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药学教育 2017年第3期33卷 1-5,26页

作者：黄海燕殷忠勇郑晓红刘会胜南京中医药大学研究生院南京210023 南京中医药大学国际处南京210023 中国药科大学研究生院南京210009

对THE、QS、***、ARWU、全国一级学科评估、中国大学评价等国内外大学评价体系指标及权重进行解析与比较研究,研析其特点、主要问题及发展趋势,论述其对中医药学科评价体系构建的启示。

关键词：学科评价体系大学排名

The Interaction of Population,Industry and Land in Process of Urbanization in China:A Case Study in Jilin Province

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Chinese Geographical Science 2018年第3期28卷 529-542页

作者： liu Yanjun ZHOU Guolei liu Degang YU huisheng ZHU Liyuan ZHANG Jing School of Geographical Sciences Northeast Normal University

Urbanization is a complex process that covers a wide range of topics, of which population, industry and land urbanization are three important aspects. Jilin Province is an important agricultural province in China. The contradiction between population, industry and land urbanization is especially prominent here, and its coupling development is of great practical significance. In this paper, the coupling degree of population-industry-land urbanization in Jilin Province in 1990, 2000 and 2010 is measured by coupling mode. The spatial pattern of the coupling degree is analyzed by trend surface analysis and global and local spatial autocorrelation. The influence factors and their spatial differentiation are discussed using multiple linear regression(MLR) model and geographic weighted regression(GWR) model. The results show that: 1) the coupling degree of population-industry-land urbanization in Jilin Province is at a low level. Judging from the change of time scale, the urbanization of most research units is becoming more and more coordinated. From the comparison of spatial scales, there is significant spatial difference in the research units of different administrative levels. 2) Judging from the global change trend, the coupling degree of population-industry-land urbanization in the central region is higher than that in western and eastern regions. The coordination of urbanization in the central region is relatively good, and the distribution of the cold and hot spots is basically the same as that overall. 3) The spatial pattern of the coupling degree is related to the cold and hot spot distribution of the influence coefficient of urban population density and per capita urban construction land. The variation of the coupling degree spatial pattern is synchronous with the spatial change of the urban population density influence coefficient. 4) The degree of agglomeration of the urban population is the main factor promoting the coupling pattern of population-industry-land

关键词： population urbanization industry urbanization land urbanization coupling relationship influence mechanism Jilin Province

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富铟磷化铟晶体中铟夹杂物基体特征分析

半导体技术 2019年第5期44卷 386-389页

作者：王昊宇杨瑞霞孙聂枫王书杰田树盛陈春梅刘惠生河北工业大学电子信息工程学院天津300401 中国电子科技集团公司第十三研究所石家庄050051 专用集成电路重点实验室石家庄050051

对富铟磷化铟(InP)晶体中铟夹杂物的基体特征进行了分析和表征。在富铟熔体中制备了InP单晶,利用金相显微镜及红外透射显微镜研究InP晶体中的铟夹杂物形态及其基体周围的影响区的形成。研究发现在铟夹杂物周围的InP基体上存在一些轮廓... 详细信息

对富铟磷化铟(InP)晶体中铟夹杂物的基体特征进行了分析和表征。在富铟熔体中制备了InP单晶,利用金相显微镜及红外透射显微镜研究InP晶体中的铟夹杂物形态及其基体周围的影响区的形成。研究发现在铟夹杂物周围的InP基体上存在一些轮廓线。基于铟夹杂物的形成过程和其对周围InP基体的影响,分析了铟夹杂物及其周围轮廓线的形成机理。通过位错腐蚀发现,铟夹杂物周围的InP基体上存在高的位错区,沿着晶体生长方向的位错密度偏高。通过力学分析发现,这种位错分布不均匀主要是由于富铟熔体结晶过程中沿着温度梯度方向的体积膨胀较大所致。

关键词： InP 晶体生长化合物半导体非配比熔体铟夹杂物

Optimization of hydrothermal pretreatment for co-utilization of xylose and glucose of cassava anaerobic residue for producing ethanol

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Chinese Journal of Chemical Engineering 2019年第4期27卷 920-927页

作者： huisheng Lü Jinyi Zhou Jiatao liu Chunliu Lü Feng Lian Yonghui Li Key Laboratory for Green Chemical Technology of Ministry of Education R&D Center for Petrochemical Technology Tianjin University Tianjin 300072 China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072 China

The development of a process that could recover biofuel from industrial cellulose waste can not only reduce the negative environmental impacts by using fossil fuels, but also bring a green idea for the waste’s disposing. In this study, hydrothermal pretreatment was optimized for cassava anaerobic residue, a cellulosic waste from cassava ethanol industry, to co-utilize xylose and glucose for producing bioethanol. The effect of the main pretreatment conditions, namely, temperature, solid content and time, was explored for the highest recovery of xylose in prehydrolysate and glucose in enzymatic hydrolysate. The single factor experiment results showed that the conditions for maximum xylose recovery in prehydrolysate and glucose recovery in enzymatic hydrolysate were 60℃, 75 min, 10% solids and 160℃, 75 min, 10% solids, respectively. Whereafter, response surface methodology(RSM) was applied to further optimize the pretreatment conditions for the maximum theoretical ethanol production through utilizing both xylose and glucose. A treatment at 163℃, for 59 min and with 9.5%solids was found optimal, with the highest ethanol production of 20.2 mg·g^-1 raw material. Furthermore, in order to assess the impacts of the pretreatment on cassava anaerobic residue, the changes in crystallinity and morphology for untreated and pretreated solids were investigated.

关键词： Waste treatment Biofuel Hydrothermal Cassava anaerobic residue Co-utilization Response surface methodology

Adsorption equilibrium for Z-ligustilide on C18-bonded silica from supercritical carbon dioxide

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Chinese Journal of Chemical Engineering 2016年第12期24卷 1680-1686页

作者： huisheng Lü Shuangyan liu Yonghui Li Fanmei Meng Dawei Yao Xufei Mo Key Laboratory for Green Chemical Technology of Ministry of Education Tianjin University R&D Center for Petrochemical Technology

Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial *** paper presents adsorption isotherms of Z-ligustilide from supercritical carbon dioxide(SC-CO_2) on C18-bonded *** behavior was studied at 305.15 K,313.15 K and 323.15 K with SC-CO_2 density varying from 0.687 g·cm^(-3) to0.863 g·cm^(-3) with the elution by characteristic points(ECP) *** adsorption amount of Z-ligustilide from SC-CO_2 on C18-bonded silica decreased with the increasing density of the mobile phase as well as the increasing *** equilibrium data were fitted by Langmuir and Freundlich isotherm models,and the Langmuir isotherm model performed better for describing the whole adsorption process on the *** monolayer saturation adsorption capacity of Z-ligustilide is in the range of 3.0 × 10^(-4) mg·cm^(-3) to5.5 × 10^(-4) mg·cm^(-3) with an average value of 4.0 × 10^(-4) mg·cm^(-3).

关键词： Z-ligustilide C18-bonded silica Pre-SFC Adsorption equilibrium Isotherm model

Multi-objective regulation in autohydrolysis process of corn stover by liquid hot water pretreatment

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Chinese Journal of Chemical Engineering 2017年第4期25卷 499-506页

作者： huisheng Lü Xingfang Shi Yonghui Li Fanmei Meng Shuangyan liu Li Yan Key Laboratory for Green Chemical Technology of Ministry of Education Tianjin University R&D Center for Petrochemical TechnologyTianjin UniversityTianjin 300072China

Increasing reducing sugars(xylose and glucose) yield for bioethanol from corn stover depends strongly on optimization of pretreatment conditions. The optimum reaction conditions of two-stage liquid hot water(LHW) pretreatment based on total sugars yield were investigated. Under optimal conditions, the recovery of glucose of corn stover after two-stage LHW pretreatment and 72 h enzymatic digestion, reached 89.55%. In addition, acetic acid-rich spent liquor pretreatment and one-stage LHW pretreatment have been carried out to make comparisons with two-stage LHW treatment. Glucose yield 89.55% is superior to the recovery 83.38% using acetic acidrich spent liquor pretreatment or 80.58% using one-stage LHW pretreatment. The production of total sugars was increased by 7.8% when compared with one-stage pretreatment. Moreover, the structural features of the treated corn stover solid residues were also investigated by XRD and SEM technology in order to clarify the effects of the reaction on corn stover. The results indicated that the two-stage LHW pretreatment was an effective pretreatment method of corn stover to get most massive resource utilization, and it could be successfully applied to corn stover.

关键词： pretreatment liquor digestion hydrolysis acetic phenols spent cellulose biomass untreated

面间煤柱与顺槽“掘-充-留”一体化科学问题与技术

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煤炭学报 2024年第8期49卷 3291-3315页

作者：王双明刘浪朱梦博蔚保宁庄登登屈慧升何伟邵成成夏磊周静西安科技大学煤炭绿色开采地质研究院陕西西安710054 西安科技大学能源学院陕西西安710054 西安科技大学地质与环境学院陕西西安710054 西安弗尔绿创矿业科技有限责任公司陕西西安710054

我国将煤炭作为兜底保障能源的局面短期内无法改变,仍将长时间面临煤炭资源保护与煤基固废利用率低的难题。通过创新采掘方法,同时实现提高煤炭资源回采率、规模化处置煤基固废,为煤炭行业绿色可持续发展提供了新途径。在深入调研煤炭... 详细信息

我国将煤炭作为兜底保障能源的局面短期内无法改变,仍将长时间面临煤炭资源保护与煤基固废利用率低的难题。通过创新采掘方法,同时实现提高煤炭资源回采率、规模化处置煤基固废,为煤炭行业绿色可持续发展提供了新途径。在深入调研煤炭资源开采技术发展现状的基础上,提出了煤矿“掘-充-留”掘进新工法。从大断面巷道快速掘进、连续高效充填和巷道安全留设3个方面,通过理论分析、数值模拟等手段,系统论述了“掘-充-留”工法的科学问题和关键技术,研究结果表明:①针对大断面巷道快速掘进、掘进工作面围岩稳定性控制等工程难题,凝练了煤岩特性与掘进机截割参数匹配机制、覆岩载荷空间传递机制与围岩变形机理、锚杆/索-顶板相互作用关系及支护机制3个科学难题,构建了以掘进区地质环境超前实时感知、落-装-运煤多工序智能协同作业、钻锚支架随掘随支围岩时效控制和大断面巷道防漏风及通风优化为核心的技术体系;②从大断面巷道承载体系及时构建及其承载性能调控两个方面凝练了连续高效充填的科学问题,包括充填体-煤层-锚杆/索协同承载机制、多元固废基充填材料水化固结机制,明晰充填体物理力学特性时空演化规律,建立了充填空间安全高效搭建、充填材料工作性能调控、充填材料流动-固结感知为核心的连续高效充填关键技术体系,相关理论与技术的突破可以为充填材料的原材料优选及配比设计、添加剂开发/选型及工作性能调控、掘进速率及充填步距优化设计、充填体固结监测等提供基础理论依据;③基于巷道安全留设及全生命周期内围岩易断裂、易片帮和易损伤等关键难题,阐述了巷道围岩应力场时空分布特征、巷道变形与损伤演化机制、巷道围岩工程质量监测与稳定性调控理论3个科学问题,形成了以巷道围岩稳定性智能预警、巷道围岩变形控制为核心的关键技术体系。开展煤矿“掘-充-留”工法的科学研究与工程示范,实现固废规模化处置-面间煤柱高效回收-顺槽快速掘进的协同,可以推动煤炭行业绿色低碳转型发展。

关键词：煤基固废面间煤柱大断面掘巷连续充填巷道留设 “掘-充-留”工法稳定性监测

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机能实验学教学改革探讨

基础医学教育 2018年第4期20卷 292-294页

作者：张莉王新凤郭媛谢雯王会生孙红刘健西安交通大学医学部基础医学院生理学与病理生理学系西安710061 西安交通大学医学部基础医学院机能实验教学中心

随着医学的发展和社会对医药卫生人才要求的不断提高,传统的医学教学模式面临新的挑战,机能实验教学改革势在必行。在教学改革中,启发指导、好学爱学成为贯穿始终的指导思想。西安交通大学在开展机能实验近二十年中,将生理学、病理生理... 详细信息

随着医学的发展和社会对医药卫生人才要求的不断提高,传统的医学教学模式面临新的挑战,机能实验教学改革势在必行。在教学改革中,启发指导、好学爱学成为贯穿始终的指导思想。西安交通大学在开展机能实验近二十年中,将生理学、病理生理学和药理学有机融合,逐渐总结经验,探索出适应国家对医卫人才要求的教学模式。

关键词：机能实验学实验教学教学改革

单分子视踪技术揭示SARS-CoV-2病毒利用动态的丝状伪足入侵细胞

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科学通报:英文版 2023年第19期68卷 2210-2224,M0004页

作者：张悦张晓玮李钟艺赵唯淞杨慧赵双双汤代骄张倩李总红刘会生李浩宇李博 Pekka Lappalainen 徐涛崔宗强酒亚明 Unit of Cell Biology and Imaging Study of Pathogen Host Interaction The Center for MicrobesDevelopment and HealthKey Laboratory of Molecular Virology and ImmunologyShanghai Institute of Immunity and InfectionChinese Academy of SciencesShanghai 200031China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China Institute of Biomechanics and Medical Engineering Applied Mechanics LaboratoryDepartment of Engineering MechanicsTsinghua UniversityBeijing 100084China Innovation Photonics and Imaging Center School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin 150080China Guangzhou Laboratory Guangzhou 510005China Institute of Biotechnology and Helsinki Institute of Life Science University of HelsinkiHelsinki 00014Finland

SARS-CoV-2病毒侵袭细胞的分子机制已被初步探索,但关于其如何调节亚细胞结构重塑从而侵袭多种器官及细胞类型尚不清楚.本文利用活细胞实时成像技术揭示了SARS-CoV-2病毒颗粒通过宿主细胞丝状伪足进入靶细胞的动态过程.利用荧光标记的SA... 详细信息

SARS-CoV-2病毒侵袭细胞的分子机制已被初步探索,但关于其如何调节亚细胞结构重塑从而侵袭多种器官及细胞类型尚不清楚.本文利用活细胞实时成像技术揭示了SARS-CoV-2病毒颗粒通过宿主细胞丝状伪足进入靶细胞的动态过程.利用荧光标记的SARS-CoV-2病毒样颗粒(VLP)和稀疏去卷积算法成像技术,发现VLP利用丝状伪足以“冲浪”和“抓取”两种模式到达入侵点,以避免病毒在细胞膜上随机搜索入侵位点,此外,结合力学模拟实验,阐明了病毒诱导丝状伪足的形成和丝状伪足的回缩速度分别取决于细胞骨架动力学和病毒重力引起的底物表面摩擦阻力.进一步研究发现SARS-CoV-2通过丝状伪足进入细胞的过程依赖于小G蛋白Cdc42(细胞分裂周期蛋白42)活性和肌动蛋白相关蛋白fasin(肌动蛋白结合蛋白)、formin(成核蛋白)和Arp2/3(肌动蛋白相关蛋白2/3复合物).综上所述,本文结果强调了SARS-CoV-2感染能对宿主细胞的微丝骨架进行时空调节,使细胞形成丝状伪足作为病毒进入的“高速轨道”,丝状伪足形成相关蛋白及其信号通路可作为潜在的抗病毒靶标.

关键词：力学模拟亚细胞结构随机搜索单分子病毒样颗粒表面摩擦阻力病毒侵袭病毒颗粒

Simulation study on delay of end-to-end data communication for protective relaying in substations

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Frontiers of Electrical and Electronic Engineering in China 2008年第2期3卷 246-250页

作者： huisheng GAO Weiwei JIN Guang liu School of Electrical and Electronic Information Engineering North China Electric Power UniversityBaoding 071003China

The end-to-end delay of protective relaying data flow in a substation was studied by dynamic simulation modeling *** distribution characteristics of protective relaying data flow and the constitution of the end-to-end delay of messages were *** simulation model for digital communication between pro-tective relaying equipment and monitoring equipment of interval layer was *** end-to-end delay of pro-tective relaying data flow in different network configurations was *** is found that the size and interval of the data frame,utilization of the link background and protocols of higher layer are key factors of real-time *** analysis results are presented.A proposal for network configuration is suggested to reduce end-to-end delay of pro-tective relaying data flow.

关键词： protective relaying OPNET network simu-lation delay