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Reduced temporal activation during a verbal fluency test in clinical high risk of psychosis: a functional near-infrared spectroscopy-based study

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General Psychiatry 2022年第2期35卷 101-108页

作者： Yanyan Wei Xiaochen Tang Tingyu Zhang Wenjun Su Lihua Xu huiru cui Zhenying Qian Tianhong Zhang Jijun Wang EEG and Neuroimaging Department Shanghai Mental Heath Center Shanghai Jiao Tong University School of MedicineShanghaiChina The Seventh Affiliated Hospital Sun Yat-sen University ShenzhenChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina CAS Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Institute of Psychology and Behavioral Science ShanghaiJiao Tong UniversityShanghaiChina

Background Clinical high risk(CHR)of psychosis is a state in which positive symptoms cause the subjects distress but do not approach a severity level that fulfils the criteria for a psychotic episode.CHR exhibits cognitive deficits;however,the underlying neurobiological mechanisms remain unclear.This study aimed to investigate whether brain activation measured by the levels of oxygenated hemoglobin(oxy-Hb)in CHR subjects could be correlated with cognitive deficits.Methods Fifty-eight CHR individuals who fulfilled the criteria for attenuated positive syndrome as specified in the Structured Interview for Prodromal Syndrome(SIPS)and the Scale of Prodromal Syndrome(SOPS)and 58 age-and sex-matched healthy participants were included in the study.All subjects completed the Measurement and Treatment Research to Improve Cognition in Schizophrenia(MATRICS)Consensus Cognitive Battery(MCCB)that includes tests measuring attention,verbal memory,verbal fluency,executive function,and general intelligence.Functional near-infrared spectroscopy(fNIRS)was used to measure the level of oxy-Hb in the dorsolateral prefrontal and frontotemporal cortices.Results We observed significantly decreased oxy-Hb levels in channel 32(located in the right superior temporal gyrus,rSTG)within the CHR individuals compared with that in the healthy controls(HCs)(t=−3.44,Bonferroni-corrected p=0.002),indicating lower brain activity.A significant positive correlation was observed between task-relatedβvalues and working memory in the CHR group(r=0.35,p=0.008).Conclusions The brain activation of rSTG is abnormal among subjects at clinicial high risk for psychosis.This abnormality is probably associated with the neural mechanisms of deficits in the working memory during the early stage of psychosis.

关键词： distress activation verbal

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Circulating Lipoproteins Mediate the Association Between Cardiovascular Risk Factors and Cognitive Decline:A Community‑Based Cohort Study

Phenomics

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Phenomics 2024年第1期4卷 51-55页

作者： Jialin Li Qingxia Huang Yingzhe Wang Mei cui Kelin Xu Chen Suo Zhenqiu Liu Yanpeng An Li Jin huiru Tang Xingdong Chen Yanfeng Jiang State Key Laboratory of Genetic Engineering Human Phenome InstituteZhangjiang Fudan International Innovation Centerand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan University2005 Songhu RdShanghai 200438China Fudan University Taizhou Institute of Health Sciences Taizhou 225326China State Key Laboratory of Genetic Engineering School of Life SciencesMetabonomics and Systems Biology Laboratory at Shanghai International Centre for Molecular PhenomicsHuman Phenome InstituteZhongshan HospitalFudan University2005 Songhu RdShanghai 200438China Department of Neurology Huashan HospitalFudan UniversityShanghai 200040China Ministry of Education Key Laboratory of Public Health Safety Department of BiostatisticsSchool of Public HealthFudan UniversityShanghai 200032China Ministry of Education Key Laboratory of Public Health Safety Department of EpidemiologySchool of Public HealthFudan UniversityShanghai 200032China Shanghai Institute of Infectious Disease and Biosecurity Shanghai 200032China Yiwu Research Institute of Fudan University Yiwu 322000ZhejiangChina International Human Phenome Institute(Shanghai) Shanghai 201203China Greater Bay Area Institute of Precision Medicine(Guangzhou) Fudan UniversityGuangzhou 511462China

Cardiovascular health metrics are now widely recognized as modifable risk factors for cognitive decline and dementia.Metabolic perturbations might play roles in the linkage of cardiovascular diseases and dementia.Circulating metabolites profling by metabolomics may improve understanding of the potential mechanism by which cardiovascular risk factors contribute to cognitive decline.In a prospective community-based cohort in China(n=725),312 serum metabolic phenotypes were quantifed,and cardiovascular health score was calculated including smoking,exercise,sleep,diet,body mass index,blood pressure,and blood glucose.Cognitive function assessments were conducted in baseline and follow-up visits to identify longitudinal cognitive decline.A better cardiovascular health was signifcantly associated with lower risk of concentration decline and orientation decline(hazard ratio(HR):0.84–0.90;p<0.05).Apolipoprotein-A1,high-density lipoprotein(HDL)cholesterol,cholesterol ester,and phospholipid concentrations were signifcantly associated with a lower risk of longitudinal memory and orientation decline(p<0.05 and adjusted-p<0.20).Mediation analysis suggested that the negative association between health status and the risk of orientation decline was partly mediated by cholesterol ester and total lipids in HDL-2 and-3(proportion of mediation:7.68–8.21%,both p<0.05).Cardiovascular risk factors were associated with greater risks of cognitive decline,which were found to be mediated by circulating lipoproteins,particularly the medium-size HDL components.These fndings underscore the potential of utilizing lipoproteins as targets for early stage dementia screening and intervention.

关键词： Cardiovascular risk factors Lipoproteins Lipids Cognition Cognitive decline

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Relationships between selfreflectiveness and clinical symptoms in individuals during pre-morbid and early clinical stages of psychosis

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General Psychiatry 2022年第3期35卷 163-172页

作者： Lihua Xu huiru cui Yanyan Wei Zhenying Qian Xiaochen Tang Yegang Hu Yingchan Wang Hao Hu Qian Guo Yingying Tang Tianhong Zhang Jijun Wang Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center Shanghai Key Laboratory of Psychotic DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Early Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina

Background Self-reflectiveness,one dimension of cognitive insight,plays a protective role in an individual’s mental state.Both high and low levels of self-reflectiveness have been reported in patients with schizophrenia and individuals at clinical high risk for the illness.Aims This study aimed to explore the relationship patterns between self-reflectiveness and clinical symptoms in individuals during the pre-morbid and early clinical stages of psychosis.Methods A total of 181 subjects,including individuals with attenuated positive symptoms(APS,n=122)and patients with first-episode psychosis(FEP,n=59),completed the Beck Cognitive Insight Scale and were evaluated using the Schedule of Assessment of Insight and Positive and Negative Syndrome Scale.All subjects were classified into three groups according to their level of selfreflectiveness:low level(LSR,n=59),medium level(MSR,n=67)and high level(HSR,n=55).Both linear and nonlinear relationships between self-reflectiveness and clinical symptoms were explored.Results More individuals with APS were classified into the MSR group,while more patients with FEP were classified into the LSR group.The LSR group demonstrated less awareness of illness than the MSR and HSR groups,more stereotyped thinking and poorer impulse control but less anxiety than the MSR group,and lower levels of blunted affect and guilt feelings than the HSR group.The MSR group demonstrated lower stereotyped thinking than the HSR group.Compared to the LSR group,the MSR group had increased selfreflectiveness,improved awareness of illness,decreased stereotyped thinking,and better impulse control,but increased feelings of guilt.The HSR group showed increased stereotyped thinking when compared to the MSR group,but the other variables did not change significantly between these two groups.Overall,self-reflectiveness demonstrated an approximately inverse S-shaped relationship with the awareness of illness,a U-shaped relationship with stereotyped thinking and poor impulse control,and an almost linear relationsh

关键词： clinical symptoms morbid

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Altered heartbeat perception sensitivity associated with brain structural alterations in generalised anxiety disorder

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General Psychiatry 2020年第1期33卷 30-36页

作者： Hui Li Bin Zhang Qiang Hu Lanlan Zhang Yi Jin Jijun Wang huiru cui Jiaoyan Pang Chunbo Li Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghaiChina Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders The Affiliated Brain Hospital of Guangzhou Medical University(Guangzhou Huiai Hospital)GuangzhouChina Ddepartment of Psychiatry Suzhou Guangji HospitalSuzhouChina Institute of Psychology Chinese Academy of SciencesShanghaiChina Ddepartment of Psychology Shanghai University of Political Science and LawShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina

Background Palpitation is a common complaint in generalised anxiety disorder(GAD).Brain imaging studies have Investigated the neural mechanism of heartbeat perception in healthy volunteers.This study explored the neuroanatomical differences of altered heartbeat perception in patients with GAD using structural MRI.Aims Based on the strong somatic-interoceptive symptoms in GAD,we explored the regional structural brain abnormalities involved in heartbeat perception in patients with GAD.Methods This study was applied to the a priori regions using neuroanatomical theories of heartbeat perception,including the insula,anterior cingulate cortex,supplementary motor area and prefrontal cortex.A total of 19 patients with GAD and 19 healthy control subjects were enrolled.We used the FMRIB Software Library voxel-based morphometry software for estimating the grey matter volume of these regions of interest and analysed the correlation between heartbeat perception sensitivity and the volume of abnormal grey matter.Results Patients with GAD showed a significantly decreased volume of grey matter in their left medial prefrontal cortex,right orbital frontal cortex and anterior cingulate cortex.The grey matter volume of the left medial prefrontal cortex negatively correlated with heartbeat perception sensitivity in patients with GAD.Conclusions It should be the first study that shows heartbeat perception is associated with brain structure in GAD.Our findings suggest that the frontal region may play an important role in aberrant heartbeat perception processing in patients with GAD,and this may be an underlying mechanism resulting in the abnormal cardiovascular complaints in GAD.This is hypothesised as a'top-down'deficiency,especially in the medial prefrontal cortex.This will provide the foundation for a more targeted region for neuromodulation intervention in the future.

关键词： cortex medial alterations

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Efficacy and safety of repetitive transcranial magnetic stimulation for generalised anxiety disorder: A metaanalysis

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General Psychiatry 2019年第5期32卷 237-248页

作者： huiru cui Lijuan Jiang Yanyan Wei Wei Li Hui Li Junjuan Zhu Jiaoyan Pang Jijun Wang Chunbo Li Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina School of government Shanghai University of Political Science and LawShanghaiChina Institute of Psychology and Behavioral Science Shanghai Jiao Tong UniversityShanghaiChina Center for Excellence in Brain Science and Intelligence Technology(CEBSIT) Chinese Academy of ScienceShanghaiChina Brain Science and Technology Research Center Shanghai Jiao Tong UniversityShanghaiChina

Background Pharmacological and conventional nonpharmacological treatments are only moderately effective in treatingeneralised anxiety disorder(GAD).Recently,repetitive transcranial magnetic stimulation(rTMS)has attracted interest because of its potential therapeutic value.Aim To investigate the efficacy and safety of rTMS treatment for GAD.Methods Literature studies published in English or Chinese were screened in 10 electronic databases up to 5 December 2018.The included studies'bias risk was assessed using Cochrane risk of bias assessment tool.Meta-analysis was performed to compute the standardised mean difference(SMD)and risk ratio(RR)along with its 95%Cis through using RevMan V.5.3.Heterogeneity was inspected by I2 and the χ2 test.We performed subgroup analysis and meta-regression to investigate heterogeneity.We used funnel plot to assess publication bias.We used the GRADE approach to assess the whole quality of evidence.Results Twenty-one studies,with a total sample size of 1481,were analysed.The risk of bias in most studies included is moderate,the majority of which are lacking of blinding methods of treatment allocation.The treatment had beneficial effects in the rTMS group compared with the control group in mean anxiety score(SMD=-0.68;95%Cl-0.89 to-0.46).None of the 21 studies included here reported severe adverse events.As for dropout rates,there are no statistically significant differences between the two groups(RR 1.14,95%Cl 0.72 to 1.82)or adverse events(RR 0.95,95%Cl 0.77 to 1.18).No particular influence on the heterogeneity of any variable was observed.The risk of publication bias was low.According to the GRADE approach,the evidence levels of primary outcome(treatment effects)and secondary outcomes(acceptability and safety)were rated as‘medium’.Conclusion The use of rTMS combined with medication treatment may have a significant positive anti-anxiety effect on patients with GAD.However,we should interpret the results cautiously due to the relatively high heterogeneity of the meta-analysis.Future hig

关键词： stimulation treatment magnetic

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富含β-葡聚糖松茸酸奶片的制备方法

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现代食品 2024年第3期30卷 73-77页

作者：孙秋崔慧如胡伟龙同溢堂药业有限公司福建漳州363200

研究一种成分中包含松茸的酸奶品的制备生产工艺,通过该方法生产出的产品含有较多的β-葡聚糖活性成分,能够满足亚健康人群的营养需求并具有松茸的特殊鲜美口感,助力于人们的高品质生活。选用松茸子实体,采用酿酒酵母发酵松茸,然后将其... 详细信息

研究一种成分中包含松茸的酸奶品的制备生产工艺,通过该方法生产出的产品含有较多的β-葡聚糖活性成分,能够满足亚健康人群的营养需求并具有松茸的特殊鲜美口感,助力于人们的高品质生活。选用松茸子实体,采用酿酒酵母发酵松茸,然后将其与牛奶、乳酸菌等益生菌通过二次发酵制备成酸奶原料,并通过实验筛选填充剂等辅料,采用干法制粒压制成片。经过两次发酵后,β-葡聚糖含量由原始松茸中的0.53%提高到1.09%,同时松茸丰富了酸奶口感。本工艺制成的酸奶片不仅保留了传统酸奶中的益生菌,同时松茸中的活性成分及β-葡聚糖也会对人体的健康发挥重要生理作用。

关键词：松茸 β-葡聚糖酿酒酵母发酵酸奶片

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Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-L-lysine-Assisted Magnetic Iron Oxide Nanoparticles

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Nano-Micro Letters 2015年第4期7卷 374-384页

作者： Xueqin Wang huiru Zhang Hongjuan Jing Liuqing cui College of Bioengineering Henan University of Technology

Cell labeling with magnetic iron oxide nanoparticles(IONPs)is increasingly a routine approach in the cellbased cancer treatment.However,cell labeling with magnetic IONPs and their leading effects on the biological properties of human lung carcinoma cells remain scarcely reported.Therefore,in the present study the magnetic c-Fe2O3nanoparticles(MNPs)were firstly synthesized and surface-modified with cationic poly-L-lysine(PLL)to construct the PLL-MNPs,which were then used to magnetically label human A549 lung cancer cells.Cell viability and proliferation were evaluated with propidium iodide/fluorescein diacetate double staining and standard 3-(4,5-dimethylthiazol-2-diphenyl-tetrazolium)bromide assay,and the cytoskeleton was immunocytochemically stained.The cell cycle of the PLL-MNPlabeled A549 lung cancer cells was analyzed using flow cytometry.Apoptotic cells were fluorescently analyzed with nuclear-specific staining after the PLL-MNP labeling.The results showed that the constructed PLL-MNPs efficiently magnetically labeled A549 lung cancer cells and that,at low concentrations,labeling did not affect cellular viability,proliferation capability,cell cycle,and apoptosis.Furthermore,the cytoskeleton in the treated cells was detected intact in comparison with the untreated counterparts.However,the results also showed that at high concentration(400 lg m L-1),the PLL-MNPs would slightly impair cell viability,proliferation,cell cycle,and apoptosis and disrupt the cytoskeleton in the treated A549 lung cancer cells.Therefore,the present results indicated that the PLL-MNPs at adequate concentrations can be efficiently used for labeling A549 lung cancer cells and could be considered as a feasible approach for magnetic targeted anti-cancer drug/gene delivery,targeted diagnosis,and therapy in lung cancer treatment.

关键词： Magnetic labeling Iron oxide nanoparticles Poly-L-lysine Human A549 lung cancer cells Cancer treatment

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Enhanced Microwave Absorption for High Filler Content Composite Molded from Polymer Coated Flaky Carbonyl Irons Modified by Silane Coupling Agents

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 42-51页

作者：崔正明 MA Guoqing WANG Mengqi LUO Chuangyu CHEN Zhihong MA huiru LI Qifan 李维 State Key Laboratory of Advanced Technology for Materials Synthesis and Processing School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China School of Science Wuhan University of TechnologyWuhan 430070China Department of Chemistry School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhan 430070China School of Physics and Electronic Science Hubei UniversityWuhan 430062China

A microwave absorbing sheet with a high complex permeability and a relatively low complex permittivity is obtained by molding of the densely coated flaky carbonyl iron particles(FCIPs)by styrenebutadiene-styrene block copolymer(SBS)in the assistance of coupling agent modification.Direct molding of the core-shell FCIPs without adding extra binder results in a large permeability due to the high filling ratio(55vol%)of absorbents.Importantly,the permittivity is well suppressed by the dense insulate polymer shell on the FCIPs,avoiding the severe impedance mismatch problem of the high filler content microwave absorbing materials.Investigations show that modifying the surface of FCIPs by proper amount of silane coupling agent is critical for the coating quality of the SBS shell,which is verified by resistivity and corrosion current density measurements,and can be interpreted by improved interfacial compatibility between the modified FCIPs and SBS.The obtained microwave absorbing sheet shows a minimum reflection loss of-38.74 dB at 1.57 GHz and has an effective absorption bandwidth from 1.1 to 2.3 GHz at a relatively small thickness of 2 mm.

关键词： microwave absorber coating quality magnetic permeability permittivity low frequency

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Paternally imprinted LATE-FLOWERING2 transcription factor contributes to paternal-excess interploidy hybridization barriers in wheat∞

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Journal of Integrative Plant Biology 2023年第12期65卷 2587-2603页

作者： Guanghui Yang Man Feng Kuohai Yu Guangxian cui Yan Zhou Lv Sun Lulu Gao Yumei Zhang huiru Peng Yingyin Yao Zhaorong Hu Vincenzo Rossi Ive De Smet Zhongfu Ni Qixin Sun Mingming Xin State Key Laboratory for Agrobiotechnology Key Laboratory of Crop Heterosis Utilization(MOE)Beijing Key Laboratory of Crop Genetic ImprovementChina Agricultural UniversityBeijing 100193China Qingdao Agricultural University Qingdao 266109China Council for Agricultural Research and Economics Research Centre for Cereal and Industrial CropsBergamo 24126Italy Department of Plant Biotechnology and Bioinformatics Ghent UniversityGhent B‐9052Belgium VIB Center for Plant Systems Biology Ghent B‐9052Belgium

Interploidy hybridization between hexaploid and tetraploid genotypes occurred repeatedly during genomic introgression events throughout wheat evolution,and is commonly employed in wheat breeding programs.Hexaploid wheat usually serves as maternal parent because the reciprocal cross generates progeny with severe defects and poor seed germination,but the underlying mechanism is poorly understood.Here,we performed detailed analysis of phenotypic variation in endosperm between two interploidy reciprocal crosses arising from tetraploid(Triticum durum,AABB)and hexaploid wheat(Triticum aestivum,AABBDD).In the paternal‐versus the maternal‐excess cross,the timing of endosperm cellularization was delayed and starch granule accumulation in the endosperm was repressed,causing reduced germination percentage.The expression profiles of genes involved in nutrient metabolism differed strongly between these endosperm types.Furthermore,expression patterns of parental alleles were dramatically disturbed in interploidy versus intraploidy crosses,leading to increased number of imprinted genes.The endosperm‐specific TaLFL2 showed a paternally imprinted expression pattern in interploidy crosses partially due to allele‐specific DNA methylation.Paternal TaLFL2 binds to and represses a nutrient accumulation regulator TaNAC019,leading to reduced storage protein and starch accumulation during endosperm development in paternal‐excess cross,as confirmed by interploidy crosses between tetraploid wild‐type and clustered regularly interspaced palindromic repeats(CRISPR)–CRISPR‐associated protein 9 generated hexaploid mutants.These findings reveal a contribution of genomic imprinting to paternal‐excess interploidy hybridization barriers during wheat evolution history and explains why experienced breeders preferentially exploit maternal‐excess interploidy crosses in wheat breeding programs.

关键词： imprinting interploidy cross wheat

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Multi-scale variability of water discharge and sediment load into the Bohai Sea from 1950 to 2011

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Journal of Geographical Sciences 2015年第1期25卷 85-100页

作者： REN huiru LI Guosheng cui Linlin HE Lei Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research CAS Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

This paper examines the changes in the time series of water discharge and sediment load of the Yellow River into the Bohai Sea. To determine the characteristics of abrupt changes and multi-scale periods of water discharge and sediment load, data from Lijin station were analyzed, and the resonance periods were then calculated. The Mann-Kendall test, order clustering, power-spectrum, and wavelet analysis were used to observe water discharge and sediment load into the sea over the last 62 years. The most significant abrupt change in water discharge into the sea occurred in 1985, and an abrupt change in sediment load happened in the same year. Significant decreases of 64.6% and 73.8% were observed in water discharge and sediment load, respectively, before 1985. More significant abrupt changes in water discharge and sediment load were observed in 1968 and 1996. The characteristics of water discharge and sediment load into the Bohai Sea show periodic oscillation at inter-annual and decadal scales. The main periods of water discharge are 9.14 years and 3.05 years, whereas the main periods of sediment load are 10.67 years, 4.27 years, and 2.78 years. The significant resonance periods between water discharge and sediment load are observed at the following temporal scales： 2.86 years, 4.44 years, and 13.33 years. Water discharge and sediment load started to decrease after 1970 and has decreased significantly since 1985 for several reasons. Firstly, the precipitation of the Yellow River drainage area has reduced since 1970. Secondly, large-scale human activities, such as the building of reservoirs and floodgates, have increased. Thirdly, water and soil conservation have taken effect since 1985.

关键词： water discharge sediment load resonance periods abrupt changes multi-scale periods Yellow River Bohai Sea

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