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Animal Diseases 2024年第3期4卷 207-216页

作者： Qiuhua Li Yanyan qu Li Yao Ning Ma Mingxing Ding Yi Ding College of Veterinary Medicine Huazhong Agricultural UniversityWuhanChina

Canine atopic dermatitis(CAD)is a prevalent genetically susceptible infammatory and pruritic allergic skin condition afecting not only the health of dogs but also the quality of life of their ***-31(IL-31)and interleukin-31 receptor alpha(IL-31RA)are essential for the development of pruritus in primates and ***,it is expected that inhibiting IL-31RA will be an efective approach to alleviate *** purpose of the study was to produce anti-canine IL-31RA polyclonal antibodies(anti-IL-31RA pAbs)and evaluate their efcacy in inhibiting house dust mite(HDM)-evoked pruritic *** were immunized with antigens formed by IL-31RA recombinant short peptides coupled to BSA to produce anti-IL-31RA *** CAD model was developed by using HDM allergen stimulation,and the efects of IL-31RA pAbs on the reduction of pruritus in CAD model dogs were *** Canine Atopic Dermatitis Extent and Severity Index(CADESI)-4 and pruritus Visual Analog Scale(pVAS)were utilized to evaluate pruritic responses,and skin tissue samples were collected from the inguinal area for pathological assessment of skin infammatory cell *** results showed that anti-IL-31RA pAbs with high titers(1:128,000)and specifcity were efectively *** the CAD model group,the severity of skin damage,pruritus score,infammatory cell infltration and level of infammatory factors were considerably ***-IL-31RA pAbs relieved pruritic behavior and dermatitis in dogs compared to placebo-treated *** conclusion,anti-IL-31RA pAbs efectively suppressed CAD in vivo and are anticipated to be an efective novel treatment for pruritic skin disorders such as CAD.

关键词： IL-31RA Atopic dermatitis Polyclonal antibody Canine

Influencer Identification of Threshold Models in Hypergraphs

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Journal of Mathematical Research with Applications 2024年第5期44卷 569-582页

作者： Xiaojuan SONG Xilong qu Ting WEI Jilei TAI Renquan ZHANG School of Mathematical Sciences Dalian University of Technology

This paper mainly studies the influence maximization problem of threshold models in hypergraphs, which aims to identify the most influential nodes in hypergraphs. Firstly, we introduce a novel information diffusion rule in hypergraphs based on Threshold Models and conduct the stability analysis. Then we extend the CI-TM algorithm, originally designed for complex networks, to hypergraphs, denoted as the H-CI-TM algorithm. Secondly, we use an iterative approach to get the globally optimal solutions. The analysis reveals that our algorithm ultimately identifies the most influential set of nodes. Based on the numerical simulations, HCI-TM algorithm outperforms several competing algorithms in both synthetic and real-world hypergraphs. Essentially, when provided with the same number of initial seeds, our algorithm can achieve a larger activation size. Our method not only accurately assesses the influence of individual nodes but also identifies a set of nodes with greater impact. Furthermore, our results demonstrate good scalability when handling intricate relationships and large-scale *** outcomes of our research provide substantial support for the applications of the threshold models across diverse fields, including social network analysis and marketing strategies.

关键词： hypergraph threshold model influence maximization information diffusion sub-critical path

Prevalence and Genomic Characterization of Multidrug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Circulating—Beijing Municipality,China,2016–2023

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China CDC weekly 2024年第33期6卷 825-833页

作者： Mei qu Ying Huang Bing Lyu Xin Zhang Yi Tian Zhaomin Feng Zhiyong Gao Daitao Zhang Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijingChina

Introduction Highly fluoroquinolone-resistant Salmonella enterica serovar Kentucky(***)of sequence type(ST)198 has emerged as a global multidrug-resistant(MDR)clone,posing a threat to public *** Whole genome sequencing and antibiotic susceptibility testing was used to characterize the population structure and evolutionary history of 54 *** isolates recovered from food and human clinical cases in Beijing from 2016 to *** All 54 *** ST198 isolates exhibited resistance to quinolones,carrying point mutations in the quinolone resistance-determining regions(gyrA_S83F and parC_S80I).Resistance to other antibiotics(folate pathway inhibitors,cephems,aminoglycosides,phenicols,rifamycin,fosfomycin,macrolides,and tetracyclines),mediated by the sul1,sul2,dfrA14,blaCTX-M,blaTEM-1B,aac(3)-Id,aadA2,aadA7,aph(3')-I,aph(3'')-Ib,rmtB,floR,arr-2,fosA,mph(A),and tet(A)genes,was also observed in different *** Beijing *** ST198 evolutionary tree was divided into clades 198.2-1 and 198.2-2,which were further differentiated into three subclades:198.2-2A,198.2-2B,and *** with the extended-spectrumβ-lactamase-encoding gene blaCTX-M-14b in 198.2-1,the co-existence of blaCTX-M-55 and blaTEM-1B,as well as chromosomally located qnrS1,was detected in most 198.2-2 isolates,which showed more complex MDR *** ST198 outbreak isolates derived from two predominant clonal sources:198.2-1 with cgST236434 and 198.2-2A with *** The *** population in Beijing is genetically diverse,consisting of multiple co-circulating lineages that have persisted since *** surveillance of food and humans will aid in implementing measures to prevent and control the spread of AMR.

关键词： Kentucky predominant Whole

Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer

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Aggregate 2024年第1期5卷 377-384页

作者： Renfa Liu Huanyu Yang Shuai qu Peipei Yang Xin Zhi Yunxue Xu Zhifei Dai Linxue Qian Department of Biomedical Engineering College of Future TechnologyNational Biomedical Imaging CenterPeking UniversityBeijingChina Department of Ultrasound Beijing Friendship HospitalCapital Medical UniversityBeijingChina

Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and ***,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ***,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal *** antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 *** micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem *** a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem *** research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.

关键词： antimicrobial peptide gemcitabine resistance intratumoral microbiota pancreatic ductal adenocarcinoma photodynamic antibacterial therapy

Generalized Newton-Busemann Law for Two-dimensional Steady Hypersonic-limit Euler Flows Passing Ramps with Skin-frictions

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Acta Mathematicae Applicatae Sinica 2024年

作者： Ai-fang qu Xue-ying SU Hai-rong YUAN School of Mathematical Sciences Key Laboratory of Mathematics and Engineering Applications (Ministry of Education) & Shanghai Key Laboratory of PMMP East China Normal University School of Mathematics and Statistics Xi'an Jiaotong University Department of Mathematics Shanghai Normal University

By considering Radon measure solutions for boundary value problems of stationary non-isentropic compressible Euler equations on hypersonic-limit flows passing ramps with frictions on their boundaries, we construct solutions with density containing Dirac measures supported on the boundaries of the ramps, which represent the infinite-thin shock layers under different assumptions on the skin-frictions. We thus derive corresponding generalizations of the celebrated Newton-Busemann law in hypersonic aerodynamics for distributions of drags/lifts on ramps.

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Multifunctional cellular carbon foams derived from chitosan toward self-cleaning, thermal insulation, and highly efficient microwave absorption properties

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Nano Research 2024年第3期17卷 927-938页

作者： Beibei Zhan Yanling Hao Xiaosi Qi Yunpeng qu Junfei Ding Jing-liang Yang Xiu Gong Yanli Chen Qiong Peng Wei Zhong College of Physics Guizhou Province Key Laboratory for Photoelectrics Technology and ApplicationGuizhou UniversityGuiyang 550025China Minzu Normal University of Xingyi Xingyi 562400China National Laboratory of Solid State Microstructures and Jiangsu Provincial Laboratory for NanoTechnology Nanjing UniversityNanjing 210093China

To adapt the practical demand,designing and constructing the multifunctional microwave absorbers(MAs)is the key future direction of research and ***,effective integrating the multiple functions into a single material remains a huge ***,cellular carbon foams(CCFs)with different porous structures were elaborately designed and fabricated in high efficiency through a facile continuous freeze-drying and carbonization processes using a sustainable biomass chitosan as the *** obtained results revealed that the thermal treated temperature and g-C_(3)N_(4) amount played a great impact on the carbonization degrees,pore sizes,and morphologies of CCFs,which led to their tunable electromagnetic(EM)parameters,improved conduction loss,and polarization loss *** to the special cellular structure,the designed CCFs samples simultaneously displayed the strong absorption capabilities,broad absorption bandwidths,and thin matching ***,the as-prepared CCFs exhibited the strong hydrophobicity and good thermal insulation,endowing its attractive functions of self-cleaning and thermal ***,our findings not only presented a facile approach to produce different porous structures of CCFs,but also provided an effective strategy to develop multifunctional high-performance MAs on basis of three-dimensional CCFs.

关键词： multifunctional microwave absorbers carbon foams cellular structure self-cleaning thermal insulation

Different processing methods and pharmacological effects of Atractylodis Rhizoma

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Chinese Journal of Natural Medicines 2024年第8期22卷 756-768页

作者： GUO Dongmei XU Kang WAN Qianyun YU Songyang MA Chaoyang ZHANG Baohui LIU Yanju qu Linghang College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China Center for Hubei TCM Processing Technology Engineering Wuhan 430065China Hubei Shizhen Laboratory Wuhan 430065China

Atractylodis Rhizoma,a traditional Chinese medicine with an extensive history of treating gastrointestinal disorders and other diseases,undergoes various processing methods in China to enhance its therapeutic efficacy for specific ***,a comprehensive report detailing the changes in chemical composition and pharmacological effects due to these processing methods is currently *** article provides a systematic review of the commonly employed processing techniques for Atractylodis Rhizoma,including raw Atractylodis Rhizoma(SCZ),bran-fried Atractylodis Rhizoma(FCZ),deep-fried Atractylodis Rhizoma(JCZ),and rice water-processed Atractylodis Rhizoma(MCZ).It examines the alterations in chemical constituents and pharmacological activities resulting from these processes and elucidates the mechanisms of action of the primary components in the various processed forms of Atractylodis Rhizoma in the treatment of gastrointestinal diseases.

关键词： Atractylodis Rhizoma Processing method Pharmacological effect Change in chemical composition Gastrointestinal disease

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Memory,Identity and Cross-Cultural Communication:The Evolution of the Image of Chinese Railway Workers in Canada and the Reconstruction of Multiculturalism

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Social Sciences in China 2024年第3期45卷 161-180页

作者： qu Guiping School of History and Culture South China Normal University

International migrants confront many new challenges from the impact of global populism and geopolitics,but we also see the growth of a new identity *** Chinese community in Canada constructs its identity through the collective memory of the image of Chinese railway workers,and realizes the cross-cultural communication of a new identity culture in the course of the interaction of symbolic cultural *** the 1980s,the image of Chinese railway workers has changed from"the indispensable evil"to"pioneers in nation-building"and"a tragic group subjected to injustice."This is a product of the collective memory of the Chinese ethnic group's pursuit of identity in Canada's multicultural *** Chinese ethnic group has reshaped an image of Chinese railway workers that has been widely disseminated through cross-cultural *** have aimed at gaining social acceptance and fundamental recognition of a Chinese-Canadian identity with the help of their"native cultural heritage and historical resources"in *** construction of this identity culture through collective memory has consolidated the foundations of multiculturalism.

关键词： Chinese railway workers collective memory identity multiculturalism

Keplerate polyoxomolybdate nanoball mediated controllable preparation of metal-doped molybdenum disulfide for electrocatalytic hydrogen evolution in acidic and alkaline media

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Chinese Chemical Letters 2024年第7期35卷 524-528页

作者： Ping Wang Ting Wang Ming Xu Ze Gao Hongyu Li Bowen Li Yuqi Wang Chaoqun qu Ming Feng Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchun 130103China School of Science Changchun University of Science and TechnologyChangchun 130022China

Rationally designed novel cost-effective hydrogen evolution reaction(HER)electrocatalysts with controlled surface composition and advanced structural superiority is extremely critical to optimize the HER ***(POMs)with structural diversity and adjustable element compositions represent a promising precursor for rational design and preparation of HER ***,a series of transition metal-doped MoS_(2)materials with different surface engineered structures(Fe,Cr,V doping and S vacancies)(M-MoS_(2)/CC,M=Fe,Cr and V)were fabricated by a simple hydrothermalvulcanization strategy using Keplerate polyoxomolybdate nanoball({Mo_(72)Fe_(30)},{Mo_(72)Cr_(30)},{Mo_(72)V_(30)},{Mo_(132)})as *** enlarged interlayer spacing as well as the integration of homogeneous transition metal doping and abundant sulfur vacancies endows prepared M-MoS_(2)/CC with superior HER electrocatalytic performance and excellent long-term working stability in both acidic and alkaline *** optimized Fe-MoS_(2)/CC afford current densities of 10 and 50 mA/cm^(2)at overpotentials of 188/272 mV and 194/394 mV in 0.5 mol/L H_(2)SO_(4)and 1.0 mol/L KOH aqueous solution,respectively,outperforming most of reported typical transition metal sulfide-based *** work represents an important breakthrough for POMs-mediated highly efficient transition metal sulfide-based HER electrocatalysts with wide range pH activity and may provide new options for the rational design of promising HER electrocatalysts and beyond.

关键词： Polyoxometalate Electrocatalytic Hydrogen evolution reaction Doping MoS_(2)

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Flat-top beam illumination for polarization-sensitive second-harmonic generation microscopy

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Chinese Optics Letters 2024年第6期22卷 164-169页

作者： Bing Wang Xiang Li Wenhui Yu Binglin Shen Rui Hu Junle qu Liwei Liu State Key Laboratory of Radio Frequency Heterogeneous Integration Shenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Guangdong Province and Ministry of Education College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China

Wide-field second-harmonic generation (SHG) was used to obtain the second-harmonic signal from the entire image area for rapid imaging, despite the fact that conventional Gaussian beam illumination has low energy utilization efficiency,which makes it easy to overexpose the intensity of the image center area. However, flat-top beam illumination has uniform spatial distribution, thereby improving the photon excitation efficiency in the entire image region and reducing laser damage and thermal effect. By combining flat-top beam illumination and wide-field SHG polarization measurement, we can calculate more myosin fibril symmetrical axis orientations through polarization analysis of 16 images at a fast imaging speed while expanding the field of view. More importantly, the application of a flat-top beam can further improve the capability of polarization measurement in SHG microscopy.

关键词： flat-top beam second-harmonic generation muscle structure

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