拟汽油环境中测试该印迹聚合物的吸附性能。结果表明,该中空结构的多孔分子印迹聚合物对BT及DBT表现出良好的选择性吸附性能,吸附容量分别为188μmol/g和212μmol/g,同时该产品可在短周期内重复使用。

关键词：分子印迹中空结构蒸馏沉淀聚合双模板

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碱催化2-取代苯并噁唑类化合物合成

山东化工 2024年第8期53卷 42-44页

作者：查鑫文陆志伟朱慧彤刘娥荆楚理工学院化工与药学院湖北荆门448000

苯并噁唑是一类重要的含氮氧杂环化合物,具有良好的生物活性。苯并噁唑化合物中2位官能团对生理活性影响最大,因此,研究2-取代苯并噁唑类化合物的合成具有重要意义。以2-氨基苯酚为起始原料,在碱性条件下合成了5种2-取代苯并噁唑类化合... 详细信息

苯并噁唑是一类重要的含氮氧杂环化合物,具有良好的生物活性。苯并噁唑化合物中2位官能团对生理活性影响最大,因此,研究2-取代苯并噁唑类化合物的合成具有重要意义。以2-氨基苯酚为起始原料,在碱性条件下合成了5种2-取代苯并噁唑类化合物,产物结构经1HNMR确证。

关键词：碱苯并噁唑 2-取代合成

不同炮制方法对黔产八角莲中4种化学成分含量的影响

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山东化工 2021年第15期50卷 30-31,36页

作者：孙晓惠陆锦锐蒙慧彤李燕黔南民族医学高等专科学校贵州黔南558000

目的:以八角莲中4’-去甲鬼臼毒素、槲皮素、山奈酚、鬼臼毒素的含量为指标,探讨不同炮制工艺对八角莲中化学成分含量变化的影响。方法:采用HPLC法测定4种化学成分含量,分析炮制前后的含量变化规律及其原因。结果:生品中4’-去甲鬼臼毒... 详细信息

目的:以八角莲中4’-去甲鬼臼毒素、槲皮素、山奈酚、鬼臼毒素的含量为指标,探讨不同炮制工艺对八角莲中化学成分含量变化的影响。方法:采用HPLC法测定4种化学成分含量,分析炮制前后的含量变化规律及其原因。结果:生品中4’-去甲鬼臼毒素、槲皮素、山奈酚、鬼臼毒素的含量分别为0.0675,0.561,1.448,8.121 mg/g;醋制品中4种成分的含量分别为0.0454,0.681,2.192,8.738 mg/g;蒸制品中4种成分的含量分别为0.0377,0.538,2.350,7.311 mg/g;姜制品中4种成分的含量分别为0.0655,0.689,1.632,8.929 mg/g。结论:与生品相比,各炮制品中4’-去甲鬼臼毒素的含量均降低,槲皮素、山奈酚炮制后均含量升高,鬼臼毒素含量炮制前后差异不大。

关键词：黔产八角莲 HPLC 炮制醋制蒸制姜制