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Paleontology Knowledge Graph for Data-Driven Discovery

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Journal of Earth Science 2024年第3期35卷 1024-1034页

作者： Yiying Deng Sicun Song Junxuan Fan Mao Luo Le Yao Shaochun Dong Yukun Shi Linna Zhang Yue Wang Haipeng Xu huiqing Xu Yingying Zhao Zhaohui pan Zhangshuai Hou Xiaoming Li Boheng Shen Xinran Chen Shuhan Zhang Xuejin Wu Lida Xing Qingqing Liang Enze Wang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Centre for Research and Education on Biological Evolution and Environment Nanjing UniversityNanjing 210023China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China

A knowledge graph(KG)is a knowledge base that integrates and represents data based on a graph-structured data model or *** have made efforts to construct geosciencerelated KGs to overcome semantic heterogeneity and facilitate knowledge representation,data integration,and text ***,there is currently no comprehensive paleontology KG or data-driven discovery based on *** this study,we constructed a two-layer model to represent the ordinal hierarchical structure of the paleontology KG following a top-down construction *** ontology containing 19365 concepts has been defined up to *** this basis,we derived the synonymy list based on the paleontology KG and designed corresponding online functions in the OneStratigraphy database to showcase the use of the KG in paleontological research.

关键词： paleontology knowledge graph ontology synonymy list OneStratigraphy big data ge-ology.

Immunoprotection Effects of Radix Pseudostellariae Fibrous Root Extraction (RPFRE) on Mice and Its Relationship with Antioxidant Function

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Animal Husbandry and Feed Science 2022年第1期14卷 32-38页

作者： Zhang Yanda pan huiqing Zhao Qi Ma Yufang Fujian Beidi Pharmaceutical Co. Ltd.Ningle 355300China University Key Laboratory for Integrated Chinese Traditional and Western Veterinary Medicine and Animal Healthcare in Fujian Province Fujian Agriculture and Forestry UniversityFuzhou 350002China

[Objective] The paper was to explore the immunoprotection effects of Radix Pseudostellariae fibrous root extraction(RPFRE) on experi-mental mice and its relationship with antioxidant function. [Method] KM male mice were randomly divided into 4 groups based on RPFRE gradient concentration, and the immune function indexes and antioxidant indexes of mice were determined at 14 d post intragastric administration of *** remaining mice in the experimental group were intraperitoneally injected with cyclophosphamide(CY) from the 15^(th) to 17^(th) day, and samples were collected to determine the above indexes on the 18^(th) day. [Result] Intragastric administration of RPFRE for 14 d improved the spleen index,thymus index, T/B cell stimulation index and total antioxidant capacity(T-AOC) of normal mice, and extremely increased the thymus index and TAOC(P<0.01). The T-AOC had extremely positive correlation with the spleen index, thymus index and B cell stimulation index( P<0.01), and had significantly positive correlation with the T cell stimulation index(P<0.05). From the 15^(th) to 17^(th) day of the experiment, the immune function indexes and antioxidant indexes of mice decreased and the malondialdehyde(MDA) content increased. The experimental groups of 0.1, 0.2 and 0.4 g/kg RPFRE promoted the immunoprotection and antioxidant effect of mice. RPFRE concentration had extremely positive correlation with 4 indexes of immune function and antioxidant indexes T-AOC and SOD(P<0.01), but had extremely negative correlation with MDA(P<0.01). There was a significantly positive correlation between immune function indexes and antioxidant indexes of mice after CY intervention( P<0.05 or P<0.01). [Conclusion] RPFRE can improve the immune function indexes and antioxidant indexes of normal mice and immunosuppressed mice and has immunopro-tection effect on immunosuppressed mice, and there is a significant correlation between immune function indexes and antioxidant indexes of mice.

关键词： Radix Pseudostellariae fibrous root(RPFR) Extract Mice Immune Antioxidant Correlation

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10 Gsps数字三维示波器关键技术研究

仪器仪表学报 2012年第12期33卷 2688-2696页

作者：叶芃曾浩潘卉青曹玲电子科技大学自动化工程学院成都611731 工业和信息化部电子工业标准化研究院北京100007

数字三维示波器不仅能捕获和显示信号的时间-幅度信息,而且能够以不同的辉度等级或颜色显示事件出现概率。系统采用自适应非均匀综合校正方法实现10 Gsps实时采样;采用实时数字频率补偿方法实现带宽1 GHz模拟通道;采用多体交叉三维映射... 详细信息

数字三维示波器不仅能捕获和显示信号的时间-幅度信息,而且能够以不同的辉度等级或颜色显示事件出现概率。系统采用自适应非均匀综合校正方法实现10 Gsps实时采样;采用实时数字频率补偿方法实现带宽1 GHz模拟通道;采用多体交叉三维映射体系实现500 000 wfms/s波形捕获率。运用这些关键技术研制了工程样机,并给出整机测试结果。实验表明该系统的各项技术指标居于国内领先,为高性能数字三维示波器奠定了技术基础。

关键词：数字三维示波器自适应非均匀综合校正频域补偿波形捕获率

BAT评分对自发性脑出血患者预后的预测价值研究

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中华急诊医学杂志 2022年第2期31卷 241-246页

作者：邢晶晶俞忠王成雨刘玲何宗应潘惠卿叶胜皖南医学院第二附属医院急诊医学科芜湖241000 皖南医学院第二附属医院神经外科芜湖241000

目的研究BAT评分对自发性脑出血(spontaneous intracerebral hemorrhage,sICH)患者预后的预测价值。方法回顾性分析2018年1月至2020年12月皖南医学院第二附属医院急诊就诊的sICH患者93例,根据患者出院后3个月格拉斯哥预后评分(glasgow o... 详细信息

目的研究BAT评分对自发性脑出血(spontaneous intracerebral hemorrhage,sICH)患者预后的预测价值。方法回顾性分析2018年1月至2020年12月皖南医学院第二附属医院急诊就诊的sICH患者93例,根据患者出院后3个月格拉斯哥预后评分(glasgow outcome score,GOS)分为预后良好组(34例)和预后不良组(59例),比较两组患者基本资料、入院生命体征、实验室指标、美国国立研究院卒中量表(national institute of health stroke scale,NIHSS)评分、BAT评分等临床资料,采用多因素Logistic回归分析影响sICH患者预后不良的危险因素;绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析BAT评分对sICH患者预后不良的预测价值。结果预后不良组患者入院收缩压、白细胞计数、高血压病并发症、急诊BAT评分及NIHSS评分均显著高于预后良好组(P<0.05);多因素Logistic回归分析结果显示,入院时收缩压(OR=1.024,95%CI:1.002~1.046,P=0.035)、急诊BAT评分(OR=2.640,95%CI:1.445~4.825,P=0.002)可准确预测sICH患者预后不良;ROC曲线分析显示,BAT评分预测sICH患者预后不良的ROC曲线下面积(area under ROC curve,AUC)为0.792,敏感度为79.3%,特异度为76.5%,收缩压预测sICH患者预后不良的AUC为0.701,敏感度为55.2%,特异度为88.2%,BAT评分联合收缩压预测sICH患者预后不良的AUC为0.835。结论BAT评分、入院收缩压能更准确地预测sICH患者3个月预后不良,二者联合预测sICH患者3个月预后不良的效能更高。

关键词：自发性脑出血急诊 BAT评分收缩压 ROC曲线预后

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腔隙性脑梗死后抑郁风险预测模型的构建

中华急诊医学杂志 2023年第10期32卷 1390-1396页

作者：方舟叶胜李韦嘉邢晶晶王兵潘惠卿许利周佩莉四川大学大学华西医院急诊科成都610000 皖南医学院第二附属医院急诊科芜湖241000 皖南医学院临床医学院芜湖241000 皖南医学院第二附属医院神经内科芜湖241000

目的本研究探讨腔隙性脑梗死患者出院3月后发生抑郁的危险因素,构建风险预测模型。方法回顾性分析2021年1月1日至2022年1月1日在皖南医学院第二附属医院诊治的237例腔隙性脑梗死患者临床资料,收集入院时人口学数据、实验室指标和心血管... 详细信息

目的本研究探讨腔隙性脑梗死患者出院3月后发生抑郁的危险因素,构建风险预测模型。方法回顾性分析2021年1月1日至2022年1月1日在皖南医学院第二附属医院诊治的237例腔隙性脑梗死患者临床资料,收集入院时人口学数据、实验室指标和心血管疾病危险因素,使用患者健康问卷(patient health questionnaire-9,PHQ-9)评分评估出院3月后患者的脑卒中后抑郁(post strokedepression,PSD)风险,采用单因素和多因素Logistic回归分析确定抑郁风险的独立危险因素,基于上述危险因素构建预测模型,采用受试者工.作特征(receiver operating characteristic,ROC)曲线评估预测效能,采用校准曲线及决策曲线衡量预测模型的临床适用性。结果54例腔隙性脑梗死患者(22.80%)在出院3月后出现抑郁症状,多因素Logistic回归显示,女性(OR=2.952,95%CI:1.403~6.213,P=0.004)、胱抑素C(OR=2.964,95%CI:1.222~7.191,P=0.016)、载脂蛋白B(OR=4.836,95%CI:1.533~15.258,P=0.007)是腔隙性脑梗死患者出院3月后出现PSD的独立危险因素,日常生活能力(activityof dailyliving,ADL)评分(OR=0.939,95%CI:0.915~0.964,P<0.001)是腔隙性脑梗死患者PSD的保护性因素。预测模型曲线下面积(area underthe curve,AUC)为0.779(95%CI:0.703~0.855,P<0.001),优于其他预测因素。Hosmer-LemeshowH检验显示模型校准良好(P=0.588),此外,决策曲线分析预测模型具有良好的临床适用性。结论基于性别、实验室指标及日程生活能力评分构建的预测模型可用于评估腔隙性脑梗死患者出院3月后PSD风险,具有良好的预测效能和临床适用性,值得临床推广应用。

关键词：腔隙性脑梗死预测模型卒中后抑郁日常生活能力载脂蛋白B 胱抑素C 预后曲线下面积

Effects of Probiotics on Breeding Environment and Intestinal Microorganisms of Livestock and Poultry

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Animal Husbandry and Feed Science 2022年第1期14卷 50-53页

作者： pan huiqing Zeng Yan Zhang Yanda Shi Shaohua Yang Rongping Zhao Qi Ningde Enterprise Technology Center of Fujian Beidi Pharmaceutical Co. Ltd.Ningde 355300China Ningde Zherong Environmental Monitoring Station Ningde 355300China Institute of Animal Science and Veterinary Medicine Fujian Academy of A gricultural SciencesFuzhou 350013China

[Objectives] The paper was to study the effects of probiotics on breeding environment of livestock and poultry and intestinal microorgan-isms of breeding animals. [Method] Chicken houses and hog houses were selected as the research objects. The breeding house supplemented with basal diet was used as the control group;the breeding house sprayed with probiotics product 1 was experimental group 1(exogenous treatment);the basal diet mixed with probiotics product 2 and drinking water mixed with product 3 was experimental group 2(endogenous treatment);and the com-bination of the two experimental groups was experimental group 3. [Results] Experimental groups 1 and 2 reduced the concentration of ammonia in hog houses and chicken houses, and the effect of experimental group 2 was better than that of experimental group 1. Experimental group 3 had the best effect, which significantly reduced the ammonia concentration in hog houses and chicken houses by 28.67% and 34.09%, respectively, and the average ammonia concentration outside the house within the range of 100-300 m was less than 2 mg/m^(3). Moreover, it significantly increased the number of intestinal lactobacillus and reduced the number of Escherichia coli. [Conclusions] Probiotics can effectively reduce the ammonia concentration in livestock and poultry breeding environment, and improve the intestinal microbial structure of breeding animals. The technology of spraying exogenous probiotics combined with the use of content-derived probiotics has great potential for popularization and application.

关键词： Probiotics Livestock and poultry Breeding environment Intestinal microorganisms

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一种并行系统时基误差自适应估计方法

仪器仪表学报 2009年第11期30卷 2268-2272页

作者：潘卉青田书林曾浩叶芃电子科技大学自动化工程学院成都611731

在并行采集系统中,通道间时基延迟的不一致性严重降低了系统性能。针对时间延迟估计算法多基于时域实现,需进行复杂的插值运算以获取采样间隔非整数倍时基延迟的问题,本文基于时基误差的频域模型,将通道间的误差信号建模为自适应滤波器... 详细信息

在并行采集系统中,通道间时基延迟的不一致性严重降低了系统性能。针对时间延迟估计算法多基于时域实现,需进行复杂的插值运算以获取采样间隔非整数倍时基延迟的问题,本文基于时基误差的频域模型,将通道间的误差信号建模为自适应滤波器,提出了一种无需插值的估计算法。计算机仿真及实际应用验证结果表明,该方法能动态跟踪时基延迟变化,有效地估计通道时延,具有迭代次数少、运算量小、实时性高的特点。

关键词：数据采集时间交替采样时基延迟频域变换自适应

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藏药烈香杜鹃质量标准提高研究

甘肃中医药大学学报 2022年第4期39卷 23-27页

作者：曹盼魏学明王秉鹏潘慧清张樱山甘肃中医药大学药学院甘肃兰州730101 甘肃省中药现代制药工程研究院甘肃兰州730010

目的建立藏药烈香杜鹃的质量标准。方法采用薄层色谱(TLC)法对藏药烈香杜鹃进行定性鉴别,采用高效液相色谱(HPLC)法对烈香杜鹃中的金丝桃苷进行含量测定,参照《中华人民共和国药典(四部)》2015年版测定烈香杜鹃中水分、灰分、浸出物... 详细信息

目的建立藏药烈香杜鹃的质量标准。方法采用薄层色谱(TLC)法对藏药烈香杜鹃进行定性鉴别,采用高效液相色谱(HPLC)法对烈香杜鹃中的金丝桃苷进行含量测定,参照《中华人民共和国药典(四部)》2015年版测定烈香杜鹃中水分、灰分、浸出物含量。色谱柱为Agilent Eclipse Plus C(250.0 mm×4.6 mm,5μm),流动相为甲醇(A)-0.1%磷酸(B),梯度洗脱,流速1.0 m L/min,进样量10μL,柱温30℃,检测波长254 nm。结果薄层鉴别斑点清晰,分离度好;金丝桃苷回归方程为Y=27 273.04X+30 964.16,r=1.0000,线性范围24.60~81.99μg;烈香杜鹃水分不得超过8.00%,总灰分不得超过10.00%,酸不溶性灰分不得超过4.00%,醇溶性浸出物不得低于16.00%。结论建立的方法简便、易操作,结果准确,能有效控制烈香杜鹃的药材质量。

关键词：烈香杜鹃金丝桃苷薄层色谱高效液相色谱含量测定

响应面法优化低高级醇高氨基氮的黄酒酿造工艺

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食品与生物技术学报 2018年第5期37卷 535-541页

作者：曹钰潘慧青陆健谢广发江南大学工业生物技术教育部重点实验室江苏无锡214122 江南大学生物工程学院江苏无锡214122 粮食发酵工艺与技术国家工程实验室江南大学江苏无锡214122 中国绍兴黄酒集团有限公司国家黄酒工程技术研究中心浙江绍兴312000

高级醇含量和氨基酸态氮含量都是成品黄酒中的重要理化指标,且酒中高级醇的形成与氨基酸态氮代谢密切相关,酿造工艺条件对两者的影响复杂而且可能存在交互作用。在前期单因素实验的基础上,选取前酵温度、酵母接种量及后酵温度进行Box-Be... 详细信息

高级醇含量和氨基酸态氮含量都是成品黄酒中的重要理化指标,且酒中高级醇的形成与氨基酸态氮代谢密切相关,酿造工艺条件对两者的影响复杂而且可能存在交互作用。在前期单因素实验的基础上,选取前酵温度、酵母接种量及后酵温度进行Box-Behnken响应面实验,通过响应面回归分析,确定了低高级醇、高氨基酸态氮的最优酿造工艺条件为:前酵温度30℃,酵母接种体积分数为3%,后酵温度为13℃。在此条件下酿造的黄酒中高级醇质量浓度为355.43mg/L,氨基酸态氮质量浓度0.98 g/L,与优化前相比高级醇降低了12.30%,氨基酸态氮提高了8.90%,有助于提高黄酒的品质。

关键词：黄酒高级醇氨基态氮响应面分析法