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微移植治疗急性髓系白血病研究现状和展望

临床血液学杂志 2022年第5期35卷 312-317页

作者：郭梅艾辉胜解放军总医院第五医学中心北京100071

急性髓系白血病(acute myeloid leukemia,AML)是成人中最常见的急性白血病类型,发病率随年龄增长而增加,60岁以上的患者约占所有AML患者的50%以上,平均发病年龄68岁。尽管强化疗和造血干细胞移植治疗AML总体上有所改善,60岁或60岁以下... 详细信息

急性髓系白血病(acute myeloid leukemia,AML)是成人中最常见的急性白血病类型,发病率随年龄增长而增加,60岁以上的患者约占所有AML患者的50%以上,平均发病年龄68岁。尽管强化疗和造血干细胞移植治疗AML总体上有所改善,60岁或60岁以下的成年AML患者中35%~40%可被治愈,但60岁以上老年AML(elderly AML,EAML)患者的预后仍然很差,2年存活率仅为10%~20%。

关键词：急性髓系白血病微移植治疗

非清髓异基因外周血造血干细胞移植后供体细胞植入证据的研究

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解放军医学杂志 2001年第1期26卷 16-17页

作者：余长林艾辉胜姚波军事医学科学院附属医院北京100039

采用染色体荧光原位杂交 (FISH)并结合常规染色体和染色体分带等方法 ,观察并比较了 4例血液病人非清髓异基因外周血干细胞移植 (NAPBSCT)后的植入情况。结果 4例病人均有不同程度的植入 ,全部形成混合性嵌合体 ,其中 2例转化为完全植... 详细信息

采用染色体荧光原位杂交 (FISH)并结合常规染色体和染色体分带等方法 ,观察并比较了 4例血液病人非清髓异基因外周血干细胞移植 (NAPBSCT)后的植入情况。结果 4例病人均有不同程度的植入 ,全部形成混合性嵌合体 ,其中 2例转化为完全植入。统计结果分析表明 ,FISH分析中期分裂相与间期细胞的结果无统计学差异。与常规染色体检查结果相比较 ,FISH分析中期分裂相或间期细胞的植入率高 ,但无统计学差异。但FISH具有操作简单、实验周期短、结果敏感可靠等优点 ,适合用于性别不合的NAPBSCT后植入证据检测。

关键词：染色体荧光原位杂交预处理血液病非清髓异基因外周血造血干细胞移植 NAPBSCT

Mismatched donor cell infusion-related syndrome following microtransplant in patients with acute myeloid leukemia

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Chinese Medical Journal 2023年第7期136卷 815-821页

作者： Bo Cai Xiaoyan Zou Xin Ning Tieqiang Liu Bingxia Li Yaqing Lei Jianhui Qiao Kaixun Hu Yangyang Lei Zhiqing Liu Bo Yao huisheng ai Yi Wang Changlin Yu Mei Guo Department of Hematology The Fifth Medical CenterChinese PLA General HospitalBeijing 100071China

Background:Immunotherapies such as adoptive immune cell infusion and immune-modulating agents are widely used for cancer treatment,and the concomitant symptoms,including cytokine release syndrome(CRS)or immune-related adverse events(irAEs),are frequently ***,clinical manifestations induced by mismatched donor granulocyte colony-stimulating factor mobilized peripheral blood mononuclear cell(GPBMC)infusion in patients receiving microtransplant(MST)have not yet been well ***:We analyzed 88 cycles of mismatched GPBMC infusion in patients with acute myeloid leukemia receiving MST and 54 cycles of chemotherapy without GPBMC infusion as a *** symptoms and their correlation with clinical features,laboratory findings,and clinical response were ***:Fever(58.0%[51/88])and chills(43.2%[38/88])were the significant early-onset symptoms after GPBMC *** possessing less human leukocyte antigen-matching loci with the donor or those with unrelated donors experienced more chills(3[2–5]loci vs.5[3–5]loci,P=0.043 and 66.7%[12/18]vs.37.1%[26/70],P=0.024).On the other hand,those with decreased CD4^(+)/CD8^(+)T-cell ratio developed more fever(0.8[0.7–1.2]vs.1.4[1.1–2.2],P=0.007).Multivariable analysis demonstrated that younger patients experienced more fever(odds ratio[OR]=0.963,95%confidence interval[CI]:0.932–0.995,P=0.022),while patients with younger donors experienced more chills(OR=0.915,95%CI:0.859–0.975,P=0.006).Elevated ultra-sensitive C-reactive protein levels in the absence of cytokine storm were observed following GPBMC infusion,which indicated mild and transient inflammatory *** no predictive value of infusion-related syndrome to leukemia burden change was found,the proportion of host pre-treatment activated T cells was positively correlated with leukemia ***:Mismatched GPBMC infusion in MST induced unique infusion-related symptoms and laboratory changes,which were associated with

关键词： Microtransplant Immunotherapy Adoptive immune cell infusion Adverse events Acute myeloid leukemia

MPOmRNA、IgHmRNA和CD_3εmRNA表达对急性白血病分型的意义

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中华血液学杂志 1997年第7期18卷 347-349页

作者：艾辉胜朱元晓沈倍奋赖春宁骈淮媛曹履先贾蜀琼军事医学科学院附属医院军事医学科学院基础医学研究所

目的：比较基因分型和免疫分型在急性白血病诊断分型中的意义。方法：采用链亲和素－胶体金细胞原位杂交技术（ＩＳＨ－ＳＡＧ），研究了６９例急性白血病的髓过氧化物酶（ＭＰＯ）ｍＲＮＡ、免疫球蛋白重链（ＩｇＨ）ｍＲＮＡ和ＣＤ３... 详细信息

目的：比较基因分型和免疫分型在急性白血病诊断分型中的意义。方法：采用链亲和素－胶体金细胞原位杂交技术（ＩＳＨ－ＳＡＧ），研究了６９例急性白血病的髓过氧化物酶（ＭＰＯ）ｍＲＮＡ、免疫球蛋白重链（ＩｇＨ）ｍＲＮＡ和ＣＤ３εｍＲＮＡ的基因表达并同时分析了白血病的免疫表型。结果和结论：ＭＰＯｍＲＮＡ和ＣＤ３εｍＲＮＡ敏感性高、特异性强，对确诊早期ＡＭＬ和Ｔ－ＡＬＬ有重要意义，ＩｇＨｍＲＮＡ则对识别更早期Ｂ细胞白血病有一定作用。用ＩＳＨ－ＳＡＧ进行基因分型是个新的更加敏感、特异的白血病诊断分型手段，将基因分型和免疫分型结合分析，对白血病更精确的诊断分型有重要意义。

关键词：基因型免疫表现型原位杂交急性白血病

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： Da Wan Shuwei Tang Shulin Bai Xiaodong Li Peng ai Wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

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多发性骨髓瘤的危险因素以及个体化治疗进展

现代肿瘤医学 2012年第7期20卷 1487-1491页

作者：康岩孙琪云艾辉胜军医进修学院北京100853 军事医学科学院附属医院血液科北京100071

多发性骨髓瘤是一种浆细胞来源的恶性血液肿瘤,具有较强的异质性。不同患者具有多样性的临床特征以及生物学特点,预后也有很大差异。对于其危险因素分析以及各种新型药物和移植的应用成为目前的研究热点。本文就目前多发性骨髓瘤的危险... 详细信息

多发性骨髓瘤是一种浆细胞来源的恶性血液肿瘤,具有较强的异质性。不同患者具有多样性的临床特征以及生物学特点,预后也有很大差异。对于其危险因素分析以及各种新型药物和移植的应用成为目前的研究热点。本文就目前多发性骨髓瘤的危险因素研究以及相应的个体化治疗进展进行综述。

关键词：多发性骨髓瘤危险因素预后个体化治疗

脂质体介导pcDNA3．1-HGF瞬时转染小鼠MSCs及转染效果检测

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北京师范大学学报（自然科学版） 2008年第3期44卷 259-262页

作者：黄雅静孙万军孙琪云王冬梅艾辉胜第二炮兵总医院 100088 军事医学科学院附属医院北京100071

肝细胞生长因子(HGF)对各种组织都具有促分裂、促迁移、促细胞形态发生的作用,尤其是肾脏、肺和肠道.间充质干细胞(MSC)是一种具有多向分化潜能的干细胞,同时还具有相对的定位归巢以及免疫调节作用,由于MSC具有较低的免疫原性,可作为良... 详细信息

肝细胞生长因子(HGF)对各种组织都具有促分裂、促迁移、促细胞形态发生的作用,尤其是肾脏、肺和肠道.间充质干细胞(MSC)是一种具有多向分化潜能的干细胞,同时还具有相对的定位归巢以及免疫调节作用,由于MSC具有较低的免疫原性,可作为良好的基因载体.为联合应用HGF和MSC的作用,本实验在分离培养小鼠MSC并鉴定后;应用脂质体介导法将pcDNA3.1-HGF瞬时转染MSC;采用半定量RT-PCR和ELISA法分别鉴定HGF的表达情况.结果表明:转染试剂对MSC的活性无影响,转染细胞形态及定向分化特性未发生改变;HGF在转染后48 h达到最高表达量,随时间推移逐渐减低,在10 d时仍略高于对照.脂质体介导pcDNA3.1-HGF瞬时转染小鼠MSC后,HGF在转染后10 d内升高表达.

关键词：间充质干细胞肝细胞生长因子脂质体

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

电离辐射对人外周血淋巴细胞GADD45基因表达的影响

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辐射研究与辐射工艺学报 2006年第2期24卷 111-114页

作者：徐丽昕艾辉胜蒋本荣姚波余长林郭梅黄雅静孙琪云中国人民解放军第三零四医院血液科北京100039 中国人民解放军军事医学科学院附属医院北京100039

观察生长抑制和DNA损伤基因45(Growth arrest and DNA damage gene 45,GADD45)X射线照射后表达的改变,并研究其与照射剂量之间的关系。外周血给予0-5 GyX线照射后分离出单个核细胞并培养,在不同时间点上用反转录聚合酶链反应(Reverse tr... 详细信息

观察生长抑制和DNA损伤基因45(Growth arrest and DNA damage gene 45,GADD45)X射线照射后表达的改变,并研究其与照射剂量之间的关系。外周血给予0-5 GyX线照射后分离出单个核细胞并培养,在不同时间点上用反转录聚合酶链反应(Reverse transcriptase-Polymerase clain reaction,RT-PCR)的方法测定 GADD45基因的相对表达量,分析该基因的剂量、效应关系。照射后GADD45基因在转录水平表达呈剂量依赖性增加,照射后4h达峰值,以后开始下降,但在24h仍未恢复到初始水平。

关键词：研究生长抑制 DNA损伤基因45 生物剂量计基因表达反转录聚合酶链反应